Drosophila Piwi functions downstream of piRNA production mediating a chromatin-based transposon silencing mechanism in female germ line

Proceedings of the National Academy of Sciences of the United States of America

Volumn 108, Issue 52, 2011, Pages 21164-21169

  Wang, Sidney H ^a   Elgin, Sarah C R ^a  

^a WASHINGTON UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEMENTARY DNA; PIWI INTERACTING RNA;

ARTICLE; CHROMATIN; CHROMATIN IMMUNOPRECIPITATION; DROSOPHILA MELANOGASTER; EGG; FEMALE; FEMALE INFERTILITY; GENE SILENCING; GERM LINE; HETEROCHROMATIN; NONHUMAN; OVARY; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TRANSPOSON;

ANIMALS; ARGONAUTE PROTEINS; BLOTTING, NORTHERN; BLOTTING, WESTERN; CHROMATIN IMMUNOPRECIPITATION; CHROMOSOMAL PROTEINS, NON-HISTONE; DNA PRIMERS; DNA TRANSPOSABLE ELEMENTS; DROSOPHILA MELANOGASTER; DROSOPHILA PROTEINS; FEMALE; GERM CELLS; HETEROCHROMATIN; MICROSCOPY, CONFOCAL; REAL-TIME POLYMERASE CHAIN REACTION; RNA INTERFERENCE; RNA, SMALL INTERFERING;

DROSOPHILA MELANOGASTER; SOLANUM MELONGENA;

EID: 84862907807     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1107892109     Document Type: Article

References (50)

1. Bannert N, Kurth R (2006) The evolutionary dynamics of human endogenous retroviral families. Annu Rev Genomics Hum Genet 7:149-173. (Pubitemid 44627926)
2. Wang T, et al. (2007) Species-specific endogenous retroviruses shape the transcriptional network of the human tumor suppressor protein p53. Proc Natl Acad Sci USA 104:18613-18618. (Pubitemid 350210745)
3. Girard A, Hannon GJ (2008) Conserved themes in small-RNA-mediated transposon control. Trends Cell Biol 18:136-148.
4. Gu W, et al. (2009) Distinct argonaute-mediated 22G-RNA pathways direct genome surveillance in the C. elegans germline. Mol Cell 36:231-244.
5. Law JA, Jacobsen SE (2010) Establishing, maintaining and modifying DNA methylation patterns in plants and animals. Nat Rev Genet 11:204-220.
6. Fire A, et al. (1998) Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans. Nature 391:806-811. (Pubitemid 28099681)
7. Saito K, Siomi MC (2010) Small RNA-mediated quiescence of transposable elements in animals. Dev Cell 19:687-697.
8. Brennecke J, et al. (2007) Discrete small RNA-generating loci as master regulators of transposon activity in Drosophila. Cell 128:1089-1103. (Pubitemid 46427877)
9. Gunawardane LS, et al. (2007) A slicer-mediated mechanism for repeat-associated siRNA 5′ end formation in Drosophila. Science 315:1587-1590. (Pubitemid 46449477)
10. Saito K, et al. (2006) Specific association of Piwi with rasiRNAs derived from retrotransposon and heterochromatic regions in the Drosophila genome. Genes Dev 20: 2214-2222.
11. Vagin VV, et al. (2006) A distinct small RNA pathway silences selfish genetic elements in the germline. Science 313:320-324. (Pubitemid 44480950)
12. Yin H, Lin H (2007) An epigenetic activation role of Piwi and a Piwi-associated piRNA in Drosophila melanogaster. Nature 450:304-308. (Pubitemid 350100538)
13. Li C, et al. (2009) Collapse of germline piRNAs in the absence of Argonaute3 reveals somatic piRNAs in flies. Cell 137:509-521.
14. Malone CD, et al. (2009) Specialized piRNA pathways act in germline and somatic tissues of the Drosophila ovary. Cell 137:522-535.
15. Saito K, et al. (2009) A regulatory circuit for piwi by the large Maf gene traffic jamin Drosophila. Nature 461:1296-1299.
16. Siomi MC, Miyoshi T, Siomi H (2010) piRNA-mediated silencing in Drosophila germlines. Semin Cell Dev Biol 21:751-759.
17. Saito K, et al. (2010) Roles for the Yb body components Armitage and Yb in primary piRNA biogenesis in Drosophila. Genes Dev 24:2493-2498.
18. Brower-Toland B, et al. (2007) Drosophila PIWI associates with chromatin and interacts directly with HP1a. Genes Dev 21:2300-2311. (Pubitemid 47443336)
19. Klattenhoff C, et al. (2009) The Drosophila HP1 homolog Rhino is required for transposon silencing and piRNA production by dual-strand clusters. Cell 138:1137-1149.
20. Klenov MS, et al. (2007) Repeat-associated siRNAs cause chromatin silencing of retrotransposons in the Drosophila melanogaster germline. Nucleic Acids Res 35:5430-5438. (Pubitemid 47423917)
21. Pal-Bhadra M, et al. (2004) Heterochromatic silencing and HP1 localization in Drosophila are dependent on the RNAi machinery. Science 303:669-672. (Pubitemid 38141632)
22. Williams RW, Rubin GM (2002) ARGONAUTE1 is required for efficient RNA interference in Drosophila embryos. Proc Natl Acad Sci USA 99:6889-6894. (Pubitemid 34526228)
23. Cox DN, et al. (1998) A novel class of evolutionarily conserved genes defined by piwi are essential for stem cell self-renewal. Genes Dev 12:3715-3727. (Pubitemid 29019652)
24. Lin H, Spradling AC (1997) A novel group of pumilio mutations affects the asymmetric division of germline stem cells in the Drosophila ovary. Development 124:2463-2476. (Pubitemid 27309745)
25. Chambeyron S, et al. (2008) piRNA-mediated nuclear accumulation of retrotransposon transcripts in the Drosophila female germline. Proc Natl Acad Sci USA 105:14964-14969.
26. Verdel A, et al. (2004) RNAi-mediated targeting of heterochromatin by the RITS complex. Science 303:672-676. (Pubitemid 38141633)
27. Mendez DL, et al. (2011) The HP1a disordered C terminus and chromo shadow domain cooperate to select target peptide partners. ChemBioChem 12:1084-1096.
28. Tracey WD, Jr., Ning X, Klingler M, Kramer SG, Gergen JP (2000) Quantitative analysis of gene function in the Drosophila embryo. Genetics 154:273-284. (Pubitemid 30045919)
29. Dietzl G, et al. (2007) A genome-wide transgenic RNAi library for conditional gene inactivation in Drosophila. Nature 448:151-156. (Pubitemid 47067374)
30. Klattenhoff C, et al. (2007) Drosophila rasiRNA pathway mutations disrupt embryonic axis specification through activation of an ATR/Chk2 DNA damage response. Dev Cell 12:45-55. (Pubitemid 46002601)
31. Ghildiyal M, Zamore PD (2009) Small silencing RNAs: An expanding universe. Nat Rev Genet 10:94-108.
32. Kalmykova AI, Klenov MS, Gvozdev VA (2005) Argonaute protein PIWI controls mobilization of retrotransposons in the Drosophila male germline. Nucleic Acids Res 33:2052-2059. (Pubitemid 41748348)
33. Chou TB, Perrimon N (1996) The autosomal FLP-DFS technique for generating germline mosaics in Drosophila melanogaster. Genetics 144:1673-1679.
34. Lim AK, Kai T (2007) Unique germ-line organelle, nuage, functions to repress selfish genetic elements in Drosophila melanogaster. Proc Natl Acad Sci USA 104:6714-6719.
35. Nishida KM, et al. (2007) Gene silencing mechanisms mediated by Aubergine piRNA complexes in Drosophila male gonad. RNA 13:1911-1922. (Pubitemid 350005217)
36. Olivieri D, Sykora MM, Sachidanandam R, Mechtler K, Brennecke J (2010) An in vivo RNAi assay identifies major genetic and cellular requirements for primary piRNA biogenesis in Drosophila. EMBO J 29:3301-3317.
37. Eissenberg JC, Elgin SC (2000) The HP1 protein family: Getting a grip on chromatin. Curr Opin Genet Dev 10:204-210. (Pubitemid 30182255)
38. Lachner M, O'Carroll D, Rea S, Mechtler K, Jenuwein T (2001) Methylation of histone H3 lysine 9 creates a binding site for HP1 proteins. Nature 410:116-120. (Pubitemid 32225847)
39. Eskeland R, Eberharter A, Imhof A (2007) HP1 binding to chromatin methylated at H3K9 is enhanced by auxiliary factors. Mol Cell Biol 27:453-465. (Pubitemid 46080116)
40. Schotta G, et al. (2002) Central role of Drosophila SU(VAR)3-9 in histone H3-K9 methylation and heterochromatic gene silencing. EMBO J 21:1121-1131. (Pubitemid 34206185)
41. Volpe TA, et al. (2002) Regulation of heterochromatic silencing and histone H3 lysine-9 methylation by RNAi. Science 297:1833-1837. (Pubitemid 35024336)
42. Brower-Toland B, Riddle NC, Jiang H, Huisinga KL, Elgin SC (2009) Multiple SET methyltransferases are required to maintain normal heterochromatin domains in the genome of Drosophila melanogaster. Genetics 181:1303-1319.
43. Rubin GM, et al. (2000) A Drosophila complementary DNA resource. Science 287:2222-2224. (Pubitemid 30177019)
44. Cooley L, Verheyen E, Ayers K (1992) chickadee encodes a profilin required for intercellular cytoplasm transport during Drosophila oogenesis. Cell 69:173-184.
45. James TC, et al. (1989) Distribution patterns of HP1, a heterochromatin-associated nonhistone chromosomal protein of Drosophila. Eur J Cell Biol 50:170-180. (Pubitemid 19261747)
46. Tomari Y, et al. (2004) RISC assembly defects in the Drosophila RNAi mutant armitage. Cell 116:831-841. (Pubitemid 38410728)
47. Miller KG, Field CM, Alberts BM (1989) Actin-binding proteins from Drosophila embryos: A complex network of interacting proteins detected by F-actin affinity chromatography. J Cell Biol 109:2963-2975. (Pubitemid 20011922)
48. Livak KJ, Schmittgen TD (2001) Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods 25:402-408. (Pubitemid 34164012)
49. Blevins T (2010) Northern blotting techniques for small RNAs. Methods Mol Biol 631:87-107.
50. Stephens GE, Slawson EE, Craig CA, Elgin SC (2005) Interaction of heterochromatin protein 2 with HP1 defines a novel HP1-binding domain. Biochemistry 44:13394-13403. (Pubitemid 41429462)