Combined infusion of glutamine and arginine: Does it make sense?

Current Opinion in Clinical Nutrition and Metabolic Care

Volumn 13, Issue 1, 2010, Pages 70-74

  Coëffier, Moïse ^a   Déchelotte, Pierre ^a  

^a ROUEN UNIVERSITY HOSPITAL   (France)

Author keywords

Arginine; Glutamine; Immunonutrition; Pharmaconutrition

Indexed keywords

ARGININE; GLUTAMINE; NITRIC OXIDE; POLYAMINE;

AMINO ACID METABOLISM; CRITICAL ILLNESS; HUMAN; INFLAMMATION; NUTRITIONAL SUPPORT; PARENTERAL NUTRITION; REVIEW; RISK BENEFIT ANALYSIS; SURGICAL PATIENT;

ARGININE; CRITICAL ILLNESS; DIETARY SUPPLEMENTS; DRUG SYNERGISM; DRUG THERAPY, COMBINATION; GLUTAMINE; HUMANS; INFLAMMATION; INTESTINAL MUCOSA; OXIDATIVE STRESS; PARENTERAL NUTRITION; POSTOPERATIVE COMPLICATIONS;

EID: 73849104162     PISSN: 13631950     EISSN: 14736519     Source Type: Journal    
DOI: 10.1097/MCO.0b013e328333c27f     Document Type: Review

References (52)

1. Gennari R, Alexander JW, Eaves-Pyles T. Effect of different combinations of dietary additives on bacterial translocation and survival in gut-derived sepsis. JPEN J Parenter Enteral Nutr 1995; 19:319-325.
2. Kul M, Vurucu S, Demirkaya E, et al. Enteral glutamine and/or arginine supplementation have favorable effects on oxidative stress parameters in neonatal rat intestine. J Pediatr Gastroenterol Nutr 2009; 49:85-89.
3. Lecleire S, Hassan A, Marion-Letellier R, et al. Combined glutamine and arginine decrease proinflammatory cytokine production by biopsies from Crohn's patients in association with changes in nuclear factor-kappaB and p38 mitogen-activated protein kinase pathways. J Nutr 2008; 138:2481-2486.
4. Labow BI, Souba WW. Glutamine. World J Surg 2000; 24:1503-1513.
5. Marik PE, Zaloga GP. Immunonutrition in critically ill patients: a systematic review and analysis of the literature. Intensive Care Med 2008; 34:1980-1990.
6. Wischmeyer PE. Glutamine: role in critical illness and ongoing clinical trials. Curr Opin Gastroenterol 2008; 24:190-197.
7. Coeffier M, Dechelotte P. The role of glutamine in intensive care unit patients: mechanisms of action and clinical outcome. Nutr Rev 2005; 63:65-69.
8. Coeffier M, Marion R, Ducrotte P, Dechelotte P. Modulating effect of glutamine on IL-1beta-induced cytokine production by human gut. Clin Nutr 2003; 22:407-413.
9. Flaring UB, Rooyackers OE, Wernerman J, Hammarqvist F. Glutamine attenuates posttraumatic glutathione depletion in human muscle. Clin Sci (Lond) 2003; 104:275-282.
10. Oehler R, Pusch E, Dungel P, et al. Glutamine depletion impairs cellular stress response in human leucocytes. Br J Nutr 2002; 87 (Suppl 1):S17-S21.
11. Ziegler TR, Ogden LG, Singleton KD, et al. Parenteral glutamine increases serum heat shock protein 70 in critically ill patients. Intensive Care Med 2005; 31:1079-1086.
12. Bakalar B, Duska F, Pachl J, et al. Parenterally administered dipeptide alanyl-glutamine prevents worsening of insulin sensitivity in multiple-trauma patients. Crit Care Med 2006; 34:381-386.
13. Dechelotte P, Hasselmann M, Cynober L, et al. L-alanyl-L-glutamine dipep-tide-supplemented total parenteral nutrition reduces infectious complications and glucose intolerance in critically ill patients: the French controlled, randomized, double-blind, multicenter study. Crit Care Med 2006; 34:598-604.
14. Coeffier M, Marion-Letellier R, Dechelotte P. Potential for amino acids supplementation during inflammatory bowel diseases. Inflamm Bowel Dis 2009 (in press).
15. Luiking YC, Deutz NE. Exogenous arginine in sepsis. Crit Care Med 2007; 35:S557-S563.
16. Popovic PJ, Zeh HJ 3rd, Ochoa JB. Arginine and immunity. J Nutr 2007; 137:1681S-1686S.
17. Hamani D, Charrueau C, Butel MJ, et al. Effect of an immune-enhancing diet on lymphocyte in head-injured rats: what is the role of arginine? Intensive Care Med 2007; 33:1076-1084.
18. Dupertuis YM, Meguid MM, Pichard C. Advancing from immunonutrition to a pharmaconutrition: a gigantic challenge. Curr Opin Clin Nutr Metab Care 2009; 12:398-403.
19. Curi R, Lagranha CJ, Doi SQ, et al. Molecular mechanisms of glutamine action. J Cell Physiol 2005; 204:392-401.
20. Roth E. Nonnutritive effects of glutamine. J Nutr 2008; 138:2025S-2031S.
21. Rhoads MJ, Wu G. Glutamine, arginine, and leucine signaling in the intestine. Amino Acids 2009; 37:111-122.
22. Evans ME, Jones DP, Ziegler TR. Glutamine prevents cytokine-induced apoptosis in human colonic epithelial cells. J Nutr 2003; 133:3065-3071.
23. Coeffier M, Claeyssens S, Hecketsweiler B, et al. Enteral glutamine stimulates protein synthesis and decreases ubiquitin mRNA level in human gut mucosa. Am J Physiol Gastrointest Liver Physiol 2003; 285:G266-G273.
24. Amasheh M, Andres S, Amasheh S, et al. Barrier effects of nutritional factors. Ann N Y Acad Sci 2009; 1165:267-273.
25. Kudsk KA, Wu Y, Fukatsu K, et al. Glutamine-enriched total parenteral nutrition maintains intestinal interleukin-4 and mucosal immunoglobulin A levels. JPEN J Parenter Enteral Nutr 2000; 24:270-274; discussion 274-275.
26. De-Souza DA, Greene LJ. Intestinal permeability and systemic infections in critically ill patients: effect of glutamine. Crit Care Med 2005; 33:1125-1135.
27. Boelens PG, HoudijkAP, FonkJC, et al. Glutamine-enriched enteral nutrition increases HLA-DR expression on monocytes of trauma patients. J Nutr 2002; 132:2580-2586.
28. Berger MM, Chiolero RL. Antioxidant supplementation in sepsis and systemic inflammatory response syndrome. Crit Care Med 2007; 35:S584-S590.
29. Curi R, Newsholme P, Procopio J, et al. Glutamine, gene expression, and cell function. Front Biosci 2007; 12:344-357.
30. Brasse-Lagnel C, Lavoinne A, Husson A. Control of mammalian gene expression by amino acids, especially glutamine. FEBS J 2009; 276:1826-1844.
31. Wu G, BazerFW, Davis TA, et al. Arginine metabolism and nutrition in growth, health and disease. Amino Acids 2009; 37:153-168.
32. Durante W, Johnson FK, Johnson RA. Arginase: a critical regulator of nitric oxide synthesis and vascular function. Clin Exp Pharmacol Physiol 2007; 34:906-911.
33. Moinard C, Cynober L, de Bandt JP. Polyamines: metabolism and implications in human diseases. Clin Nutr 2005; 24:184-197.
34. Luiking YC, Poeze M, Ramsay G, Deutz NE. Reduced citrulline production in sepsis is related to diminished de novo arginine and nitric oxide production. Am J Clin Nutr 2009; 89:142-152.
35. Chin MP, Schauer DB, Deen WM. Prediction of nitric oxide concentrations in colonic crypts during inflammation. Nitric Oxide 2008; 19:266-275.
36. Horowitz S, Binion DG, Nelson VM, et al. Increased arginase activity and endothelial dysfunction in human inflammatory bowel disease. Am J Physiol Gastrointest Liver Physiol 2007; 292:G1323-G1336.
37. Wu G. Amino acids: metabolism, functions, and nutrition. Amino Acids 2009; 37:1-17.
38. Crenn P, Messing B, Cynober L. Citrulline as a biomarker of intestinal failure due to enterocyte mass reduction. Clin Nutr 2008; 27:328-339.
39. Ligthart-Melis GC, van de Poll MC, Boelens PG, et al. Glutamine is an important precursor for de novo synthesis of arginine in humans. Am J Clin Nutr 2008; 87:1282-1289.
40. Wu G, Meininger CJ. Nitric oxide and vascular insulin resistance. Biofactors 2009; 35:21-27.
41. Marion R, Coeffier M, Lemoulan S, et al. L-Arginine modulates CXC chemo-kines in the human intestinal epithelial cell line HCT-8 by the NO pathway. Biochimie 2005; 87:1048-1055.
42. Marion R, Coeffier M, Leplingard A, et al. Cytokine-stimulated nitric oxide production and inducible NO-synthase mRNA level in human intestinal cells: lack of modulation by glutamine. Clin Nutr 2003; 22:523-528.
43. Barcelo-Batllori S, Andre M, Servis C, et al. Proteomic analysis of cytokine induced proteins in human intestinal epithelial cells: implications for inflammatory bowel diseases. Proteomics 2002; 2:551-560.
44. Brasse-Lagnel C, Lavoinne A, Loeber D, et al. Glutamine and interleukin-1beta interact at the level of Sp1 and nuclear factor-kappaB to regulate arginino-succinate synthetase gene expression. FEBS J 2007; 274:5250-5262.
45. Nakajo T, Yamatsuji T, Ban H, et al. Glutamine is a key regulator for ami no acid-controlled cell growth through the mTOR signaling pathway in rat intestinal epithelial cells. Biochem Biophys Res Commun 2005; 326:174-180.
46. Corl BA, Odle J, Niu X, et al. Arginine activates intestinal p70(S6k) and protein synthesis in piglet rotavirus enteritis. J Nutr 2008; 138:24-29.
47. Yao K, Yin YL, Chu W, et al. Dietary arginine supplementation increases mTOR signaling activity in skeletal muscle of neonatal pigs. J Nutr 2008; 138:867-872.
48. Bertolo RF, Brunton JA, Pencharz PB, et al. Arginine, ornithine, and proline interconversion is dependent on small intestinal metabolism in neonatal pigs. Am J Physiol Endocrinol Metab 2003; 284:E915-E922.
49. Urschel KL, Rafii M, Pencharz PB, et al. A multitracer stable isotope quantification of the effects of arginine intake on whole body arginine metabolism in neonatal piglets. Am J Physiol Endocrinol Metab 2007; 293:E811-E81 8.
50. Tomlinson C, Rafii M, Sgro M, et al. Arginine is synthetized from proline not glutamate in enterally fed preterm human infants. FASEB J 2008; 22:869.28 [Abstract].
51. Kudsk KA, Minard G, Croce MA, et al. A randomized trial of isonitrogenous enteral diets after severe trauma. An immune-enhancing diet reduces septic complications. Ann Surg 1996; 224:531-540; discussion 540-1533
52. Moore FA, Moore EE, Kudsk KA, et al. Clinical benefits of an immune-enhancing diet for early postinjury enteral feeding. J Trauma 1994; 37:607-615.