Depletion of suppressor of cytokine signaling-1a causes hepatic steatosis and insulin resistance in zebrafish

American Journal of Physiology - Endocrinology and Metabolism

Volumn 308, Issue 10, 2015, Pages E849-E859

  Dai1, Ziru ^b   Wang, Hualin ^c   Jin, Xia ^b   Wang, Houpeng ^c   He, Jiangyan ^b   Liu, Mugen ^a   Yin, Zhan ^a,b   Sun, Yonghua ^c   Lou, Qiyong ^b  

^a HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^b INSTITUTE OF HYDROBIOLOGY   (China)

^c State Key Laboratory of Freshwater Ecology and Biotechnology   (China)

Author keywords

Gene targeting; Hepatic steatosis; Insulin resistance; Suppressor of cytokine signaling 1a; Zebrafish

Indexed keywords

ACYL COENZYME A DESATURASE; AMINO ACID; APOLIPOPROTEIN A4; GAMMA INTERFERON; GENOMIC DNA; GLUCOKINASE; GLUCOSE 6 PHOSPHATASE; HYPOXIA INDUCIBLE FACTOR 1ALPHA; INSULIN; INSULIN RECEPTOR; INTERFERON CONSENSUS SEQUENCE BINDING PROTEIN; INTERFERON REGULATORY FACTOR 7; INTERLEUKIN 1; INTERLEUKIN 10 RECEPTOR ALPHA; INTERLEUKIN 2 RECEPTOR GAMMA; INTERLEUKIN 21 RECEPTOR; INTERLEUKIN 4 RECEPTOR; INTERLEUKIN 6; JANUS KINASE; LOW DENSITY LIPOPROTEIN RECEPTOR; PHOSPHOENOLPYRUVATE CARBOXYKINASE (GTP); STAT5 PROTEIN; SUPPRESSOR OF CYTOKINE SIGNALING 1; SUPPRESSOR OF CYTOKINE SIGNALING 1A; TRANSCRIPTION ACTIVATOR LIKE EFFECTOR NUCLEASE; TRANSCRIPTION FACTOR FKHR; TRANSCRIPTION FACTOR GATA 1; TRANSCRIPTOME; TRIACYLGLYCEROL; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; GROWTH HORMONE; SOCS1 PROTEIN, ZEBRAFISH; STAT PROTEIN; SUPPRESSOR OF CYTOKINE SIGNALING; ZEBRAFISH PROTEIN;

ADIPOSE TISSUE; ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY GROWTH; COMPARATIVE STUDY; CONTROLLED STUDY; DEVELOPMENTAL STAGE; ENZYME ACTIVATION; ERYTHROPOIESIS; FATTY LIVER; FEMALE; GENE EXPRESSION; GENOTYPE; GLUCONEOGENESIS; GLYCOLYSIS; INSULIN RESISTANCE; INSULIN SENSITIVITY; LIPID COMPOSITION; LIPID METABOLISM; LIPID STORAGE; LIPODYSTROPHY; LIPOGENESIS; LIPOLYSIS; LIVER CELL; LIVER HISTOLOGY; MALE; NONHUMAN; OBESITY; PHENOTYPE; PRIORITY JOURNAL; PROTEIN DEPLETION; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; REAL TIME POLYMERASE CHAIN REACTION; SEQUENCE ANALYSIS; SIGNAL TRANSDUCTION; TRANSCRIPTOMICS; ZEBRA FISH; ANIMAL; ANIMAL EMBRYO; EMBRYOLOGY; GENE DELETION; GENETICS; METABOLISM; MOLECULAR GENETICS; NUCLEOTIDE SEQUENCE; TRANSGENIC ANIMAL;

ANIMALS; ANIMALS, GENETICALLY MODIFIED; BASE SEQUENCE; EMBRYO, NONMAMMALIAN; FATTY LIVER; GENE DELETION; GROWTH HORMONE; INSULIN RESISTANCE; JANUS KINASES; MOLECULAR SEQUENCE DATA; SIGNAL TRANSDUCTION; STAT TRANSCRIPTION FACTORS; SUPPRESSOR OF CYTOKINE SIGNALING PROTEINS; ZEBRAFISH; ZEBRAFISH PROTEINS;

EID: 84930838934     PISSN: 01931849     EISSN: 15221555     Source Type: Journal    
DOI: 10.1152/ajpendo.00540.2014     Document Type: Article

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