Gut failure in the ICU

Seminars in Respiratory and Critical Care Medicine

Volumn 32, Issue 5, 2011, Pages 626-638

  Puleo, Francesco ^a   Arvanitakis, Marianna ^a   Van Gossum, André ^a   Preiser, Jean Charles ^a  

^a ERASME HOSPITAL   (Belgium)

Author keywords

bacterial translocation; critical care; Gut failure; multiple organ failure; sepsis

Indexed keywords

ARGININE; CHLORHEXIDINE; CHOLECYSTOKININ; COLISTIN; DOBUTAMINE; DOPAMINE; DOPEXAMINE; FISH OIL; GHRELIN; GLUCAGON LIKE PEPTIDE 1; GLUTAMINE; MOTILIN; NEOMYCIN; PEPTIDE YY; PROBIOTIC AGENT; TOBRAMYCIN; VANCOMYCIN;

ABDOMINAL PRESSURE; ANTIBIOTIC RESISTANCE; ANTIBIOTIC THERAPY; ARTICLE; ATROPHY; BACTERIAL INFECTION; BACTERIAL OVERGROWTH; BACTERIAL TRANSLOCATION; CLINICAL ASSESSMENT; COCHRANE LIBRARY; CRITICALLY ILL PATIENT; CYTOKINE PRODUCTION; DIARRHEA; DIGESTIVE FUNCTION; EMERGENCY SURGERY; ENTERIC FEEDING; ENTERITIS; ESCHERICHIA COLI; FEEDING DISORDER; GASTROINTESTINAL HEMORRHAGE; GUT LYMPH THEORY; HORMONE RELEASE; HUMAN; ILEUS; IMMUNE SYSTEM; INTENSIVE CARE UNIT; INTERMETHOD COMPARISON; INTESTINE BLOOD FLOW; INTESTINE EPITHELIUM; INTESTINE EPITHELIUM CELL; INTESTINE FLORA; INTESTINE FUNCTION; INTESTINE FUNCTION DISORDER; INTESTINE INNERVATION; INTESTINE ISCHEMIA; INTESTINE OBSTRUCTION; INTRAABDOMINAL HYPERTENSION; JAUNDICE; META ANALYSIS (TOPIC); MORTALITY; MULTIPLE ORGAN FAILURE; PATHOPHYSIOLOGY; PREVALENCE; PRIORITY JOURNAL; PROGNOSIS; RANDOMIZED CONTROLLED TRIAL (TOPIC); RISK FACTOR; SEPSIS; STARVATION; SYSTEMIC INFLAMMATORY RESPONSE SYNDROME; THEORY; THREE HIT MODEL THEORY; TOTAL PARENTERAL NUTRITION;

ANIMALS; BACTERIAL TRANSLOCATION; CRITICAL ILLNESS; GASTROINTESTINAL DISEASES; GASTROINTESTINAL TRACT; HUMANS; INTENSIVE CARE UNITS; MULTIPLE ORGAN FAILURE; SEPSIS; SYSTEMIC INFLAMMATORY RESPONSE SYNDROME;

EID: 80054064602     PISSN: 10693424     EISSN: 10989048     Source Type: Journal    
DOI: 10.1055/s-0031-1287871     Document Type: Article

References (145)

1. Gatt M, Reddy B S., MacFie J. Review article: bacterial translocation in the critically illevidence and methods of prevention. Aliment Pharmacol Ther 2007 25 7 741-757 (Pubitemid 46437210)
2. Reintam A, Parm P, Kitus R, Kern H, Starkopf J. Gastrointestinal symptoms in intensive care patients. Acta Anaesthesiol Scand 2009 53 3 318-324
3. Piton G, Manzon C, Cypriani B, Carbonnel F, Capellier G. Acute intestinal failure in critically ill patients: is plasma citrulline the right marker? Intensive Care Med 2011 37 6 911-917
4. Le Gall J R., Lemeshow S, Saulnier F. A new Simplified Acute Physiology Score (SAPS II) based on a European/North American multicenter study. JAMA 1993 270 24 2957-2963 (Pubitemid 24000804)
5. Vincent J L., Moreno R, Takala J et al. The SOFA (sepsis-related organ failure assessment) score to describe organ dysfunction/failure. On behalf of the Working Group on Sepsis-Related Problems of the European Society of Intensive Care Medicine. Intensive Care Med 1996 22 7 707-710
6. Fagon J Y., Chastre J, Novara A, Medioni P, Gibert C. Characterization of intensive care unit patients using a model based on the presence or absence of organ dysfunctions and/or infection: the ODIN model. Intensive Care Med 1993 19 3 137-144 (Pubitemid 23193705)
7. Crenn P, Messing B, Cynober L. Citrulline as a biomarker of intestinal failure due to enterocyte mass reduction. Clin Nutr 2008 27 3 328-339
8. Cummings J H., Antoine J M., Azpiroz F et al. PASSCLAIMgut health and immunity. Eur J Nutr 2004 43 Suppl 2 II118-II173
9. Cheng H, Leblond C P. Origin, differentiation and renewal of the four main epithelial cell types in the mouse small intestine, V: Unitarian theory of the origin of the four epithelial cell types. Am J Anat 1974 141 4 537-561
10. Hall P A., Coates P J., Ansari B, Hopwood D. Regulation of cell number in the mammalian gastrointestinal tract: the importance of apoptosis. J Cell Sci 1994 107 Pt 12 3569-3577
11. Grootjans J, Hodin C M., de Haan J J. et al. Level of activation of the unfolded protein response correlates with Paneth cell apoptosis in human small intestine exposed to ischemia/reperfusion. Gastroenterology 2011 140 2 529-539 e3
12. Utech M, Brüwer M, Nusrat A. Tight junctions and cell-cell interactions. Methods Mol Biol 2006 341 185-195
13. Coopersmith C M., Stromberg P E., Davis C G. et al. Sepsis from Pseudomonas aeruginosa pneumonia decreases intestinal proliferation and induces gut epithelial cell cycle arrest. Crit Care Med 2003 31 6 1630-1637 (Pubitemid 36714214)
14. Husain K D., Stromberg P E., Woolsey C A. et al. Mechanisms of decreased intestinal epithelial proliferation and increased apoptosis in murine acute lung injury. Crit Care Med 2005 33 10 2350-2357 (Pubitemid 41437492)
15. Potoka D A., Upperman J S., Zhang X R. et al. Peroxynitrite inhibits enterocyte proliferation and modulates Src kinase activity in vitro. Am J Physiol Gastrointest Liver Physiol 2003 285 5 G861-G869 (Pubitemid 37310065)
16. Rafferty J F., Noguchi Y, Fischer J E., Hasselgren P O. Sepsis in rats stimulates cellular proliferation in the mucosa of the small intestine. Gastroenterology 1994 107 1 121-127 (Pubitemid 24195354)
17. Clark J A., Coopersmith C M. Intestinal crosstalk: a new paradigm for understanding the gut as the motor of critical illness. Shock 2007 28 4 384-393 (Pubitemid 47421846)
18. Fukatsu K, Sakamoto S, Hara E et al. Gut ischemia-reperfusion affects gut mucosal immunity: a possible mechanism for infectious complications after severe surgical insults. Crit Care Med 2006 34 1 182-187 (Pubitemid 43032396)
19. Bäckhed F, Ley R E., Sonnenburg J L., Peterson D A., Gordon J I. Host-bacterial mutualism in the human intestine. Science 2005 307 5717 1915-1920 (Pubitemid 40404694)
20. Alverdy J C., Laughlin R S., Wu L. Influence of the critically ill state on host-pathogen interactions within the intestine: gut-derived sepsis redefined. Crit Care Med 2003 31 2 598-607 (Pubitemid 36232961)
21. Lazazzera B A. Quorum sensing and starvation: signals for entry into stationary phase. Curr Opin Microbiol 2000 3 2 177-182 (Pubitemid 30180070)
22. Kinney K S., Austin C E., Morton D S., Sonnenfeld G. Norepinephrine as a growth stimulating factor in bacteriamechanistic studies. Life Sci 2000 67 25 3075-3085
23. Deane A, Chapman M J., Fraser R JL, Horowitz M. Bench-to-bedside review: the gut as an endocrine organ in the critically ill. Crit Care 2010 14 5 228-238
24. Nind G, Chen W H., Protheroe R et al. Mechanisms of gastroesophageal reflux in critically ill mechanically ventilated patients. Gastroenterology 2005 128 3 600-606 (Pubitemid 40585361)
25. Nguyen N Q., Fraser R J., Chapman M et al. Proximal gastric response to small intestinal nutrients is abnormal in mechanically ventilated critically ill patients. World J Gastroenterol 2006 12 27 4383-4388 (Pubitemid 44194533)
26. Chapman M, Fraser R, Vozzo R et al. Antro-pyloro-duodenal motor responses to gastric and duodenal nutrient in critically ill patients. Gut 2005 54 10 1384-1390 (Pubitemid 41375193)
27. Deane A M., Fraser R J., Chapman M J. Prokinetic drugs for feed intolerance in critical illness: current and potential therapies. Crit Care Resusc 2009 11 2 132-143
28. Chapman M J., Fraser R J., Bryant L K. et al. Gastric emptying and the organization of antro-duodenal pressures in the critically ill. Neurogastroenterol Motil 2008 20 1 27-35 (Pubitemid 350277447)
29. Johnston J D., Harvey C J., Menzies I S., Treacher D F. Gastrointestinal permeability and absorptive capacity in sepsis. Crit Care Med 1996 24 7 1144-1149 (Pubitemid 26249364)
30. Chapman M J., Fraser R J., Matthews G et al. Glucose absorption and gastric emptying in critical illness. Crit Care 2009 13 4 R140
31. Wren A M., Seal L J., Cohen M A. et al. Ghrelin enhances appetite and increases food intake in humans. J Clin Endocrinol Metab 2001 86 12 5992-5995 (Pubitemid 33152655)
32. Parker B A., Doran S, Wishart J, Horowitz M, Chapman I M. Effects of small intestinal and gastric glucose administration on the suppression of plasma ghrelin concentrations in healthy older men and women. Clin Endocrinol (Oxf) 2005 62 5 539-546 (Pubitemid 40646719)
33. Tack J, Depoortere I, Bisschops R, Verbeke K, Janssens J, Peeters T. Influence of ghrelin on gastric emptying and meal-related symptoms in idiopathic gastroparesis. Aliment Pharmacol Ther 2005 22 9 847-853 (Pubitemid 41568544)
34. Murray C D., Martin N M., Patterson M et al. Ghrelin enhances gastric emptying in diabetic gastroparesis: a double blind, placebo controlled, crossover study. Gut 2005 54 12 1693-1698 (Pubitemid 41697666)
35. De Winter B Y., De Man J G., Seerden T C. et al. Effect of ghrelin and growth hormone-releasing peptide 6 on septic ileus in mice. Neurogastroenterol Motil 2004 16 4 439-446 (Pubitemid 39140639)
36. Nematy M, O'Flynn J E., Wandrag L et al. Changes in appetite related gut hormones in intensive care unit patients: a pilot cohort study. Crit Care 2006 10 1 R10
37. Vantrappen G, Janssens J, Peeters T L., Bloom S R., Christofides N D., Hellemans J. Motilin and the interdigestive migrating motor complex in man. Dig Dis Sci 1979 24 7 497-500 (Pubitemid 9236877)
38. Peeters T L., Muls E, Janssens J et al. Effect of motilin on gastric emptying in patients with diabetic gastroparesis. Gastroenterology 1992 102 1 97-101
39. Pilichiewicz A N., Chaikomin R, Brennan I M. et al. Load-dependent effects of duodenal glucose on glycemia, gastrointestinal hormones, antropyloroduodenal motility, and energy intake in healthy men. Am J Physiol Endocrinol Metab 2007 293 3 E743-E753 (Pubitemid 47358986)
40. Fried M, Erlacher U, Schwizer W et al. Role of cholecystokinin in the regulation of gastric emptying and pancreatic enzyme secretion in humans. Studies with the cholecystokinin-receptor antagonist loxiglumide. Gastroenterology 1991 101 2 503-511
41. Schwizer W, Borovicka J, Kunz P et al. Role of cholecystokinin in the regulation of liquid gastric emptying and gastric motility in humans: studies with the CCK antagonist loxiglumide. Gut 1997 41 4 500-504 (Pubitemid 27448782)
42. Hildebrand P, Beglinger C, Gyr K et al. Effects of a cholecystokinin receptor antagonist on intestinal phase of pancreatic and biliary responses in man. J Clin Invest 1990 85 3 640-646 (Pubitemid 20087463)
43. Nguyen N Q., Fraser R J., Chapman M J. et al. Feed intolerance in critical illness is associated with increased basal and nutrient-stimulated plasma cholecystokinin concentrations. Crit Care Med 2007 35 1 82-88 (Pubitemid 46035681)
44. Adrian T E., Ferri G L., Bacarese-Hamilton A J., Fuessl H S., Polak J M., Bloom S R. Human distribution and release of a putative new gut hormone, peptide YY. Gastroenterology 1985 89 5 1070-1077 (Pubitemid 16231572)
45. Savage A P., Adrian T E., Carolan G, Chatterjee V K., Bloom S R. Effects of peptide YY (PYY) on mouth to caecum intestinal transit time and on the rate of gastric emptying in healthy volunteers. Gut 1987 28 2 166-170 (Pubitemid 17027386)
46. Nguyen N Q., Fraser R J., Bryant L K. et al. The relationship between gastric emptying, plasma cholecystokinin, and peptide YY in critically ill patients. Crit Care 2007 11 6 R132
47. Meier J J., Nauck M A. Glucagon-like peptide 1(GLP-1) in biology and pathology. Diabetes Metab Res Rev 2005 21 2 91-117 (Pubitemid 40467658)
48. Nauck M A., Heimesaat M M., Orskov C, Holst J J., Ebert R, Creutzfeldt W. Preserved incretin activity of glucagon-like peptide 1 [7-36 amide] but not of synthetic human gastric inhibitory polypeptide in patients with type-2 diabetes mellitus. J Clin Invest 1993 91 1 301-307 (Pubitemid 23037285)
49. Nauck M A. Is glucagon-like peptide 1 an incretin hormone? Diabetologia 1999 42 3 373-379
50. Meier J J., Gallwitz B, Schmidt W E., Nauck M A. Glucagon-like peptide 1 as a regulator of food intake and body weight: therapeutic perspectives. Eur J Pharmacol 2002 440 2-3 269-279 (Pubitemid 34460704)
51. Chaikomin R, Doran S, Jones K L. et al. Initially more rapid small intestinal glucose delivery increases plasma insulin, GIP, and GLP-1 but does not improve overall glycemia in healthy subjects. Am J Physiol Endocrinol Metab 2005 289 3 E504-E507 (Pubitemid 41192706)
52. Meier J J., Weyhe D, Michaely M et al. Intravenous glucagon-like peptide 1 normalizes blood glucose after major surgery in patients with type 2 diabetes. Crit Care Med 2004 32 3 848-851 (Pubitemid 38340086)
53. Müssig K, Oncü A, Lindauer P et al. Effects of intravenous glucagon-like peptide-1 on glucose control and hemodynamics after coronary artery bypass surgery in patients with type 2 diabetes. Am J Cardiol 2008 102 5 646-647
54. Deane A M., Chapman M J., Fraser R J., Burgstad C M., Besanko L K., Horowitz M. The effect of exogenous glucagon-like peptide-1 on the glycaemic response to small intestinal nutrient in the critically ill: a randomised double-blind placebo-controlled cross over study. Crit Care 2009 13 3 R67
55. Straub R H., Wiest R, Strauch U G., Härle P, Schölmerich J. The role of the sympathetic nervous system in intestinal inflammation. Gut 2006 55 11 1640-1649 (Pubitemid 44629216)
56. Miksa M, Wu R, Zhou M, Wang P. Sympathetic excitotoxicity in sepsis: pro-inflammatory priming of macrophages by norepinephrine. Front Biosci 2005 10 2217-2229 (Pubitemid 40905293)
57. Keita A V., Söderholm J D. The intestinal barrier and its regulation by neuroimmune factors. Neurogastroenterol Motil 2010 22 7 718-733
58. Santos J, Saunders P R., Hanssen N P. et al. Corticotropin-releasing hormone mimics stress-induced colonic epithelial pathophysiology in the rat. Am J Physiol 1999 277 2 Pt 1 G391-G399 (Pubitemid 29415067)
59. Santos J, Yates D, Guilarte M, Vicario M, Alonso C, Perdue M H. Stress neuropeptides evoke epithelial responses via mast cell activation in the rat colon. Psychoneuroendocrinology 2008 33 9 1248-1256
60. Smith F, Clark J E., Overman B L. et al. Early weaning stress impairs development of mucosal barrier function in the porcine intestine. Am J Physiol Gastrointest Liver Physiol 2010 298 3 G352-G363
61. Wallon C, Yang P C., Keita A V. et al. Corticotropin-releasing hormone (CRH) regulates macromolecular permeability via mast cells in normal human colonic biopsies in vitro. Gut 2008 57 1 50-58
62. Moeser A J., Klok C V., Ryan K A. et al. Stress signaling pathways activated by weaning mediate intestinal dysfunction in the pig. Am J Physiol Gastrointest Liver Physiol 2007 292 1 G173-G181 (Pubitemid 46098884)
63. Crowe S E., Perdue M H. Anti-immunoglobin E-stimulated ion transport in human large and small intestine. Gastroenterology 1993 105 3 764-772 (Pubitemid 23249486)
64. Santos J, Saperas E, Nogueiras C et al. Release of mast cell mediators into the jejunum by cold pain stress in humans. Gastroenterology 1998 114 4 640-648 (Pubitemid 28160398)
65. Berg R D., Garlington A W. Translocation of certain indigenous bacteria from the gastrointestinal tract to the mesenteric lymph nodes and other organs in a gnotobiotic mouse model. Infect Immun 1979 23 2 403-411 (Pubitemid 9119845)
66. Carrico C J., Meakins J L., Marshall J C., Fry D, Maier R V. Multiple-organ-failure syndrome. Arch Surg 1986 121 2 196-208
67. Dominguez J A., Coopersmith C M. Can we protect the gut in critical illness? The role of growth factors and other novel approaches. Crit Care Clin 2010 26 3 549-565 x
68. Alverdy J C., Laughlin R S., Wu L. Influence of the critically ill state on host-pathogen interactions within the intestine: gut-derived sepsis redefined. Crit Care Med 2003 31 2 598-607 (Pubitemid 36232961)
69. Deitch E A. Bacterial translocation or lymphatic drainage of toxic products from the gut: what is important in human beings? Surgery 2002 131 3 241-244 (Pubitemid 34229775)
70. Deitch E A., Xu D, Kaise V L. Role of the gut in the development of injury- and shock induced SIRS and MODS: the gut-lymph hypothesis, a review. Front Biosci 2006 11 520-528 (Pubitemid 43258161)
71. Deitch E A. Role of the gut lymphatic system in multiple organ failure. Curr Opin Crit Care 2001 7 2 92-98 (Pubitemid 32411397)
72. Senthil M, Brown M, Xu D Z., Lu Q, Feketeova E, Deitch E A. Gut-lymph hypothesis of systemic inflammatory response syndrome/multiple-organ dysfunction syndrome: validating studies in a porcine model. J Trauma 2006 60 5 958-965 discussion 965-967 (Pubitemid 43778621)
73. Deitch E A., Forsythe R, Anjaria D et al. The role of lymph factors in lung injury, bone marrow suppression, and endothelial cell dysfunction in a primate model of trauma-hemorrhagic shock. Shock 2004 22 3 221-228 (Pubitemid 39468986)
74. Steinberg S M. Bacterial translocation: what it is and what it is not. Am J Surg 2003 186 3 301-305 (Pubitemid 38368633)
75. Spahn T W., Kucharzik T. Modulating the intestinal immune system: the role of lymphotoxin and GALT organs. Gut 2004 53 3 456-465 (Pubitemid 38241347)
76. Garside P, Millington O, Smith K M. The anatomy of mucosal immune responses. Ann N Y Acad Sci 2004 1029 9-15 (Pubitemid 40298510)
77. Song F, Whitacre C C. The role of the gut lymphoid tissue in induction of oral tolerance. Curr Opin Investig Drugs 2001 2 10 1382-1386 (Pubitemid 32994388)
78. O'Boyle C J., MacFie J, Mitchell C J., Johnstone D, Sagar P M., Sedman P C. Microbiology of bacterial translocation in humans. Gut 1998 42 1 29-35 (Pubitemid 28228384)
79. MacFie J, Reddy B S., Gatt M, Jain P K., Sowdi R, Mitchell C J. Bacterial translocation studied in 927 patients over 13 years. Br J Surg 2006 93 1 87-93 (Pubitemid 43117311)
80. Sedman P C., Macfie J, Sagar P et al. The prevalence of gut translocation in humans. Gastroenterology 1994 107 3 643-649 (Pubitemid 24265509)
81. Reynolds J V., Murchan P, Leonard N, Clarke P, Keane F B., Tanner W A. Gut barrier failure in experimental obstructive jaundice. J Surg Res 1996 62 1 11-16 (Pubitemid 26114110)
82. Hua T C., Moochhala S M. Role of nitric oxide in hemorrhagic shock-induced bacterial translocation. J Surg Res 2000 93 2 247-256
83. de Madaria E, Martínez J, Lozano B et al. Detection and identification of bacterial DNA in serum from patients with acute pancreatitis. Gut 2005 54 9 1293-1297 (Pubitemid 41199908)
84. Küçükaydin M, Kocaolu C, Köksal F, Konta O. Detection of intestinal bacterial translocation in subclinical ischemia-reperfusion using the polymerase chain reaction technique. J Pediatr Surg 2000 35 1 41-43 (Pubitemid 30062831)
85. Galeev Y M., Lishmanov Y B., Grigorev E G., Popov M V., Aparcin K A., Salato O V. Scintigraphic visualization of bacterial translocation in experimental strangulated intestinal obstruction. Eur J Nucl Med Mol Imaging 2009 36 11 1822-1828
86. Kabaroudis A, Papaziogas B, Koutelidakis I, Kyparissi-Kanellaki M, Kouzi-Koliakou K, Papaziogas T. Disruption of the small-intestine mucosal barrier after intestinal occlusion: a study with light and electron microscopy. J Invest Surg 2003 16 1 23-28 (Pubitemid 36372581)
87. Antequera R, Bretaña A, Cirac A, Brito A, Romera M A., Zapata R. Disruption of the intestinal barrier and bacterial translocation in an experimental model of intestinal obstruction. Acta Cient Venez 2000 51 1 18-26 (Pubitemid 32633755)
88. Samel S, Keese M, Kleczka M et al. Microscopy of bacterial translocation during small bowel obstruction and ischemia in vivoa new animal model. BMC Surg 2002 2 6-13
89. Sagar P M., MacFie J, Sedman P, May J, Mancey-Jones B, Johnstone D. Intestinal obstruction promotes gut translocation of bacteria. Dis Colon Rectum 1995 38 6 640-644
90. Deitch E A., Sittig K, Li M, Berg R, Specian R D. Obstructive jaundice promotes bacterial translocation from the gut. Am J Surg 1990 159 1 79-84 (Pubitemid 20045315)
91. Karsten T M., van Gulik T M., Spanjaard L et al. Bacterial translocation from the biliary tract to blood and lymph in rats with obstructive jaundice. J Surg Res 1998 74 2 125-130 (Pubitemid 28270360)
92. Ogata Y, Nishi M, Nakayama H, Kuwahara T, Ohnishi Y, Tashiro S. Role of bile in intestinal barrier function and its inhibitory effect on bacterial translocation in obstructive jaundice in rats. J Surg Res 2003 115 1 18-23 (Pubitemid 37323943)
93. Cakmakci M, Tirnaksiz B, Hayran M, Belek S, Gürbüz T, Sayek I. Effects of obstructive jaundice and external biliary diversion on bacterial translocation in rats. Eur J Surg 1996 162 7 567-571 (Pubitemid 126440366)
94. Ding J W., Andersson R, Soltesz V, Willén R, Bengmark S. Obstructive jaundice impairs reticuloendothelial function and promotes bacterial translocation in the rat. J Surg Res 1994 57 2 238-245 (Pubitemid 24262394)
95. Reynolds J V., Murchan P, Redmond H P. et al. Failure of macrophage activation in experimental obstructive jaundice: association with bacterial translocation. Br J Surg 1995 82 4 534-538
96. Sheen-Chen S M., Chau P, Harris H W. Obstructive jaundice alters Kupffer cell function independent of bacterial translocation. J Surg Res 1998 80 2 205-209 (Pubitemid 29019671)
97. Parks R W., Stuart Cameron C H., Gannon C D., Pope C, Diamond T, Rowlands B J. Changes in gastrointestinal morphology associated with obstructive jaundice. J Pathol 2000 192 4 526-532
98. Reynolds J V., Murchan P, Leonard N, Clarke P, Keane F B., Tanner W A. Gut barrier failure in experimental obstructive jaundice. J Surg Res 1996 62 1 11-16 (Pubitemid 26114110)
99. Wells C L., Jechorek R P., Erlandsen S L. Inhibitory effect of bile on bacterial invasion of enterocytes: possible mechanism for increased translocation associated with obstructive jaundice. Crit Care Med 1995 23 2 301-307
100. Parks R W., Clements W D., Smye M G., Pope C, Rowlands B J., Diamond T. Intestinal barrier dysfunction in clinical and experimental obstructive jaundice and its reversal by internal biliary drainage. Br J Surg 1996 83 10 1345-1349 (Pubitemid 26342150)
101. Kuzu M A., Kale I T., Cöl C, Tekeli A, Tanik A, Köksoy C. Obstructive jaundice promotes bacterial translocation in humans. Hepatogastroenterology 1999 46 28 2159-2164 (Pubitemid 29454062)
102. Al-Bahrani A Z., Darwish A, Hamza N et al. Gut barrier dysfunction in critically ill surgical patients with abdominal compartment syndrome. Pancreas 2010 39 7 1064-1069
103. Byers R J., Eddleston J M., Pearson R C., Bigley G, McMahon R F. Dopexamine reduces the incidence of acute inflammation in the gut mucosa after abdominal surgery in high-risk patients. Crit Care Med 1999 27 9 1787-1793 (Pubitemid 29455105)
104. Lisbon A. Dopexamine, dobutamine, and dopamine increase splanchnic blood flow: what is the evidence? Chest 2003 123 5, Suppl 460S-463S (Pubitemid 36549814)
105. MacFie J, O'Boyle C, Mitchell C J., Buckley P M., Johnstone D, Sudworth P. Gut origin of sepsis: a prospective study investigating associations between bacterial translocation, gastric microflora, and septic morbidity. Gut 1999 45 2 223-228 (Pubitemid 29333771)
106. Cheung N W., Napier B, Zaccaria C, Fletcher J P. Hyperglycemia is associated with adverse outcomes in patients receiving total parenteral nutrition. Diabetes Care 2005 28 10 2367-2371 (Pubitemid 41384278)
107. Jeejeebhoy K N. Total parenteral nutrition: potion or poison? Am J Clin Nutr 2001 74 2 160-163 (Pubitemid 32702480)
108. Miura S, Tanaka S, Yoshioka M et al. Changes in intestinal absorption of nutrients and brush border glycoproteins after total parenteral nutrition in rats. Gut 1992 33 4 484-489
109. Guedon C, Schmitz J, Lerebours E et al. Decreased brush border hydrolase activities without gross morphologic changes in human intestinal mucosa after prolonged total parenteral nutrition of adults. Gastroenterology 1986 90 2 373-378 (Pubitemid 16136679)
110. Rossi T M., Lee P C., Young C, Tjota A. Small intestinal mucosa changes, including epithelial cell proliferative activity, of children receiving total parenteral nutrition (TPN). Dig Dis Sci 1993 38 9 1608-1613 (Pubitemid 23271414)
111. Pironi L, Paganelli G M., Miglioli M et al. Morphologic and cytoproliferative patterns of duodenal mucosa in two patients after long-term total parenteral nutrition: changes with oral refeeding and relation to intestinal resection. JPEN J Parenter Enteral Nutr 1994 18 4 351-354 (Pubitemid 24222352)
112. Sedman P C., MacFie J, Palmer M D., Mitchell C J., Sagar P M. Preoperative total parenteral nutrition is not associated with mucosal atrophy or bacterial translocation in humans. Br J Surg 1995 82 12 1663-1667
113. Groos S, Hunefeld G, Luciano L. Parenteral versus enteral nutrition: morphological changes in human adult intestinal mucosa. J Submicrosc Cytol Pathol 1996 28 1 61-74 (Pubitemid 126451207)
114. Moore F A., Moore E E., Jones T N., McCroskey B L., Peterson V M. TEN versus TPN following major abdominal traumareduced septic morbidity. J Trauma 1989 29 7 916-922 discussion 922-923
115. Kudsk K A., Croce M A., Fabian T C. et al. Enteral versus parenteral feeding: effects on septic morbidity after blunt and penetrating abdominal trauma. Ann Surg 1992 215 5 503-511 discussion 511-513
116. Lipman T O. Bacterial translocation and enteral nutrition in humans: an outsider looks in. JPEN J Parenter Enteral Nutr 1995 19 2 156-165
117. Alpers D H. Enteral feeding and gut atrophy. Curr Opin Clin Nutr Metab Care 2002 5 6 679-683 (Pubitemid 40691195)
118. Thibault R, Pichard C. Parenteral nutrition in critical illness: can it safely improve outcomes? Crit Care Clin 2010 26 3 467-480 viii
119. Al-Omran M, Albalawi Z H., Tashkandi M F., Al-Ansary L A. Enteral versus parenteral nutrition for acute pancreatitis. Cochrane Database Syst Rev 2010 1 CD002837
120. van Saene H K., Petros A J., Ramsay G, Baxby D. All great truths are iconoclastic: selective decontamination of the digestive tract moves from heresy to level 1 truth. Intensive Care Med 2003 29 5 677-690 (Pubitemid 36609557)
121. Silvestri L, van Saene H K., Zandstra D F., Marshall J C., Gregori D, Gullo A. Impact of selective decontamination of the digestive tract on multiple organ dysfunction syndrome: systematic review of randomized controlled trials. Crit Care Med 2010 38 5 1370-1376
122. de Smet A M., Kluytmans J A., Cooper B S. et al. Decontamination of the digestive tract and oropharynx in ICU patients. N Engl J Med 2009 360 1 20-31
123. Chan E Y., Ruest A, Meade M O., Cook D J. Oral decontamination for prevention of pneumonia in mechanically ventilated adults: systematic review and meta-analysis. BMJ 2007 334 7599 889-900
124. Fedorak R N. Probiotics in the management of ulcerative colitis. Gastroenterol Hepatol (N Y) 2010 6 11 688-690
125. O'Flaherty S, Saulnier D M., Pot B, Versalovic J. How can probiotics and prebiotics impact mucosal immunity? Gut Microbes 2010 1 5 293-300
126. Alberda C, Gramlich L, Meddings J et al. Effects of probiotic therapy in critically ill patients: a randomized, double-blind, placebo-controlled trial. Am J Clin Nutr 2007 85 3 816-823 (Pubitemid 46393515)
127. McNabb B, Isakow W. Probiotics for the prevention of nosocomial pneumonia: current evidence and opinions. Curr Opin Pulm Med 2008 14 3 168-175 (Pubitemid 351572317)
128. Jacobi C A., Schulz C, Malfertheiner P. Treating critically ill patients with probiotics: Beneficial or dangerous? Gut Pathog 2011 3 1 2-7
129. Besselink M G., van Santvoort H C., Buskens E et al, Dutch Acute Pancreatitis Study Group. Probiotic prophylaxis in predicted severe acute pancreatitis: a randomised, double-blind, placebo-controlled trial. Lancet 2008 371 9613 651-659
130. Duggan C, Gannon J, Walker W A. Protective nutrients and functional foods for the gastrointestinal tract. Am J Clin Nutr 2002 75 5 789-808 (Pubitemid 34441247)
131. Lardy H, Mouillé B, Thomas M et al. Enterocyte metabolism during early adaptation after extensive intestinal resection in a rat model. Surgery 2004 135 6 649-656 (Pubitemid 38879348)
132. Hayashi Y, Sawa Y, Fukuyama N, Nakazawa H, Matsuda H. Preoperative glutamine administration induces heat-shock protein 70 expression and attenuates cardiopulmonary bypass-induced inflammatory response by regulating nitric oxide synthase activity. Circulation 2002 106 20 2601-2607 (Pubitemid 35340697)
133. Wischmeyer P E., Kahana M, Wolfson R, Ren H, Musch M M., Chang E B. Glutamine reduces cytokine release, organ damage, and mortality in a rat model of endotoxemia. Shock 2001 16 5 398-402 (Pubitemid 33598218)
134. Tremel H, Kienle B, Weilemann L S., Stehle P, Fürst P. Glutamine dipeptide-supplemented parenteral nutrition maintains intestinal function in the critically ill. Gastroenterology 1994 107 6 1595-1601
135. Klimberg V S., Souba W W., Dolson D J. et al. Prophylactic glutamine protects the intestinal mucosa from radiation injury. Cancer 1990 66 1 62-68 (Pubitemid 20197086)
136. Alverdy J C. Effects of glutamine-supplemented diets on immunology of the gut. JPEN J Parenter Enteral Nutr 1990 14 4, Suppl 109S-113S
137. Ziegler T R., Young L S., Benfell K et al. Clinical and metabolic efficacy of glutamine-supplemented parenteral nutrition after bone marrow transplantation. A randomized, double-blind, controlled study. Ann Intern Med 1992 116 10 821-828 (Pubitemid 23034759)
138. Wischmeyer P E. Glutamine: mode of action in critical illness. Crit Care Med 2007 35 9, Suppl S541-S544 (Pubitemid 47312192)
139. Novak F, Heyland D K., Avenell A, Drover J W., Su X. Glutamine supplementation in serious illness: a systematic review of the evidence. Crit Care Med 2002 30 9 2022-2029
140. Gianotti L, Alexander J W., Gennari R, Pyles T, Babcock G F. Oral glutamine decreases bacterial translocation and improves survival in experimental gut-origin sepsis. JPEN J Parenter Enteral Nutr 1995 19 1 69-74
141. Mizock B A. Immunonutrition and critical illness: an update. Nutrition 2010 26 7-8 701-707
142. Berthe M C., Darquy S, Breuillard C et al. High plasma citrulline and arginine levels ensured by sustained-release citrulline supplementation in rats. Nutrition 2011 April 8. [Epub ahead of print]
143. Bertolini G, Iapichino G, Radrizzani D et al. Early enteral immunonutrition in patients with severe sepsis: results of an interim analysis of a randomized multicentre clinical trial. Intensive Care Med 2003 29 5 834-840 (Pubitemid 36609578)
144. Marik P E., Zaloga G P. Immunonutrition in critically ill patients: a systematic review and analysis of the literature. Intensive Care Med 2008 34 11 1980-1990
145. Gopal S, Jayakumar D, Nelson P N. Meta-analysis on the effect of dopexamine on in-hospital mortality. Anaesthesia 2009 64 6 589-594