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Volumn 31, Issue 6, 2015, Pages 344-351

Repairing organs: Lessons from intestine and liver

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 22; NOTCH RECEPTOR; PROTEIN; R SPONDIN PROTEIN; UNCLASSIFIED DRUG; WNT PROTEIN;

EID: 84930474168     PISSN: 01689525     EISSN: 13624555     Source Type: Journal    
DOI: 10.1016/j.tig.2015.04.005     Document Type: Review
Times cited : (25)

References (97)
  • 1
    • 84880548336 scopus 로고    scopus 로고
    • The intestinal crypt, a prototype stem cell compartment
    • Clevers H. The intestinal crypt, a prototype stem cell compartment. Cell 2013, 154:274-284.
    • (2013) Cell , vol.154 , pp. 274-284
    • Clevers, H.1
  • 2
    • 67650957717 scopus 로고    scopus 로고
    • Stem cells and liver regeneration
    • Duncan A.W., et al. Stem cells and liver regeneration. Gastroenterology 2009, 137:466-481.
    • (2009) Gastroenterology , vol.137 , pp. 466-481
    • Duncan, A.W.1
  • 3
    • 0016325705 scopus 로고
    • Origin, differentiation and renewal of the four main epithelial cell types in the mouse small intestine. V. Unitarian theory of the origin of the four epithelial cell types
    • Cheng H., Leblond C.P. Origin, differentiation and renewal of the four main epithelial cell types in the mouse small intestine. V. Unitarian theory of the origin of the four epithelial cell types. Am. J. Anat. 1974, 141:537-561.
    • (1974) Am. J. Anat. , vol.141 , pp. 537-561
    • Cheng, H.1    Leblond, C.P.2
  • 4
    • 35548974423 scopus 로고    scopus 로고
    • Identification of stem cells in small intestine and colon by marker gene Lgr5
    • Barker N., et al. Identification of stem cells in small intestine and colon by marker gene Lgr5. Nature 2007, 449:1003-1007.
    • (2007) Nature , vol.449 , pp. 1003-1007
    • Barker, N.1
  • 5
    • 77957223906 scopus 로고    scopus 로고
    • Intestinal crypt homeostasis results from neutral competition between symmetrically dividing Lgr5 stem cells
    • Snippert H.J., et al. Intestinal crypt homeostasis results from neutral competition between symmetrically dividing Lgr5 stem cells. Cell 2010, 143:134-144.
    • (2010) Cell , vol.143 , pp. 134-144
    • Snippert, H.J.1
  • 6
    • 77958485383 scopus 로고    scopus 로고
    • Intestinal stem cell replacement follows a pattern of neutral drift
    • Lopez-Garcia C., et al. Intestinal stem cell replacement follows a pattern of neutral drift. Science 2010, 330:822-825.
    • (2010) Science , vol.330 , pp. 822-825
    • Lopez-Garcia, C.1
  • 7
    • 84859196824 scopus 로고    scopus 로고
    • The pan-ErbB negative regulator Lrig1 is an intestinal stem cell marker that functions as a tumor suppressor
    • Powell A.E., et al. The pan-ErbB negative regulator Lrig1 is an intestinal stem cell marker that functions as a tumor suppressor. Cell 2012, 149:146-158.
    • (2012) Cell , vol.149 , pp. 146-158
    • Powell, A.E.1
  • 8
    • 83255193921 scopus 로고    scopus 로고
    • Interconversion between intestinal stem cell populations in distinct niches
    • Takeda N., et al. Interconversion between intestinal stem cell populations in distinct niches. Science 2011, 334:1420-1424.
    • (2011) Science , vol.334 , pp. 1420-1424
    • Takeda, N.1
  • 9
    • 46249128798 scopus 로고    scopus 로고
    • Bmi1 is expressed in vivo in intestinal stem cells
    • Sangiorgi E., Capecchi M.R. Bmi1 is expressed in vivo in intestinal stem cells. Nat. Genet. 2008, 40:915-920.
    • (2008) Nat. Genet. , vol.40 , pp. 915-920
    • Sangiorgi, E.1    Capecchi, M.R.2
  • 10
    • 78651067425 scopus 로고    scopus 로고
    • Mouse telomerase reverse transcriptase (mTert) expression marks slowly cycling intestinal stem cells
    • Montgomery R.K., et al. Mouse telomerase reverse transcriptase (mTert) expression marks slowly cycling intestinal stem cells. Proc. Natl. Acad. Sci. U.S.A. 2011, 108:179-184.
    • (2011) Proc. Natl. Acad. Sci. U.S.A. , vol.108 , pp. 179-184
    • Montgomery, R.K.1
  • 11
    • 48749086322 scopus 로고    scopus 로고
    • Generation of mTert-GFP mice as a model to identify and study tissue progenitor cells
    • Breault D.T., et al. Generation of mTert-GFP mice as a model to identify and study tissue progenitor cells. Proc. Natl. Acad. Sci. U.S.A. 2008, 105:10420-10425.
    • (2008) Proc. Natl. Acad. Sci. U.S.A. , vol.105 , pp. 10420-10425
    • Breault, D.T.1
  • 12
    • 84922542256 scopus 로고    scopus 로고
    • Single-cell analysis of proxy reporter allele-marked epithelial cells establishes intestinal stem cell hierarchy
    • Li N., et al. Single-cell analysis of proxy reporter allele-marked epithelial cells establishes intestinal stem cell hierarchy. Stem Cell Rep. 2014, 3:876-891.
    • (2014) Stem Cell Rep. , vol.3 , pp. 876-891
    • Li, N.1
  • 13
    • 84864131103 scopus 로고    scopus 로고
    • The Lgr5 intestinal stem cell signature: robust expression of proposed quiescent '+4' cell markers
    • Munoz J., et al. The Lgr5 intestinal stem cell signature: robust expression of proposed quiescent '+4' cell markers. EMBO J. 2012, 31:3079-3091.
    • (2012) EMBO J. , vol.31 , pp. 3079-3091
    • Munoz, J.1
  • 14
    • 84859430024 scopus 로고    scopus 로고
    • Lrig1 controls intestinal stem-cell homeostasis by negative regulation of ErbB signalling
    • Wong V.W., et al. Lrig1 controls intestinal stem-cell homeostasis by negative regulation of ErbB signalling. Nat. Cell Biol. 2012, 14:401-408.
    • (2012) Nat. Cell Biol. , vol.14 , pp. 401-408
    • Wong, V.W.1
  • 15
    • 69749121859 scopus 로고    scopus 로고
    • Regeneration of intestinal stem/progenitor cells following doxorubicin treatment of mice
    • Dekaney C.M., et al. Regeneration of intestinal stem/progenitor cells following doxorubicin treatment of mice. Am. J. Physiol. Gastrointest. Liver Physiol. 2009, 297:G461-G470.
    • (2009) Am. J. Physiol. Gastrointest. Liver Physiol. , vol.297 , pp. G461-G470
    • Dekaney, C.M.1
  • 16
    • 84867097416 scopus 로고    scopus 로고
    • + secretory progenitor cells revert to stem cells upon crypt damage
    • + secretory progenitor cells revert to stem cells upon crypt damage. Nat. Cell Biol. 2012, 14:1099-1104.
    • (2012) Nat. Cell Biol. , vol.14 , pp. 1099-1104
    • van Es, J.H.1
  • 17
    • 80054041585 scopus 로고    scopus 로고
    • A reserve stem cell population in small intestine renders Lgr5-positive cells dispensable
    • Tian H., et al. A reserve stem cell population in small intestine renders Lgr5-positive cells dispensable. Nature 2011, 478:255-259.
    • (2011) Nature , vol.478 , pp. 255-259
    • Tian, H.1
  • 18
    • 84893768750 scopus 로고    scopus 로고
    • + stem cells are indispensable for radiation-induced intestinal regeneration
    • + stem cells are indispensable for radiation-induced intestinal regeneration. Cell Stem Cell 2014, 14:149-159.
    • (2014) Cell Stem Cell , vol.14 , pp. 149-159
    • Metcalfe, C.1
  • 19
    • 84862946094 scopus 로고    scopus 로고
    • The intestinal stem cell markers Bmi1 and Lgr5 identify two functionally distinct populations
    • Yan K.S., et al. The intestinal stem cell markers Bmi1 and Lgr5 identify two functionally distinct populations. Proc. Natl. Acad. Sci. U.S.A. 2012, 109:466-471.
    • (2012) Proc. Natl. Acad. Sci. U.S.A. , vol.109 , pp. 466-471
    • Yan, K.S.1
  • 20
    • 84874730918 scopus 로고    scopus 로고
    • Intestinal label-retaining cells are secretory precursors expressing Lgr5
    • Buczacki S.J., et al. Intestinal label-retaining cells are secretory precursors expressing Lgr5. Nature 2013, 495:65-69.
    • (2013) Nature , vol.495 , pp. 65-69
    • Buczacki, S.J.1
  • 21
    • 84896691636 scopus 로고    scopus 로고
    • Broadly permissive intestinal chromatin underlies lateral inhibition and cell plasticity
    • Kim T.H., et al. Broadly permissive intestinal chromatin underlies lateral inhibition and cell plasticity. Nature 2014, 506:511-515.
    • (2014) Nature , vol.506 , pp. 511-515
    • Kim, T.H.1
  • 22
    • 84885001955 scopus 로고    scopus 로고
    • DNA methylation and differentiation: silencing, upregulation and modulation of gene expression
    • Ehrlich M., Lacey M. DNA methylation and differentiation: silencing, upregulation and modulation of gene expression. Epigenomics 2013, 5:553-568.
    • (2013) Epigenomics , vol.5 , pp. 553-568
    • Ehrlich, M.1    Lacey, M.2
  • 23
    • 0022318864 scopus 로고
    • The streaming liver
    • Zajicek G., et al. The streaming liver. Liver 1985, 5:293-300.
    • (1985) Liver , vol.5 , pp. 293-300
    • Zajicek, G.1
  • 24
    • 66149112853 scopus 로고    scopus 로고
    • Locating the stem cell niche and tracing hepatocyte lineages in human liver
    • Fellous T.G., et al. Locating the stem cell niche and tracing hepatocyte lineages in human liver. Hepatology 2009, 49:1655-1663.
    • (2009) Hepatology , vol.49 , pp. 1655-1663
    • Fellous, T.G.1
  • 25
    • 78651228289 scopus 로고    scopus 로고
    • Continuous cell supply from a Sox9-expressing progenitor zone in adult liver, exocrine pancreas and intestine
    • Furuyama K., et al. Continuous cell supply from a Sox9-expressing progenitor zone in adult liver, exocrine pancreas and intestine. Nat. Genet. 2011, 43:34-41.
    • (2011) Nat. Genet. , vol.43 , pp. 34-41
    • Furuyama, K.1
  • 26
    • 80053610191 scopus 로고    scopus 로고
    • Embryonic ductal plate cells give rise to cholangiocytes, periportal hepatocytes, and adult liver progenitor cells
    • Carpentier R., et al. Embryonic ductal plate cells give rise to cholangiocytes, periportal hepatocytes, and adult liver progenitor cells. Gastroenterology 2011, 141:1432-1438.
    • (2011) Gastroenterology , vol.141 , pp. 1432-1438
    • Carpentier, R.1
  • 27
    • 84869751765 scopus 로고    scopus 로고
    • Liver progenitor cells yield functional hepatocytes in response to chronic liver injury in mice
    • Espanol-Suner R., et al. Liver progenitor cells yield functional hepatocytes in response to chronic liver injury in mice. Gastroenterology 2012, 143:1564-1575.
    • (2012) Gastroenterology , vol.143 , pp. 1564-1575
    • Espanol-Suner, R.1
  • 28
    • 84925092021 scopus 로고    scopus 로고
    • Adult hepatocytes are generated by self-duplication rather than stem cell differentiation
    • Yanger K., et al. Adult hepatocytes are generated by self-duplication rather than stem cell differentiation. Cell Stem Cell 2014, 15:340-349.
    • (2014) Cell Stem Cell , vol.15 , pp. 340-349
    • Yanger, K.1
  • 29
    • 0001276586 scopus 로고
    • Experimental pathology of the liver: I. Restoration of the liver of the white rat following surgical removal
    • Higgins G. Experimental pathology of the liver: I. Restoration of the liver of the white rat following surgical removal. Arch. Pathol. 1931, 12:186-202.
    • (1931) Arch. Pathol. , vol.12 , pp. 186-202
    • Higgins, G.1
  • 30
    • 84961012817 scopus 로고
    • Similarities in the sequence of early histological changes induced in the liver of the rat by ethionine, 2-acetylamino-fluorene, and 3'-methyl-4-dimethylaminoazobenzene
    • Farber E. Similarities in the sequence of early histological changes induced in the liver of the rat by ethionine, 2-acetylamino-fluorene, and 3'-methyl-4-dimethylaminoazobenzene. Cancer Res. 1956, 16:142-148.
    • (1956) Cancer Res. , vol.16 , pp. 142-148
    • Farber, E.1
  • 31
    • 0028122926 scopus 로고
    • Origin and fate of oval cells in dipin-induced hepatocarcinogenesis in the mouse
    • Factor V.M., et al. Origin and fate of oval cells in dipin-induced hepatocarcinogenesis in the mouse. Am. J. Pathol. 1994, 145:409-422.
    • (1994) Am. J. Pathol. , vol.145 , pp. 409-422
    • Factor, V.M.1
  • 32
    • 84908355955 scopus 로고    scopus 로고
    • Evidence against a stem cell origin of new hepatocytes in a common mouse model of chronic liver injury
    • Schaub J.R., et al. Evidence against a stem cell origin of new hepatocytes in a common mouse model of chronic liver injury. Cell Rep. 2014, 8:933-939.
    • (2014) Cell Rep. , vol.8 , pp. 933-939
    • Schaub, J.R.1
  • 33
    • 84927782108 scopus 로고    scopus 로고
    • The biliary epithelium gives rise to liver progenitor cells
    • Rodrigo-Torres D., et al. The biliary epithelium gives rise to liver progenitor cells. Hepatology 2014, 60:1367-1377.
    • (2014) Hepatology , vol.60 , pp. 1367-1377
    • Rodrigo-Torres, D.1
  • 34
    • 84894330173 scopus 로고    scopus 로고
    • Extensive conversion of hepatic biliary epithelial cells to hepatocytes after near total loss of hepatocytes in zebrafish
    • Choi T.Y., et al. Extensive conversion of hepatic biliary epithelial cells to hepatocytes after near total loss of hepatocytes in zebrafish. Gastroenterology 2014, 146:776-788.
    • (2014) Gastroenterology , vol.146 , pp. 776-788
    • Choi, T.Y.1
  • 35
    • 84894291020 scopus 로고    scopus 로고
    • Regeneration of liver after extreme hepatocyte loss occurs mainly via biliary transdifferentiation in zebrafish
    • He J., et al. Regeneration of liver after extreme hepatocyte loss occurs mainly via biliary transdifferentiation in zebrafish. Gastroenterology 2014, 146:789-800.
    • (2014) Gastroenterology , vol.146 , pp. 789-800
    • He, J.1
  • 36
    • 80055051680 scopus 로고    scopus 로고
    • Ductular reactions in human liver: diversity at the interface
    • Gouw A.S., et al. Ductular reactions in human liver: diversity at the interface. Hepatology 2011, 54:1853-1863.
    • (2011) Hepatology , vol.54 , pp. 1853-1863
    • Gouw, A.S.1
  • 37
    • 0037853158 scopus 로고    scopus 로고
    • Regeneration of hepatocyte 'buds' in cirrhosis from intrabiliary stem cells
    • Falkowski O., et al. Regeneration of hepatocyte 'buds' in cirrhosis from intrabiliary stem cells. J. Hepatol. 2003, 39:357-364.
    • (2003) J. Hepatol. , vol.39 , pp. 357-364
    • Falkowski, O.1
  • 38
    • 79952230767 scopus 로고    scopus 로고
    • Epithelial cell adhesion molecule (EpCAM) marks hepatocytes newly derived from stem/progenitor cells in humans
    • Yoon S.M., et al. Epithelial cell adhesion molecule (EpCAM) marks hepatocytes newly derived from stem/progenitor cells in humans. Hepatology 2011, 53:964-973.
    • (2011) Hepatology , vol.53 , pp. 964-973
    • Yoon, S.M.1
  • 39
    • 84876278823 scopus 로고    scopus 로고
    • Robust cellular reprogramming occurs spontaneously during liver regeneration
    • Yanger K., et al. Robust cellular reprogramming occurs spontaneously during liver regeneration. Genes Dev. 2013, 27:719-724.
    • (2013) Genes Dev. , vol.27 , pp. 719-724
    • Yanger, K.1
  • 40
    • 84922750939 scopus 로고    scopus 로고
    • Bipotential adult liver progenitors are derived from chronically injured mature hepatocytes
    • Tarlow B.D., et al. Bipotential adult liver progenitors are derived from chronically injured mature hepatocytes. Cell Stem Cell 2014, 15:605-618.
    • (2014) Cell Stem Cell , vol.15 , pp. 605-618
    • Tarlow, B.D.1
  • 41
    • 84887619426 scopus 로고    scopus 로고
    • Dedifferentiation of committed epithelial cells into stem cells in vivo
    • Tata P.R., et al. Dedifferentiation of committed epithelial cells into stem cells in vivo. Nature 2013, 503:218-223.
    • (2013) Nature , vol.503 , pp. 218-223
    • Tata, P.R.1
  • 42
    • 84885672388 scopus 로고    scopus 로고
    • + chief cells act as reserve stem cells to generate all lineages of the stomach epithelium
    • + chief cells act as reserve stem cells to generate all lineages of the stomach epithelium. Cell 2013, 155:357-368.
    • (2013) Cell , vol.155 , pp. 357-368
    • Stange, D.E.1
  • 43
    • 84873111871 scopus 로고    scopus 로고
    • Spatiotemporal patterns of multipotentiality in Ptf1a-expressing cells during pancreas organogenesis and injury-induced facultative restoration
    • Pan F.C., et al. Spatiotemporal patterns of multipotentiality in Ptf1a-expressing cells during pancreas organogenesis and injury-induced facultative restoration. Development 2013, 140:751-764.
    • (2013) Development , vol.140 , pp. 751-764
    • Pan, F.C.1
  • 44
    • 84884722129 scopus 로고    scopus 로고
    • Adrenocortical zonation results from lineage conversion of differentiated zona glomerulosa cells
    • Freedman B.D., et al. Adrenocortical zonation results from lineage conversion of differentiated zona glomerulosa cells. Dev. Cell 2013, 26:666-673.
    • (2013) Dev. Cell , vol.26 , pp. 666-673
    • Freedman, B.D.1
  • 45
    • 84921629064 scopus 로고    scopus 로고
    • Plasticity within stem cell hierarchies in mammalian epithelia
    • Tetteh P.W., et al. Plasticity within stem cell hierarchies in mammalian epithelia. Trends Cell Biol. 2015, 25:100-108.
    • (2015) Trends Cell Biol. , vol.25 , pp. 100-108
    • Tetteh, P.W.1
  • 46
    • 0031848068 scopus 로고    scopus 로고
    • Depletion of epithelial stem-cell compartments in the small intestine of mice lacking Tcf-4
    • Korinek V., et al. Depletion of epithelial stem-cell compartments in the small intestine of mice lacking Tcf-4. Nat. Genet. 1998, 19:379-383.
    • (1998) Nat. Genet. , vol.19 , pp. 379-383
    • Korinek, V.1
  • 47
    • 80051926611 scopus 로고    scopus 로고
    • Lgr5 homologues associate with Wnt receptors and mediate R-spondin signalling
    • de Lau W., et al. Lgr5 homologues associate with Wnt receptors and mediate R-spondin signalling. Nature 2011, 476:293-297.
    • (2011) Nature , vol.476 , pp. 293-297
    • de Lau, W.1
  • 48
    • 79953204955 scopus 로고    scopus 로고
    • Dll1- and dll4-mediated notch signaling are required for homeostasis of intestinal stem cells
    • Pellegrinet L., et al. dll1- and dll4-mediated notch signaling are required for homeostasis of intestinal stem cells. Gastroenterology 2011, 140:1230-1240.
    • (2011) Gastroenterology , vol.140 , pp. 1230-1240
    • Pellegrinet, L.1
  • 49
    • 1542618115 scopus 로고    scopus 로고
    • De novo crypt formation and juvenile polyposis on BMP inhibition in mouse intestine
    • Haramis A.P., et al. De novo crypt formation and juvenile polyposis on BMP inhibition in mouse intestine. Science 2004, 303:1684-1686.
    • (2004) Science , vol.303 , pp. 1684-1686
    • Haramis, A.P.1
  • 50
    • 84869864069 scopus 로고    scopus 로고
    • Redundant sources of Wnt regulate intestinal stem cells and promote formation of Paneth cells
    • Farin H.F., et al. Redundant sources of Wnt regulate intestinal stem cells and promote formation of Paneth cells. Gastroenterology 2012, 143:1518-1529.
    • (2012) Gastroenterology , vol.143 , pp. 1518-1529
    • Farin, H.F.1
  • 51
    • 84861372662 scopus 로고    scopus 로고
    • A critical role for the Wnt effector Tcf4 in adult intestinal homeostatic self-renewal
    • van Es J.H., et al. A critical role for the Wnt effector Tcf4 in adult intestinal homeostatic self-renewal. Mol. Cell. Biol. 2012, 32:1918-1927.
    • (2012) Mol. Cell. Biol. , vol.32 , pp. 1918-1927
    • van Es, J.H.1
  • 52
    • 77951728697 scopus 로고    scopus 로고
    • Characterisation of a stereotypical cellular and extracellular adult liver progenitor cell niche in rodents and diseased human liver
    • Lorenzini S., et al. Characterisation of a stereotypical cellular and extracellular adult liver progenitor cell niche in rodents and diseased human liver. Gut 2010, 59:645-654.
    • (2010) Gut , vol.59 , pp. 645-654
    • Lorenzini, S.1
  • 53
    • 84859614232 scopus 로고    scopus 로고
    • Macrophage-derived Wnt opposes Notch signaling to specify hepatic progenitor cell fate in chronic liver disease
    • Boulter L., et al. Macrophage-derived Wnt opposes Notch signaling to specify hepatic progenitor cell fate in chronic liver disease. Nat. Med. 2012, 18:572-579.
    • (2012) Nat. Med. , vol.18 , pp. 572-579
    • Boulter, L.1
  • 54
    • 38649103789 scopus 로고    scopus 로고
    • Wnt/beta-catenin signaling mediates oval cell response in rodents
    • Apte U., et al. Wnt/beta-catenin signaling mediates oval cell response in rodents. Hepatology 2008, 47:288-295.
    • (2008) Hepatology , vol.47 , pp. 288-295
    • Apte, U.1
  • 55
    • 49249122615 scopus 로고    scopus 로고
    • Wnt/beta-catenin signaling contributes to activation of normal and tumorigenic liver progenitor cells
    • Yang W., et al. Wnt/beta-catenin signaling contributes to activation of normal and tumorigenic liver progenitor cells. Cancer Res. 2008, 68:4287-4295.
    • (2008) Cancer Res. , vol.68 , pp. 4287-4295
    • Yang, W.1
  • 56
    • 79960990066 scopus 로고    scopus 로고
    • R-spondins function as ligands of the orphan receptors LGR4 and LGR5 to regulate Wnt/beta-catenin signaling
    • Carmon K.S., et al. R-spondins function as ligands of the orphan receptors LGR4 and LGR5 to regulate Wnt/beta-catenin signaling. Proc. Natl. Acad. Sci. U.S.A. 2011, 108:11452-11457.
    • (2011) Proc. Natl. Acad. Sci. U.S.A. , vol.108 , pp. 11452-11457
    • Carmon, K.S.1
  • 57
    • 80053560465 scopus 로고    scopus 로고
    • LGR4 and LGR5 are R-spondin receptors mediating Wnt/beta-catenin and Wnt/PCP signalling
    • Glinka A., et al. LGR4 and LGR5 are R-spondin receptors mediating Wnt/beta-catenin and Wnt/PCP signalling. EMBO Rep. 2011, 12:1055-1061.
    • (2011) EMBO Rep. , vol.12 , pp. 1055-1061
    • Glinka, A.1
  • 58
    • 84873712443 scopus 로고    scopus 로고
    • + liver stem cells induced by Wnt-driven regeneration
    • + liver stem cells induced by Wnt-driven regeneration. Nature 2013, 494:247-250.
    • (2013) Nature , vol.494 , pp. 247-250
    • Huch, M.1
  • 59
    • 84916886178 scopus 로고    scopus 로고
    • R-spondin1 arguments hepatic fibrogenesis in vivo and in vitro
    • Xinguang Y., et al. R-spondin1 arguments hepatic fibrogenesis in vivo and in vitro. J. Surg. Res. 2015, 193:598-605.
    • (2015) J. Surg. Res. , vol.193 , pp. 598-605
    • Xinguang, Y.1
  • 60
    • 20544460148 scopus 로고    scopus 로고
    • Notch/γ-secretase inhibition turns proliferative cells in intestinal crypts and adenomas into goblet cells
    • van Es J.H., et al. Notch/γ-secretase inhibition turns proliferative cells in intestinal crypts and adenomas into goblet cells. Nature 2005, 435:959-963.
    • (2005) Nature , vol.435 , pp. 959-963
    • van Es, J.H.1
  • 61
    • 34548324268 scopus 로고    scopus 로고
    • Analysis of liver repair mechanisms in Alagille syndrome and biliary atresia reveals a role for Notch signaling
    • Fabris L., et al. Analysis of liver repair mechanisms in Alagille syndrome and biliary atresia reveals a role for Notch signaling. Am. J. Pathol. 2007, 171:641-653.
    • (2007) Am. J. Pathol. , vol.171 , pp. 641-653
    • Fabris, L.1
  • 62
    • 84865401664 scopus 로고    scopus 로고
    • Interleukin-22 protects intestinal stem cells from immune-mediated tissue damage and regulates sensitivity to graft versus host disease
    • Hanash A.M., et al. Interleukin-22 protects intestinal stem cells from immune-mediated tissue damage and regulates sensitivity to graft versus host disease. Immunity 2012, 37:339-350.
    • (2012) Immunity , vol.37 , pp. 339-350
    • Hanash, A.M.1
  • 63
    • 79952986650 scopus 로고    scopus 로고
    • + innate lymphoid cells regulate intestinal homeostasis by integrating negative signals from the symbiotic microbiota
    • + innate lymphoid cells regulate intestinal homeostasis by integrating negative signals from the symbiotic microbiota. Nat. Immunol. 2011, 12:320-326.
    • (2011) Nat. Immunol. , vol.12 , pp. 320-326
    • Sawa, S.1
  • 64
    • 84862769727 scopus 로고    scopus 로고
    • Interleukin-22 promotes proliferation of liver stem/progenitor cells in mice and patients with chronic hepatitis B virus infection
    • Feng D., et al. Interleukin-22 promotes proliferation of liver stem/progenitor cells in mice and patients with chronic hepatitis B virus infection. Gastroenterology 2012, 143:188-198.
    • (2012) Gastroenterology , vol.143 , pp. 188-198
    • Feng, D.1
  • 65
    • 84871789026 scopus 로고    scopus 로고
    • Restriction of intestinal stem cell expansion and the regenerative response by YAP
    • Barry E.R., et al. Restriction of intestinal stem cell expansion and the regenerative response by YAP. Nature 2013, 493:106-110.
    • (2013) Nature , vol.493 , pp. 106-110
    • Barry, E.R.1
  • 66
    • 84902081616 scopus 로고    scopus 로고
    • Hippo pathway activity influences liver cell fate
    • Yimlamai D., et al. Hippo pathway activity influences liver cell fate. Cell 2014, 157:1324-1338.
    • (2014) Cell , vol.157 , pp. 1324-1338
    • Yimlamai, D.1
  • 67
    • 84857059414 scopus 로고    scopus 로고
    • Current status of hepatocyte transplantation
    • Hughes R.D., et al. Current status of hepatocyte transplantation. Transplantation 2012, 93:342-347.
    • (2012) Transplantation , vol.93 , pp. 342-347
    • Hughes, R.D.1
  • 68
    • 79551686425 scopus 로고    scopus 로고
    • Directed differentiation of human pluripotent stem cells into intestinal tissue in vitro
    • Spence J.R., et al. Directed differentiation of human pluripotent stem cells into intestinal tissue in vitro. Nature 2011, 470:105-109.
    • (2011) Nature , vol.470 , pp. 105-109
    • Spence, J.R.1
  • 69
    • 84964313624 scopus 로고    scopus 로고
    • An in vivo model of human small intestine using pluripotent stem cells
    • Watson C.L., et al. An in vivo model of human small intestine using pluripotent stem cells. Nat. Med. 2014, 20:1310-1314.
    • (2014) Nat. Med. , vol.20 , pp. 1310-1314
    • Watson, C.L.1
  • 70
    • 34248634898 scopus 로고    scopus 로고
    • Directed differentiation of human embryonic stem cells into functional hepatic cells
    • Cai J., et al. Directed differentiation of human embryonic stem cells into functional hepatic cells. Hepatology 2007, 45:1229-1239.
    • (2007) Hepatology , vol.45 , pp. 1229-1239
    • Cai, J.1
  • 71
    • 77951480489 scopus 로고    scopus 로고
    • Generation of functional hepatocytes from human embryonic stem cells under chemically defined conditions that recapitulate liver development
    • Touboul T., et al. Generation of functional hepatocytes from human embryonic stem cells under chemically defined conditions that recapitulate liver development. Hepatology 2010, 51:1754-1765.
    • (2010) Hepatology , vol.51 , pp. 1754-1765
    • Touboul, T.1
  • 72
    • 60449098836 scopus 로고    scopus 로고
    • Differentiation and transplantation of human embryonic stem cell-derived hepatocytes
    • Basma H., et al. Differentiation and transplantation of human embryonic stem cell-derived hepatocytes. Gastroenterology 2009, 136:990-999.
    • (2009) Gastroenterology , vol.136 , pp. 990-999
    • Basma, H.1
  • 73
    • 36248966518 scopus 로고    scopus 로고
    • Induction of pluripotent stem cells from adult human fibroblasts by defined factors
    • Takahashi K., et al. Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Cell 2007, 131:861-872.
    • (2007) Cell , vol.131 , pp. 861-872
    • Takahashi, K.1
  • 74
    • 70449534874 scopus 로고    scopus 로고
    • Efficient generation of hepatocyte-like cells from human induced pluripotent stem cells
    • Song Z., et al. Efficient generation of hepatocyte-like cells from human induced pluripotent stem cells. Cell Res. 2009, 19:1233-1242.
    • (2009) Cell Res. , vol.19 , pp. 1233-1242
    • Song, Z.1
  • 75
    • 84878756211 scopus 로고    scopus 로고
    • Highly efficient differentiation of functional hepatocytes from human induced pluripotent stem cells
    • Ma X., et al. Highly efficient differentiation of functional hepatocytes from human induced pluripotent stem cells. Stem Cells Transl. Med. 2013, 2:409-419.
    • (2013) Stem Cells Transl. Med. , vol.2 , pp. 409-419
    • Ma, X.1
  • 76
    • 84897570580 scopus 로고    scopus 로고
    • Mouse liver repopulation with hepatocytes generated from human fibroblasts
    • Zhu S., et al. Mouse liver repopulation with hepatocytes generated from human fibroblasts. Nature 2014, 508:93-97.
    • (2014) Nature , vol.508 , pp. 93-97
    • Zhu, S.1
  • 77
    • 84863116200 scopus 로고    scopus 로고
    • Direct and indirect contribution of human embryonic stem cell-derived hepatocyte-like cells to liver repair in mice
    • Woo D.H., et al. Direct and indirect contribution of human embryonic stem cell-derived hepatocyte-like cells to liver repair in mice. Gastroenterology 2012, 142:602-611.
    • (2012) Gastroenterology , vol.142 , pp. 602-611
    • Woo, D.H.1
  • 78
    • 79955904906 scopus 로고    scopus 로고
    • In vivo liver regeneration potential of human induced pluripotent stem cells from diverse origins
    • 82ra39
    • Liu H., et al. In vivo liver regeneration potential of human induced pluripotent stem cells from diverse origins. Sci. Transl. Med. 2011, 3:82ra39.
    • (2011) Sci. Transl. Med. , vol.3
    • Liu, H.1
  • 80
    • 84880165180 scopus 로고    scopus 로고
    • Nonviral methods for inducing pluripotency to cells
    • O'Doherty R., et al. Nonviral methods for inducing pluripotency to cells. Biomed Res. Int. 2013, 2013:705902.
    • (2013) Biomed Res. Int. , vol.2013 , pp. 705902
    • O'Doherty, R.1
  • 81
    • 84881186856 scopus 로고    scopus 로고
    • Genetic and epigenetic variations in iPSCs: potential causes and implications for application
    • Liang G., Zhang Y. Genetic and epigenetic variations in iPSCs: potential causes and implications for application. Cell Stem Cell 2013, 13:149-159.
    • (2013) Cell Stem Cell , vol.13 , pp. 149-159
    • Liang, G.1    Zhang, Y.2
  • 82
    • 78650971216 scopus 로고    scopus 로고
    • Dynamic changes in the copy number of pluripotency and cell proliferation genes in human ESCs and iPSCs during reprogramming and time in culture
    • Laurent L.C., et al. Dynamic changes in the copy number of pluripotency and cell proliferation genes in human ESCs and iPSCs during reprogramming and time in culture. Cell Stem Cell 2011, 8:106-118.
    • (2011) Cell Stem Cell , vol.8 , pp. 106-118
    • Laurent, L.C.1
  • 83
    • 79952126043 scopus 로고    scopus 로고
    • Copy number variation and selection during reprogramming to pluripotency
    • Hussein S.M., et al. Copy number variation and selection during reprogramming to pluripotency. Nature 2011, 471:58-62.
    • (2011) Nature , vol.471 , pp. 58-62
    • Hussein, S.M.1
  • 84
    • 79952258224 scopus 로고    scopus 로고
    • Somatic coding mutations in human induced pluripotent stem cells
    • Gore A., et al. Somatic coding mutations in human induced pluripotent stem cells. Nature 2011, 471:63-67.
    • (2011) Nature , vol.471 , pp. 63-67
    • Gore, A.1
  • 85
    • 0016729431 scopus 로고
    • Serial cultivation of strains of human epidermal keratinocytes: the formation of keratinizing colonies from single cells
    • Rheinwald J.G., Green H. Serial cultivation of strains of human epidermal keratinocytes: the formation of keratinizing colonies from single cells. Cell 1975, 6:331-343.
    • (1975) Cell , vol.6 , pp. 331-343
    • Rheinwald, J.G.1    Green, H.2
  • 86
    • 0030896153 scopus 로고    scopus 로고
    • Long-term restoration of damaged corneal surfaces with autologous cultivated corneal epithelium
    • Pellegrini G., et al. Long-term restoration of damaged corneal surfaces with autologous cultivated corneal epithelium. Lancet 1997, 349:990-993.
    • (1997) Lancet , vol.349 , pp. 990-993
    • Pellegrini, G.1
  • 87
    • 67349123408 scopus 로고    scopus 로고
    • Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche
    • Sato T., et al. Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche. Nature 2009, 459:262-265.
    • (2009) Nature , vol.459 , pp. 262-265
    • Sato, T.1
  • 88
    • 84862777784 scopus 로고    scopus 로고
    • + stem cell
    • + stem cell. Nat. Med. 2012, 18:618-623.
    • (2012) Nat. Med. , vol.18 , pp. 618-623
    • Yui, S.1
  • 89
    • 80054857419 scopus 로고    scopus 로고
    • Long-term expansion of epithelial organoids from human colon, adenoma, adenocarcinoma, and Barrett's epithelium
    • Sato T., et al. Long-term expansion of epithelial organoids from human colon, adenoma, adenocarcinoma, and Barrett's epithelium. Gastroenterology 2011, 141:1762-1772.
    • (2011) Gastroenterology , vol.141 , pp. 1762-1772
    • Sato, T.1
  • 90
    • 84906093308 scopus 로고    scopus 로고
    • Small intestinal stem cell identity is maintained with functional Paneth cells in heterotopically grafted epithelium onto the colon
    • Fukuda M., et al. Small intestinal stem cell identity is maintained with functional Paneth cells in heterotopically grafted epithelium onto the colon. Genes Dev. 2014, 28:1752-1757.
    • (2014) Genes Dev. , vol.28 , pp. 1752-1757
    • Fukuda, M.1
  • 91
    • 84890051386 scopus 로고    scopus 로고
    • Transplantation of expanded fetal intestinal progenitors contributes to colon regeneration after injury
    • Fordham R.P., et al. Transplantation of expanded fetal intestinal progenitors contributes to colon regeneration after injury. Cell Stem Cell 2013, 13:734-744.
    • (2013) Cell Stem Cell , vol.13 , pp. 734-744
    • Fordham, R.P.1
  • 92
    • 84890033064 scopus 로고    scopus 로고
    • Functional repair of CFTR by CRISPR/Cas9 in intestinal stem cell organoids of cystic fibrosis patients
    • Schwank G., et al. Functional repair of CFTR by CRISPR/Cas9 in intestinal stem cell organoids of cystic fibrosis patients. Cell Stem Cell 2013, 13:653-658.
    • (2013) Cell Stem Cell , vol.13 , pp. 653-658
    • Schwank, G.1
  • 93
    • 84922875352 scopus 로고    scopus 로고
    • In vitro expansion of human gastric epithelial stem cells and their responses to bacterial infection
    • Bartfeld S., et al. In vitro expansion of human gastric epithelial stem cells and their responses to bacterial infection. Gastroenterology 2015, 148:126-136.
    • (2015) Gastroenterology , vol.148 , pp. 126-136
    • Bartfeld, S.1
  • 94
    • 84920983131 scopus 로고    scopus 로고
    • Organoid models of human and mouse ductal pancreatic cancer
    • Boj S.F., et al. Organoid models of human and mouse ductal pancreatic cancer. Cell 2015, 160:324-338.
    • (2015) Cell , vol.160 , pp. 324-338
    • Boj, S.F.1
  • 95
    • 84907552531 scopus 로고    scopus 로고
    • Identification of multipotent luminal progenitor cells in human prostate organoid cultures
    • Karthaus W.R., et al. Identification of multipotent luminal progenitor cells in human prostate organoid cultures. Cell 2014, 159:163-175.
    • (2014) Cell , vol.159 , pp. 163-175
    • Karthaus, W.R.1
  • 96
    • 84920989984 scopus 로고    scopus 로고
    • Long-term culture of genome-stable bipotent stem cells from adult human liver
    • Huch M., et al. Long-term culture of genome-stable bipotent stem cells from adult human liver. Cell 2015, 160:299-312.
    • (2015) Cell , vol.160 , pp. 299-312
    • Huch, M.1
  • 97
    • 84873729095 scopus 로고    scopus 로고
    • Multiplex genome engineering using CRISPR/Cas systems
    • Cong L., et al. Multiplex genome engineering using CRISPR/Cas systems. Science 2013, 339:819-823.
    • (2013) Science , vol.339 , pp. 819-823
    • Cong, L.1


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