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Vincent, J.-L.1
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2
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The effect of selective decontamination of the digestive tract on colonisation and infection rate in multiple trauma patients
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4
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77950167097
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Antibiotic prophylaxis to reduce respiratory tract infections and mortality in adults receiving intensive care
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CD000022
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Liberati A, D'Amico R, Pifferi S, et al. Antibiotic prophylaxis to reduce respiratory tract infections and mortality in adults receiving intensive care. The Cochrane Database Syst Rev 2009:CD000022.
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The Cochrane Database Syst Rev
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Liberati, A.1
D'Amico, R.2
Pifferi, S.3
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5
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Effects of selective decontamination of digestive tract on mortality and acquisition of resistant bacteria in intensive care: A randomised controlled trial
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DOI 10.1016/S0140-6736(03)14409-1
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de Jonge E, Schultz M, Spanjaard L, et al. Effects of selective decontamination of the digestive tract on mortality and acquisition of resistant bacteria in intensive care: a randomised controlled trial. Lancet 2003; 362:1011-1016. (Pubitemid 37186877)
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De Jonge, E.1
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Vroom, M.B.5
Dankert, J.6
Kesecioglu, J.7
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0035422606
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Prevention of ventilator-associated pneumonia by oral decontamination: A prospective, randomized, double-blind, placebo-controlled study
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Bergmans DC, Bonten MJ, Gaillard CA, et al. Prevention of ventilator-associated pneumonia by oral decontamination: a prospective, randomized, double-blind, placebo-controlled study. Am J Respir Crit Care Med 2001; 164:382-388. (Pubitemid 32778203)
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Bergmans, D.C.J.J.1
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Paling, J.C.4
Van Der, G.S.5
Van Tiel, F.H.6
Beysens, A.J.7
De Leeuw, P.W.8
Stobberingh, E.E.9
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7
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58249094505
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Decontamination of the digestive tract and oropharynx in intensive care patients
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de Smet AM, Kluytmans JA, Cooper BS, et al. Decontamination of the digestive tract and oropharynx in intensive care patients. N Engl J Med 2009; 360:20-31.
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De Smet, A.M.1
Kluytmans, J.A.2
Cooper, B.S.3
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8
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79955474823
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Selective digestive tract decontamination and selective oropharyngeal decontamination and antibiotic resistance in patients in intensive-care units: An open-label, clustered group-randomised, crossover study
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Largest prospective evaluation of topical antimicrobial prophylaxis in ICU patients showing that SDD was associated with a 48% reduced bacteremia rate with highly resistant pathogens, and both SDD and SOD yielded reductions in acquired respiratory tract colonization with highly resistant pathogens. SDD was associated with reduced acquisition rates with bacteria resistant to cefotaxime and colistin
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de Smet AM, Kluytmans JA, Blok HE, et al. Selective digestive tract decontamination and selective oropharyngeal decontamination and antibiotic resistance in patients in intensive-care units: an open-label, clustered group-randomised, crossover study. Lancet Infect Dis 2011; 11:372-380. Largest prospective evaluation of topical antimicrobial prophylaxis in ICU patients showing that SDD was associated with a 48% reduced bacteremia rate with highly resistant pathogens, and both SDD and SOD yielded reductions in acquired respiratory tract colonization with highly resistant pathogens. SDD was associated with reduced acquisition rates with bacteria resistant to cefotaxime and colistin.
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(2011)
Lancet Infect Dis
, vol.11
, pp. 372-380
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De Smet, A.M.1
Kluytmans, J.A.2
Blok, H.E.3
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9
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0038631961
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Selective decontamination of the digestive tract: To stimulate or stifle?
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Bonten MJ, Brun-Buisson C, Weinstein RA. Selective decontamination of the digestive tract: to stimulate or to stifle? Intensive CareMed2003; 29:672-676. (Pubitemid 36609556)
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Bonten, M.J.M.1
Brun-Buisson, C.2
Weinstein, R.A.3
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10
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0037108543
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Influence of combined intravenous and topical antibiotic prophylaxis on the incidence of infections, organ dysfunctions, and mortality in critically III surgical patients: A prospective, stratified, randomized, double-blind, placebo-controlled clinical trial
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DOI 10.1164/rccm.2105141
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Krueger WA, Lenhart FP, Neeser G, et al. Influence of combined intravenous and topical antibiotic prophylaxis on the incidence of infections, organ dysfunctions, and mortality in critically ill surgical patients: a prospective, stratified, randomized, double-blind, placebo-controlled clinical trial. Am J Respir Crit Care Med 2002; 166:1029-1037. (Pubitemid 35178699)
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American Journal of Respiratory and Critical Care Medicine
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Krueger, W.A.1
Lenhart, F.-P.2
Neeser, G.3
Ruckdeschel, G.4
Schreckhase, H.5
Eissner, H.-J.6
Forst, H.7
Eckart, J.8
Peter, K.9
Unertl, K.E.10
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11
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77649109107
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Ecological effects of selective decontamination on resistant Gram-negative bacterial colonization
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Intriguing ecological analysis in which unit-wide reductions in prevalence of antibiotic resistant Gram-negative bacteria in the respiratory tract during the periods of SDD of SOD were observed. After discontinuation of SOD and SDD a unit-wide increase in ceftazidime resistance was also observed. The implications of this 'rebound-effect' are not clear
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Oostdijk EA, de Smet AM, Blok HE, et al. Ecological effects of selective decontamination on resistant Gram-negative bacterial colonization. Am J Respir Crit Care Med 2010; 181:452-457. Intriguing ecological analysis in which unit-wide reductions in prevalence of antibiotic resistant Gram-negative bacteria in the respiratory tract during the periods of SDD of SOD were observed. After discontinuation of SOD and SDD a unit-wide increase in ceftazidime resistance was also observed. The implications of this 'rebound-effect' are not clear.
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(2010)
Am J Respir Crit Care Med
, vol.181
, pp. 452-457
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Oostdijk, E.A.1
De Smet, A.M.2
Blok, H.E.3
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12
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80054764481
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Long-termuse of selective decontamination of the digestive tract does not increase antibiotic resistance: A 5-year prospective cohort study
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This is a recent long-term observational study in a setting with higher antibiotic resistance levels compared with Dutch settings confirming earlier results of other studies showing that SDD (with vancomycin) does not increase antibiotic resistance
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Ochoa-Ardila ME, García-Cañas A, Gómez-Mediavilla K, et al. Long-termuse of selective decontamination of the digestive tract does not increase antibiotic resistance: a 5-year prospective cohort study. Intensive Care Med 2011; 37:1458-1465. This is a recent long-term observational study in a setting with higher antibiotic resistance levels compared with Dutch settings confirming earlier results of other studies showing that SDD (with vancomycin) does not increase antibiotic resistance.
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(2011)
Intensive Care Med
, vol.37
, pp. 1458-1465
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Ochoa-Ardila, M.E.1
García-Cañas, A.2
Gómez-Mediavilla, K.3
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13
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0031878768
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Changing bacterial ecology during a five year period of selective intestinal decontamination
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DOI 10.1016/S0195-6701(98)90258-4
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Lingnau W, Berger J, Javorsky F, et al. Changing bacterial ecology during a five-year period of selective intestinal decontamination. J Hosp Infect 1998; 39:195-206. (Pubitemid 28362385)
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Allerberger, F.5
Benzer, H.6
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14
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Survival benefit in critically ill burned patients receiving selective decontamination of the digestive tract: A randomized, placebo-controlled, double-blind trial
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DOI 10.1097/01.sla.0000154148.58154.d5
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dela Cal MA, Cerdá E,Garcí-Hierro P, et al. Survival benefit in critically illburned patients receiving selective de contamination of the digestive tract: a randomized, placebo-controlled, double-blind trial. Ann Surg 2005; 241:424-430. (Pubitemid 40299718)
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De La, C.M.A.1
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Gomez-Santos, D.5
Negro, E.6
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Emergence of CC17 Enterococcus faecium: From commensal to hospital-adapted pathogen
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DOI 10.1111/j.1574-695X.2008.00383.x
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Top J, Willems R, Bonten M. Emergence of CC17 Enterococcus faecium: from commensal to hospital-adapted pathogen. FEMS Immunol Med Microbiol 2008; 52:297-308. (Pubitemid 351420752)
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Top, J.1
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Emergence of clonal complex 17 Enterococcus faeciumin TheNetherlands
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Top J, Willems R, van der Velden S, et al. Emergence of clonal complex 17 Enterococcus faeciumin TheNetherlands. J Clin Microbiol 2008; 46:214-219.
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Top, J.1
Willems, R.2
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Chlorhexidine gluconate to cleanse patients in a medical intensive care unit: The effectiveness of source control to reduce the bioburden of vancomycin-resistant enterococci
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Vernon MO, Hayden MK, Trick WE, et al., Chicago Antimicrobial Resistance Project (CARP). Chlorhexidine gluconate to cleanse patients in a medical intensive care unit: the effectiveness of source control to reduce the bioburden of vancomycin-resistant enterococci. Arch Intern Med 2006; 166:306-312. (Pubitemid 43244318)
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Archives of Internal Medicine
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Weinstein, R.A.6
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18
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66449116150
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The effect of daily bathing with chlorhexidine on the acquisition of methicillin-resistant Staphylococcus aureus, vancomycin-resistant Enterococcus, and healthcare-associated bloodstream infections: Results of a quasi-experimental multicenter trial
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Climo MW, Sepkowitz KA, Zuccotti G, et al. The effect of daily bathing with chlorhexidine on the acquisition of methicillin-resistant Staphylococcus aureus, vancomycin-resistant Enterococcus, and healthcare-associated bloodstream infections: results of a quasi-experimental multicenter trial. Crit Care Med 2009; 37:1858-1865.
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Crit Care Med
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Climo, M.W.1
Sepkowitz, K.A.2
Zuccotti, G.3
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19
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82555186407
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Prevention of ventilator-associated pneumonia with oral antiseptics: A systematic review and metaanalysis
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Recent meta-analysis with 14 (five new trials not included in earlier meta-analyses) randomized trials that provided evidence that chlorhexidine (and povidone-iodine) reduce the rate of VAP. Cardiosurgical patients benefited more than a mixed intensive care population
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Labeau SO, Van de Vyver K, Brusselaers N, et al. Prevention of ventilator-associated pneumonia with oral antiseptics: a systematic review and metaanalysis. Lancet Infect Dis 2011; 11:845-854. Recent meta-analysis with 14 (five new trials not included in earlier meta-analyses) randomized trials that provided evidence that chlorhexidine (and povidone-iodine) reduce the rate of VAP. Cardiosurgical patients benefited more than a mixed intensive care population.
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Lancet Infect Dis
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Labeau, S.O.1
Van De Vyver, K.2
Brusselaers, N.3
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20
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Selective decontamination of the digestive tract in surgical patients: A systematic review of the evidence
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DOI 10.1001/archsurg.134.2.170
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Nathens AB, Marshall JC. Selective decontamination of the digestive tract in surgical patients: a systematic review of the evidence. Arch Surg 1999; 134:170-176. (Pubitemid 29088969)
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Nathens, A.B.1
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84855702069
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Effects of decontamination of the digestive tract and oropharynx in surgical and non-surgical ICU patients: A subgroup analysis
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doi: 10.1002/bjs.7703. [Epub ahead of print] First head-to-head comparison of SDD and SOD in surgical and nonsurgical patients demonstrating different efficacies of SDD and SOD in these patient groups. The results suggest that SDD has similar effects in surgical and nonsurgical patients, whereas nonsurgical patients benefit more from SOD than surgical patients. This indicates that appropriate patient selection may be important to obtain the best effects from antibiotic prophylaxis in ICU patients
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Melsen WG, de Smet AM, Kluytmans JA, Bonten MJ. Effects of decontamination of the digestive tract and oropharynx in surgical and non-surgical ICU patients: a subgroup analysis. Brit J Surg 2011. doi: 10.1002/bjs.7703. [Epub ahead of print] First head-to-head comparison of SDD and SOD in surgical and nonsurgical patients demonstrating different efficacies of SDD and SOD in these patient groups. The results suggest that SDD has similar effects in surgical and nonsurgical patients, whereas nonsurgical patients benefit more from SOD than surgical patients. This indicates that appropriate patient selection may be important to obtain the best effects from antibiotic prophylaxis in ICU patients.
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(2011)
Brit J Surg
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Melsen, W.G.1
De Smet, A.M.2
Kluytmans, J.A.3
Bonten, M.J.4
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22
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80052425987
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Randomized clinical trial of perioperative selective decontamination of the digestive tract versus placebo in elective gastrointestinal surgery
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Randomized controlled double-blind study, not primarily in ICU settings in which the gastrointestinal part of SDD was administered preoperatively resulting in a significant decrease in anastomotic leakage in patients undergoing elective gastrointestinal surgery
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Roos D, Dijksman LM, Oudemans-van Straaten HM, et al. Randomized clinical trial of perioperative selective decontamination of the digestive tract versus placebo in elective gastrointestinal surgery. Br J Surg 2011; 98:1365-1372. Randomized controlled double-blind study, not primarily in ICU settings in which the gastrointestinal part of SDD was administered preoperatively resulting in a significant decrease in anastomotic leakage in patients undergoing elective gastrointestinal surgery.
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(2011)
Br J Surg
, vol.98
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Roos, D.1
Dijksman, L.M.2
Oudemans-van Straaten, H.M.3
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23
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79955483742
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The role of intestinal colonization with Gram-negative bacteria as a source for intensive care unit-acquired bacteremia
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Dutch SOD-SDD Trialists Group This study addresses the question how SDD improves patient outcomes in ICU patients. Intestinal decontamination of Gram-negative bacteria was associated with a three-fold reduction in ICU-acquired Gram-negative bacteremia
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Oostdijk EA, de Smet AM, Kesecioglu J, Bonten MJ, Dutch SOD-SDD Trialists Group. The role of intestinal colonization with Gram-negative bacteria as a source for intensive care unit-acquired bacteremia. Crit Care Med 2011; 39:961-966. This study addresses the question how SDD improves patient outcomes in ICU patients. Intestinal decontamination of Gram-negative bacteria was associated with a three-fold reduction in ICU-acquired Gram-negative bacteremia.
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(2011)
Crit Care Med
, vol.39
, pp. 961-966
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Oostdijk, E.A.1
De Smet, A.M.2
Kesecioglu, J.3
Bonten, M.J.4
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24
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85027934185
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Probiotics versus antibiotic decontamination of the digestive tract: Infection and mortality
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Oudhuis GJ, Bergmans DC, Dormans T, et al. Probiotics versus antibiotic decontamination of the digestive tract: infection and mortality. Intensive Care Med 2011; 37:110-117.
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Intensive Care Med
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Oudhuis, G.J.1
Bergmans, D.C.2
Dormans, T.3
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25
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77958006512
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Probiotic prophylaxis of ventilator associated pneumonia. A blinded, randomized, controlled trial
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Morrow LE, Kollef MH, Casale TB. Probiotic prophylaxis of ventilator associated pneumonia. A blinded, randomized, controlled trial. Am J Respir Crit Care Med 2010; 182:1058-1064.
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Am J Respir Crit Care Med
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Morrow, L.E.1
Kollef, M.H.2
Casale, T.B.3
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