Gut failure in critical care: Old school versus new school

Annals of Gastroenterology

Volumn 28, Issue 3, 2015, Pages 307-320

  Sertaridou, Eleni ^a   Papaioannou, Vasilios ^a   Kolios, George ^b   Pneumatikos, Ioannis ^a  

^a DEMOCRITUS UNIVERSITY OF THRACE   (Greece)

^b DEMOCRITUS UNIVERSITY OF THRACE   (Greece)

Author keywords

Bacterial translocation; Gut failure; Immunonutrition; Selective gut decontamination

Indexed keywords

ANTIBIOTIC AGENT; CYTOKINE; IMMUNOGLOBULIN; PREBIOTIC AGENT; PROBIOTIC AGENT;

ARTICLE; BACTERIAL TRANSLOCATION; DIET SUPPLEMENTATION; DISEASE ASSOCIATION; DISEASE CONTROL; ENTERIC FEEDING; HUMAN; IMMUNE RESPONSE; INFLAMMATION; INTENSIVE CARE; INTERMETHOD COMPARISON; INTESTINE FLORA; INTESTINE FUNCTION DISORDER; INTESTINE MOTILITY; INTESTINE MUCOSA PERMEABILITY; INTESTINE PERFUSION; MESENTERY LYMPH NODE; MULTIPLE ORGAN FAILURE; NONHUMAN; PARENTERAL NUTRITION; PATHOPHYSIOLOGY; PORTAL VEIN BLOOD; REPERFUSION INJURY; RESUSCITATION; SEPSIS; SYMPTOMATOLOGY; SYSTEMIC CIRCULATION; SYSTEMIC INFLAMMATORY RESPONSE SYNDROME;

EID: 84931313748     PISSN: 11087471     EISSN: 17927463     Source Type: Journal    
DOI: None     Document Type: Article

References (157)

1. Deitch EA Bacterial translocation or lymphatic drainage of toxic products from the gut: what is important in human beings? Surgery 2002;131:241-244
2. Reintam A, Kern H, Starkopf J. Defining gastro intestinal failure. Acta Clin Belg Suppl 2007;1:168-172
3. Gatt M, Reddy BS, MacFie J. Review article: bacterial translocationin the critically ill - evidence and methods of prevention. Aliment Pharmacol Ther 2007;25:741-757
4. Louis K, Netea MG, Carrer DP, et al. Bacterial translocation inan experimental model of multiple organ dysfunctions. J Surg Res 2013;183:686-694
5. Mittal R, Coopersmith CM. Redefining the gut as the motor ofcritical illness. Trends Mol Med 2014;20:214-223
6. Schweinburg FB, Frank HA, Frank ED, Heimberg F, Fine J. Transmural migration of intestinal bacteria during peritoneal irrigation in uremic dogs. Proc Soc Exp Biol Med 1949;71:150-153
7. Fine J. The bacterial factor in traumatic shock. Springfield, IL:Charles C. Thomas Publisher, 1954
8. Polk HC, Shields CL. Remote organ failure: a valid sign of occultintra-abdominal infection. Surgery 1977;81:310-313
9. Fry DE, Pearlstein L, Fulton RL, Polk HC Jr. Multiple systemorgan failure. The role of uncontrolled infection. Arch Surg 1980;115:136-140
10. Berg RD, Garlington AW. Translocation of certain indigenousbacteria from the gastrointestinal tract to the mesenteric lymphnodes and other organs in a gnotobiotic mouse model. Infect Immun 1979;23:403-411
11. Piton G, Manzon C, Cypriani B, Carbonnel F, Capellier G. Acuteintestinal failure in critically ill patients: is plasma citrulline theright marker? Intensive Care Med 2011;37:911-917
12. Steinberg SM. Bacterial translocation: what it is and what it isnot. Am J Surg 2003;186:301-305
13. Gümüs M, Tekin R, Firat U, et al. The effects of pomegranate onbacterial translocation in rats with obstructive jaundice. Eur Rev Med Pharmacol Sci 2013;17:1488-1494
14. Deitch EA. Gut-origin sepsis: evolution of a concept. Surgeon 2012;10:350-356
15. Puleo F, Arvanitakis M, Gossum VA, Preiser CJ. Gut failure in the ICU. Semin Respir Crit Care Med 2011;32:626-638
16. MacFie J, Reddy BS, Gatt M, Jain PK, Sowdi R, Mitchell CJ. Bacterial translocation studied in 927 patients over 13 years. Br J Surg 2006;93:87-93
17. Reintam A, Parm P, Kitus R, Kern H, Starkopf J. Gastro intestinal symptoms in intensive care patients. Acta Anaesthesiol Scand 2009;53:318-324
18. Crenn P, Messing B, Cynober L. Citrulline as a biomarker of intestinal failure due to entero cyte mass reduction. Clin Nutr 2008;27:328-339
19. de Madaria E, Martínez J, Lozano B, et al. Detection and identification of bacterial DNA in serum from patients withacute pancreatitis. Gut 2005;54:1293-1297
20. Küçükaydin M, Kocaoğlu C, Köksal F, Kontaş O. Detection of intestinal bacterial translocation in sub clinical is chemi are perfusion using the polymerase chain reaction technique. J Pediatr Surg 2000;35:41-43
21. Galeev YM, Lishmanov YB, Grigorev EG, Popov MV, Aparcin KA, Salato OV. Scinti graphic visualization of bacterial translocationin experimental strangulated intestinal obstruction. Eur J Nucl Med Mol Imaging 2009;36:1822-1828
22. Evennett NJ, Petrov MS, Mittal A, Windsor JA. Systematic review and pooled estimates for the diagnostic accuracy of serological markers for intestinal is chemia. World J Surg 2009;33:1374-1383
23. Matsumoto S, Sekine K, Funaoka H, et al. Diagnostic performance of plasma biomarkers in patients with acute intestinal ischaemia. Br J Surg 2014;101:232-238
24. Gollin G, Marks C, Marks WH. Intestinal fatty acid binding protein in serum and urine reflects early ischemic injury to thesmall bowel. Surgery 1993;113:545-551
25. Thuijls G, van Wijck K, Grootjans J, et al. Early diagnosis of intestinal is chemia using urinary and plasma fatty acid binding proteins. Ann Surg 2011;253:303-308
26. Güzel M, Sözüer EM, Salt Ö, İkizceli İ, Akdur O, Yazıcı C. The value of the serum I-FABP level for diagnosing acute mesentericis chemia. Surg Today 2014;44:2072-2076
27. Clark JA, Coopersmith CM. Intestinal cross talk: a new paradigm for understanding the gut as the “motor” of critical illness. Shock 2007;28:384-393
28. Meng J, Yu H, Ma J, et al. Morphine induces bacterial translocation in mice by compromising intestinal barrier function in a TLR-dependent manner. PLoS One 2013;8:e54040
29. Hang CH, Shi JX, Li JS, Wu W, Yin HX. Alterations of intestinal mucosa structure and barrier function following traumatic brain injury in rats. World J Gastroenterol 2003;9:2776-2781
30. Fukatsu K, Sakamoto S, Hara E, et al. Gut is chemia-reper fusion affects gut mucosal immunity: a possible mechanism for infectious complications after severe surgical insults. Crit Care Med 2006;34:182-187
31. Bäckhed F, Ley RE, Sonnenburg JL, Peterson DA, Gordon JI. Host-bacterial mutualism in the human intestine. Science 2005;307:1915-1920
32. Schuijt TJ, van der Poll T, de Vos WM, Wiersinga WJ.The intestinal microbiota and host immune inter actions in the critically ill. Trends Micro biol 2013;21:221-229
33. Seal JB, Alverdy JC, Zaborina O, An G. Agent based dynamic knowledge representation of Pseudomonasaeruginosa virulence activation in the stressed gut: towardscharacterizing host-pathogen interactions in gut-derived sepsis. Theor Biol Med Model 2011;8:33
34. Breslow JM, Monroy MA, Daly JM, et al. Morphine, but nottrauma, sensitizes to systemic Acinetobacter baumannii infection. J Neuroimmune Pharmacol 2011;6:551-565
35. Babrowski T, Holbrook C, Moss J, et al. Pseudomonas aeruginosa virulence expression is directly activated by morphine and iscapable of causing lethal gut-derived sepsis in mice during chronic morphine administration. Ann Surg 2012;255:386-393
36. Shimizu K, Ogura H, Goto M, et al. Altered gut flora and environment in patients with severe SIRS. J Trauma 2006;60:126-133
37. Zandstra DF, Van Saene HK. Selective decontamination of thedigestive tract as infection prevention in the critically ill. A level 1evidence-based strategy. Minerva Anestesiol 2011;77:212-219
38. Ritz MA, Fraser R, Tam W, Dent J. Impacts and patterns of disturbed gastro intestinal function in critically ill patients. Am J Gastroenterol 2000;95:3044-3052
39. Carrico CJ, Meakins JL, Marshall JC, Fry D, Maier RV. Multipleorgan-failure syndrome. Arch Surg 1986;121:196-208
40. Zanoni FL, Benabou S, Greco KV, et al. Mesenteric micro circulatory dysfunctions and translocation of indigenous bacteria in a rat model of strangulated small bowel obstruction. Clinics (Sao Paulo) 2009;64:911-919
41. Santos RG, Quirino IE, Viana ML, et al. Effects of nitricoxide synthase inhibition on glutamine action in a bacterial translocation model. Br J Nutr 2014;111:93-100
42. Ambrose NS, Johnson M, Burdon DW, Keighley MR. Incidenceof pathogenic bacteria from mesenteric lymph nodes and ilealserosa during Crohn’s disease surgery. Br J Surg 1984;71:623-625
43. Chin KF, Kallam R, O’Boyle C, MacFie J. Bacterial translocationmay influence the long-term survival in colorectal cancerpatients. Dis Colon Rectum 2007;50:323-330
44. Reddy BS, MacFie J, Gatt M, Macfarlane-Smith L, Bitzopoulou K, Snelling AM. Commensal bacteria do translocate across theintestinal barrier in surgical patients. Clin Nutr 2007;26:208-215
45. Deitch EA. Simple intestinal obstruction causes bacterialtranslocation in man. Arch Surg 1989;124:699-701
46. Kazantsev GB, Hecht DW, Rao R, et al. Plasmid labeling confirmsbacterial translocation in pancreatitis. Am J Surg 1994;167:201-206
47. Ammori BJ, Leeder PC, King RF, et al. Early increase in intestinalpermeability in patients with severe acute pancreatitis: correlationwith endotoxemia, organ failure, and mortality. J Gastrointest Surg 1999;3:252-262
48. Cirera I, Bauer TM, Navasa M, et al. Bacterial translocation ofenteric organisms in patients with cirrhosis. J Hepatol 2001;34:32-37
49. Ginés P, Rimola A, Planas R, et al. Norfloxacin preventsspontaneous bacterial peritonitis recurrence in cirrhosis:results of a double-blind, placebo-controlled trial. Hepatology1990;12:716-724
50. Van Goor H, Rosman C, Grond J, Kooi K, Wübbels GH, Bleichrodt RP. Translocation of bacteria and endotoxin in organdonors. Arch Surg 1994;129: 1063-1066
51. Woodcock NP, Sudheer V, El-Barghouti N, Perry EP, MacFie J. Bacterial translocation in patients undergoing abdominal aorticaneurysm repair. Br J Surg 2000;87:439-442
52. Fritz S, Hackert T, Hartwig W, et al. Bacterial translocation and infected pancreatic necrosis in acute necrotizing pancreatitis derives from small bowel rather than from colon. Am J Surg 2010;200:111-117
53. Chang JX, Chen S, Ma LP, et al. Functional and morphological changes of the gut barrier during the restitution process afterhemorrhagic shock. World J Gastro enterol 2005;11:5485-5491
54. Song F, Whitacre CC. The role of the gut lymphoid tissue ininduction of oral tolerance. Curr Opin Investig Drugs 2001;2:1382-1386
55. Sedman PC, Macfie J, Sagar P, et al. The prevalence of guttrans location in humans. Gastroenterology 1994;107:643-649
56. Watkins AC, Caputo FJ, Badami C, et al. Mesentericlymph duct ligation attenuates lung injury and neutron philactivation after intra peritoneal injection of endotoxin in rats. J Trauma 2008;64:126-130
57. Badami CD, Senthil M, Caputo FJ, et al. Mesenteric lymphduct ligation improves survival in a lethal shock model. Shock 2008;30:680-685
58. Hassoun HT, Kone BC, Mercer DW, Moody FG, Weisbrodt NW, Moore FA. Post-injury multiple organ failure: the role of the gut. Shock 2001;15:1-10
59. Senthil M, Watkins A, Barlos D, et al. Intravenous injection oftrauma-hemorrhagic shock mesenteric lymph causes lung injury that is dependent upon activation of the inducible nitric oxide synthase pathway. Ann Surg 2007;246:822-830
60. Sambol JT, Lee MA, Caputo FJ, et al. Mesenteric lymph duct ligation prevents trauma/hemorrhage shock-induced cardiac contractile dysfunction. J Appl Physiol 2009;106:57-65
61. Lee MA, Yatani A, Sambol JT, Deitch EA. Role of gutlymphfactors in the induction of burn-induced and traumashock-induced acute heart failure. Int J Clin Exp Med 2008;1:171-180
62. Kawai K, Kawai T, Sambol JT, et al. Cellular mechanisms of burn related changes in contractility and its prevention by mesenteric lymph ligation. Am J Physiol Heart Circ Physiol 2007;292:2475-2484
63. Deitch EA, Ulloa L. Fat and the gut: more than empty calories. Crit Care Med 2010;38:1608-1609
64. Mitsuoka H, Kistler EB, Schmid-Schonbein GW. Generation ofin vivo activating factors in the ischemic intestine by pancreatic enzymes. Proc Natl Acad Sci U S A 2000;97:1772-1777
65. Cohen DB, Magnotti LJ, Lu Q, et al. Pancreatic duct ligation reduces lung injury following trauma and hemorrhagic shock. Ann Surg 2004;240:885-891
66. Jackson GD, Dai Y, Sewell WA. Bile mediates intestinal pathologyin endotoxemia in rats. Infect Immun 2000;68:4714-4719
67. de Haan JJ, Thuijls G, Lubbers T, et al. Protection against earlyintestinal compromise by lipid-rich enteral nutrition through cholecystokinin receptors. Crit Care Med 2010;38:1592-1597
68. Tracey KJ. Fat meets the cholinergic antiinflammatory pathway. J Exp Med 2005;202: 1017-1021
69. Luyer MD, Greve JW, Hadfoune M, Jacobs JA, Dejong CH, Buurman WA. Nutritional stimulation of cholecystokininreceptors inhibits inflammation via the vagus nerve. J Exp Med 2005;202:1023-1029
70. Yang S, Koo DJ, Zhou M, Chaudry IH, Wang P. Gut-derived norepinephrine plays a critical role in producing hepato cellular dysfunction during early sepsis. Am J Physiol Gastro intest Liver Physiol 2000;279:1274-1281
71. Alverdy JC, Chang EB. The re-emerging role of the intestinal microflora in critical illness and inflammation: why the guthy pothesis of sepsis syndrome will not go away. J Leukoc Biol 2008;83:461-466
72. Kirton OC, Windsor J, Wedderburn R, et al. Failure of splanchnicresuscitation in the acutely injured trauma patient correlates with multiple organ system failure and length of stay in the ICU. Chest 1998;113:1064-1069
73. Moore EE, Moore FA, Franciose RJ, Kim FJ, Biffl WL, Banerjee A. The postischemic gut serves as a priming bed for circulating neutrophils that provoke multiple organ failure. J Trauma 1994;37:881-887
74. Wu R, Dong W, Wang Z, Jacob A, Cui T, Wang P. Enhancing apoptotic cell clearance mitigates bacterial translocation and promotes tissue repair after gut ischemia-reperfusion injury. Int J Mol Med 2012;30:593-598
75. Medeiros Ada C, Araújo-Filho I, Tôrres ML, Sá Cde V, Jácome DT, Rêgo AC. Ischemic preconditioning in different times and its effect on bacterial translocation induced by intestinal is chemia and reperfusion in rats. Rev Col Bras Cir 2013;40:55-59
76. Chiu CJ, McArdle AH, Brown R, Scott HJ, Gurd FN. Intestinalmucosal lesion in low-flow states. I. A morphological,hemodynamic, and metabolic reappraisal. Arch Surg 1970;101:478-483
77. Sukhotnik I, Bejar J, Srugo I, et al. Adverse effects of increased intra-abdominal pressure on small bowel structure and bacterial translocation in the rat. J Laparoendosc Adv Surg Tech A 2006;16:404-410
78. Kaussen T, Srinivasan PK, Afify M, et al. Influence of two different levels of intra-abdominal hypertensionon bacterial translocation in a porcine model. Ann IntensiveCare 2012;2(Suppl 1):S17
79. De Backer D, Creteur J, Silva E, Vincent JL. Effects of dopamine,norepinephrine, and epinephrine on the splanchnic circulationin septic shock: which is best? Crit Care Med 2003;31:1659-1667
80. Sautner T, Wessely C, Riegler M, et al. Early effects of catecholamine therapy on mucosal integrity, intestinal blood flow, and oxygen metabolism in porcine endotoxin shock. AnnSurg 1998;228:239-248
81. Jeejeebhoy KN. Total parenteral nutrition: potion or poison? AmJ Clin Nutr 2001;74:160-163
82. Thibault R, Pichard C. Parenteral nutrition in critical illness: can it safely improve outcomes? Crit Care Clin 2010;26:467-480
83. Petrov MS, van Santvoort HC, Besselink MG, van der Heijden GJ, Windsor JA, Gooszen HG. Enteral nutrition and the risk ofmortality and infectious complications in patients with severe acute pancreatitis: a meta-analysis of randomized trials. ArchSurg 2008;143:1111-1117
84. Lewis SJ, Andersen HK, Thomas S. Early enteral nutrition within24 h of intestinal surgery versus later commencement of feeding:a systematic review and meta-analysis. J Gastro intest Surg2009;13:569-575
85. Wang G, Wen J, Xu L, et al. Effect of enteral nutrition and eco immunonutrition on bacterial translocation and cytokine production in patients with severe acute pancreatitis. J Surg Res 2013;183:592-597
86. Heyland D, Cook DJ, Winder B, Brylowski L, Van de Mark H, Guyatt G. Enteral nutrition in the critically ill patient: aprospective survey. Crit Care Med 1995;23:1055-1060
87. Al-Omran M, Albalawi ZH, Tashkandi MF, Al-Ansary LA. Enteral versus parenteral nutrition for acute pancreatitis. Cochrane Database Syst Rev 2010;1:CD002837
88. Yi F, Ge L, Zhao J, et al. Meta-analysis: total parenteral nutrition versus total enteral nutrition in predicted severe acute pancreatitis. Intern Med 2012;51:523-530.
89. Wu XM, Ji KQ, Wang HY, Li GF, Zang B, Chen WM. Total enteral nutrition in prevention of pancreatic necrotic infection in severe acute pancreatitis. Pancreas 2010;39:248-251
90. Singh N, Sharma B, Sharma M, et al. Evaluation of early enteral feeding through nasogastric and nasoje junal tube in severe acute pancreatitis: a non inferiority randomized controlled trial. Pancreas 2012;41:153-159
91. Leone M, Albanese J, Antonini F, Nguyen-Michel A, Martin C. Long-term (6-year) effect of selective digestive decontamination non antimicrobial resistance in intensive care, multiple-traumapatients. Crit Care Med 2003;31:2090-2095
92. Silvestri L, van Saene HK, Zandstra DF, Marshall JC, Gregori D, Gullo A. Impact of selective decontamination of the digestivetract on multiple organ dysfunction syndrome: systematic reviewof randomized controlled trials. Crit Care Med 2010;38:1370-1376
93. Shiloh AL, Eisen LA, Savel RH. Selective decontaminationof the digestive tract: what outcomes matter? Crit CareMed 2010;38:1386-1387
94. Silvestri L, de la Cal MA, Taylor N, van Saene HK, Parodi PC. Selective decontamination of the digestive tract in burn patients:an evidence-based maneuver that reduces mortality. J Burn CareRes 2010;31:372-373
95. Silvestri L, van Saene HK. Selective decontamination of the digestive tract: an update of the evidence. HSR Proc IntensiveCare Cardiovasc Anesth 2012;4:21-29
96. Stoutenbeek CP, van Saene HK, Miranda DR, Zandstra DF. The effect of selective decontamination of the digestive tracton colonisation and infection rate in multiple trauma patients. Intensive Care Med 1984;10:185-192
97. Silvestri L, van Saene HK, Casarin A, Berlot G, Gullo A. Impactof selective decontamination of the digestive tract on carriageand infection due to Gram-negative and Gram-positive bacteria:a systematic review of randomised controlled trials. Anaesth Intensive Care 2008;36:324-338
98. Zandstra DF, Petros AJ, Silvestri L, et al. Selective decontaminationof the digestive tract: selectivity is not required. Intensive Care Med 2010;36:1783-1784
99. Stoutenbeek CP, van Saene HK, Little RA, Whitehead A; WorkingGroup on Selective Decontamination of the Digestive Tract.The effect of selective decontamination of the digestive tract onmortality in multiple trauma patients: a multicenter randomizedcontrolled trial. Intensive Care Med 2007;33:261-270
100. Silvestri L, van Saene HK, Weir I, Gullo A. Survival benefit of the full selective digestive decontamination regimen. J Crit Care 2009;24:474.7-14
101. de Smet AM, Kluytmans JA, Cooper BS, et al. Decontamination ofthe digestive tract and oropharynx in ICU patients. N Engl JMed 2009;360:20-31
102. Liberati A, D’Amico R, Pifferi S, Torri V, Brazzi L, Parmelli E. Antibiotic prophylaxis to reduce respiratory tract infections and mortality in adults receiving intensive care. Cochrane Database Syst Rev 2009;4:CD000022
103. Silvestri L, Milanese M, Taylor N, Piacente N, Zandstra DF, vanSaene HK. Selective digestive decontamination reduces ventilator associated tracheobronchitis. Respir Med 2010;104:1953-1955
104. Melsen WG, de Smet AM, Kluytmans JA, Bonten MJ; Dutch SOD-SDD Trialists’ Group Selective decontamination of the oraland digestive tract in surgical versus non-surgical patients inintensive care in a cluster-randomized trial. Br J Surg 2012;99:232-237
105. de Smet AM, Bonten MJ, Kluytmans JA. For whom should weuse selective decontamination of the digestive tract? Curr OpinInfect Dis 2012;25:211-217
106. Nathens AB, Marshall JC. Selective decontamination of the digestive tract in surgical patients: a systematic review of the evidence. Arch Surg 1999;134:170-176
107. Oostdijk EA, de Smet AM, Kesecioglu J, Bonten MJ; DutchSOD-SDD Trialists Group. The role of intestinal colonizationwith gram-negative bacteria as a source for intensive care unitacquiredbacteremia. Crit Care Med 2011;39:961-966
108. Oostdijk EA, de Smet AM, Blok HE, et al. Ecological effects ofselective decontamination on resistant gram-negative bacterialcolonization. Am J Respir Crit Care Med 2010;181:452-457
109. Trouillet JL, Chastre J, Vuagnat A, et al. Ventilator-associatedpneumonia caused by potentially drug-resistant bacteria. Am J Respir Crit Care Med 1998;157:531-539
110. de Smet AM, Kluytmans JA, Blok HE, et al. Selective digestive tractdecontamination and selective oropharyngeal decontaminationand antibiotic resistance in patients in intensive-care units: an open-label, clustered group-randomised, cross over study. Lancet Infect Dis 2011;11:372-380
111. Daneman N, Sarwar S, Fowler RA, Cuthbertson BH; Su DDICU Canadian Study Group Effect of selective decontamination on antimicrobial resistance in intensive care units: a systematic review and meta-analysis. Lancet Infect Dis 2013;13:328-341
112. Houben AJ, Oostdijk EA, van der Voort PH, Monen JC, Bonten MJ, van der Bij AK; on behalf of the ISIS–AR Study Group. Selective decontamination of the oropharynx and the digestive tract, and anti microbial resistance: a 4 year ecological study in 38 intensive care units in the Netherlands. J Antimicrob Chemother 2014;69:797-804
113. van Saene HK, Silvestri L, de la Cal MA, Sarginson RE. Selectivedecontamination of the digestive tract reduces lower airway andbloodstream infection and mortality and prevents emergence ofantimicrobial resistance. Microbes Infect 2006;8:953-954
114. Silvestri L, van Saene HK, de la Cal MA, Sarginson RE, Thomann C. Prevention of ventilator-associated pneumoniaby selective decontamination of the digestive tract. Eur Respir J 2008;32:241-243
115. Oostdijk EA, de Wit GA, Bakker M, de Smet AM, Bonten MJ; Dutch SOD-SDD trialists group. Selective decontamination ofthe digestive tract and selective oropharyn geal decontamination in intensive care unit patients: a cost-effectiveness analysis. BMJ Open 2013;3:pii: e002529
116. Jacobi CA, Schulz C, Malfertheiner P. Treating critically ill patients with probiotics: Beneficial or dangerous? Gut Pathog 2011;3:2
117. Morrow LE, Gogineni V, Malesker MA. Probiotics in the intensive care unit. Nutr Clin Pract 2012;27:235-241
118. de Vrese M, Schrezenmeir J. Probiotics, prebiotics, and synbiotics. Adv Biochem Eng Biotechnol 2008;111:1-66
119. McNabb B, Isakow W. Probiotics for the prevention of nosocomialpneumonia: current evidence and opinions. Curr Opin Pulm Med 2008;14:168-175
120. Pitsouni E, Alexiou V, Saridakis V, Peppas G, Falagas ME. Doesthe use of probiotics/synbiotics prevent postoperative infectionsin patients undergoing abdominal surgery? A meta-analysis ofrandomized controlled trials. Eur J Clin Pharmacol 2009;65:561-570
121. Kotzampassi K, Giamerellos-Bourboulis EJ, Voudouris A, Kazamias P, Eleftheriadis E. Benefits of Synbiotic 2000 Fortein critically ill trauma patients-early results of a randomizedcontrolled trial. World J Surg 2006;30:1848-1855
122. Spindler-Vesel A, Bengmark S, Vovk I, Cerovic O, Kompan L. Synbiotics, prebiotics, glutamine, or peptide in early enteralnutrition: A randomized study in trauma patients. JPEN JParenter Enteral Nutr 2007;31: 119-126
123. Giamarellos-Bourboulis EJ, Bengmark S, Kanellakopoulou K, Kotzampassi K. Pro-andsynbiotics to control inflammationand infection in patients with multiple injuries. J Trauma 2009;67:815-821
124. Koutelidakis IM, Bezirtzoglou E, Giamarellos-Bourboulis EJ, Grosomanidis V, Kotzampassi K. Impact of synbiotics on theintestinal flora of critically ill patients with multiple injuries. Int J Antimicrob Agents 2010;36:90-91
125. Oláh A, Belágyi T, Pótó L, Romics L Jr, Bengmark S. Synbioticcontrol of inflammation and infection in severe acute pancreatitis:a prospective, randomized, double blind study. Hepato gastro enterology 2007;54:590-594
126. Besselink MG, van Santvoort HC, Buskens E, et al. Probioticprophylaxis in patients with predicted severe acute pancreatitis: arandomised, double-blind, placebo-controlled trial. Ned Tijdschr Geneeskd 2008;152:685-696
127. Besselink MG, van Santvoort HC, Renooij W, et al. Intestinalbarrier dysfunction in a randomized trial of a specific probioticcomposition in acute pancreatitis. Ann Surg 2009;250:712-719
128. Lolis N, Veldekis D, Moraitou H, et al. Saccharomyces boulardiifungaemia in an intensive care unit patient treated withcaspofungin. Crit Care 2008;12:414
129. Martindale RG, McClave SA, Vanek VW, et al. Guidelines forthe provision and assessment of nutrition support therapy in theadult critically ill patient: Society of Critical Care Medicine andAmerican Society for Parenteral and Enteral Nutrition: ExecutiveSummary. Crit Care Med 2009;37:1757-1761
130. Mizock BA. Immunonutrition and critical illness: an update. Nutrition 2010;26:701-707
131. Marik PE, Zaloga GP. Immuno nutrition in high-risk surgicalpatients: a systematic review and analysis of the literature. JPEN J Parenter Enteral Nutr 2010;34:378-386
132. Li Y, Chen Y, Zhang J, et al. Protective effect of glutamineen richedearly enteral nutrition on intestinal mucosal barrier injury after liver transplantation in rats. Am J Surg 2010;199:35-42
133. Aldemir M, Geyik MF, Kökoğlu OF, Büyükbayram H, Hoşoğlu S, Yağmur Y. Effects of ursodeoxycholic acid, glutamine andpolyclonal immuno globulins on bacterial translocation incommon bile duct ligated rats. ANZ J Surg 2003;73:722-726
134. Carr EL, Kelman A, Wu GS, et al. Glutamine uptake andmetabolism are coordinately regulated by ERK/MAPK during Tlymphocyte activation. J Immunol 2010;185:1037-1044
135. Fan J, Meng Q, Guo G, et al. Effects of enteral nutrition supplemented with glutamine on intestinal mucosal immunity inburned mice. Nutrition 2009;25:233-239
136. Cetinbas F, Yelken B, Gulbas Z. Role of glutamine administrationon cellular immunity after total parenteral nutrition enrichedwith glutamine in patients with systemic inflammatory responsesyndrome. J Crit Care 2010;25:661
137. Ding LA, Li JS. Effects of glutamine on intestinal permeabilityand bacterial translocation in TPN-rats with endotoxemia. World J Gastro enterol 2003;9:1327-1332
138. de Oliveira MA, Lemos DS, Diniz SO, Coelho JV, Cardoso VN. Prevention of bacterial translocation using glutamine: a newstrategy of investigation. Nutrition 2006;22: 419-424
139. Demirkan A, Savaş B, Melli M. Endotoxin level in ischem areper fusion injury in rats: Effect of glutamine pretreatment onendotoxin levels and gut morphology. Nutrition 2010;26:106-111
140. Wischmeyer PE. Glutamine: role in gut protection in critical illness. Curr Opin Clin Nutr Metab Care 2006;9:607-612
141. Zhou M, Martindale RG. Arginine in the critical care setting. J Nutr 2007;137:1687-1692.
142. Quirino IE, Correia MI, Cardoso VN. The impact of arginine onbacterial translocation in an intestinal obstruction model in rats. Clin Nutr 2007;26:335-340
143. Viana ML, Santos RG, Generoso SV, Arantes RM, Correia MI, Cardoso VN. Pretreatment with arginine preserves intestinalbarrier integrity and reduces bacterial translocation in mice. Nutrition 2010;26:218-223
144. Kul M, Vurucu S, Demirkaya E, et al. Enteral glutamineand/or arginine supplementation have favorable effects onoxidative stress parameters in neonatal rat intestine. J PediatrGastroenterol Nutr 2009;49:85-89
145. Chamorro S, de Blas C, Grant G, Badiola I, Menoyo D, Carabaño R. Effect of dietary supplementation with glutamineand a combination of glutamine-arginine on intestinal health intwenty-five-day-old weaned rabbits. J Anim Sci 2010;88:170-180
146. Coëffier M, Déchelotte P. Combined infusion of glutamineand arginine: does it make sense? Curr Opin Clin Nutr Metab Care 2010;13:70-74
147. Zhou X, Wu X, Yin Y, Zhang C, He L. Preventive oral supplementation with glutamine and arginine has beneficial effects on the intestinal mucosa and inflammatory cytokines inendotoxemic rats. Amino Acids 2012;43:813-821
148. Chiarla C, Giovannini I, Siegel JH. Plasma arginine correlationsin trauma and sepsis. Amino Acids 2006;30:81-86
149. Ortiz Leyba C, Montejo González JC, Vaquerizo Alonso C; Metabolism and Nutrition Working Group of the Spanish Societyof Intensive Care Medicine and Coronary units. Guidelines forspecialized nutritional and metabolic support in the critically-illpatient: update. Consensus SEMICYUC-SENPE: septic patient. Nutr Hosp 2011;26:67-71.
150. Marik PE, Zaloga GP. Immunonutrition in critically ill patients: a systematic review and analysis of the literature. Intensive Care Med 2008;34:1980-1990.
151. Hegazi RA, Hustead DS, Evans DC. Preoperative standard oral nutrition supplements vs immunonutrition: results of a systematic review and meta-analysis. J Am Coll Surg 2014;219:1078-1087.
152. Senkal M, Haaker R, Linseisen J, Wolfram G, Homann HH, Stehle P. Preoperative oral supplementation with long-chain Omega-3 fatty acids beneficially alters phospholipid fatty acid patterns in liver, gut mucosa, and tumor tissue. JPEN J Parenter Enteral Nutr 2005;29:236-240.
153. Berger MM, Delodder F, Liaudet L, et al. Three short perioperative infusions of n-3 PUFAs reduce systemic inflammation induced by cardiopulmonary bypass surgery: a randomized controlled trial. Am J Clin Nutr 2013;97:246-254.
154. Sorensen LS, Rasmussen HH, Aardestrup IV, et al. Rapid incorporation of ω-3 fatty acids into Colonic tissue after oral supplementation in patients with colorectal cancer: a randomized, placebo-controlled intervention trial. JPEN J Parenter Enteral Nutr 2013;38:617-624.
155. Heyland DK, Novak F, Drover JW, Jain M, Su X, Suchner U. Should immunonutrition become routine in critically ill patients? A systematic review of the evidence. JAMA 2001;286:944-953.
156. Sacks GS, Genton L, Kudsk KA. Controversy of immunonutrition for surgical critical-illness patients. Curr Opin Crit Care 2003;9:300-305.
157. Kudsk KA. Immunonutrition in surgery and critical care. Annu Rev Nutr 2006;26:463-479.