Quercetin, luteolin and epigallocatechin gallate alleviate TXNIP and NLRP3-mediated inflammation and apoptosis with regulation of AMPK in endothelial cells

European Journal of Pharmacology

Volumn 745, Issue , 2015, Pages 59-68

  Wu, Jianjun ^a,b   Xu, Xiaoshan ^a,b   Li, Yi ^a,b   Kou, Junping ^a   Huang, Fang ^a,b   Liu, Baolin ^a,b   Liu, Kang ^a,b  

^a CHINA PHARMACEUTICAL UNIVERSITY   (China)

^b NANJING UNIVERSITY OF CHINESE MEDICINE   (China)

Author keywords

Endoplasmic reticulum stress; Endothelial cells; Flavonoids; NLRP3; TXNIP

Indexed keywords

ADENYLATE KINASE; CASPASE 3; CRYOPYRIN; ENDOTHELIAL NITRIC OXIDE SYNTHASE; EPIGALLOCATECHIN GALLATE; INFLAMMASOME; INTERLEUKIN 1BETA; LUTEOLIN; MESSENGER RNA; NITRIC OXIDE; PALMITIC ACID; QUERCETIN; REACTIVE OXYGEN METABOLITE; THIOREDOXIN INTERACTING PROTEIN; VASCULAR CELL ADHESION MOLECULE 1; CARRIER PROTEIN; CATECHIN; ENDOTHELIN 1; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; NLRP3 PROTEIN, HUMAN; PROTEIN KINASE INHIBITOR; TXNIP PROTEIN, HUMAN;

ANTIINFLAMMATORY ACTIVITY; APOPTOSIS; ARTICLE; CELL PROTECTION; CONTROLLED STUDY; CYTOKINE PRODUCTION; DOWN REGULATION; DRUG EFFECT; ENDOPLASMIC RETICULUM STRESS; ENDOTHELIAL DYSFUNCTION; ENDOTHELIUM CELL; ENOS GENE; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; ENZYME REGULATION; ET 1 GENE; GENE; GENE EXPRESSION REGULATION; HUMAN; HUMAN CELL; MITOCHONDRIAL MEMBRANE POTENTIAL; OXIDATIVE STRESS; PROTEIN EXPRESSION; ANALOGS AND DERIVATIVES; ANTAGONISTS AND INHIBITORS; CELL LINE; DRUG EFFECTS; GENE EXPRESSION; GENETICS; INFLAMMATION; METABOLISM; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; UMBILICAL VEIN ENDOTHELIAL CELL;

AMP-ACTIVATED PROTEIN KINASES; APOPTOSIS; CARRIER PROTEINS; CATECHIN; CELL LINE; ENDOPLASMIC RETICULUM STRESS; ENDOTHELIAL CELLS; ENDOTHELIN-1; GENE EXPRESSION; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; HUMANS; INFLAMMASOMES; INFLAMMATION; LUTEOLIN; OXIDATIVE STRESS; PALMITIC ACID; PROTEIN KINASE INHIBITORS; QUERCETIN;

EID: 84918802345     PISSN: 00142999     EISSN: 18790712     Source Type: Journal    
DOI: 10.1016/j.ejphar.2014.09.046     Document Type: Article

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