메뉴 건너뛰기




Volumn 28, Issue 10, 2014, Pages 4394-4407

Down-regulation of MIF by NFκB under hypoxia accelerated neuronal loss during stroke

Author keywords

Caspase 3; Macrophage migration inhibitory factor; Nuclear factor B

Indexed keywords

CASPASE 3; HYDROGEN PEROXIDE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MACROPHAGE MIGRATION INHIBITION FACTOR; ISOMERASE; MIF PROTEIN, MOUSE;

EID: 84907710316     PISSN: 08926638     EISSN: 15306860     Source Type: Journal    
DOI: 10.1096/fj.14-253625     Document Type: Article
Times cited : (45)

References (64)
  • 2
    • 65549098614 scopus 로고    scopus 로고
    • Apoptotic mechanisms after cerebral ischemia
    • Broughton, B. R., Reutens, D. C., and Sobey, C. G. (2009) Apoptotic mechanisms after cerebral ischemia. Stroke 40, e331-339
    • (2009) Stroke , vol.40 , pp. e331-339
    • Broughton, B.R.1    Reutens, D.C.2    Sobey, C.G.3
  • 3
    • 79960141471 scopus 로고    scopus 로고
    • The immunology of stroke: From mechanisms to translation
    • Iadecola, C., and Anrather, J. (2011) The immunology of stroke: from mechanisms to translation. Nat. Med. 17, 796-808
    • (2011) Nat. Med. , vol.17 , pp. 796-808
    • Iadecola, C.1    Anrather, J.2
  • 4
    • 0032845121 scopus 로고    scopus 로고
    • Ischemic cell death in brain neurons
    • Lipton, P. (1999) Ischemic cell death in brain neurons. Physiol. Rev. 79, 1431-1568
    • (1999) Physiol. Rev. , vol.79 , pp. 1431-1568
    • Lipton, P.1
  • 6
    • 73949090103 scopus 로고    scopus 로고
    • Inflammation in neurodegenerative diseases
    • Amor, S., Puentes, F., Baker, D., and van der Valk, P. (2010) Inflammation in neurodegenerative diseases. Immunology 129, 154-169
    • (2010) Immunology , vol.129 , pp. 154-169
    • Amor, S.1    Puentes, F.2    Baker, D.3    Van Der Valk, P.4
  • 7
    • 79959999864 scopus 로고    scopus 로고
    • Increased brain injury and worsened neurological outcome in interleukin-4 knockout mice after transient focal cerebral ischemia
    • Xiong, X., Barreto, G. E., Xu, L., Ouyang, Y. B., Xie, X., and Giffard, R. G. (2011) Increased brain injury and worsened neurological outcome in interleukin-4 knockout mice after transient focal cerebral ischemia. Stroke 42, 2026-2032
    • (2011) Stroke , vol.42 , pp. 2026-2032
    • Xiong, X.1    Barreto, G.E.2    Xu, L.3    Ouyang, Y.B.4    Xie, X.5    Giffard, R.G.6
  • 8
    • 79551633839 scopus 로고    scopus 로고
    • Blocking TLR2 in vivo protects against accumulation of inflammatory cells and neuronal injury in experimental stroke
    • Ziegler, G., Freyer, D., Harhausen, D., Khojasteh, U., Nietfeld, W., and Trendelenburg, G. (2011) Blocking TLR2 in vivo protects against accumulation of inflammatory cells and neuronal injury in experimental stroke. J. Cereb. Blood Flow Metab. 31, 757-766
    • (2011) J. Cereb. Blood Flow Metab. , vol.31 , pp. 757-766
    • Ziegler, G.1    Freyer, D.2    Harhausen, D.3    Khojasteh, U.4    Nietfeld, W.5    Trendelenburg, G.6
  • 9
    • 0038506990 scopus 로고    scopus 로고
    • Effects of a selective CD11b/CD18 antagonist and recombinant human tissue plasminogen activator treatment alone and in combination in a rat embolic model of stroke
    • Zhang, L., Zhang, Z. G., Zhang, R. L., Lu, M., Krams, M., and Chopp, M. (2003) Effects of a selective CD11b/CD18 antagonist and recombinant human tissue plasminogen activator treatment alone and in combination in a rat embolic model of stroke. Stroke 34, 1790-1795
    • (2003) Stroke , vol.34 , pp. 1790-1795
    • Zhang, L.1    Zhang, Z.G.2    Zhang, R.L.3    Lu, M.4    Krams, M.5    Chopp, M.6
  • 10
    • 26444459796 scopus 로고    scopus 로고
    • Neuroinflammation and both cytotoxic and vasogenic edema are reduced in interleukin-1 type 1 receptor-deficient mice conferring neuroprotection
    • Lazovic, J., Basu, A., Lin, H. W., Rothstein, R. P., Krady, J. K., Smith, M. B., and Levison, S. W. (2005) Neuroinflammation and both cytotoxic and vasogenic edema are reduced in interleukin-1 type 1 receptor-deficient mice conferring neuroprotection. Stroke 36, 2226-2231
    • (2005) Stroke , vol.36 , pp. 2226-2231
    • Lazovic, J.1    Basu, A.2    Lin, H.W.3    Rothstein, R.P.4    Krady, J.K.5    Smith, M.B.6    Levison, S.W.7
  • 11
    • 0142259734 scopus 로고    scopus 로고
    • Macrophage migration inhibitory factor: A regulator of innate immunity
    • Calandra, T., and Roger, T. (2003) Macrophage migration inhibitory factor: a regulator of innate immunity. Nat. Rev. Immunol. 3, 791-800
    • (2003) Nat. Rev. Immunol. , vol.3 , pp. 791-800
    • Calandra, T.1    Roger, T.2
  • 15
    • 0037039308 scopus 로고    scopus 로고
    • Macrophage migration inhibitory factor (MIF) sustains macrophage proinflammatory function by inhibiting p53: Regulatory role in the innate immune response
    • Mitchell, R. A., Liao, H., Chesney, J., Fingerle-Rowson, G., Baugh, J., David, J., and Bucala, R. (2002) Macrophage migration inhibitory factor (MIF) sustains macrophage proinflammatory function by inhibiting p53: regulatory role in the innate immune response. Proc. Natl. Acad. Sci. U. S. A. 99, 345-350
    • (2002) Proc. Natl. Acad. Sci. U. S. A. , vol.99 , pp. 345-350
    • Mitchell, R.A.1    Liao, H.2    Chesney, J.3    Fingerle-Rowson, G.4    Baugh, J.5    David, J.6    Bucala, R.7
  • 16
    • 38349013153 scopus 로고    scopus 로고
    • The role of macrophage migration inhibitory factor in the cascade of events leading to reperfusioninduced inflammatory injury and lethality
    • Amaral, F. A., Fagundes, C. T., Guabiraba, R., Vieira, A. T., Souza, A. L., Russo, R. C., Soares, M. P., Teixeira, M. M., and Souza, D. G. (2007) The role of macrophage migration inhibitory factor in the cascade of events leading to reperfusioninduced inflammatory injury and lethality. Am. J. Pathol. 171, 1887-1893
    • (2007) Am. J. Pathol. , vol.171 , pp. 1887-1893
    • Amaral, F.A.1    Fagundes, C.T.2    Guabiraba, R.3    Vieira, A.T.4    Souza, A.L.5    Russo, R.C.6    Soares, M.P.7    Teixeira, M.M.8    Souza, D.G.9
  • 17
    • 38749137749 scopus 로고    scopus 로고
    • Macrophage migration inhibitory factor stimulates AMP-activated protein kinase in the ischaemic heart
    • Miller, E. J., Li, J., Leng, L., McDonald, C., Atsumi, T., Bucala, R., and Young, L. H. (2008) Macrophage migration inhibitory factor stimulates AMP-activated protein kinase in the ischaemic heart. Nature 451, 578-582
    • (2008) Nature , vol.451 , pp. 578-582
    • Miller, E.J.1    Li, J.2    Leng, L.3    McDonald, C.4    Atsumi, T.5    Bucala, R.6    Young, L.H.7
  • 18
    • 79952369026 scopus 로고    scopus 로고
    • Macrophage migration inhibitory factor provides cardioprotection during ischemia/reperfusion by reducing oxidative stress
    • Koga, K., Kenessey, A., Powell, S., Sison, C. P., Miller, E. J., and Ojamaa, K. (2011) Macrophage migration inhibitory factor provides cardioprotection during ischemia/reperfusion by reducing oxidative stress. Antioxid. Redox Signal. 14, 1191-1202
    • (2011) Antioxid. Redox Signal. , vol.14 , pp. 1191-1202
    • Koga, K.1    Kenessey, A.2    Powell, S.3    Sison, C.P.4    Miller, E.J.5    Ojamaa, K.6
  • 19
    • 0141446025 scopus 로고    scopus 로고
    • A 16-residue peptide fragment of macrophage migration inhibitory factor, MIF-(50-65), exhibits redox activity and has MIFlike biological functions
    • Nguyen, M. T., Beck, J., Lue, H., Funfzig, H., Kleemann, R., Koolwijk, P., Kapurniotu, A., and Bernhagen, J. (2003) A 16-residue peptide fragment of macrophage migration inhibitory factor, MIF-(50-65), exhibits redox activity and has MIFlike biological functions. J. Biol. Chem. 278, 33654-33671
    • (2003) J. Biol. Chem. , vol.278 , pp. 33654-33671
    • Nguyen, M.T.1    Beck, J.2    Lue, H.3    Funfzig, H.4    Kleemann, R.5    Koolwijk, P.6    Kapurniotu, A.7    Bernhagen, J.8
  • 22
    • 79959642545 scopus 로고    scopus 로고
    • Lack of macrophage migration inhibitory factor in mice does not affect hallmarks of the inflammatory/immune response during the first week after stroke
    • Inacio, A. R., Bucala, R., and Deierborg, T. (2011) Lack of macrophage migration inhibitory factor in mice does not affect hallmarks of the inflammatory/immune response during the first week after stroke. J. Neuroinflammation 8, 75
    • (2011) J. Neuroinflammation , vol.8 , pp. 75
    • Inacio, A.R.1    Bucala, R.2    Deierborg, T.3
  • 23
    • 79953269823 scopus 로고    scopus 로고
    • Macrophage migration inhibitory factor promotes cell death and aggravates neurologic deficits after experimental stroke
    • Inacio, A. R., Ruscher, K., Leng, L., Bucala, R., and Deierborg, T. (2011) Macrophage migration inhibitory factor promotes cell death and aggravates neurologic deficits after experimental stroke. J. Cereb. Blood Flow Metab. 31, 1093-1106
    • (2011) J. Cereb. Blood Flow Metab. , vol.31 , pp. 1093-1106
    • Inacio, A.R.1    Ruscher, K.2    Leng, L.3    Bucala, R.4    Deierborg, T.5
  • 24
    • 0027972744 scopus 로고
    • Cloning the human gene for macrophage migration inhibitory factor (MIF)
    • Paralkar, V., and Wistow, G. (1994) Cloning the human gene for macrophage migration inhibitory factor (MIF). Genomics 19, 48-51
    • (1994) Genomics , vol.19 , pp. 48-51
    • Paralkar, V.1    Wistow, G.2
  • 26
    • 0028305693 scopus 로고
    • The macrophage is an important and previously unrecognized source of macrophage migration inhibitory factor
    • Calandra, T., Bernhagen, J., Mitchell, R. A., and Bucala, R. (1994) The macrophage is an important and previously unrecognized source of macrophage migration inhibitory factor. J. Exp. Med. 179, 1895-1902
    • (1994) J. Exp. Med. , vol.179 , pp. 1895-1902
    • Calandra, T.1    Bernhagen, J.2    Mitchell, R.A.3    Bucala, R.4
  • 27
    • 0032230294 scopus 로고    scopus 로고
    • Transcriptional activation of the macrophage migration-inhibitory factor gene by the corticotropin-releasing factor is mediated by the cyclic adenosine 3=,5=- monophosphate responsive element-binding protein CREB in pituitary cells
    • Waeber, G., Thompson, N., Chautard, T., Steinmann, M., Nicod, P., Pralong, F. P., Calandra, T., and Gaillard, R. C. (1998) Transcriptional activation of the macrophage migration-inhibitory factor gene by the corticotropin-releasing factor is mediated by the cyclic adenosine 3=,5=- monophosphate responsive element-binding protein CREB in pituitary cells. Mol. Endocrinol. 12, 698-705
    • (1998) Mol. Endocrinol. , vol.12 , pp. 698-705
    • Waeber, G.1    Thompson, N.2    Chautard, T.3    Steinmann, M.4    Nicod, P.5    Pralong, F.P.6    Calandra, T.7    Gaillard, R.C.8
  • 28
    • 33746369144 scopus 로고    scopus 로고
    • Dual regulation of macrophage migration inhibitory factor (MIF) expression in hypoxia by CREB and HIF-1
    • Baugh, J. A., Gantier, M., Li, L., Byrne, A., Buckley, A., and Donnelly, S. C. (2006) Dual regulation of macrophage migration inhibitory factor (MIF) expression in hypoxia by CREB and HIF-1. Biochem. Biophys. Res. Commun. 347, 895-903
    • (2006) Biochem. Biophys. Res. Commun. , vol.347 , pp. 895-903
    • Baugh, J.A.1    Gantier, M.2    Li, L.3    Byrne, A.4    Buckley, A.5    Donnelly, S.C.6
  • 30
    • 0026970404 scopus 로고
    • Nuclear factor kappa B: An oxidative stress-responsive transcription factor of eukaryotic cells (a review)
    • Schreck, R., Albermann, K., and Baeuerle, P. A. (1992) Nuclear factor kappa B: an oxidative stress-responsive transcription factor of eukaryotic cells (a review). Free Radic. Res. Commun. 17, 221-237
    • (1992) Free Radic. Res. Commun. , vol.17 , pp. 221-237
    • Schreck, R.1    Albermann, K.2    Baeuerle, P.A.3
  • 31
    • 0028174061 scopus 로고
    • Function and activation of NF-kappa B in the immune system
    • Baeuerle, P. A., and Henkel, T. (1994) Function and activation of NF-kappa B in the immune system. Annu. Rev. Immunol. 12, 141-179
    • (1994) Annu. Rev. Immunol. , vol.12 , pp. 141-179
    • Baeuerle, P.A.1    Henkel, T.2
  • 32
    • 34250847115 scopus 로고    scopus 로고
    • The proteins BACE1 and BACE2 and beta-secretase activity in normal and Alzheimer's disease brain
    • Stockley, J. H., and O'Neill, C. (2007) The proteins BACE1 and BACE2 and beta-secretase activity in normal and Alzheimer's disease brain. Biochem. Soc. Trans. 35, 574-576
    • (2007) Biochem. Soc. Trans. , vol.35 , pp. 574-576
    • Stockley, J.H.1    O'neill, C.2
  • 33
    • 84856428468 scopus 로고    scopus 로고
    • Increased NF-kappaB signalling up-regulates BACE1 expression and its therapeutic potential in Alzheimer's disease
    • Chen, C. H., Zhou, W., Liu, S., Deng, Y., Cai, F., Tone, M., Tone, Y., Tong, Y., and Song, W. (2012) Increased NF-kappaB signalling up-regulates BACE1 expression and its therapeutic potential in Alzheimer's disease. Int. J. Neuropsychopharmacol. 15, 77-90
    • (2012) Int. J. Neuropsychopharmacol. , vol.15 , pp. 77-90
    • Chen, C.H.1    Zhou, W.2    Liu, S.3    Deng, Y.4    Cai, F.5    Tone, M.6    Tone, Y.7    Tong, Y.8    Song, W.9
  • 36
    • 59349107204 scopus 로고    scopus 로고
    • NF-kappaB signaling in cerebral ischemia
    • Ridder, D. A., and Schwaninger, M. (2009) NF-kappaB signaling in cerebral ischemia. Neuroscience 158, 995-1006
    • (2009) Neuroscience , vol.158 , pp. 995-1006
    • Ridder, D.A.1    Schwaninger, M.2
  • 37
    • 0033913058 scopus 로고    scopus 로고
    • Apoptotic and antiapoptotic mechanisms in stroke
    • Mattson, M. P., Culmsee, C., and Yu, Z. F. (2000) Apoptotic and antiapoptotic mechanisms in stroke. Cell Tissue Res. 301, 173-187
    • (2000) Cell Tissue Res. , vol.301 , pp. 173-187
    • Mattson, M.P.1    Culmsee, C.2    Yu, Z.F.3
  • 38
    • 0029874138 scopus 로고    scopus 로고
    • The NF-kappa B and i kappa B proteins: New discoveries and insights
    • Baldwin, A. S., Jr. (1996) The NF-kappa B and I kappa B proteins: new discoveries and insights. Annu. Rev. Immunol. 14, 649-683
    • (1996) Annu. Rev. Immunol. , vol.14 , pp. 649-683
    • Baldwin, A.S.1
  • 39
    • 0028834881 scopus 로고
    • Rel/NF-kappa B/I kappa B story
    • Miyamoto, S., and Verma, I. M. (1995) Rel/NF-kappa B/I kappa B story. Adv. Cancer Res. 66, 255-292
    • (1995) Adv. Cancer Res. , vol.66 , pp. 255-292
    • Miyamoto, S.1    Verma, I.M.2
  • 40
    • 0041837487 scopus 로고    scopus 로고
    • Early NFkappaB activation is inhibited during focal cerebral ischemia in interleukin-1beta-converting enzyme deficient mice
    • Huang, F. P., Wang, Z. Q., Wu, D. C., Schielke, G. P., Sun, Y., and Yang, G. Y. (2003) Early NFkappaB activation is inhibited during focal cerebral ischemia in interleukin-1beta-converting enzyme deficient mice. J. Neurosci. Res. 73, 698-707
    • (2003) J. Neurosci. Res. , vol.73 , pp. 698-707
    • Huang, F.P.1    Wang, Z.Q.2    Wu, D.C.3    Schielke, G.P.4    Sun, Y.5    Yang, G.Y.6
  • 42
    • 33646244775 scopus 로고    scopus 로고
    • Leaky scanning and reinitiation regulate BACE1 gene expression
    • Zhou, W., and Song, W. (2006) Leaky scanning and reinitiation regulate BACE1 gene expression. Mol. Cell. Biol. 26, 3353-3364
    • (2006) Mol. Cell. Biol. , vol.26 , pp. 3353-3364
    • Zhou, W.1    Song, W.2
  • 44
    • 84856459283 scopus 로고    scopus 로고
    • Increased NF-kappaB signalling up-regulates BACE1 expression and its therapeutic potential in Alzheimer's disease
    • Chen, C. H., Zhou, W., Liu, S., Deng, Y., Cai, F., Tone, M., Tone, Y., Tong, Y., and Song, W. (2011) Increased NF-kappaB signalling up-regulates BACE1 expression and its therapeutic potential in Alzheimer's disease. Int. J. Neuropsychopharmacol. 18, 1-14
    • (2011) Int. J. Neuropsychopharmacol. , vol.18 , pp. 1-14
    • Chen, C.H.1    Zhou, W.2    Liu, S.3    Deng, Y.4    Cai, F.5    Tone, M.6    Tone, Y.7    Tong, Y.8    Song, W.9
  • 45
    • 84863336321 scopus 로고    scopus 로고
    • Hypoxia regulation of ATP13A2 (PARK9) gene transcription
    • Xu, Q., Guo, H., Zhang, X., Tang, B., Cai, F., Zhou, W., and Song, W. (2012) Hypoxia regulation of ATP13A2 (PARK9) gene transcription. J. Neurochem. 122, 251-259
    • (2012) J. Neurochem. , vol.122 , pp. 251-259
    • Xu, Q.1    Guo, H.2    Zhang, X.3    Tang, B.4    Cai, F.5    Zhou, W.6    Song, W.7
  • 47
    • 0022545394 scopus 로고
    • A model of focal ischemic stroke in the rat: Reproducible extensive cortical infarction
    • Chen, S. T., Hsu, C. Y., Hogan, E. L., Maricq, H., and Balentine, J. D. (1986) A model of focal ischemic stroke in the rat: reproducible extensive cortical infarction. Stroke 17, 738-743
    • (1986) Stroke , vol.17 , pp. 738-743
    • Chen, S.T.1    Hsu, C.Y.2    Hogan, E.L.3    Maricq, H.4    Balentine, J.D.5
  • 48
    • 33746549926 scopus 로고    scopus 로고
    • BACE2, as a novel APP theta-secretase, is not responsible for the pathogenesis of Alzheimer's disease in Down syndrome
    • Sun, X., He, G., and Song, W. (2006) BACE2, as a novel APP theta-secretase, is not responsible for the pathogenesis of Alzheimer's disease in Down syndrome. FASEB J. 20, 1369-1376
    • (2006) FASEB J. , vol.20 , pp. 1369-1376
    • Sun, X.1    He, G.2    Song, W.3
  • 50
    • 64349101903 scopus 로고    scopus 로고
    • Oxidative stress and mitochondrial dysfunction as determinants of ischemic neuronal death and survival
    • Niizuma, K., Endo, H., and Chan, P. H. (2009) Oxidative stress and mitochondrial dysfunction as determinants of ischemic neuronal death and survival. J. Neurochem. 109(Suppl. 1), 133-138
    • (2009) J. Neurochem. , vol.109 , pp. 133-138
    • Niizuma, K.1    Endo, H.2    Chan, P.H.3
  • 51
    • 84899065409 scopus 로고    scopus 로고
    • Macrophage migration inhibitory factor in myocardial ischaemia/reperfusion injury
    • Rassaf, T., Weber, C., and Bernhagen, J. (2014) Macrophage migration inhibitory factor in myocardial ischaemia/reperfusion injury. Cardiovasc. Res. 102, 321-328
    • (2014) Cardiovasc. Res. , vol.102 , pp. 321-328
    • Rassaf, T.1    Weber, C.2    Bernhagen, J.3
  • 53
    • 84881257480 scopus 로고    scopus 로고
    • CAMP-response element-binding protein (CREB) and NF-kappaB transcription factors are activated during prolonged hypoxia and cooperatively regulate the induction of matrix metalloproteinase MMP1
    • Nakayama, K. (2013) cAMP-response element-binding protein (CREB) and NF-kappaB transcription factors are activated during prolonged hypoxia and cooperatively regulate the induction of matrix metalloproteinase MMP1. J. Biol. Chem. 288, 22584-22595
    • (2013) J. Biol. Chem. , vol.288 , pp. 22584-22595
    • Nakayama, K.1
  • 54
    • 65549107435 scopus 로고    scopus 로고
    • Cerebellar neurons possess a vesicular compartment structurally and functionally similar to Glut4-storage vesicles from peripheral insulin-sensitive tissues
    • Bakirtzi, K., Belfort, G., Lopez-Coviella, I., Kuruppu, D., Cao, L., Abel, E. D., Brownell, A. L., and Kandror, K. V. (2009) Cerebellar neurons possess a vesicular compartment structurally and functionally similar to Glut4-storage vesicles from peripheral insulin-sensitive tissues. J. Neurosci. 29, 5193-5201
    • (2009) J. Neurosci. , vol.29 , pp. 5193-5201
    • Bakirtzi, K.1    Belfort, G.2    Lopez-Coviella, I.3    Kuruppu, D.4    Cao, L.5    Abel, E.D.6    Brownell, A.L.7    Kandror, K.V.8
  • 55
    • 79952369026 scopus 로고    scopus 로고
    • Macrophage migration inhibitory factor provides cardioprotection during ischemia/reperfusion by reducing oxidative stress
    • Koga, K., Kenessey, A., Powell, S. R., Sison, C. P., Miller, E. J., and Ojamaa, K. (2011) Macrophage migration inhibitory factor provides cardioprotection during ischemia/reperfusion by reducing oxidative stress. Antioxid. Redox Signal. 14, 1191-1202
    • (2011) Antioxid. Redox Signal. , vol.14 , pp. 1191-1202
    • Koga, K.1    Kenessey, A.2    Powell, S.R.3    Sison, C.P.4    Miller, E.J.5    Ojamaa, K.6
  • 56
    • 33748201552 scopus 로고    scopus 로고
    • Mitochondria-targeted peptide antioxidants: Novel neuroprotective agents
    • Szeto, H. H. (2006) Mitochondria-targeted peptide antioxidants: novel neuroprotective agents. AAPS J. 8, E521-E531
    • (2006) AAPS J. , vol.8 , pp. E521-E531
    • Szeto, H.H.1
  • 58
    • 0008290616 scopus 로고    scopus 로고
    • Diverse functions of JNK signaling and c-Jun in stress response and apoptosis
    • Leppa, S., and Bohmann, D. (1999) Diverse functions of JNK signaling and c-Jun in stress response and apoptosis. Oncogene 18, 6158-6162
    • (1999) Oncogene , vol.18 , pp. 6158-6162
    • Leppa, S.1    Bohmann, D.2
  • 59
    • 67749117934 scopus 로고    scopus 로고
    • Signal integration by JNK and p38 MAPK pathways in cancer development
    • Wagner, E. F., and Nebreda, A. R. (2009) Signal integration by JNK and p38 MAPK pathways in cancer development. Nat. Rev. Cancer 9, 537-549
    • (2009) Nat. Rev. Cancer , vol.9 , pp. 537-549
    • Wagner, E.F.1    Nebreda, A.R.2
  • 63
    • 33745190762 scopus 로고    scopus 로고
    • MIF: A new cytokine link between rheumatoid arthritis and atherosclerosis
    • Morand, E. F., Leech, M., and Bernhagen, J. (2006) MIF: a new cytokine link between rheumatoid arthritis and atherosclerosis. Nat. Rev. Drug Discov. 5, 399-410
    • (2006) Nat. Rev. Drug Discov. , vol.5 , pp. 399-410
    • Morand, E.F.1    Leech, M.2    Bernhagen, J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.