Ecological effects of selective decontamination on resistant gram-negative bacterial colonization

American Journal of Respiratory and Critical Care Medicine

Volumn 181, Issue 5, 2010, Pages 452-457

  Oostdijk, Evelien A N ^a   De Smet, Anne Marie G A ^a   Blok, Hetty E M ^a   Thieme Groen, Emily S ^a   Van Asselt, Gerard J ^b   Benus, Robin F J ^c   Bernards, Sandra A T ^d   Frénay, Ine H M E ^e   Jansz, Arjan R ^f   De Jongh, Bartelt M ^g   Kaan, Jan A ^h   Leverstein van Hall, Maurine A ^a   Mascini, Ellen M ⁱ   Pauw, Wouter ^j   Sturm, Patrick D J ^k   Thijsen, Steven F T ^l   Kluytmans, Jan A J W ^m,n   Bonten, Marc J M ^a  

^a UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^b MEDICAL CENTER HAAGLANDEN   (Netherlands)

^c UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

^d LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^e ALBERT SCHWEITZER HOSPITAL   (Netherlands)

^f CATHARINA HOSPITAL   (Netherlands)

^g ST ANTONIUS HOSPITAL   (Netherlands)

^h Mesos Medical Centre   (Netherlands)

ⁱ RIJNSTATE HOSPITAL   (Netherlands)

^j SLOTERVAART HOSPITAL   (Netherlands)

^k RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

^l DEPARTMENT OF SURGERY   (Netherlands)

^m AMPHIA HOSPITAL   (Netherlands)

ⁿ VU UNIVERSITY MEDICAL CENTER   (Netherlands)

more..

Author keywords

Intensive care; Intensive care unit; Resistance; Selective digestive tract decontamination; Selective oropharyngeal decontamination

Indexed keywords

AMPHOTERICIN B; CEFOTAXIME; CEFTAZIDIME; CIPROFLOXACIN; COLISTIN; TOBRAMYCIN;

ANTIBIOTIC RESISTANCE; ANTIMICROBIAL THERAPY; ARTICLE; BACTERIAL COLONIZATION; BACTERIUM CARRIER; BACTERIUM CULTURE; BACTERIUM DETECTION; CLINICAL ARTICLE; COMPARATIVE STUDY; ENTEROBACTER CLOACAE; ESCHERICHIA COLI; GRAM NEGATIVE BACTERIUM; HEALTH SURVEY; HUMAN; INTENSIVE CARE UNIT; KLEBSIELLA PNEUMONIAE; OUTCOME ASSESSMENT; PATIENT CARE; PREVALENCE; PRIORITY JOURNAL; PSEUDOMONAS AERUGINOSA; QUANTITATIVE ANALYSIS; REBOUND; RECTUM; RESPIRATORY SYSTEM; SAMPLE; SELECTIVE DIGESTIVE TRACT DECONTAMINATION; SELECTIVE OROPHARYNGEAL DECONTAMINATION; THERAPY EFFECT;

ANTI-BACTERIAL AGENTS; ANTIBIOTIC PROPHYLAXIS; CEFTAZIDIME; CIPROFLOXACIN; CROSS INFECTION; DRUG RESISTANCE, BACTERIAL; GRAM-NEGATIVE BACTERIA; GRAM-NEGATIVE BACTERIAL INFECTIONS; HUMANS; INTENSIVE CARE UNITS; LONGITUDINAL STUDIES; RECTUM; RESPIRATORY SYSTEM; RESPIRATORY TRACT INFECTIONS; TOBRAMYCIN;

EID: 77649109107     PISSN: 1073449X     EISSN: 15354970     Source Type: Journal    
DOI: 10.1164/rccm.200908-1210OC     Document Type: Article

References (26)

1. Stoutenbeek CP, van Saene HK, Miranda DR, Zandstra DF. The effect of selective decontamination of the digestive tract on colonisation and infection rate in multiple trauma patients. Intensive Care Med 1984; 10:185-192.
2. Bergmans DC, Bonten MJ, Gaillard CA, Paling JC, van der Geest S, van Tiel FH, Beysens AJ, de Leeuw PW, Stobberingh EE. Prevention of ventilator- associated pneumonia by oral decontamination: a prospective, randomized, double-blind, placebo-controlled study. Am J Respir Crit Care Med 2001;164:382-388.
3. D'Amico R, Pifferi S, Leonetti C, Torri V, Tinazzi A, Liberati A. Effectiveness of antibiotic prophylaxis in critically ill adult patients: systematic review of randomised controlled trials. BMJ 1998;316:1275-1285.
4. Collard HR, Saint S, Matthay MA. Prevention of ventilator-associated pneumonia: an evidence-based systematic review. Ann Intern Med 2003;138:494-501.
5. de Smet AM, Kluytmans JA, Cooper BS, Mascini EM, Benus RF, van der Werf TS, van der Hoeven JG, Pickkers P, Bogaers-Hofman D, van der Meer NJ, et al. Decontamination of the digestive tract and oropharynx in ICU patients. N Engl J Med 2009;360:20-31.
6. de Jonge E, Schultz MJ, Spanjaard L, Bossuyt PM, Vroom MB, Dankert J, Kesecioglu J. Effects of selective decontamination of digestive tract on mortality and acquisition of resistant bacteria in intensive care: a randomised controlled trial. Lancet 2003;362:1011-1016.
7. Bonten MJ, Kullberg BJ, van Dalen R, Girbes AR, Hoepelman IM, Hustinx W, van der Meer JW, Speelman P, Stobberingh EE, Verbrugh HA, et al.; Dutch Working Group on Antibiotic Policy. Selective digestive decontamination in patients in intensive care. J Antimicrob Chemother 2000;46:351-362.
8. Donskey CJ. The role of the intestinal tract as a reservoir and source for transmission of nosocomial pathogens. Clin Infect Dis 2004;39:219-226.
9. Kollef MH. Selective digestive decontamination should not be routinely employed. Chest 2003;123:464S-468S.
10. Ebner W, Kropec-Hubner A, Daschner FD. Bacterial resistance and overgrowth due to selective decontamination of the digestive tract. Eur J Clin Microbiol Infect Dis 2000;19:243-247.
11. de Jonge E. Effects of selective decontamination of digestive tract on mortality and antibiotic resistance in the intensive-care unit. Curr Opin Crit Care 2005;11:144-149.
12. Krueger WA, Lenhart FP, Neeser G, Ruckdeschel G, Schreckhase H, Eissner HJ, Forst H, Eckart J, Peter K, Unertl KE. Influence of combined intravenous and topical antibiotic prophylaxis on the incidence of infections, organ dysfunctions, and mortality in critically ill surgical patients: a prospective, stratified, randomized, double-blind, placebo-controlled clinical trial. Am J Respir Crit Care Med 2002;166:1029-1037.
13. Silvestri L, van Saene HK, Casarin A, Berlot G, Gullo A. Impact of selective decontamination of the digestive tract on carriage and infection due to gram-negative and gram-positive bacteria: a systematic review of randomised controlled trials. Anaesth Intensive Care 2008;36:324-338.
14. Al Naiemi N, Heddema ER, Bart A, de Jonge E, Vandenbroucke-Grauls CM, Savelkoul PH, Duim B. Emergence of multidrug-resistant gram-negative bacteria during selective decontamination of the digestive tract on an intensive care unit. J Antimicrob Chemother 2006;58:853-856.
15. Lingnau W, Berger J, Javorsky F, Fille M, Allerberger F, Benzer H. Changing bacterial ecology during a five-year period of selective intestinal decontamination. J Hosp Infect 1998;39:195-206.
16. Verwaest C, Verhaegen J, Ferdinande P, Schetz M, Van den Berghe G, Verbist L, Lauwers P. Randomized, controlled trial of selective digestive decontamination in 600 mechanically ventilated patients in a multidisciplinary intensive care unit. Crit Care Med 1997;25:63-71.
17. Kianifard F, Gallo PP. Poisson regression analysis in clinical research. J Biopharm Stat 1995;5:115-129.
18. Shardell M, Harris AD, El-Kamary SS, Furuno JP, Miller RR, Perencevich EN. Statistical analysis and application of quasi experiments to antimicrobial resistance intervention studies. Clin Infect Dis 2007;45:901-907.
19. Hammond JM, Potgieter PD. Long-term effects of selective decontamination on antimicrobial resistance. Crit Care Med 1995;23:637-645.
20. Leone M, Albanese J, Antonini F, Nguyen-Michel A, Martin C. Longterm (6-year) effect of selective digestive decontamination on antimicrobial resistance in intensive care, multiple-trauma patients. Crit Care Med 2003;31:2090-2095.
21. Livermore DM, Woodford N. The β-lactamase threat in Enterobacteriaceae, Pseudomonas and Acinetobacter. Trends Microbiol 2006;14: 413-420.
22. Denton M. Enterobacteriaceae. Int J Antimicrob Agents 2007;29:S9-S22.
23. Braunholtz DA, Edwards SJ, Lilford RJ. Are randomized clinical trials good for us (in the short term)? Evidence for a "trial effect." J Clin Epidemiol 2001;54:217-224.
24. McCarney R, Warner J, Iliffe S, van Haselen R, Griffin M, Fisher P. The Hawthorne effect: a randomised, controlled trial. BMC Med Res Methodol 2007;7:30.
25. Harris AD, Lautenbach E, Perencevich E. A systematic review of quasi-experimental study designs in the fields of infection control and antibiotic resistance. Clin Infect Dis 2005;41:77-82.
26. Wagner AK, Soumerai SB, Zhang F, Ross-Degnan D. Segmented regression analysis of interrupted time series studies in medication use research. J Clin Pharm Ther 2002;27:299-309.