MOV10L1 is necessary for protection of spermatocytes against retrotransposons by Piwi-interacting RNAs

Proceedings of the National Academy of Sciences of the United States of America

Volumn 107, Issue 26, 2010, Pages 11847-11852

  Frost, Robert J A ^a   Hamra, F Kent ^b   Richardson, James A ^a,c   Qi, Xiaoxia ^a   Bassel Duby, Rhonda ^a   Olson, Eric N ^a  

^a UNIVERSITY OF TEXAS AT DALLAS   (United States)

^b UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^c UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

Armitage; Meiosis; RNA helicase

Indexed keywords

HEAT SHOCK PROTEIN 70; PIWI PROTEIN; PROTEIN MOV10L1; RNA BINDING PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CELL PROTECTION; GENE DELETION; GENE INTERACTION; GENE REPRESSION; GENE SILENCING; GENETIC TRANSCRIPTION; MALE; MALE INFERTILITY; MEIOSIS; MOUSE; NONHUMAN; PACHYTENE; PRIORITY JOURNAL; PROPHASE; PROTEIN EXPRESSION; RETROPOSON; SPERMATOCYTE; SPERMATOGENESIS;

AMINO ACID SEQUENCE; ANIMALS; BASE SEQUENCE; DNA METHYLATION; DNA PRIMERS; FERTILITY; HSP70 HEAT-SHOCK PROTEINS; MALE; MEIOSIS; MICE; MICE, KNOCKOUT; MODELS, BIOLOGICAL; MOLECULAR SEQUENCE DATA; MUTATION; PROTEINS; RETROELEMENTS; RNA HELICASES; RNA, SMALL INTERFERING; SEQUENCE HOMOLOGY, AMINO ACID; SPERMATOCYTES; SPERMATOGENESIS; TESTIS;

MAMMALIA; MUS;

EID: 77955409741     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1007158107     Document Type: Article

References (28)

1. Cordaux R, Batzer MA (2009) The impact of retrotransposons on human genome evolution. Nat Rev Genet 10:691-703.
2. Babushok DV, Kazazian HH, Jr (2007) Progress in understanding the biology of the human mutagen LINE-1. Hum Mutat 28:527-539.
3. Brouha B, et al. (2003) Hot L1s account for the bulk of retrotransposition in the human population. Proc Natl Acad Sci USA 100:5280-5285.
4. Kazazian HH, Jr (2004) Mobile elements: Drivers of genome evolution. Science 303: 1626-1632.
5. Aravin AA, Bourc'his D (2008) Small RNA guides for de novo DNA methylation in mammalian germ cells. Genes Dev 22:970-975.
6. Ahmed EA, de Rooij DG (2009) Staging of mouse seminiferous tubule cross-sections. Methods Mol Biol 558:263-277.
7. Aravin AA, Hannon GJ (2008) Small RNA silencing pathways in germ and stem cells. Cold Spring Harb Symp Quant Biol 73:283-290.
8. Girard A, Sachidanandam R, Hannon GJ, Carmell MA (2006) A germline-specific class of small RNAs binds mammalian Piwi proteins. Nature 442:199-202.
9. Liu ZP, et al. (2001) CHAMP, a novel cardiac-specific helicase regulated by MEF2C. Dev Biol 234:497-509.
10. Meister G, et al. (2005) Identification of novel argonaute-associated proteins. Curr Biol 15:2149-2155.
11. Malone CD, et al. (2009) Specialized piRNA pathways act in germline and somatic tissues of the Drosophila ovary. Cell 137:522-535.
12. Vagin VV, et al. (2006) A distinct small RNA pathway silences selfish genetic elements in the germline. Science 313:320-324.
13. Ueyama T, Kasahara H, Ishiwata T, Yamasaki N, Izumo S (2003) Csm, a cardiac-specific isoform of the RNA helicase Mov10l1, is regulated by Nkx2.5 in embryonic heart. J Biol Chem 278:28750-28757.
14. Wang PJ, McCarrey JR, Yang F, Page DC (2001) An abundance of X-linked genes expressed in spermatogonia. Nat Genet 27:422-426.
15. Liu ZP, Olson EN (2002) Suppression of proliferation and cardiomyocyte hypertrophy by CHAMP, a cardiac-specific RNA helicase. Proc Natl Acad Sci USA 99:2043-2048.
16. Lovasco LA, et al. (2010) Accelerated ovarian aging in the absence of the transcription regulator TAF4B in mice. Biol Reprod 82:23-34.
17. Deng W, Lin H (2002) miwi, a murine homolog of piwi, encodes a cytoplasmic protein essential for spermatogenesis. Dev Cell 2:819-830.
18. Kuramochi-Miyagawa S, et al. (2004) Mili, a mammalian member of piwi family gene, is essential for spermatogenesis. Development 131:839-849.
19. Carmell MA, et al. (2007) MIWI2 is essential for spermatogenesis and repression of transposons in the mouse male germline. Dev Cell 12:503-514.
20. Ma L, et al. (2009) GASZ is essential for male meiosis and suppression of retrotransposon expression in the male germline. PLoS Genet 5:e1000635.
21. Shoji M, et al. (2009) The TDRD9-MIWI2 complex is essential for piRNA-mediated retrotransposon silencing in the mouse male germline. Dev Cell 17:775-787.
22. Unhavaithaya Y, et al. (2009) MILI, a PIWI-interacting RNA-binding protein, is required for germ line stem cell self-renewal and appears to positively regulate translation. J Biol Chem 284:6507-6519.
23. Buaas FW, et al. (2004) Plzf is required in adult male germ cells for stem cell self-renewal. Nat Genet 36:647-652.
24. Maatouk DM, Loveland KL, McManus MT, Moore K, Harfe BD (2008) Dicer1 is required for differentiation of the mouse male germline. Biol Reprod 79:696-703.
25. Soper SF, et al. (2008) Mouse maelstrom, a component of nuage, is essential for spermatogenesis and transposon repression in meiosis. Dev Cell 15:285-297.
26. Dix DJ, et al. (1996) Targeted gene disruption of Hsp70-2 results in failed meiosis, germ cell apoptosis, and male infertility. Proc Natl Acad Sci USA 93:3264-3268.
27. Inselman AL, et al. (2010) Heat shock protein 2 promoter drives cre expression in spermatocytes of transgenic mice. Genesis 48:114-120.
28. Cedenho AP, et al. (2006) Oligozoospermia and heat-shock protein expression in ejaculated spermatozoa. Hum Reprod 21:1791-1794.