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Volumn 14, Issue 2, 2015, Pages 194-207

MicroRNAs: Newcomers into the ALS picture

Author keywords

Amyotrophic lateral sclerosis; FUS TLS; miRNA; SOD1 G93A; TDP43

Indexed keywords

AMYLOID PRECURSOR PROTEIN; COPPER ZINC SUPEROXIDE DISMUTASE; FUSED IN SARCOMA PROTEIN; MICRORNA; TAR DNA BINDING PROTEIN;

EID: 84930911362     PISSN: 18715273     EISSN: 19963181     Source Type: Journal    
DOI: 10.2174/1871527314666150116125506     Document Type: Article
Times cited : (38)

References (148)
  • 1
    • 0027751663 scopus 로고
    • The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14
    • Lee RC, Feinbaum RL, Ambros V. The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14. Cell 1993; 75(5): 843-54.
    • (1993) Cell , vol.75 , Issue.5 , pp. 843-854
    • Lee, R.C.1    Feinbaum, R.L.2    Ambros, V.3
  • 2
    • 58249088751 scopus 로고    scopus 로고
    • MicroRNAs: Target recognition and regulatory functions
    • Bartel DP. MicroRNAs: target recognition and regulatory functions. Cell 2009; 136(2): 215-33.
    • (2009) Cell , vol.136 , Issue.2 , pp. 215-233
    • Bartel, D.P.1
  • 3
    • 84893567085 scopus 로고    scopus 로고
    • MicroRNAs in brain development and function: A matter of flexibility and stability
    • Follert P, Cremer H, Beclin C. MicroRNAs in brain development and function: a matter of flexibility and stability. Front Mol Neurosci 2014; 7: 5.
    • (2014) Front Mol Neurosci , vol.7 , pp. 5
    • Follert, P.1    Cremer, H.2    Beclin, C.3
  • 4
    • 84871609151 scopus 로고    scopus 로고
    • MicroRNAs and neurodegeneration: Role and impact
    • Abe M, Bonini NM. MicroRNAs and neurodegeneration: role and impact. Trends Cell Biol 2013; 23(1): 30-6.
    • (2013) Trends Cell Biol , vol.23 , Issue.1 , pp. 30-36
    • Abe, M.1    Bonini, N.M.2
  • 5
    • 84860388339 scopus 로고    scopus 로고
    • MicroRNAs in neuronal function and dysfunction
    • Im HI, Kenny PJ. MicroRNAs in neuronal function and dysfunction. Trends Neurosci 2012; 35(5): 325-34.
    • (2012) Trends Neurosci , vol.35 , Issue.5 , pp. 325-334
    • Im, H.I.1    Kenny, P.J.2
  • 6
    • 77955902024 scopus 로고    scopus 로고
    • The widespread regulation of microRNA biogenesis, function and decay
    • Krol J, Loedige I, Filipowicz W. The widespread regulation of microRNA biogenesis, function and decay. Nat Rev Genet 2010; 11(9): 597-610.
    • (2010) Nat Rev Genet , vol.11 , Issue.9 , pp. 597-610
    • Krol, J.1    Loedige, I.2    Filipowicz, W.3
  • 7
    • 77954517267 scopus 로고    scopus 로고
    • MicroRNAs and gene regulatory networks: Managing the impact of noise in biological systems
    • Herranz H, Cohen SM. MicroRNAs and gene regulatory networks: managing the impact of noise in biological systems. Genes Dev 2010; 24(13): 1339-44.
    • (2010) Genes Dev , vol.24 , Issue.13 , pp. 1339-1344
    • Herranz, H.1    Cohen, S.M.2
  • 8
    • 0347444723 scopus 로고    scopus 로고
    • MicroRNAs: Genomics, biogenesis, mechanism, and function
    • Bartel DP. MicroRNAs: genomics, biogenesis, mechanism, and function. Cell 2004; 116(2): 281-97.
    • (2004) Cell , vol.116 , Issue.2 , pp. 281-297
    • Bartel, D.P.1
  • 9
    • 60149095444 scopus 로고    scopus 로고
    • Most mammalian mRNAs are conserved targets of microRNAs
    • Friedman RC, Farh KK, Burge CB, Bartel DP. Most mammalian mRNAs are conserved targets of microRNAs. Genome Res 2009; 19(1): 92-105.
    • (2009) Genome Res , vol.19 , Issue.1 , pp. 92-105
    • Friedman, R.C.1    Farh, K.K.2    Burge, C.B.3    Bartel, D.P.4
  • 10
    • 33846945735 scopus 로고    scopus 로고
    • Processing of intronic microRNAs
    • Kim YK, Kim VN. Processing of intronic microRNAs. EMBO J 2007; 26(3): 775-83.
    • (2007) EMBO J , vol.26 , Issue.3 , pp. 775-783
    • Kim, Y.K.1    Kim, V.N.2
  • 11
    • 6344281172 scopus 로고    scopus 로고
    • Identification of mammalian microRNA host genes and transcription units
    • Rodriguez A, Griffiths-Jones S, Ashurst JL, Bradley A. Identification of mammalian microRNA host genes and transcription units. Genome Res 2004; 14(10A): 1902-10.
    • (2004) Genome Res , vol.14 , Issue.10 A , pp. 1902-1910
    • Rodriguez, A.1    Griffiths-Jones, S.2    Ashurst, J.L.3    Bradley, A.4
  • 13
    • 18344369543 scopus 로고    scopus 로고
    • MicroRNA biogenesis: Coordinated cropping and dicing
    • Kim VN. MicroRNA biogenesis: coordinated cropping and dicing. Nat Rev Mol Cell Biol 2005; 6(5): 376-85.
    • (2005) Nat Rev Mol Cell Biol , vol.6 , Issue.5 , pp. 376-385
    • Kim, V.N.1
  • 14
    • 84886255734 scopus 로고    scopus 로고
    • Epigenetics and ncRNAs in brain function and disease: Mechanisms and prospects for therapy
    • Varela MA, Roberts TC, Wood MJ. Epigenetics and ncRNAs in brain function and disease: mechanisms and prospects for therapy. Neurotherapeutics 2013; 10(4): 621-31.
    • (2013) Neurotherapeutics , vol.10 , Issue.4 , pp. 621-631
    • Varela, M.A.1    Roberts, T.C.2    Wood, M.J.3
  • 15
    • 84911008143 scopus 로고    scopus 로고
    • Regulation of Neurotropic Signaling by the Inducible, NF-kBSensitive miRNA-125b in Alzheimer's Disease (AD) and in Primary Human Neuronal-Glial (HNG) Cells
    • Zhao Y, Bhattacharjee S, Jones BM, Hill J, Dua P, Lukiw WJ. Regulation of Neurotropic Signaling by the Inducible, NF-kBSensitive miRNA-125b in Alzheimer's Disease (AD) and in Primary Human Neuronal-Glial (HNG) Cells. Mol Neurobiol 2013; 50(1): 97-106.
    • (2013) Mol Neurobiol , vol.50 , Issue.1 , pp. 97-106
    • Zhao, Y.1    Bhattacharjee, S.2    Jones, B.M.3    Hill, J.4    Dua, P.5    Lukiw, W.J.6
  • 16
    • 84934434624 scopus 로고    scopus 로고
    • Coordinated networks of microRNAs and transcription factors with evolutionary perspectives
    • Iwama H. Coordinated networks of microRNAs and transcription factors with evolutionary perspectives. Adv Exp Med Biol 2013; 774: 169-87.
    • (2013) Adv Exp Med Biol , vol.774 , pp. 169-187
    • Iwama, H.1
  • 17
    • 41149117385 scopus 로고    scopus 로고
    • MicroRNAs flex their muscles
    • van Rooij E, Liu N, Olson EN. MicroRNAs flex their muscles. Trends Genet 2008; 24(4): 159-66.
    • (2008) Trends Genet , vol.24 , Issue.4 , pp. 159-166
    • van Rooij, E.1    Liu, N.2    Olson, E.N.3
  • 18
    • 72149131804 scopus 로고    scopus 로고
    • MicroRNA-206 delays ALS progression and promotes regeneration of neuromuscular synapses in mice
    • Williams AH, Valdez G, Moresi V, et al. MicroRNA-206 delays ALS progression and promotes regeneration of neuromuscular synapses in mice. Science 2009; 326(5959): 1549-54.
    • (2009) Science , vol.326 , Issue.5959 , pp. 1549-1554
    • Williams, A.H.1    Valdez, G.2    Moresi, V.3
  • 19
    • 12544255565 scopus 로고    scopus 로고
    • Recognition and cleavage of primary microRNA precursors by the nuclear processing enzyme Drosha
    • Zeng Y, Yi R, Cullen BR. Recognition and cleavage of primary microRNA precursors by the nuclear processing enzyme Drosha. EMBO J 2005; 24(1): 138-48.
    • (2005) EMBO J , vol.24 , Issue.1 , pp. 138-148
    • Zeng, Y.1    Yi, R.2    Cullen, B.R.3
  • 20
    • 70350442963 scopus 로고    scopus 로고
    • Coupled RNA processing and transcription of intergenic primary microRNAs
    • Ballarino M, Pagano F, Girardi E, et al. Coupled RNA processing and transcription of intergenic primary microRNAs. Mol Cell Biol 2009; 29(20): 5632-8.
    • (2009) Mol Cell Biol , vol.29 , Issue.20 , pp. 5632-5638
    • Ballarino, M.1    Pagano, F.2    Girardi, E.3
  • 21
    • 47549105524 scopus 로고    scopus 로고
    • Primary microRNA transcript retention at sites of transcription leads to enhanced microRNA production
    • Pawlicki JM, Steitz JA. Primary microRNA transcript retention at sites of transcription leads to enhanced microRNA production. J Cell Biol 2008; 182(1): 61-76.
    • (2008) J Cell Biol , vol.182 , Issue.1 , pp. 61-76
    • Pawlicki, J.M.1    Steitz, J.A.2
  • 22
    • 9144224451 scopus 로고    scopus 로고
    • Processing of primary microRNAs by the Microprocessor complex
    • Denli AM, Tops BB, Plasterk RH, Ketting RF, Hannon GJ. Processing of primary microRNAs by the Microprocessor complex. Nature 2004; 432(7014): 231-5.
    • (2004) Nature , vol.432 , Issue.7014 , pp. 231-235
    • Denli, A.M.1    Tops, B.B.2    Plasterk, R.H.3    Ketting, R.F.4    Hannon, G.J.5
  • 23
    • 10344248903 scopus 로고    scopus 로고
    • The human DiGeorge syndrome critical region gene 8 and Its D. melanogaster homolog are required for miRNA biogenesis
    • Landthaler M, Yalcin A, Tuschl T. The human DiGeorge syndrome critical region gene 8 and Its D. melanogaster homolog are required for miRNA biogenesis. Curr Biol 2004; 14(23): 2162-7.
    • (2004) Curr Biol , vol.14 , Issue.23 , pp. 2162-2167
    • Landthaler, M.1    Yalcin, A.2    Tuschl, T.3
  • 24
    • 0141843656 scopus 로고    scopus 로고
    • The nuclear RNase III Drosha initiates microRNA processing
    • Lee Y, Ahn C, Han J, et al. The nuclear RNase III Drosha initiates microRNA processing. Nature 2003; 425(6956): 415-9.
    • (2003) Nature , vol.425 , Issue.6956 , pp. 415-419
    • Lee, Y.1    Ahn, C.2    Han, J.3
  • 25
    • 0347361541 scopus 로고    scopus 로고
    • Exportin-5 mediates the nuclear export of pre-microRNAs and short hairpin RNAs
    • Yi R, Qin Y, Macara IG, Cullen BR. Exportin-5 mediates the nuclear export of pre-microRNAs and short hairpin RNAs. Genes Dev 2003; 17(24): 3011-6.
    • (2003) Genes Dev , vol.17 , Issue.24 , pp. 3011-3016
    • Yi, R.1    Qin, Y.2    Macara, I.G.3    Cullen, B.R.4
  • 26
    • 0142165224 scopus 로고    scopus 로고
    • Functional siRNAs and miRNAs exhibit strand bias
    • Khvorova A, Reynolds A, Jayasena SD. Functional siRNAs and miRNAs exhibit strand bias. Cell 2003; 115(2): 209-16.
    • (2003) Cell , vol.115 , Issue.2 , pp. 209-216
    • Khvorova, A.1    Reynolds, A.2    Jayasena, S.D.3
  • 28
    • 38349169664 scopus 로고    scopus 로고
    • Mechanisms of post-transcriptional regulation by microRNAs: Are the answers in sight?
    • Filipowicz W, Bhattacharyya SN, Sonenberg N. Mechanisms of post-transcriptional regulation by microRNAs: are the answers in sight? Nat Rev Genet 2008; 9(2): 102-14.
    • (2008) Nat Rev Genet , vol.9 , Issue.2 , pp. 102-114
    • Filipowicz, W.1    Bhattacharyya, S.N.2    Sonenberg, N.3
  • 29
    • 78751477191 scopus 로고    scopus 로고
    • Gene silencing by microRNAs: Contributions of translational repression and mRNA decay
    • Huntzinger E, Izaurralde E. Gene silencing by microRNAs: contributions of translational repression and mRNA decay. Nat Rev Genet 2011; 12(2): 99-110.
    • (2011) Nat Rev Genet , vol.12 , Issue.2 , pp. 99-110
    • Huntzinger, E.1    Izaurralde, E.2
  • 30
    • 78650306521 scopus 로고    scopus 로고
    • Small RNA sorting: Matchmaking for Argonautes
    • Czech B, Hannon GJ. Small RNA sorting: matchmaking for Argonautes. Nat Rev Genet 2011; 12(1): 19-31.
    • (2011) Nat Rev Genet , vol.12 , Issue.1 , pp. 19-31
    • Czech, B.1    Hannon, G.J.2
  • 31
    • 84856440598 scopus 로고    scopus 로고
    • MicroRNAs in neurodegenerative diseases and their therapeutic potential
    • Junn E, Mouradian MM. MicroRNAs in neurodegenerative diseases and their therapeutic potential. Pharmacol Ther 2012; 133(2): 142-50.
    • (2012) Pharmacol Ther , vol.133 , Issue.2 , pp. 142-150
    • Junn, E.1    Mouradian, M.M.2
  • 32
    • 9144225636 scopus 로고    scopus 로고
    • The Microprocessor complex mediates the genesis of microRNAs
    • Gregory RI, Yan KP, Amuthan G, et al. The Microprocessor complex mediates the genesis of microRNAs. Nature 2004; 432(7014): 235-40.
    • (2004) Nature , vol.432 , Issue.7014 , pp. 235-240
    • Gregory, R.I.1    Yan, K.P.2    Amuthan, G.3
  • 33
    • 84857772495 scopus 로고    scopus 로고
    • TDP-43 promotes microRNA biogenesis as a component of the Drosha and Dicer complexes
    • Kawahara Y, Mieda-Sato A. TDP-43 promotes microRNA biogenesis as a component of the Drosha and Dicer complexes. Proc Natl Acad Sci USA 2012; 109(9): 3347-52.
    • (2012) Proc Natl Acad Sci USA , vol.109 , Issue.9 , pp. 3347-3352
    • Kawahara, Y.1    Mieda-Sato, A.2
  • 34
    • 34247876168 scopus 로고    scopus 로고
    • DEAD-box RNA helicase subunits of the Drosha complex are required for processing of rRNA and a subset of microRNAs
    • Fukuda T, Yamagata K, Fujiyama S, et al. DEAD-box RNA helicase subunits of the Drosha complex are required for processing of rRNA and a subset of microRNAs. Nat Cell Biol 2007; 9(5): 604-11.
    • (2007) Nat Cell Biol , vol.9 , Issue.5 , pp. 604-611
    • Fukuda, T.1    Yamagata, K.2    Fujiyama, S.3
  • 36
    • 84901006597 scopus 로고    scopus 로고
    • The RNA Binding Protein TDP- 43 Selectively Disrupts MicroRNA-1/206 Incorporation into the RNA-Induced Silencing Complex
    • King I, Yartseva V, Salas D, et al. The RNA Binding Protein TDP- 43 Selectively Disrupts MicroRNA-1/206 Incorporation into the RNA-Induced Silencing Complex. J Biol Chem 2014; 289(20): 14263-71.
    • (2014) J Biol Chem , vol.289 , Issue.20 , pp. 14263-14271
    • King, I.1    Yartseva, V.2    Salas, D.3
  • 37
    • 77955784599 scopus 로고    scopus 로고
    • ALS-associated mutations in TDP-43 increase its stability and promote TDP-43 complexes with FUS/TLS
    • Ling SC, Albuquerque CP, Han JS, et al. ALS-associated mutations in TDP-43 increase its stability and promote TDP-43 complexes with FUS/TLS. Proc Natl Acad Sci USA 2010; 107(30): 13318-23.
    • (2010) Proc Natl Acad Sci USA , vol.107 , Issue.30 , pp. 13318-13323
    • Ling, S.C.1    Albuquerque, C.P.2    Han, J.S.3
  • 39
    • 58749113430 scopus 로고    scopus 로고
    • A three-dimensional view of the molecular machinery of RNA interference
    • Jinek M, Doudna JA. A three-dimensional view of the molecular machinery of RNA interference. Nature 2009; 457(7228): 405-12.
    • (2009) Nature , vol.457 , Issue.7228 , pp. 405-412
    • Jinek, M.1    Doudna, J.A.2
  • 40
    • 11844278458 scopus 로고    scopus 로고
    • Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets
    • Lewis BP, Burge CB, Bartel DP. Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets. Cell 2005; 120(1): 15-20.
    • (2005) Cell , vol.120 , Issue.1 , pp. 15-20
    • Lewis, B.P.1    Burge, C.B.2    Bartel, D.P.3
  • 42
    • 80455154984 scopus 로고    scopus 로고
    • Weak seed-pairing stability and high target-site abundance decrease the proficiency of lsy-6 and other microRNAs
    • Garcia DM, Baek D, Shin C, Bell GW, Grimson A, Bartel DP. Weak seed-pairing stability and high target-site abundance decrease the proficiency of lsy-6 and other microRNAs. Nat Struct Mol Biol 2011; 18(10): 1139-46.
    • (2011) Nat Struct Mol Biol , vol.18 , Issue.10 , pp. 1139-1146
    • Garcia, D.M.1    Baek, D.2    Shin, C.3    Bell, G.W.4    Grimson, A.5    Bartel, D.P.6
  • 44
    • 77955963884 scopus 로고    scopus 로고
    • Comprehensive modeling of microRNA targets predicts functional non-conserved and non-canonical sites
    • Betel D, Koppal A, Agius P, Sander C, Leslie C. Comprehensive modeling of microRNA targets predicts functional non-conserved and non-canonical sites. Genome Biol 2010; 11(8): R90.
    • (2010) Genome Biol , vol.11 , Issue.8
    • Betel, D.1    Koppal, A.2    Agius, P.3    Sander, C.4    Leslie, C.5
  • 45
    • 20944450160 scopus 로고    scopus 로고
    • Combinatorial microRNA target predictions
    • Krek A, Grun D, Poy MN, et al. Combinatorial microRNA target predictions. Nat Genet 2005; 37(5): 495-500.
    • (2005) Nat Genet , vol.37 , Issue.5 , pp. 495-500
    • Krek, A.1    Grun, D.2    Poy, M.N.3
  • 46
    • 33748587841 scopus 로고    scopus 로고
    • A pattern-based method for the identification of MicroRNA binding sites and their corresponding heteroduplexes
    • Miranda KC, Huynh T, Tay Y, et al. A pattern-based method for the identification of MicroRNA binding sites and their corresponding heteroduplexes. Cell 2006; 126(6): 1203-17.
    • (2006) Cell , vol.126 , Issue.6 , pp. 1203-1217
    • Miranda, K.C.1    Huynh, T.2    Tay, Y.3
  • 47
    • 84870829245 scopus 로고    scopus 로고
    • Interactive exploration of RNA22 microRNA target predictions
    • Loher P, Rigoutsos I. Interactive exploration of RNA22 microRNA target predictions. Bioinformatics 2012; 28(24): 3322-3.
    • (2012) Bioinformatics , vol.28 , Issue.24 , pp. 3322-3323
    • Loher, P.1    Rigoutsos, I.2
  • 48
    • 34748821761 scopus 로고    scopus 로고
    • The role of site accessibility in microRNA target recognition
    • Kertesz M, Iovino N, Unnerstall U, Gaul U, Segal E. The role of site accessibility in microRNA target recognition. Nat Genet 2007; 39(10): 1278-84.
    • (2007) Nat Genet , vol.39 , Issue.10 , pp. 1278-1284
    • Kertesz, M.1    Iovino, N.2    Unnerstall, U.3    Gaul, U.4    Segal, E.5
  • 49
    • 84883579190 scopus 로고    scopus 로고
    • DIANAmicroT web server v5.0: Service integration into miRNA functional analysis workflows
    • Paraskevopoulou MD, Georgakilas G, Kostoulas N, et al. DIANAmicroT web server v5.0: service integration into miRNA functional analysis workflows. Nucleic Acids Res 2013; 41: W169-73.
    • (2013) Nucleic Acids Res , vol.41 , pp. 169-173
    • Paraskevopoulou, M.D.1    Georgakilas, G.2    Kostoulas, N.3
  • 51
    • 4644237189 scopus 로고    scopus 로고
    • Fast and effective prediction of microRNA/target duplexes
    • Rehmsmeier M, Steffen P, Hochsmann M, Giegerich R. Fast and effective prediction of microRNA/target duplexes. RNA 2004; 10(10): 1507-17.
    • (2004) RNA , vol.10 , Issue.10 , pp. 1507-1517
    • Rehmsmeier, M.1    Steffen, P.2    Hochsmann, M.3    Giegerich, R.4
  • 52
    • 33747849920 scopus 로고    scopus 로고
    • RNA hybrid: MicroRNA target prediction easy, fast and flexible
    • Kruger J, Rehmsmeier M. RNA hybrid: microRNA target prediction easy, fast and flexible. Nucleic Acids Res 2006; 34: W451-4.
    • (2006) Nucleic Acids Res , vol.34 , pp. 451-454
    • Kruger, J.1    Rehmsmeier, M.2
  • 54
    • 58849093262 scopus 로고    scopus 로고
    • Revisiting the principles of microRNA target recognition and mode of action
    • Brodersen P, Voinnet O. Revisiting the principles of microRNA target recognition and mode of action. Nat Rev Mol Cell Biol 2009; 10(2): 141-8.
    • (2009) Nat Rev Mol Cell Biol , vol.10 , Issue.2 , pp. 141-148
    • Brodersen, P.1    Voinnet, O.2
  • 55
    • 77955475953 scopus 로고    scopus 로고
    • Expanding the microRNA targeting code: Functional sites with centered pairing
    • Shin C, Nam JW, Farh KK, Chiang HR, Shkumatava A, Bartel DP. Expanding the microRNA targeting code: functional sites with centered pairing. Mol Cell 2010; 38(6): 789-802.
    • (2010) Mol Cell , vol.38 , Issue.6 , pp. 789-802
    • Shin, C.1    Nam, J.W.2    Farh, K.K.3    Chiang, H.R.4    Shkumatava, A.5    Bartel, D.P.6
  • 56
    • 33748346026 scopus 로고    scopus 로고
    • Perfect seed pairing is not a generally reliable predictor for miRNA-target interactions
    • Didiano D, Hobert O. Perfect seed pairing is not a generally reliable predictor for miRNA-target interactions. Nat Struct Mol Biol 2006; 13(9): 849-51.
    • (2006) Nat Struct Mol Biol , vol.13 , Issue.9 , pp. 849-851
    • Didiano, D.1    Hobert, O.2
  • 57
    • 73549104488 scopus 로고    scopus 로고
    • Dicer ablation in oligodendrocytes provokes neuronal impairment in mice
    • Shin D, Shin JY, McManus MT, Ptacek LJ, Fu YH. Dicer ablation in oligodendrocytes provokes neuronal impairment in mice. Ann Neurol 2009; 66(6): 843-57.
    • (2009) Ann Neurol , vol.66 , Issue.6 , pp. 843-857
    • Shin, D.1    Shin, J.Y.2    McManus, M.T.3    Ptacek, L.J.4    Fu, Y.H.5
  • 58
    • 80052451056 scopus 로고    scopus 로고
    • Experimental strategies for microRNA target identification
    • Thomson DW, Bracken CP, Goodall GJ. Experimental strategies for microRNA target identification. Nucleic Acids Res 2011; 39(16): 6845-53.
    • (2011) Nucleic Acids Res , vol.39 , Issue.16 , pp. 6845-6853
    • Thomson, D.W.1    Bracken, C.P.2    Goodall, G.J.3
  • 61
    • 67749132423 scopus 로고    scopus 로고
    • Argonaute HITS-CLIP decodes microRNA-mRNA interaction maps
    • Chi SW, Zang JB, Mele A, Darnell RB. Argonaute HITS-CLIP decodes microRNA-mRNA interaction maps. Nature 2009; 460(7254): 479-86.
    • (2009) Nature , vol.460 , Issue.7254 , pp. 479-486
    • Chi, S.W.1    Zang, J.B.2    Mele, A.3    Darnell, R.B.4
  • 62
    • 34447521718 scopus 로고    scopus 로고
    • Isolation of microRNA targets by miRNP immunopurification
    • Easow G, Teleman AA, Cohen SM. Isolation of microRNA targets by miRNP immunopurification. RNA 2007; 13(8): 1198-204.
    • (2007) RNA , vol.13 , Issue.8 , pp. 1198-1204
    • Easow, G.1    Teleman, A.A.2    Cohen, S.M.3
  • 63
    • 37648999735 scopus 로고    scopus 로고
    • A biochemical approach to identifying microRNA targets
    • Karginov FV, Conaco C, Xuan Z, et al. A biochemical approach to identifying microRNA targets. Proc Natl Acad Sci USA 2007; 104(49): 19291-6.
    • (2007) Proc Natl Acad Sci USA , vol.104 , Issue.49 , pp. 19291-19296
    • Karginov, F.V.1    Conaco, C.2    Xuan, Z.3
  • 64
    • 77950920903 scopus 로고    scopus 로고
    • Transcriptome-wide identification of RNA-binding protein and microRNA target sites by PAR-CLIP
    • Hafner M, Landthaler M, Burger L, et al. Transcriptome-wide identification of RNA-binding protein and microRNA target sites by PAR-CLIP. Cell 2010; 141(1): 129-41.
    • (2010) Cell , vol.141 , Issue.1 , pp. 129-141
    • Hafner, M.1    Landthaler, M.2    Burger, L.3
  • 65
    • 78649702372 scopus 로고    scopus 로고
    • Strategies to identify microRNA targets: New advances
    • Jin H, Tuo W, Lian H, Liu Q, Zhu XQ, Gao H. Strategies to identify microRNA targets: new advances. N Biotechnol 2010; 27(6): 734-8.
    • (2010) N Biotechnol , vol.27 , Issue.6 , pp. 734-738
    • Jin, H.1    Tuo, W.2    Lian, H.3    Liu, Q.4    Zhu, X.Q.5    Gao, H.6
  • 66
    • 3943087720 scopus 로고    scopus 로고
    • Analyzing cellular biochemistry in terms of molecular networks
    • Xia Y, Yu H, Jansen R, et al. Analyzing cellular biochemistry in terms of molecular networks. Annu Rev Biochem 2004; 73: 1051- 87.
    • (2004) Annu Rev Biochem , vol.73 , pp. 1051-1087
    • Xia, Y.1    Yu, H.2    Jansen, R.3
  • 67
    • 0036013593 scopus 로고    scopus 로고
    • Statistical mechanics of complex networks
    • Barabási RAaA-L. Statistical mechanics of complex networks. Rev Mod Phys 2002; 74: 47-94.
    • (2002) Rev Mod Phys , vol.74 , pp. 47-94
    • Barabási, R.A.A.-L.1
  • 68
    • 0001540595 scopus 로고
    • On Random Graphs. I
    • Erdős P, Rényi A. On Random Graphs. I. Publ Mathem 1959; 6: 290-7.
    • (1959) Publ Mathem , vol.6 , pp. 290-297
    • Erdős, P.1    Rényi, A.2
  • 69
    • 60849093466 scopus 로고    scopus 로고
    • Current hypotheses for the underlying biology of amyotrophic lateral sclerosis
    • Rothstein JD. Current hypotheses for the underlying biology of amyotrophic lateral sclerosis. Ann Neurol 2009; 65(Suppl 1): S3-9.
    • (2009) Ann Neurol , vol.65 , pp. 3-9
    • Rothstein, J.D.1
  • 70
    • 80755133370 scopus 로고    scopus 로고
    • Clinical genetics of amyotrophic lateral sclerosis: What do we really know?
    • Andersen PM, Al-Chalabi A. Clinical genetics of amyotrophic lateral sclerosis: what do we really know? Nat Rev Neurol 2011; 7(11): 603-15.
    • (2011) Nat Rev Neurol , vol.7 , Issue.11 , pp. 603-615
    • Andersen, P.M.1    Al-Chalabi, A.2
  • 71
    • 80054837386 scopus 로고    scopus 로고
    • A hexanucleotide repeat expansion in C9ORF72 is the cause of chromosome 9p21-linked ALS-FTD
    • Renton AE, Majounie E, Waite A, et al. A hexanucleotide repeat expansion in C9ORF72 is the cause of chromosome 9p21-linked ALS-FTD. Neuron 2011; 72(2): 257-68.
    • (2011) Neuron , vol.72 , Issue.2 , pp. 257-268
    • Renton, A.E.1    Majounie, E.2    Waite, A.3
  • 72
    • 80054832080 scopus 로고    scopus 로고
    • Expanded GGGGCC hexanucleotide repeat in noncoding region of C9ORF72 causes chromosome 9p-linked FTD and ALS
    • DeJesus-Hernandez M, Mackenzie IR, Boeve BF, et al. Expanded GGGGCC hexanucleotide repeat in noncoding region of C9ORF72 causes chromosome 9p-linked FTD and ALS. Neuron 2011; 72(2): 245-56.
    • (2011) Neuron , vol.72 , Issue.2 , pp. 245-256
    • DeJesus-Hernandez, M.1    McKenzie, I.R.2    Boeve, B.F.3
  • 73
    • 84885608405 scopus 로고    scopus 로고
    • Amyotrophic lateral sclerosis: Problems and prospects
    • Sreedharan J, Brown RH Jr. Amyotrophic lateral sclerosis: Problems and prospects. Ann Neurol 2013; 74(3): 309-16.
    • (2013) Ann Neurol , vol.74 , Issue.3 , pp. 309-316
    • Sreedharan, J.1    Brown, R.H.2
  • 74
    • 84928686083 scopus 로고    scopus 로고
    • Potential Therapeutic Drugs and Methods for the Treatment of Amyotrophic Lateral Sclerosis
    • Yacila G, Sari Y. Potential Therapeutic Drugs and Methods for the Treatment of Amyotrophic Lateral Sclerosis. Curr Med Chem 2014; 21(31): 3583-93.
    • (2014) Curr Med Chem , vol.21 , Issue.31 , pp. 3583-3593
    • Yacila, G.1    Sari, Y.2
  • 75
    • 73149116008 scopus 로고    scopus 로고
    • T cell-microglial dialogue in Parkinson's disease and amyotrophic lateral sclerosis: Are we listening?
    • Appel SH, Beers DR, Henkel JS. T cell-microglial dialogue in Parkinson's disease and amyotrophic lateral sclerosis: are we listening? Trends Immunol 2010; 31(1): 7-17.
    • (2010) Trends Immunol , vol.31 , Issue.1 , pp. 7-17
    • Appel, S.H.1    Beers, D.R.2    Henkel, J.S.3
  • 77
    • 79961022340 scopus 로고    scopus 로고
    • Spinal inhibitory interneuron pathology follows motor neuron degeneration independent of glial mutant superoxide dismutase 1 expression in SOD1-ALS mice
    • Hossaini M, Cardona Cano S, van Dis V, et al. Spinal inhibitory interneuron pathology follows motor neuron degeneration independent of glial mutant superoxide dismutase 1 expression in SOD1-ALS mice. J Neuropathol Exp Neurol 2011; 70(8): 662-77.
    • (2011) J Neuropathol Exp Neurol , vol.70 , Issue.8 , pp. 662-677
    • Hossaini, M.1    Cardona Cano, S.2    van Dis, V.3
  • 78
    • 84884213153 scopus 로고    scopus 로고
    • Early interneuron dysfunction in ALS: Insights from a mutant sod1 zebrafish model
    • McGown A, McDearmid JR, Panagiotaki N, et al. Early interneuron dysfunction in ALS: insights from a mutant sod1 zebrafish model. Ann Neurol 2013; 73(2): 246-58.
    • (2013) Ann Neurol , vol.73 , Issue.2 , pp. 246-258
    • McGown, A.1    McDearmid, J.R.2    Panagiotaki, N.3
  • 79
    • 74049164709 scopus 로고    scopus 로고
    • Non-cell autonomous toxicity in neurodegenerative disorders: ALS and beyond
    • Ilieva H, Polymenidou M, Cleveland DW. Non-cell autonomous toxicity in neurodegenerative disorders: ALS and beyond. J Cell Biol 2009; 187(6): 761-72.
    • (2009) J Cell Biol , vol.187 , Issue.6 , pp. 761-772
    • Ilieva, H.1    Polymenidou, M.2    Cleveland, D.W.3
  • 80
    • 77950458426 scopus 로고    scopus 로고
    • Inducible nitric oxide synthase is present in motor neuron mitochondria and Schwann cells and contributes to disease mechanisms in ALS mice
    • Chen K, Northington FJ, Martin LJ. Inducible nitric oxide synthase is present in motor neuron mitochondria and Schwann cells and contributes to disease mechanisms in ALS mice. Brain Struct Funct 2010; 214(2-3): 219-34.
    • (2010) Brain Struct Funct , vol.214 , Issue.2-3 , pp. 219-234
    • Chen, K.1    Northington, F.J.2    Martin, L.J.3
  • 81
    • 65949094823 scopus 로고    scopus 로고
    • Neuromuscular junction destruction during amyotrophic lateral sclerosis: Insights from transgenic models
    • Dupuis L, Loeffler JP. Neuromuscular junction destruction during amyotrophic lateral sclerosis: insights from transgenic models. Curr Opin Pharmacol 2009; 9(3): 341-6.
    • (2009) Curr Opin Pharmacol , vol.9 , Issue.3 , pp. 341-346
    • Dupuis, L.1    Loeffler, J.P.2
  • 82
    • 0141642203 scopus 로고    scopus 로고
    • Wild-type nonneuronal cells extend survival of SOD1 mutant motor neurons in ALS mice
    • Clement AM, Nguyen MD, Roberts EA, et al. Wild-type nonneuronal cells extend survival of SOD1 mutant motor neurons in ALS mice. Science 2003; 302(5642): 113-7.
    • (2003) Science , vol.302 , Issue.5642 , pp. 113-117
    • Clement, A.M.1    Nguyen, M.D.2    Roberts, E.A.3
  • 83
    • 33749056809 scopus 로고    scopus 로고
    • ALS: A disease of motor neurons and their nonneuronal neighbors
    • Boillee S, Vande Velde C, Cleveland DW. ALS: a disease of motor neurons and their nonneuronal neighbors. Neuron 2006; 52(1): 39- 59.
    • (2006) Neuron , vol.52 , Issue.1 , pp. 39-59
    • Boillee, S.1    Vande Velde, C.2    Cleveland, D.W.3
  • 84
    • 44649152645 scopus 로고    scopus 로고
    • Mutant SOD1 in cell types other than motor neurons and oligodendrocytes accelerates onset of disease in ALS mice
    • Yamanaka K, Boillee S, Roberts EA, et al. Mutant SOD1 in cell types other than motor neurons and oligodendrocytes accelerates onset of disease in ALS mice. Proc Natl Acad Sci USA 2008; 105(21): 7594-9.
    • (2008) Proc Natl Acad Sci USA , vol.105 , Issue.21 , pp. 7594-7599
    • Yamanaka, K.1    Boillee, S.2    Roberts, E.A.3
  • 85
    • 63149141363 scopus 로고    scopus 로고
    • Schwann cells expressing dismutase active mutant SOD1 unexpectedly slow disease progression in ALS mice
    • Lobsiger CS, Boillee S, McAlonis-Downes M, et al. Schwann cells expressing dismutase active mutant SOD1 unexpectedly slow disease progression in ALS mice. Proc Natl Acad Sci USA 2009; 106(11): 4465-70.
    • (2009) Proc Natl Acad Sci USA , vol.106 , Issue.11 , pp. 4465-4470
    • Lobsiger, C.S.1    Boillee, S.2    McAlonis-Downes, M.3
  • 86
    • 34247473080 scopus 로고    scopus 로고
    • Noncell autonomous effect of glia on motor neurons in an embryonic stem cell-based ALS model
    • Di Giorgio FP, Carrasco MA, Siao MC, Maniatis T, Eggan K. Noncell autonomous effect of glia on motor neurons in an embryonic stem cell-based ALS model. Nat Neurosci 2007; 10(5): 608-14.
    • (2007) Nat Neurosci , vol.10 , Issue.5 , pp. 608-614
    • Di Giorgio, F.P.1    Carrasco, M.A.2    Siao, M.C.3    Maniatis, T.4    Eggan, K.5
  • 87
    • 34247475338 scopus 로고    scopus 로고
    • Astrocytes expressing ALSlinked mutated SOD1 release factors selectively toxic to motor neurons
    • Nagai M, Re DB, Nagata T, et al. Astrocytes expressing ALSlinked mutated SOD1 release factors selectively toxic to motor neurons. Nat Neurosci 2007; 10(5): 615-22.
    • (2007) Nat Neurosci , vol.10 , Issue.5 , pp. 615-622
    • Nagai, M.1    Re, D.B.2    Nagata, T.3
  • 88
    • 84884294596 scopus 로고    scopus 로고
    • Trehalose delays the progression of amyotrophic lateral sclerosis by enhancing autophagy in motoneurons
    • Castillo K, Nassif M, Valenzuela V, et al. Trehalose delays the progression of amyotrophic lateral sclerosis by enhancing autophagy in motoneurons. Autophagy 2013; 9(9): 1308-20.
    • (2013) Autophagy , vol.9 , Issue.9 , pp. 1308-1320
    • Castillo, K.1    Nassif, M.2    Valenzuela, V.3
  • 89
    • 84878641421 scopus 로고    scopus 로고
    • Mutant SOD1-expressing astrocytes release toxic factors that trigger motoneuron death by inducing hyperexcitability
    • Fritz E, Izaurieta P, Weiss A, et al. Mutant SOD1-expressing astrocytes release toxic factors that trigger motoneuron death by inducing hyperexcitability. J Neurophysiol 2013; 109(11): 2803-14.
    • (2013) J Neurophysiol , vol.109 , Issue.11 , pp. 2803-2814
    • Fritz, E.1    Izaurieta, P.2    Weiss, A.3
  • 90
    • 33645881327 scopus 로고    scopus 로고
    • Increased glutathione biosynthesis by Nrf2 activation in astrocytes prevents p75NTR-dependent motor neuron apoptosis
    • Vargas MR, Pehar M, Cassina P, Beckman JS, Barbeito L. Increased glutathione biosynthesis by Nrf2 activation in astrocytes prevents p75NTR-dependent motor neuron apoptosis. J Neurochem 2006; 97(3): 687-96.
    • (2006) J Neurochem , vol.97 , Issue.3 , pp. 687-696
    • Vargas, M.R.1    Pehar, M.2    Cassina, P.3    Beckman, J.S.4    Barbeito, L.5
  • 91
    • 42949166848 scopus 로고    scopus 로고
    • Mitochondrial dysfunction in SOD1G93A-bearing astrocytes promotes motor neuron degeneration: Prevention by mitochondrial-targeted antioxidants
    • Cassina P, Cassina A, Pehar M, et al. Mitochondrial dysfunction in SOD1G93A-bearing astrocytes promotes motor neuron degeneration: prevention by mitochondrial-targeted antioxidants. J Neurosci 2008; 28(16): 4115-22.
    • (2008) J Neurosci , vol.28 , Issue.16 , pp. 4115-4122
    • Cassina, P.1    Cassina, A.2    Pehar, M.3
  • 92
    • 56549115885 scopus 로고    scopus 로고
    • Non-cell-autonomous effect of human SOD1 G37R astrocytes on motor neurons derived from human embryonic stem cells
    • Marchetto MC, Muotri AR, Mu Y, Smith AM, Cezar GG, Gage FH. Non-cell-autonomous effect of human SOD1 G37R astrocytes on motor neurons derived from human embryonic stem cells. Cell Stem Cell 2008; 3(6): 649-57.
    • (2008) Cell Stem Cell , vol.3 , Issue.6 , pp. 649-657
    • Marchetto, M.C.1    Muotri, A.R.2    Mu, Y.3    Smith, A.M.4    Cezar, G.G.5    Gage, F.H.6
  • 93
    • 80052783545 scopus 로고    scopus 로고
    • Astrocytes from familial and sporadic ALS patients are toxic to motor neurons
    • Haidet-Phillips AM, Hester ME, Miranda CJ, et al. Astrocytes from familial and sporadic ALS patients are toxic to motor neurons. Nat Biotechnol 2011; 29(9): 824-8.
    • (2011) Nat Biotechnol , vol.29 , Issue.9 , pp. 824-828
    • Haidet-Phillips, A.M.1    Hester, M.E.2    Miranda, C.J.3
  • 94
    • 84892572544 scopus 로고    scopus 로고
    • Direct conversion of patient fibroblasts demonstrates non-cell autonomous toxicity of astrocytes to motor neurons in familial and sporadic ALS
    • Meyer K, Ferraiuolo L, Miranda CJ, et al. Direct conversion of patient fibroblasts demonstrates non-cell autonomous toxicity of astrocytes to motor neurons in familial and sporadic ALS. Proc Natl Acad Sci USA 2014; 111(2): 829-32.
    • (2014) Proc Natl Acad Sci USA , vol.111 , Issue.2 , pp. 829-832
    • Meyer, K.1    Ferraiuolo, L.2    Miranda, C.J.3
  • 95
    • 84875275232 scopus 로고    scopus 로고
    • Astrocyte pathology and the absence of non-cell autonomy in an induced pluripotent stem cell model of TDP-43 proteinopathy
    • Serio A, Bilican B, Barmada SJ, et al. Astrocyte pathology and the absence of non-cell autonomy in an induced pluripotent stem cell model of TDP-43 proteinopathy. Proc Natl Acad Sci USA 2013; 110(12): 4697-702.
    • (2013) Proc Natl Acad Sci USA , vol.110 , Issue.12 , pp. 4697-4702
    • Serio, A.1    Bilican, B.2    Barmada, S.J.3
  • 96
    • 70450255155 scopus 로고    scopus 로고
    • Understanding microRNAs in neurodegeneration
    • Eacker SM, Dawson TM, Dawson VL. Understanding microRNAs in neurodegeneration. Nat Rev Neurosci 2009; 10(12): 837-41.
    • (2009) Nat Rev Neurosci , vol.10 , Issue.12 , pp. 837-841
    • Eacker, S.M.1    Dawson, T.M.2    Dawson, V.L.3
  • 97
    • 77952584652 scopus 로고    scopus 로고
    • Dysregulated microRNAs in neurodegenerative disorders
    • Lau P, de Strooper B. Dysregulated microRNAs in neurodegenerative disorders. Semin Cell Dev Biol 2010; 21(7): 768-73.
    • (2010) Semin Cell Dev Biol , vol.21 , Issue.7 , pp. 768-773
    • Lau, P.1    de Strooper, B.2
  • 98
    • 77952675535 scopus 로고    scopus 로고
    • MicroRNAs and deregulated gene expression networks in neurodegeneration
    • Sonntag KC. MicroRNAs and deregulated gene expression networks in neurodegeneration. Brain Res 2010; 1338: 48-57.
    • (2010) Brain Res , vol.1338 , pp. 48-57
    • Sonntag, K.C.1
  • 99
    • 34447261382 scopus 로고    scopus 로고
    • Cerebellar neurodegeneration in the absence of microRNAs
    • Schaefer A, O'Carroll D, Tan CL, et al. Cerebellar neurodegeneration in the absence of microRNAs. J Exp Med 2007; 204(7): 1553-8.
    • (2007) J Exp Med , vol.204 , Issue.7 , pp. 1553-1558
    • Schaefer, A.1    O'Carroll, D.2    Tan, C.L.3
  • 100
    • 44449132518 scopus 로고    scopus 로고
    • Dicer loss in striatal neurons produces behavioral and neuroanatomical phenotypes in the absence of neurodegeneration
    • Cuellar TL, Davis TH, Nelson PT, et al. Dicer loss in striatal neurons produces behavioral and neuroanatomical phenotypes in the absence of neurodegeneration. Proc Natl Acad Sci USA 2008; 105(14): 5614-9.
    • (2008) Proc Natl Acad Sci USA , vol.105 , Issue.14 , pp. 5614-5619
    • Cuellar, T.L.1    Davis, T.H.2    Nelson, P.T.3
  • 101
    • 44949139634 scopus 로고    scopus 로고
    • Dicer inactivation leads to progressive functional and structural degeneration of the mouse retina
    • Damiani D, Alexander JJ, O'Rourke JR, et al. Dicer inactivation leads to progressive functional and structural degeneration of the mouse retina. J Neurosci 2008; 28(19): 4878-87.
    • (2008) J Neurosci , vol.28 , Issue.19 , pp. 4878-4887
    • Damiani, D.1    Alexander, J.J.2    O'Rourke, J.R.3
  • 102
    • 43749120042 scopus 로고    scopus 로고
    • Conditional loss of Dicer disrupts cellular and tissue morphogenesis in the cortex and hippocampus
    • Davis TH, Cuellar TL, Koch SM, et al. Conditional loss of Dicer disrupts cellular and tissue morphogenesis in the cortex and hippocampus. J Neurosci 2008; 28(17): 4322-30.
    • (2008) J Neurosci , vol.28 , Issue.17 , pp. 4322-4330
    • Davis, T.H.1    Cuellar, T.L.2    Koch, S.M.3
  • 103
    • 77955599311 scopus 로고    scopus 로고
    • miRNA malfunction causes spinal motor neuron disease
    • Haramati S, Chapnik E, Sztainberg Y, et al. miRNA malfunction causes spinal motor neuron disease. Proc Natl Acad Sci USA 2010; 107(29): 13111-6.
    • (2010) Proc Natl Acad Sci USA , vol.107 , Issue.29 , pp. 13111-13116
    • Haramati, S.1    Chapnik, E.2    Sztainberg, Y.3
  • 104
    • 79958020894 scopus 로고    scopus 로고
    • Deletion of astroglial Dicer causes noncell- autonomous neuronal dysfunction and degeneration
    • Tao J, Wu H, Lin Q, et al. Deletion of astroglial Dicer causes noncell- autonomous neuronal dysfunction and degeneration. J Neurosci 2011; 31(22): 8306-19.
    • (2011) J Neurosci , vol.31 , Issue.22 , pp. 8306-8319
    • Tao, J.1    Wu, H.2    Lin, Q.3
  • 105
    • 77952387782 scopus 로고    scopus 로고
    • Dicer in Schwann cells is required for myelination and axonal integrity
    • Pereira JA, Baumann R, Norrmen C, et al. Dicer in Schwann cells is required for myelination and axonal integrity. J Neurosci 2010; 30(19): 6763-75.
    • (2010) J Neurosci , vol.30 , Issue.19 , pp. 6763-6775
    • Pereira, J.A.1    Baumann, R.2    Norrmen, C.3
  • 107
    • 33749632259 scopus 로고    scopus 로고
    • Ubiquitinated TDP- 43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis
    • Neumann M, Sampathu DM, Kwong LK, et al. Ubiquitinated TDP- 43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis. Science 2006; 314(5796): 130-3.
    • (2006) Science , vol.314 , Issue.5796 , pp. 130-133
    • Neumann, M.1    Sampathu, D.M.2    Kwong, L.K.3
  • 108
    • 33750716074 scopus 로고    scopus 로고
    • TDP-43 is a component of ubiquitin-positive tau-negative inclusions in frontotemporal lobar degeneration and amyotrophic lateral sclerosis
    • Arai T, Hasegawa M, Akiyama H, et al. TDP-43 is a component of ubiquitin-positive tau-negative inclusions in frontotemporal lobar degeneration and amyotrophic lateral sclerosis. Biochem Biophys Res Commun 2006; 351(3): 602-11.
    • (2006) Biochem Biophys Res Commun , vol.351 , Issue.3 , pp. 602-611
    • Arai, T.1    Hasegawa, M.2    Akiyama, H.3
  • 109
    • 61349162349 scopus 로고    scopus 로고
    • Mutations in FUS, an RNA processing protein, cause familial amyotrophic lateral sclerosis type 6
    • Vance C, Rogelj B, Hortobagyi T, et al. Mutations in FUS, an RNA processing protein, cause familial amyotrophic lateral sclerosis type 6. Science 2009; 323(5918): 1208-11.
    • (2009) Science , vol.323 , Issue.5918 , pp. 1208-1211
    • Vance, C.1    Rogelj, B.2    Hortobagyi, T.3
  • 110
    • 61349156118 scopus 로고    scopus 로고
    • Mutations in the FUS/TLS gene on chromosome 16 cause familial amyotrophic lateral sclerosis
    • Kwiatkowski TJ Jr, Bosco DA, Leclerc AL, et al. Mutations in the FUS/TLS gene on chromosome 16 cause familial amyotrophic lateral sclerosis. Science 2009; 323(5918): 1205-8.
    • (2009) Science , vol.323 , Issue.5918 , pp. 1205-1208
    • Kwiatkowski, T.J.1    Bosco, D.A.2    Leclerc, A.L.3
  • 111
    • 65449130022 scopus 로고    scopus 로고
    • TARDBP (TDP-43) sequence analysis in patients with familial and sporadic ALS: Identification of two novel mutations
    • Del Bo R, Ghezzi S, Corti S, et al. TARDBP (TDP-43) sequence analysis in patients with familial and sporadic ALS: identification of two novel mutations. Eur J Neurol 2009; 16(6): 727-32.
    • (2009) Eur J Neurol , vol.16 , Issue.6 , pp. 727-732
    • Del Bo, R.1    Ghezzi, S.2    Corti, S.3
  • 112
    • 84871590013 scopus 로고    scopus 로고
    • The FTD/ALS-associated RNAbinding protein TDP-43 regulates the robustness of neuronal specification through microRNA-9a in Drosophila
    • Li Z, Lu Y, Xu XL, Gao FB. The FTD/ALS-associated RNAbinding protein TDP-43 regulates the robustness of neuronal specification through microRNA-9a in Drosophila. Hum Mol Genet 2013; 22(2): 218-25.
    • (2013) Hum Mol Genet , vol.22 , Issue.2 , pp. 218-225
    • Li, Z.1    Lu, Y.2    Xu, X.L.3    Gao, F.B.4
  • 113
    • 84887855885 scopus 로고    scopus 로고
    • TDP-43 regulates the microprocessor complex activity during in vitro neuronal differentiation
    • Di Carlo V, Grossi E, Laneve P, et al. TDP-43 regulates the microprocessor complex activity during in vitro neuronal differentiation. Mol Neurobiol 2013; 48(3): 952-63.
    • (2013) Mol Neurobiol , vol.48 , Issue.3 , pp. 952-963
    • Di Carlo, V.1    Grossi, E.2    Laneve, P.3
  • 114
    • 84871002507 scopus 로고    scopus 로고
    • FUS stimulates microRNA biogenesis by facilitating co-transcriptional Drosha recruitment
    • Morlando M, Dini Modigliani S, Torrelli G, et al. FUS stimulates microRNA biogenesis by facilitating co-transcriptional Drosha recruitment. EMBO J 2012; 31(24): 4502-10.
    • (2012) EMBO J , vol.31 , Issue.24 , pp. 4502-4510
    • Morlando, M.1    Dini Modigliani, S.2    Torrelli, G.3
  • 115
    • 85005808152 scopus 로고    scopus 로고
    • Systemic dysregulation of TDP-43 binding microRNAs in amyotrophic lateral sclerosis
    • Freischmidt A, Muller K, Ludolph AC, Weishaupt JH. Systemic dysregulation of TDP-43 binding microRNAs in amyotrophic lateral sclerosis. Acta Neuropathol Commun 2013; 1(1): 42.
    • (2013) Acta Neuropathol Commun , vol.1 , Issue.1 , pp. 42
    • Freischmidt, A.1    Muller, K.2    Ludolph, A.C.3    Weishaupt, J.H.4
  • 116
    • 84887510924 scopus 로고    scopus 로고
    • Mutations in the 3' untranslated region of FUS causing FUS overexpression are associated with amyotrophic lateral sclerosis
    • Sabatelli M, Moncada A, Conte A, et al. Mutations in the 3' untranslated region of FUS causing FUS overexpression are associated with amyotrophic lateral sclerosis. Hum Mol Genet 2013; 22(23): 4748-55.
    • (2013) Hum Mol Genet , vol.22 , Issue.23 , pp. 4748-4755
    • Sabatelli, M.1    Moncada, A.2    Conte, A.3
  • 117
    • 84904195219 scopus 로고    scopus 로고
    • An ALS-associated mutation in the FUS 3'-UTR disrupts a microRNA-FUS regulatory circuitry
    • Dini Modigliani S, Morlando M, Errichelli L, Sabatelli M, Bozzoni I. An ALS-associated mutation in the FUS 3'-UTR disrupts a microRNA-FUS regulatory circuitry. Nat Commun 2014; 5: 4335.
    • (2014) Nat Commun , vol.5 , pp. 4335
    • Dini Modigliani, S.1    Morlando, M.2    Errichelli, L.3    Sabatelli, M.4    Bozzoni, I.5
  • 118
    • 84891941306 scopus 로고    scopus 로고
    • Altered miRNA expression is associated with neuronal fate in G93A-SOD1 ependymal stem progenitor cells
    • Marcuzzo S, Kapetis D, Mantegazza R, et al. Altered miRNA expression is associated with neuronal fate in G93A-SOD1 ependymal stem progenitor cells. Exp Neurol 2014; 253: 91-101.
    • (2014) Exp Neurol , vol.253 , pp. 91-101
    • Marcuzzo, S.1    Kapetis, D.2    Mantegazza, R.3
  • 119
    • 84885357213 scopus 로고    scopus 로고
    • miRNA-9 expression is upregulated in the spinal cord of G93A-SOD1 transgenic mice
    • Zhou F, Guan Y, Chen Y, et al. miRNA-9 expression is upregulated in the spinal cord of G93A-SOD1 transgenic mice. Int J Clin Exp Pathol 2013; 6(9): 1826-38.
    • (2013) Int J Clin Exp Pathol , vol.6 , Issue.9 , pp. 1826-1838
    • Zhou, F.1    Guan, Y.2    Chen, Y.3
  • 120
    • 84885444052 scopus 로고    scopus 로고
    • Downregulation of microRNA-9 in iPSC-derived neurons of FTD/ALS patients with TDP-43 mutations
    • Zhang Z, Almeida S, Lu Y, et al. Downregulation of microRNA-9 in iPSC-derived neurons of FTD/ALS patients with TDP-43 mutations. PLoS One 2013; 8(10): e76055.
    • (2013) PLoS One , vol.8 , Issue.10
    • Zhang, Z.1    Almeida, S.2    Lu, Y.3
  • 121
    • 84902134581 scopus 로고    scopus 로고
    • Modeling ALS with iPSCs Reveals that Mutant SOD1 Misregulates Neurofilament Balance in Motor Neurons
    • Chen H, Qian K, Du Z, et al. Modeling ALS with iPSCs Reveals that Mutant SOD1 Misregulates Neurofilament Balance in Motor Neurons. Cell Stem Cell 2014; 14(6): 796-809.
    • (2014) Cell Stem Cell , vol.14 , Issue.6 , pp. 796-809
    • Chen, H.1    Qian, K.2    Du, Z.3
  • 122
    • 84869498484 scopus 로고    scopus 로고
    • Elevated cerebrospinal fluid neurofilament light levels in patients with amyotrophic lateral sclerosis: A possible marker of disease severity and progression
    • Tortelli R, Ruggieri M, Cortese R, et al. Elevated cerebrospinal fluid neurofilament light levels in patients with amyotrophic lateral sclerosis: a possible marker of disease severity and progression. Eur J Neurol 2012; 19(12): 1561-7.
    • (2012) Eur J Neurol , vol.19 , Issue.12 , pp. 1561-1567
    • Tortelli, R.1    Ruggieri, M.2    Cortese, R.3
  • 123
    • 84878005741 scopus 로고    scopus 로고
    • Altered microRNA expression profile in Amyotrophic Lateral Sclerosis: A role in the regulation of NFL mRNA levels
    • Campos-Melo D, Droppelmann CA, He Z, Volkening K, Strong MJ. Altered microRNA expression profile in Amyotrophic Lateral Sclerosis: a role in the regulation of NFL mRNA levels. Mol Brain 2013; 6: 26.
    • (2013) Mol Brain , vol.6 , pp. 26
    • Campos-Melo, D.1    Droppelmann, C.A.2    He, Z.3    Volkening, K.4    Strong, M.J.5
  • 124
    • 84898606538 scopus 로고    scopus 로고
    • Analysis of novel NEFL mRNA targeting microRNAs in amyotrophic lateral sclerosis
    • Ishtiaq M, Campos-Melo D, Volkening K, Strong MJ. Analysis of novel NEFL mRNA targeting microRNAs in amyotrophic lateral sclerosis. PLoS One 2014; 9(1): e85653.
    • (2014) PLoS One , vol.9 , Issue.1
    • Ishtiaq, M.1    Campos-Melo, D.2    Volkening, K.3    Strong, M.J.4
  • 125
    • 84865987121 scopus 로고    scopus 로고
    • Modulating inflammatory monocytes with a unique microRNA gene signature ameliorates murine ALS
    • Butovsky O, Siddiqui S, Gabriely G, et al. Modulating inflammatory monocytes with a unique microRNA gene signature ameliorates murine ALS. J Clin Invest 2012; 122(9): 3063-87.
    • (2012) J Clin Invest , vol.122 , Issue.9 , pp. 3063-3087
    • Butovsky, O.1    Siddiqui, S.2    Gabriely, G.3
  • 126
    • 84891767879 scopus 로고    scopus 로고
    • Dysregulated microRNAs in amyotrophic lateral sclerosis microglia modulate genes linked to neuroinflammation
    • Parisi C, Arisi I, D'Ambrosi N, et al. Dysregulated microRNAs in amyotrophic lateral sclerosis microglia modulate genes linked to neuroinflammation. Cell Death Dis 2013; 4: e959.
    • (2013) Cell Death Dis , vol.4
    • Parisi, C.1    Arisi, I.2    D'Ambrosi, N.3
  • 127
    • 56649100689 scopus 로고    scopus 로고
    • T lymphocytes potentiate endogenous neuroprotective inflammation in a mouse model of ALS
    • Chiu IM, Chen A, Zheng Y, et al. T lymphocytes potentiate endogenous neuroprotective inflammation in a mouse model of ALS. Proc Natl Acad Sci USA 2008; 105(46): 17913-8.
    • (2008) Proc Natl Acad Sci USA , vol.105 , Issue.46 , pp. 17913-17918
    • Chiu, I.M.1    Chen, A.2    Zheng, Y.3
  • 128
    • 70449732762 scopus 로고    scopus 로고
    • The proinflammatory action of microglial P2 receptors is enhanced in SOD1 models for amyotrophic lateral sclerosis
    • D'Ambrosi N, Finocchi P, Apolloni S, et al. The proinflammatory action of microglial P2 receptors is enhanced in SOD1 models for amyotrophic lateral sclerosis. J Immunol 2009; 183(7): 4648-56.
    • (2009) J Immunol , vol.183 , Issue.7 , pp. 4648-4656
    • D'Ambrosi, N.1    Finocchi, P.2    Apolloni, S.3
  • 129
    • 0034733968 scopus 로고    scopus 로고
    • Circulating levels of tumour necrosis factor-alpha and its soluble receptors are increased in the blood of patients with amyotrophic lateral sclerosis
    • Poloni M, Facchetti D, Mai R, et al. Circulating levels of tumour necrosis factor-alpha and its soluble receptors are increased in the blood of patients with amyotrophic lateral sclerosis. Neurosci Lett 2000; 287(3): 211-4.
    • (2000) Neurosci Lett , vol.287 , Issue.3 , pp. 211-214
    • Poloni, M.1    Facchetti, D.2    Mai, R.3
  • 130
    • 0041833409 scopus 로고    scopus 로고
    • Message and proteinlevel elevation of tumor necrosis factor alpha (TNF alpha) and TNF alpha-modulating cytokines in spinal cords of the G93A-SOD1 mouse model for amyotrophic lateral sclerosis
    • Hensley K, Fedynyshyn J, Ferrell S, et al. Message and proteinlevel elevation of tumor necrosis factor alpha (TNF alpha) and TNF alpha-modulating cytokines in spinal cords of the G93A-SOD1 mouse model for amyotrophic lateral sclerosis. Neurobiol Dis 2003; 14(1): 74-80.
    • (2003) Neurobiol Dis , vol.14 , Issue.1 , pp. 74-80
    • Hensley, K.1    Fedynyshyn, J.2    Ferrell, S.3
  • 131
    • 66749154197 scopus 로고    scopus 로고
    • Glutamate transporters and the excitotoxic path to motor neuron degeneration in amyotrophic lateral sclerosis
    • Foran E, Trotti D. Glutamate transporters and the excitotoxic path to motor neuron degeneration in amyotrophic lateral sclerosis. Antioxid Redox Signal 2009; 11(7): 1587-602.
    • (2009) Antioxid Redox Signal , vol.11 , Issue.7 , pp. 1587-1602
    • Foran, E.1    Trotti, D.2
  • 132
    • 0036787803 scopus 로고    scopus 로고
    • Update on the glutamatergic neurotransmitter system and the role of excitotoxicity in amyotrophic lateral sclerosis
    • Heath PR, Shaw PJ. Update on the glutamatergic neurotransmitter system and the role of excitotoxicity in amyotrophic lateral sclerosis. Muscle Nerve 2002; 26(4): 438-58.
    • (2002) Muscle Nerve , vol.26 , Issue.4 , pp. 438-458
    • Heath, P.R.1    Shaw, P.J.2
  • 133
    • 84874833693 scopus 로고    scopus 로고
    • Neuronal exosomal miRNA-dependent translational regulation of astroglial glutamate transporter GLT1
    • Morel L, Regan M, Higashimori H, et al. Neuronal exosomal miRNA-dependent translational regulation of astroglial glutamate transporter GLT1. J Biol Chem 2013; 288(10): 7105-16.
    • (2013) J Biol Chem , vol.288 , Issue.10 , pp. 7105-7116
    • Morel, L.1    Regan, M.2    Higashimori, H.3
  • 134
    • 84866491615 scopus 로고    scopus 로고
    • Disruption of skeletal muscle mitochondrial network genes and miRNAs in amyotrophic lateral sclerosis
    • Russell AP, Wada S, Vergani L, et al. Disruption of skeletal muscle mitochondrial network genes and miRNAs in amyotrophic lateral sclerosis. Neurobiol Dis 2012; 49C: 107-17.
    • (2012) Neurobiol Dis , vol.49 C , pp. 107-117
    • Russell, A.P.1    Wada, S.2    Vergani, L.3
  • 135
    • 84875589716 scopus 로고    scopus 로고
    • Mitochondria and ALS: Implications from novel genes and pathways
    • Cozzolino M, Ferri A, Valle C, Carri MT. Mitochondria and ALS: implications from novel genes and pathways. Mol Cell Neurosci 2013; 55: 44-9.
    • (2013) Mol Cell Neurosci , vol.55 , pp. 44-49
    • Cozzolino, M.1    Ferri, A.2    Valle, C.3    Carri, M.T.4
  • 136
    • 84865536102 scopus 로고    scopus 로고
    • A miRNA signature in leukocytes from sporadic amyotrophic lateral sclerosis
    • De Felice B, Guida M, Guida M, Coppola C, De Mieri G, Cotrufo R. A miRNA signature in leukocytes from sporadic amyotrophic lateral sclerosis. Gene 2012; 508(1): 35-40.
    • (2012) Gene , vol.508 , Issue.1 , pp. 35-40
    • De Felice, B.1    Guida, M.2    Guida, M.3    Coppola, C.4    De Mieri, G.5    Cotrufo, R.6
  • 137
    • 77952336221 scopus 로고    scopus 로고
    • Aberrant microRNA expression in the brains of neurodegenerative diseases: MiR-29a decreased in Alzheimer disease brains targets neurone navigator 3
    • Shioya M, Obayashi S, Tabunoki H, et al. Aberrant microRNA expression in the brains of neurodegenerative diseases: miR-29a decreased in Alzheimer disease brains targets neurone navigator 3. Neuropathol Appl Neurobiol 2010; 36(4): 320-30.
    • (2010) Neuropathol Appl Neurobiol , vol.36 , Issue.4 , pp. 320-330
    • Shioya, M.1    Obayashi, S.2    Tabunoki, H.3
  • 139
    • 80053946666 scopus 로고    scopus 로고
    • Circulating microRNAs: Association with disease and potential use as biomarkers
    • Reid G, Kirschner MB, van Zandwijk N. Circulating microRNAs: Association with disease and potential use as biomarkers. Crit Rev Oncol Hematol 2011; 80(2): 193-208.
    • (2011) Crit Rev Oncol Hematol , vol.80 , Issue.2 , pp. 193-208
    • Reid, G.1    Kirschner, M.B.2    van Zandwijk, N.3
  • 140
    • 34249302620 scopus 로고    scopus 로고
    • Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells
    • Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO. Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells. Nat Cell Biol 2007; 9(6): 654-9.
    • (2007) Nat Cell Biol , vol.9 , Issue.6 , pp. 654-659
    • Valadi, H.1    Ekstrom, K.2    Bossios, A.3    Sjostrand, M.4    Lee, J.J.5    Lotvall, J.O.6
  • 141
    • 84895875610 scopus 로고    scopus 로고
    • MicroRNA-206: A potential circulating biomarker candidate for amyotrophic lateral sclerosis
    • Toivonen JM, Manzano R, Olivan S, Zaragoza P, Garcia-Redondo A, Osta R. MicroRNA-206: a potential circulating biomarker candidate for amyotrophic lateral sclerosis. PLoS One 2014; 9(2): e89065.
    • (2014) PLoS One , vol.9 , Issue.2
    • Toivonen, J.M.1    Manzano, R.2    Olivan, S.3    Zaragoza, P.4    Garcia-Redondo, A.5    Osta, R.6
  • 142
    • 84921782219 scopus 로고    scopus 로고
    • Gene expression signatures in motor neuron disease fibroblasts reveal dysregulation of metabolism, hypoxia-response and RNA processing functions
    • Raman R, Allen SP, Goodall EF, et al. Gene expression signatures in motor neuron disease fibroblasts reveal dysregulation of metabolism, hypoxia-response and RNA processing functions. Neuropathol Appl Neurobiol 2014; 41(2): 201-26.
    • (2014) Neuropathol Appl Neurobiol , vol.41 , Issue.2 , pp. 201-226
    • Raman, R.1    Allen, S.P.2    Goodall, E.F.3
  • 143
    • 84891093032 scopus 로고    scopus 로고
    • The involvement of microRNAs in neurodegenerative diseases
    • Maciotta S, Meregalli M, Torrente Y. The involvement of microRNAs in neurodegenerative diseases. Front Cell Neurosci 2013; 7: 265.
    • (2013) Front Cell Neurosci , vol.7 , pp. 265
    • McIotta, S.1    Meregalli, M.2    Torrente, Y.3
  • 144
    • 84880960483 scopus 로고    scopus 로고
    • Muscle histone deacetylase 4 upregulation in amyotrophic lateral sclerosis: Potential role in reinnervation ability and disease progression
    • Bruneteau G, Simonet T, Bauche S, et al. Muscle histone deacetylase 4 upregulation in amyotrophic lateral sclerosis: potential role in reinnervation ability and disease progression. Brain 2013; 136(Pt 8): 2359-68.
    • (2013) Brain , vol.136 , pp. 2359-2368
    • Bruneteau, G.1    Simonet, T.2    Bauche, S.3
  • 145
    • 84899715456 scopus 로고    scopus 로고
    • The role of muscle microRNAs in repairing the neuromuscular junction
    • Valdez G, Heyer MP, Feng G, Sanes JR. The role of muscle microRNAs in repairing the neuromuscular junction. PLoS One 2014; 9(3): e93140.
    • (2014) PLoS One , vol.9 , Issue.3
    • Valdez, G.1    Heyer, M.P.2    Feng, G.3    Sanes, J.R.4
  • 146
    • 84884712642 scopus 로고    scopus 로고
    • Method for widespread microRNA-155 inhibition prolongs survival in ALS-model mice
    • Koval ED, Shaner C, Zhang P, et al. Method for widespread microRNA-155 inhibition prolongs survival in ALS-model mice. Hum Mol Genet 2013; 22(20): 4127-35.
    • (2013) Hum Mol Genet , vol.22 , Issue.20 , pp. 4127-4135
    • Koval, E.D.1    Shaner, C.2    Zhang, P.3


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