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Volumn 25, Issue 2, 2015, Pages 161-176

Aberrant methylation patterns in cancer: A clinical view

Author keywords

Biomarkers; CpG islands; DNA methylation; Epigenetics; Molecular diagnostics

Indexed keywords

ADAMTS1 PROTEIN; BIOLOGICAL MARKER; BRCA1 PROTEIN; BRCA2 PROTEIN; DEATH ASSOCIATED PROTEIN KINASE; DNA METHYLTRANSFERASE; EPITHELIAL CELL ADHESION MOLECULE; GLUTATHIONE TRANSFERASE P1; METHYLATED DNA PROTEIN CYSTEINE METHYLTRANSFERASE; NEUROGENIN 1; OSTEOGENIN; PROTEIN; PROTEIN MLH1; PROTEIN MSH2; PROTEIN MSH6; PROTEIN P15; PROTEIN P16; RAS ASSOCIATION DOMAIN FAMILY PROTEIN 1A; SECRETED FRIZZLED RELATED PROTEIN 2; SEPTIN 9 PROTEIN; SHORT STATURE HOMEOBOX 2 PROTEIN; SOMATOMEDIN B RECEPTOR; SUPPRESSOR OF CYTOKINE SIGNALING 1; TRANSCRIPTION FACTOR RUNX3; UNCLASSIFIED DRUG; UVOMORULIN; VON HIPPEL LINDAU PROTEIN; DNA; LONG UNTRANSLATED RNA; RNA; TUMOR MARKER; TUMOR PROTEIN;

EID: 84930440762     PISSN: 13300962     EISSN: None     Source Type: Journal    
DOI: 10.11613/BM.2015.017     Document Type: Review
Times cited : (86)

References (101)
  • 3
    • 84857143959 scopus 로고    scopus 로고
    • Basic concepts of epigenetics: Impact of environmental signals on gene expression
    • Mazzio EA, Soliman KF. Basic concepts of epigenetics: impact of environmental signals on gene expression. Epigenetics 2012;7:119-30. http://dx.doi.org/10.4161/epi.7.2.18764.
    • (2012) Epigenetics , vol.7 , pp. 119-130
    • Mazzio, E.A.1    Soliman, K.F.2
  • 4
    • 67649305191 scopus 로고    scopus 로고
    • Epigenetics in cancer: Targeting chromatin modifications
    • Ellis L, Atadja PW, Johnstone RW. Epigenetics in cancer: targeting chromatin modifications. Mol Cancer Ther 2009; 8:1409-20. http://dx.doi.org/10.1158/1535-7163.MCT-08-0860.
    • (2009) Mol Cancer Ther , vol.8 , pp. 1409-1420
    • Ellis, L.1    Atadja, P.W.2    Johnstone, R.W.3
  • 5
    • 84858439628 scopus 로고    scopus 로고
    • Cancer epigenomics: Beyond genomics
    • Sandoval J, Esteller M. Cancer epigenomics: beyond genomics. Curr Opin Genet Dev 2012;22:50-5. http://dx.doi. org/10.1016/j.gde.2012.02.008.
    • (2012) Curr Opin Genet Dev , vol.22 , pp. 50-55
    • Sandoval, J.1    Esteller, M.2
  • 6
    • 84879374089 scopus 로고    scopus 로고
    • Epigenetic biomarkers in laboratory diagnostics: Emerging approaches and opportunities
    • Sandoval J, Peiro-Chova L, Pallardo FV, Garcia-Gimenez JL. Epigenetic biomarkers in laboratory diagnostics: emerging approaches and opportunities. Expert Rev Mol Diagn 2013;13:457-71. http://dx.doi.org/10.1586/erm.13.37.
    • (2013) Expert Rev Mol Diagn , vol.13 , pp. 457-471
    • Sandoval, J.1    Peiro-Chova, L.2    Pallardo, F.V.3    Garcia-Gimenez, J.L.4
  • 7
    • 73649107635 scopus 로고    scopus 로고
    • Epigenetics: Molecular mechanisms and implications for disease
    • Handel AE, Ebers GC, Ramagopalan SV. Epigenetics: molecular mechanisms and implications for disease. Trends Mol Med 2010;16:7-16. http://dx.doi.org/10.1016/j.molmed. 2009.11.003.
    • (2010) Trends Mol Med , vol.16 , pp. 7-16
    • Handel, A.E.1    Ebers, G.C.2    Ramagopalan, S.V.3
  • 8
    • 84867398818 scopus 로고    scopus 로고
    • The role of nutrition on epigenetic modifications and their implications on health
    • Jiménez-Chillarón JC, Díaz R, Martínez D, Pentinat T, Ramón-Krauel M, Ribó S, et al. The role of nutrition on epigenetic modifications and their implications on health. Biochimie 2012;94:2242-63. http://dx.doi.org/10.1016/j.biochi. 2012.06.012.
    • (2012) Biochimie , vol.94 , pp. 2242-2263
    • Jiménez-Chillarón, J.C.1    Díaz, R.2    Martínez, D.3    Pentinat, T.4    Ramón-Krauel, M.5    Ribó, S.6
  • 9
    • 84902085794 scopus 로고    scopus 로고
    • Epigenetics: An emerging player in gastric cancer
    • Kang C, Song JJ, Lee J, Kim MY. Epigenetics: an emerging player in gastric cancer. World J Gastroenterol 2014;20:6433-47. http://dx.doi.org/10.3748/wjg.v20.i21.6433.
    • (2014) World J Gastroenterol , vol.20 , pp. 6433-6447
    • Kang, C.1    Song, J.J.2    Lee, J.3    Kim, M.Y.4
  • 11
    • 0020699979 scopus 로고
    • Hypomethylation distinguishes genes of some human cancers from their normal counterparts
    • Feinberg AP, Vogelstein B. Hypomethylation distinguishes genes of some human cancers from their normal counterparts. Nature 1983;301:89-92. http://dx.doi. org/10.1038/301089a0.
    • (1983) Nature , vol.301 , pp. 89-92
    • Feinberg, A.P.1    Vogelstein, B.2
  • 12
    • 83055194242 scopus 로고    scopus 로고
    • Epigenetics and colorectal cancer
    • Lao VV, Grady WM. Epigenetics and colorectal cancer. Nat Rev Gastroenterol Hepatol 2011;8:686-700. http://dx.doi. org/10.1038/nrgastro.2011.173.
    • (2011) Nat Rev Gastroenterol Hepatol , vol.8 , pp. 686-700
    • Lao, V.V.1    Grady, W.M.2
  • 13
    • 60149103624 scopus 로고    scopus 로고
    • Epigenetic mechanisms in mammals
    • Kim JK, Samaranayake M, Pradhan S. Epigenetic mechanisms in mammals. Cell Mol Life Sci 2009;66:596-612. http:// dx.doi.org/10.1007/s00018-008-8432-4.
    • (2009) Cell Mol Life Sci , vol.66 , pp. 596-612
    • Kim, J.K.1    Samaranayake, M.2    Pradhan, S.3
  • 14
    • 70649095120 scopus 로고    scopus 로고
    • Differential methylation of tissue- and cancer-specific CpG island shores distinguishes human induced pluripotent stem cells, embryonic stem cells and fibroblasts
    • Doi A, Park IH, Wen B, Murakami P, Aryee MJ, Irizarry R, et al. Differential methylation of tissue- and cancer-specific CpG island shores distinguishes human induced pluripotent stem cells, embryonic stem cells and fibroblasts. Nat Genet 2009;41:1350-3. http://dx.doi.org/10.1038/ng.471.
    • (2009) Nat Genet , vol.41 , pp. 1350-1353
    • Doi, A.1    Park, I.H.2    Wen, B.3    Murakami, P.4    Aryee, M.J.5    Irizarry, R.6
  • 15
    • 59149084538 scopus 로고    scopus 로고
    • The human colon cancer methylome shows similar hypo- and hypermethylation at conserved tissue- specific CpG island shores
    • Irizarry RA, Ladd-Acosta C, Wen B, Wu Z, Montano C, Onyango P, et al. The human colon cancer methylome shows similar hypo- and hypermethylation at conserved tissue- specific CpG island shores. Nat Genet 2009;41:178-86. http://dx.doi.org/10.1038/ng.298.
    • (2009) Nat Genet , vol.41 , pp. 178-186
    • Irizarry, R.A.1    Ladd-Acosta, C.2    Wen, B.3    Wu, Z.4    Montano, C.5    Onyango, P.6
  • 16
    • 84923642506 scopus 로고    scopus 로고
    • DNA methylation biomarkers: Cancer and beyond
    • Mikeska T, Craig JM. DNA methylation biomarkers: cancer and beyond. Genes (Basel) 2014;5:821-64. http://dx.doi. org/10.3390/genes5030821.
    • (2014) Genes (Basel) , vol.5 , pp. 821-864
    • Mikeska, T.1    Craig, J.M.2
  • 17
    • 77249137168 scopus 로고    scopus 로고
    • Principles and challenges of genomewide DNA methylation analysis
    • Laird PW. Principles and challenges of genomewide DNA methylation analysis. Nat Rev Genet 2010;11:191-203. http://dx.doi.org/10.1038/nrg2732.
    • (2010) Nat Rev Genet , vol.11 , pp. 191-203
    • Laird, P.W.1
  • 18
    • 84881101642 scopus 로고    scopus 로고
    • Combining genomic and proteomic approaches for epigenetics research
    • Han Y, Garcia BA. Combining genomic and proteomic approaches for epigenetics research. Epigenomics 2013;5:439-52. http://dx.doi.org/10.2217/epi.13.37.
    • (2013) Epigenomics , vol.5 , pp. 439-452
    • Han, Y.1    Garcia, B.A.2
  • 19
    • 77957350610 scopus 로고    scopus 로고
    • Identification of driver and passenger DNA methylation in cancer by epigenomic analysis
    • Kalari S, Pfeifer GP. Identification of driver and passenger DNA methylation in cancer by epigenomic analysis. Adv Genet 2010;70:277-308. http://dx.doi.org/10.1016/B978-0- 12-380866-0.60010-1.
    • (2010) Adv Genet , vol.70 , pp. 277-308
    • Kalari, S.1    Pfeifer, G.P.2
  • 20
    • 84899444670 scopus 로고    scopus 로고
    • Performance evaluation of kits for bisulfite-conversion of DNA from tissues, cell lines, FFPE tissues, aspirates, lavages, effusions, plasma, serum, and urine
    • Holmes EE, Jung M, Meller S, Leisse A, Sailer V, Zech J, et al. Performance evaluation of kits for bisulfite-conversion of DNA from tissues, cell lines, FFPE tissues, aspirates, lavages, effusions, plasma, serum, and urine. PLoS ONE 2014;9:e93933. http://dx.doi.org/10.1371/journal. pone.0093933.
    • (2014) PLoS ONE , vol.9
    • Holmes, E.E.1    Jung, M.2    Meller, S.3    Leisse, A.4    Sailer, V.5    Zech, J.6
  • 21
    • 84862535291 scopus 로고    scopus 로고
    • DNA methylation biomarkers in cancer: Progress towards clinical implementation
    • Mikeska T, Bock C, Do H, Dobrovic A. DNA methylation biomarkers in cancer: progress towards clinical implementation. Expert Rev Mol Diagn 2012;12:473-87. http://dx.doi. org/10.1586/erm.12.45.
    • (2012) Expert Rev Mol Diagn , vol.12 , pp. 473-487
    • Mikeska, T.1    Bock, C.2    Do, H.3    Dobrovic, A.4
  • 23
    • 68149163117 scopus 로고    scopus 로고
    • PCR-based methods for detecting single-locus DNA methylation biomarkers in cancer diagnostics, prognostics, and response to treatment
    • Kristensen LS, Hansen LL. PCR-based methods for detecting single-locus DNA methylation biomarkers in cancer diagnostics, prognostics, and response to treatment. Clin Chem 2009;55:1471-83. http://dx.doi.org/10.1373/ clinchem.2008.121962
    • (2009) Clin Chem , vol.55 , pp. 1471-1483
    • Kristensen, L.S.1    Hansen, L.L.2
  • 24
    • 82955207575 scopus 로고    scopus 로고
    • Methylation-sensitive high-resolution melting in the context of legislative requirements for validation of analytical procedures for diagnostic applications
    • Wojdacz TK. Methylation-sensitive high-resolution melting in the context of legislative requirements for validation of analytical procedures for diagnostic applications. Expert Rev Mol Diagn 2012;12:39-47. http://dx.doi.org/10.1586/ erm.11.88.
    • (2012) Expert Rev Mol Diagn , vol.12 , pp. 39-47
    • Wojdacz, T.K.1
  • 25
    • 84896717678 scopus 로고    scopus 로고
    • Validation of methylation-sensitive high-resolution melting (MSHRM) for the detection of stool DNA methylation in colorectal neoplasms
    • Xiao Z, Li B, Wang G, Zhu W, Wang Z, Lin J, et al. Validation of methylation-sensitive high-resolution melting (MSHRM) for the detection of stool DNA methylation in colorectal neoplasms. Clin Chim Acta 2014;431:154-63. http:// dx.doi.org/10.1016/j.cca.2014.01.044.
    • (2014) Clin Chim Acta , vol.431 , pp. 154-163
    • Xiao, Z.1    Li, B.2    Wang, G.3    Zhu, W.4    Wang, Z.5    Lin, J.6
  • 26
    • 74249112134 scopus 로고    scopus 로고
    • Quality assessment of DNA derived from up to 30 years old formalin fixed paraffin embedded (FFPE) tissue for PCR-based methylation analysis using SMARTMSP and MS-HRM
    • Kristensen LS, Wojdacz TK, Thestrup BB, Wiuf C, Hager H, Hansen LL. Quality assessment of DNA derived from up to 30 years old formalin fixed paraffin embedded (FFPE) tissue for PCR-based methylation analysis using SMARTMSP and MS-HRM. BMC cancer 2009;9:453. http://dx.doi. org/10.1186/1471-2407-9-453.
    • (2009) BMC cancer , vol.9 , pp. 453
    • Kristensen, L.S.1    Wojdacz, T.K.2    Thestrup, B.B.3    Wiuf, C.4    Hager, H.5    Hansen, L.L.6
  • 27
    • 35648937679 scopus 로고    scopus 로고
    • Genomic profiling of CpG methylation and allelic specificity using quantitative high-throughput mass spectrometry: Critical evaluation and improvements
    • Coolen MW, Statham AL, Gardiner-Garden M, Clark SJ. Genomic profiling of CpG methylation and allelic specificity using quantitative high-throughput mass spectrometry: critical evaluation and improvements. Nucleic Acids Res 2007;35:e119. http://dx.doi.org/10.1093/nar/gkm662.
    • (2007) Nucleic Acids Res , vol.35
    • Coolen, M.W.1    Statham, A.L.2    Gardiner-Garden, M.3    Clark, S.J.4
  • 29
    • 34548734299 scopus 로고    scopus 로고
    • Ultradeep bisulfite sequencing analysis of DNA methylation patterns in multiple gene promoters by 454 sequencing
    • Taylor KH, Kramer RS, Davis JW, Guo J, Duff DJ, Xu D, et al. Ultradeep bisulfite sequencing analysis of DNA methylation patterns in multiple gene promoters by 454 sequencing. Cancer Res 2007;67:8511-8. http://dx.doi. org/10.1158/0008-5472.CAN-07-1016.
    • (2007) Cancer Res , vol.67 , pp. 8511-8518
    • Taylor, K.H.1    Kramer, R.S.2    Davis, J.W.3    Guo, J.4    Duff, D.J.5    Xu, D.6
  • 30
    • 79958754527 scopus 로고    scopus 로고
    • Validation of a DNA methylation microarray for 450,000 CpG sites in the human genome
    • Sandoval J, Heyn H, Moran S, Serra-Musach J, Pujana MA, Bibikova M, et al. Validation of a DNA methylation microarray for 450,000 CpG sites in the human genome. Epigenetics 2014;6:692-702. http://dx.doi.org/10.4161/ epi.6.6.16196.
    • (2014) Epigenetics , vol.6 , pp. 692-702
    • Sandoval, J.1    Heyn, H.2    Moran, S.3    Serra-Musach, J.4    Pujana, M.A.5    Bibikova, M.6
  • 31
    • 84857217981 scopus 로고    scopus 로고
    • Interpretation of genome-wide infinium methylation data from ligated DNA in formalin-fixed, paraffin- embedded paired tumor and normal tissue
    • Jasmine F, Rahaman R, Roy S, Raza M, Paul R, Rakibuz- Zaman M, et al. Interpretation of genome-wide infinium methylation data from ligated DNA in formalin-fixed, paraffin- embedded paired tumor and normal tissue. BMC Res Notes 2012;5:117. http://dx.doi.org/10.1186/1756-0500-5- 117.
    • (2012) BMC Res Notes , vol.5 , pp. 117
    • Jasmine, F.1    Rahaman, R.2    Roy, S.3    Raza, M.4    Paul, R.5    Rakibuz-Zaman, M.6
  • 32
    • 84867809455 scopus 로고    scopus 로고
    • DNA methylation biomarkers and their utility for solid cancer diagnostics
    • Heichman KA, Warren JD. DNA methylation biomarkers and their utility for solid cancer diagnostics. Clin Chem Lab Med 2012;50:1707-21. http://dx.doi.org/10.1515/cclm- 2011-0935.
    • (2012) Clin Chem Lab Med , vol.50 , pp. 1707-1721
    • Heichman, K.A.1    Warren, J.D.2
  • 33
    • 84867188369 scopus 로고    scopus 로고
    • DNA methylation in peripheral blood: A potential biomarker for cancer molecular epidemiology
    • Li L, Choi JY, Lee KM, Sung H, Park SK, Oze I, et al. DNA methylation in peripheral blood: a potential biomarker for cancer molecular epidemiology. J Epidemiol 2012;22:384-94. http://dx.doi.org/10.2188/jea.JE20120003.
    • (2012) J Epidemiol , vol.22 , pp. 384-394
    • Li, L.1    Choi, J.Y.2    Lee, K.M.3    Sung, H.4    Park, S.K.5    Oze, I.6
  • 34
    • 84881086323 scopus 로고    scopus 로고
    • Cancer as a dysregulated epigenome allowing cellular growth advantage at the expense of the host
    • Timp W, Feinberg AP. Cancer as a dysregulated epigenome allowing cellular growth advantage at the expense of the host. Nat Rev Cancer 2013;13:497-510. http://dx.doi. org/10.1038/nrc3486.
    • (2013) Nat Rev Cancer , vol.13 , pp. 497-510
    • Timp, W.1    Feinberg, A.P.2
  • 35
    • 84878242633 scopus 로고    scopus 로고
    • Methylated DNA and microRNA in Body Fluids as Biomarkers for Cancer Detection
    • Ma Y, Wang X, Jin H. Methylated DNA and microRNA in Body Fluids as Biomarkers for Cancer Detection. Int J Mol Sci 2013;14:10307-31. http://dx.doi.org/10.3390/ ijms140510307.
    • (2013) Int J Mol Sci , vol.14 , pp. 10307-10331
    • Ma, Y.1    Wang, X.2    Jin, H.3
  • 36
    • 84858295994 scopus 로고    scopus 로고
    • Epigenetic modifications in cancer
    • Kanwal Gupta S, R. Epigenetic modifications in cancer. Clin Genet 2013;81:303-11. http://dx.doi.org/10.1111/j.1399- 0004.2011.01809.x.
    • (2013) Clin Genet , vol.81 , pp. 303-311
    • Kanwal Gupta, S.R.1
  • 37
    • 84867400649 scopus 로고    scopus 로고
    • DNA methylation based biomarkers: Practical considerations and applications
    • How Kit A, Nielsen HM, Tost J. DNA methylation based biomarkers: practical considerations and applications. Biochimie 2012;94:2314-37. http://dx.doi.org/10.1016/j.biochi. 2012.07.014.
    • (2012) Biochimie , vol.94 , pp. 2314-2337
    • How Kit, A.1    Nielsen, H.M.2    Tost, J.3
  • 38
    • 84906970275 scopus 로고    scopus 로고
    • The prognostic value of global DNA hypomethylation in cancer: A meta-analysis
    • Li J, Huang Q, Zeng F, Li W, He Z, Chen W, et al. The prognostic value of global DNA hypomethylation in cancer: a meta-analysis. PLoS ONE 2014;9:e106290. http://dx.doi. org/10.1371/journal.pone.0106290.
    • (2014) PLoS ONE , vol.9
    • Li, J.1    Huang, Q.2    Zeng, F.3    Li, W.4    He, Z.5    Chen, W.6
  • 39
    • 84923333026 scopus 로고    scopus 로고
    • A DNA methylation-based definition of biologically distinct breast cancer subtypes
    • Stefansson OA, Moran S, Gomez A, Sayols S, Arribas-Jorba C, Sandoval J, et al. A DNA methylation-based definition of biologically distinct breast cancer subtypes. Mol Oncol 2015;9:555-68.http://dx.doi.org/10.1016/j.molonc. 2014.10.012.
    • (2015) Mol Oncol , vol.9 , pp. 555-568
    • Stefansson, O.A.1    Moran, S.2    Gomez, A.3    Sayols, S.4    Arribas-Jorba, C.5    Sandoval, J.6
  • 41
    • 78650803552 scopus 로고    scopus 로고
    • Constitutional methylation of the BRCA1 promoter is specifically associated with BRCA1 mutationassociated pathology in early-onset breast cancer
    • Wong EM, Southey MC, Fox SB, Brown MA, Dowty JG, Jenkins MA, et al. Constitutional methylation of the BRCA1 promoter is specifically associated with BRCA1 mutationassociated pathology in early-onset breast cancer. Cancer Prev Res 2011;4:23-33. http://dx.doi.org/10.1158/1940-6207.CAPR-10-0212.
    • (2011) Cancer Prev Res , vol.4 , pp. 23-33
    • Wong, E.M.1    Southey, M.C.2    Fox, S.B.3    Brown, M.A.4    Dowty, J.G.5    Jenkins, M.A.6
  • 42
    • 84898819164 scopus 로고    scopus 로고
    • Pyrosequencing analysis of BRCA1 methylation level in breast cancer cells
    • Cai F, Ge I, Wang M, Biskup E, Lin X, Zhong X. Pyrosequencing analysis of BRCA1 methylation level in breast cancer cells. Tumour Biol 2014;35:3839-44. http://dx.doi. org/10.1007/s13277-013-1508-2.
    • (2014) Tumour Biol , vol.35 , pp. 3839-3844
    • Cai, F.1    Ge, I.2    Wang, M.3    Biskup, E.4    Lin, X.5    Zhong, X.6
  • 43
    • 84899550486 scopus 로고    scopus 로고
    • Novel methylated biomarkers and a robust assay to detect circulating tumor DNA in metastatic breast cancer
    • Fackler MJ, Lopez Bujanda Z, Umbricht C, Teo WW, Cho S, Zhang Z, et al. Novel methylated biomarkers and a robust assay to detect circulating tumor DNA in metastatic breast cancer. Cancer Res 2014;74:2160-70. http://dx.doi. org/10.1158/0008-5472.CAN-13-3392.
    • (2014) Cancer Res , vol.74 , pp. 2160-2170
    • Fackler, M.J.1    Lopez Bujanda, Z.2    Umbricht, C.3    Teo, W.W.4    Cho, S.5    Zhang, Z.6
  • 44
    • 84872168031 scopus 로고    scopus 로고
    • Promoter hypermethylation of the tumor- suppressor genes ITIH5, DKK3, and RASSF1A as novel biomarkers for blood-based breast cancer screening
    • Kloten V, Becker B, Winner K, Schrauder MG, Fasching PA, Anzeneder T, et al. Promoter hypermethylation of the tumor- suppressor genes ITIH5, DKK3, and RASSF1A as novel biomarkers for blood-based breast cancer screening. Breast Cancer Res 2013;15:R4. http://dx.doi.org/10.1186/ bcr3375.
    • (2013) Breast Cancer Res , vol.15
    • Kloten, V.1    Becker, B.2    Winner, K.3    Schrauder, M.G.4    Fasching, P.A.5    Anzeneder, T.6
  • 45
    • 69249129052 scopus 로고    scopus 로고
    • Methylation profiles of 22 candidate genes in breast cancer using high-throughput MALDI-TOF mass array
    • Radpour R, Kohler C, Haghighi MM, Fan AX, Holzgreve W, Zhong XY. Methylation profiles of 22 candidate genes in breast cancer using high-throughput MALDI-TOF mass array. Oncogene 2009;28:2969-78.http://dx.doi. org/10.1038/onc.2009.149.
    • (2009) Oncogene , vol.28 , pp. 2969-2978
    • Radpour, R.1    Kohler, C.2    Haghighi, M.M.3    Fan, A.X.4    Holzgreve, W.5    Zhong, X.Y.6
  • 46
    • 79551513940 scopus 로고    scopus 로고
    • Hypermethylation of tumor suppressor genes involved in critical regulatory pathways for developing a blood-based test in breast cancer
    • Radpour R, Barekati Z, Kohler C, Lv Q, Burki N, Diesch C, et al. Hypermethylation of tumor suppressor genes involved in critical regulatory pathways for developing a blood-based test in breast cancer. PLoS ONE 2011;6:e16080. http:// dx.doi.org/10.1371/journal.pone.0016080.
    • (2011) PLoS ONE , vol.6
    • Radpour, R.1    Barekati, Z.2    Kohler, C.3    Lv, Q.4    Burki, N.5    Diesch, C.6
  • 47
    • 84867560594 scopus 로고    scopus 로고
    • Circulating cell-free DNA: A promising marker of regional lymphonode metastasis in breast cancer patients
    • Agostini M, Enzo MV, Bedin C, Belardinelli V, Goldin E, Del Bianco P, et al. Circulating cell-free DNA: a promising marker of regional lymphonode metastasis in breast cancer patients. Cancer Biomark 2012;11:89-98.
    • (2012) Cancer Biomark , vol.11 , pp. 89-98
    • Agostini, M.1    Enzo, M.V.2    Bedin, C.3    Belardinelli, V.4    Goldin, E.5    Del Bianco, P.6
  • 48
    • 84896405425 scopus 로고    scopus 로고
    • Integrated analysis of high-resolution DNA methylation profiles, gene expression, germline genotypes and clinical end points in breast cancer patients
    • Fleischer T, Edvardsen H, Solvang HK, Daviaud C, Naume B, Borresen-Dale AL, et al. Integrated analysis of high-resolution DNA methylation profiles, gene expression, germline genotypes and clinical end points in breast cancer patients. Int J Cancer 2014;134:2615-25. http://dx.doi.org/10.1002/ ijc.28606.
    • (2014) Int J Cancer , vol.134 , pp. 2615-2625
    • Fleischer, T.1    Edvardsen, H.2    Solvang, H.K.3    Daviaud, C.4    Naume, B.5    Borresen-Dale, A.L.6
  • 49
    • 84879364361 scopus 로고    scopus 로고
    • Potential epigenetic biomarkers for the diagnosis and prognosis of pancreatic ductal adenocarcinomas
    • Hinton J, Callan R, Bodine C, Glasgow W, Brower S, Jiang SW, et al. Potential epigenetic biomarkers for the diagnosis and prognosis of pancreatic ductal adenocarcinomas. Expert Rev Mol Diagn 2013;13:431-43. http://dx.doi. org/10.1586/erm.13.38.
    • (2013) Expert Rev Mol Diagn , vol.13 , pp. 431-443
    • Hinton, J.1    Callan, R.2    Bodine, C.3    Glasgow, W.4    Brower, S.5    Jiang, S.W.6
  • 50
    • 84922393167 scopus 로고    scopus 로고
    • Diagnostic value of serum carbohydrate antigen 19-9 in pancreatic cancer: A meta-analysis
    • Huang Z, Liu F. Diagnostic value of serum carbohydrate antigen 19-9 in pancreatic cancer: a meta-analysis. Tumour Biol 2014;35:7459-65. http://dx.doi.org/10.1007/s13277- 014-1995-9.
    • (2014) Tumour Biol , vol.35 , pp. 7459-7465
    • Huang, Z.1    Liu, F.2
  • 52
    • 84888201440 scopus 로고    scopus 로고
    • Road to early detection of pancreatic cancer: Attempts to utilize epigenetic biomarkers
    • Fukushige S, Horii A. Road to early detection of pancreatic cancer: Attempts to utilize epigenetic biomarkers. Cancer Lett 2014;342:231-7. http://dx.doi.org/10.1016/j.canlet. 2012.03.022.
    • (2014) Cancer Lett , vol.342 , pp. 231-237
    • Fukushige, S.1    Horii, A.2
  • 53
    • 84903144996 scopus 로고    scopus 로고
    • Epigenetics and pancreatic cancer: Pathophysiology and novel treatment aspects
    • Neureiter D, Jager T, Ocker M, Kiesslich T. Epigenetics and pancreatic cancer: pathophysiology and novel treatment aspects. World J Gastroenterol 2014;20:7830-48. http:// dx.doi.org/10.3748/wjg.v20.i24.7830.
    • (2014) World J Gastroenterol , vol.20 , pp. 7830-7848
    • Neureiter, D.1    Jager, T.2    Ocker, M.3    Kiesslich, T.4
  • 55
  • 56
    • 0037742210 scopus 로고    scopus 로고
    • Discovery of novel targets for aberrant methylation in pancreatic carcinoma using high-throughput microarrays
    • Sato N, Fukushima N, Maitra A, Matsubayashi H, Yeo CJ, Cameron JL et al. Discovery of novel targets for aberrant methylation in pancreatic carcinoma using high-throughput microarrays. Cancer Res 2003;63:3735-42.
    • (2003) Cancer Res , vol.63 , pp. 3735-3742
    • Sato, N.1    Fukushima, N.2    Maitra, A.3    Matsubayashi, H.4    Yeo, C.J.5    Cameron, J.L.6
  • 57
    • 84655163824 scopus 로고    scopus 로고
    • The role of quantitative NPTX2 hypermethylation as a novel serum diagnostic marker in pancreatic cancer
    • Park JK, Ryu JK, Yoon WJ, Lee SH, Lee GY, Jeong KS, et al. The role of quantitative NPTX2 hypermethylation as a novel serum diagnostic marker in pancreatic cancer. Pancreas 2012;41:95-101. http://dx.doi.org/10.1097/MPA.0b013e318221c903.
    • (2012) Pancreas , vol.41 , pp. 95-101
    • Park, J.K.1    Ryu, J.K.2    Yoon, W.J.3    Lee, S.H.4    Lee, G.Y.5    Jeong, K.S.6
  • 58
    • 79953046715 scopus 로고    scopus 로고
    • Leukocyte DNA methylation signature differentiates pancreatic cancer patients from healthy controls
    • Pedersen KS, Bamlet WR, Oberg AL, de Andrade M, Matsumoto ME, Tang H, et al. Leukocyte DNA methylation signature differentiates pancreatic cancer patients from healthy controls. PLoS ONE 2011;6:e18223. http://dx.doi. org/10.1371/journal.pone.0018223.
    • (2011) PLoS ONE , vol.6
    • Pedersen, K.S.1    Bamlet, W.R.2    Oberg, A.L.3    de Andrade, M.4    Matsumoto, M.E.5    Tang, H.6
  • 59
    • 84861325788 scopus 로고    scopus 로고
    • Whole blood DNA aberrant methylation in pancreatic adenocarcinoma shows association with the course of the disease: A pilot study
    • Dauksa A, Gulbinas A, Barauskas G, Pundzius J, Oldenburg J, El-Maarri O. Whole blood DNA aberrant methylation in pancreatic adenocarcinoma shows association with the course of the disease: a pilot study. PLoS ONE 2012;7:e37509. http://dx.doi.org/10.1371/journal.pone.0037509.
    • (2012) PLoS ONE , vol.7
    • Dauksa, A.1    Gulbinas, A.2    Barauskas, G.3    Pundzius, J.4    Oldenburg, J.5    El-Maarri, O.6
  • 60
    • 84961291738 scopus 로고    scopus 로고
    • Genomic era diagnosis and management of hereditary and sporadic colon cancer
    • Esplin ED, Snyder MP. Genomic era diagnosis and management of hereditary and sporadic colon cancer. World J Clin Oncol 2014;5:1036-47. http://dx.doi.org/10.5306/wjco. v5.i5.1036.
    • (2014) World J Clin Oncol , vol.5 , pp. 1036-1047
    • Esplin, E.D.1    Snyder, M.P.2
  • 61
    • 84893197219 scopus 로고    scopus 로고
    • A panel of genes methylated with high frequency in colorectal cancer
    • Mitchell SM, Ross JP, Drew HR, Ho T, Brown GS, Saunders NF, et al. A panel of genes methylated with high frequency in colorectal cancer. BMC cancer 2014;14:54. http://dx.doi. org/10.1186/1471-2407-14-54.
    • (2014) BMC cancer , vol.14 , pp. 54
    • Mitchell, S.M.1    Ross, J.P.2    Drew, H.R.3    Ho, T.4    Brown, G.S.5    Saunders, N.F.6
  • 62
    • 84870326702 scopus 로고    scopus 로고
    • Genome-scale discovery of DNA-methylation biomarkers for blood-based detection of colorectal cancer
    • Lange CP, Campan M, Hinoue T, Schmitz RF, van der Meulen- de Jong AE, Slingerland H, et al. Genome-scale discovery of DNA-methylation biomarkers for blood-based detection of colorectal cancer. PLoS ONE 2012;7:e50266. http://dx.doi.org/10.1371/journal.pone.0050266.
    • (2012) PLoS ONE , vol.7
    • Lange, C.P.1    Campan, M.2    Hinoue, T.3    Schmitz, R.F.4    van der Meulen-De Jong, A.E.5    Slingerland, H.6
  • 63
    • 84866707635 scopus 로고    scopus 로고
    • A high degree of LINE-1 hypomethylation is a unique feature of early-onset colorectal cancer
    • Antelo M, Balaguer F, Shia J, Shen Y, Hur K, Moreira L, et al. A high degree of LINE-1 hypomethylation is a unique feature of early-onset colorectal cancer. PLoS ONE 2012;7:e45357. http://dx.doi.org/10.1371/journal.pone.0045357.
    • (2012) PLoS ONE , vol.7
    • Antelo, M.1    Balaguer, F.2    Shia, J.3    Shen, Y.4    Hur, K.5    Moreira, L.6
  • 64
    • 84905833580 scopus 로고    scopus 로고
    • IGF2 differentially methylated region hypomethylation in relation to pathological and molecular features of serrated lesions
    • Naito T, Nosho K, Ito M, Igarashi H, Mitsuhashi K, Yoshii S, et al. IGF2 differentially methylated region hypomethylation in relation to pathological and molecular features of serrated lesions. World J Gastroenterol 2014;20:10050-61. http://dx.doi.org/10.3748/wjg.v20.i29.10050.
    • (2014) World J Gastroenterol , vol.20 , pp. 10050-10061
    • Naito, T.1    Nosho, K.2    Ito, M.3    Igarashi, H.4    Mitsuhashi, K.5    Yoshii, S.6
  • 65
    • 79960927422 scopus 로고    scopus 로고
    • Increased methylation variation in epigenetic domains across cancer types
    • Hansen KD, Timp W, Bravo HC, Sabunciyan S, Langmead B, McDonald OG, et al. Increased methylation variation in epigenetic domains across cancer types. Nat Genet 2011;43:768-75. http://dx.doi.org/10.1038/ng.865.
    • (2011) Nat Genet , vol.43 , pp. 768-775
    • Hansen, K.D.1    Timp, W.2    Bravo, H.C.3    Sabunciyan, S.4    Langmead, B.5    McDonald, O.G.6
  • 66
    • 84655162785 scopus 로고    scopus 로고
    • Regions of focal DNA hypermethylation and long-range hypomethylation in colorectal cancer coincide with nuclear lamina-associated domains
    • Berman BP, Weisenberger DJ, Aman JF, Hinoue T, Ramjan Z, Liu Y, et al. Regions of focal DNA hypermethylation and long-range hypomethylation in colorectal cancer coincide with nuclear lamina-associated domains. Nat Genet 2012;44:40-6. http://dx.doi.org/10.1038/ng.969.
    • (2012) Nat Genet , vol.44 , pp. 40-46
    • Berman, B.P.1    Weisenberger, D.J.2    Aman, J.F.3    Hinoue, T.4    Ramjan, Z.5    Liu, Y.6
  • 67
    • 84862639469 scopus 로고    scopus 로고
    • DNA sequence-dependent compartmentalization and silencing of chromatin at the nuclear lamina
    • Zullo JM, Demarco IA, Pique-Regi R, Gaffney DJ, Epstein CB, Spooner CJ, et al. DNA sequence-dependent compartmentalization and silencing of chromatin at the nuclear lamina. Cell 2012;149:1474-87. http://dx.doi.org/10.1016/j. cell.2012.04.035.
    • (2012) Cell , vol.149 , pp. 1474-1487
    • Zullo, J.M.1    Demarco, I.A.2    Pique-Regi, R.3    Gaffney, D.J.4    Epstein, C.B.5    Spooner, C.J.6
  • 68
    • 66749164756 scopus 로고    scopus 로고
    • Classifying MLH1 and MSH2 variants using bioinformatic prediction, splicing assays, segregation, and tumor characteristics
    • Arnold S, Buchanan DD, Barker M, Jaskowski L, Walsh MD, Birney G, et al. Classifying MLH1 and MSH2 variants using bioinformatic prediction, splicing assays, segregation, and tumor characteristics. Hum Mutat 2009;30:757-70. http:// dx.doi.org/10.1002/humu.20936.
    • (2009) Hum Mutat , vol.30 , pp. 757-770
    • Arnold, S.1    Buchanan, D.D.2    Barker, M.3    Jaskowski, L.4    Walsh, M.D.5    Birney, G.6
  • 69
    • 84884859439 scopus 로고    scopus 로고
    • Functional examination of MLH1, MSH2, and MSH6 intronic mutations identified in Danish colorectal cancer patients
    • Petersen SM, Dandanell M, Rasmussen LJ, Gerdes AM, Krogh LN, Bernstein I, et al. Functional examination of MLH1, MSH2, and MSH6 intronic mutations identified in Danish colorectal cancer patients. BMC Med Genet 2013;14:103. http://dx.doi.org/10.1186/1471-2350-14-103.
    • (2013) BMC Med Genet , vol.14 , pp. 103
    • Petersen, S.M.1    Dandanell, M.2    Rasmussen, L.J.3    Gerdes, A.M.4    Krogh, L.N.5    Bernstein, I.6
  • 70
    • 71149100270 scopus 로고    scopus 로고
    • Assessing pathogenicity of MLH1 variants by co-expression of human MLH1 and PMS2 genes in yeast
    • Vogelsang M, Comino A, Zupanec N, Hudler P, Komel R. Assessing pathogenicity of MLH1 variants by co-expression of human MLH1 and PMS2 genes in yeast. BMC cancer 2009;9:382. http://dx.doi.org/10.1186/1471-2407-9-382.
    • (2009) BMC cancer , vol.9 , pp. 382
    • Vogelsang, M.1    Comino, A.2    Zupanec, N.3    Hudler, P.4    Komel, R.5
  • 71
    • 67650385667 scopus 로고    scopus 로고
    • MGMT and MLH1 promoter methylation versus APC, KRAS and BRAF gene mutations in colorectal cancer: Indications for distinct pathways and sequence of events
    • de Vogel S, Weijenberg MP, Herman JG, Wouters KA, de Goeij AF, van den Brandt PA, et al. MGMT and MLH1 promoter methylation versus APC, KRAS and BRAF gene mutations in colorectal cancer: indications for distinct pathways and sequence of events. Ann Oncol 2009;20:1216-22. http://dx.doi.org/10.1093/annonc/mdn782.
    • (2009) Ann Oncol , vol.20 , pp. 1216-1222
    • de Vogel, S.1    Weijenberg, M.P.2    Herman, J.G.3    Wouters, K.A.4    de Goeij, A.F.5    van den Brandt, P.A.6
  • 72
    • 71149121511 scopus 로고    scopus 로고
    • MGMT methylation is associated primarily with the germline C>T SNP (rs16906252) in colorectal cancer and normal colonic mucosa
    • Hawkins NJ, Lee JH, Wong JJ, Kwok CT, Ward RL, Hitchins MP. MGMT methylation is associated primarily with the germline C>T SNP (rs16906252) in colorectal cancer and normal colonic mucosa. Mod Pathol 2009;22:1588-99. http://dx.doi.org/10.1038/modpathol.2009.130.
    • (2009) Mod Pathol , vol.22 , pp. 1588-1599
    • Hawkins, N.J.1    Lee, J.H.2    Wong, J.J.3    Kwok, C.T.4    Ward, R.L.5    Hitchins, M.P.6
  • 73
    • 79951726143 scopus 로고    scopus 로고
    • MGMT promoter methylation, loss of expression and prognosis in 855 colorectal cancers
    • Shima K, Morikawa T, Baba Y, Nosho K, Suzuki M, Yamauchi M, et al. MGMT promoter methylation, loss of expression and prognosis in 855 colorectal cancers. Cancer Causes Control 2011;22:301-9. http://dx.doi.org/10.1007/s10552-010-9698-z.
    • (2011) Cancer Causes Control , vol.22 , pp. 301-309
    • Shima, K.1    Morikawa, T.2    Baba, Y.3    Nosho, K.4    Suzuki, M.5    Yamauchi, M.6
  • 74
    • 77956143206 scopus 로고    scopus 로고
    • Development of a multiplex MethyLight assay for the detection of multigene methylation in human colorectal cancer
    • He Q, Chen HY, Bai EQ, Luo YX, Fu RJ, He YS, et al. Development of a multiplex MethyLight assay for the detection of multigene methylation in human colorectal cancer. Cancer Genet Cytogenet 2010;202:1-10. http://dx.doi. org/10.1016/j.cancergencyto.2010.05.018.
    • (2010) Cancer Genet Cytogenet , vol.202 , pp. 1-10
    • He, Q.1    Chen, H.Y.2    Bai, E.Q.3    Luo, Y.X.4    Fu, R.J.5    He, Y.S.6
  • 75
    • 84930435236 scopus 로고    scopus 로고
    • Determination of the CpG Island Methylator Phenotype (CIMP) in colorectal cancer using MethyLight
    • Weisenberger DJ, Campan M, Long TI, Laird PW. Determination of the CpG Island Methylator Phenotype (CIMP) in colorectal cancer using MethyLight. Protocol Exchange 2006. http://dx.doi.org/10.1038/nprot.2006.152.
    • (2006) Protocol Exchange
    • Weisenberger, D.J.1    Campan, M.2    Long, T.I.3    Laird, P.W.4
  • 76
    • 67650077151 scopus 로고    scopus 로고
    • Circulating methylated SEPT9 DNA in plasma is a biomarker for colorectal cancer
    • deVos T, Tetzner R, Model F, Weiss G, Schuster M, Distler J, et al. Circulating methylated SEPT9 DNA in plasma is a biomarker for colorectal cancer. Clin Chem 2009;55:1337-46. http://dx.doi.org/10.1373/clinchem.2008.115808.
    • (2009) Clin Chem , vol.55 , pp. 1337-1346
    • deVos, T.1    Tetzner, R.2    Model, F.3    Weiss, G.4    Schuster, M.5    Distler, J.6
  • 77
    • 82955185854 scopus 로고    scopus 로고
    • Fecal DNA testing for Colorectal Cancer Screening: The ColoSure test
    • Ned RM, Melillo S, and Marrone M. Fecal DNA testing for Colorectal Cancer Screening: the ColoSure test. PLoS Curr 2011;3:RRN1220. http://dx.doi.org/10.1371/currents.RRN1220.
    • (2011) PLoS Curr , vol.3
    • Ned, R.M.1    Melillo, S.2    Marrone, M.3
  • 78
    • 78751555131 scopus 로고    scopus 로고
    • Detection of vimentin (VIM) methylation in the serum of colorectal cancer patients
    • Shirahata A, Sakuraba K, Goto T, Saito M, Ishibashi K, Kigawa G et al. Detection of vimentin (VIM) methylation in the serum of colorectal cancer patients. Anticancer Res 2010;30:5015-8.
    • (2010) Anticancer Res , vol.30 , pp. 5015-5018
    • Shirahata, A.1    Sakuraba, K.2    Goto, T.3    Saito, M.4    Ishibashi, K.5    Kigawa, G.6
  • 79
    • 84884130685 scopus 로고    scopus 로고
    • Colorectal cancer screening with blood-based biomarkers: Cost-effectiveness of methylated septin 9 DNA versus current strategies
    • Ladabaum U, Allen J, Wandell M, Ramsey S. Colorectal cancer screening with blood-based biomarkers: cost-effectiveness of methylated septin 9 DNA versus current strategies. Cancer Epidemiol Biomarkers Prev 2013;22:1567-76. http:// dx.doi.org/10.1158/1055-9965.EPI-13-0204.
    • (2013) Cancer Epidemiol Biomarkers Prev , vol.22 , pp. 1567-1576
    • Ladabaum, U.1    Allen, J.2    Wandell, M.3    Ramsey, S.4
  • 80
    • 77955442473 scopus 로고    scopus 로고
    • From discovery to the clinic: The novel DNA methylation biomarker (m)SEPT9 for the detection of colorectal cancer in blood
    • Payne SR. From discovery to the clinic: the novel DNA methylation biomarker (m)SEPT9 for the detection of colorectal cancer in blood. Epigenomics 2010;2:575-85. http:// dx.doi.org/10.2217/epi.10.35.
    • (2010) Epigenomics , vol.2 , pp. 575-585
    • Payne, S.R.1
  • 81
    • 83355163991 scopus 로고    scopus 로고
    • Septin 9 methylated DNA is a sensitive and specific blood test for colorectal cancer
    • Warren JD, Xiong W, Bunker AM, Vaughn CP, Furtado LV, Roberts WL, et al. Septin 9 methylated DNA is a sensitive and specific blood test for colorectal cancer. BMC Med 2011;9:133. http://dx.doi.org/10.1186/1741-7015-9-133.
    • (2011) BMC Med , vol.9 , pp. 133
    • Warren, J.D.1    Xiong, W.2    Bunker, A.M.3    Vaughn, C.P.4    Furtado, L.V.5    Roberts, W.L.6
  • 82
    • 84877018955 scopus 로고    scopus 로고
    • Gastric cancer: Epidemiology and risk factors
    • de Martel C, Forman D, Plummer M. Gastric cancer: epidemiology and risk factors. Gastroenterol Clin North Am 2013;42:219-40. http://dx.doi.org/10.1016/j. gtc.2013.01.003.
    • (2013) Gastroenterol Clin North Am , vol.42 , pp. 219-240
    • de Martel, C.1    Forman, D.2    Plummer, M.3
  • 83
    • 84861089134 scopus 로고    scopus 로고
    • Genetic aspects of gastric cancer instability
    • Hudler P. Genetic aspects of gastric cancer instability. ScientificWorldJournal 2012;2012:761909. http://dx.doi. org/10.1100/2012/761909.
    • (2012) ScientificWorldJournal , vol.2012
    • Hudler, P.1
  • 84
    • 84893824634 scopus 로고    scopus 로고
    • Proteomic approaches in biomarker discovery: New perspectives in cancer diagnostics
    • Hudler P, Kocevar N, Komel R. Proteomic approaches in biomarker discovery: new perspectives in cancer diagnostics. ScientificWorldJournal 2014;2014:260348. http://dx.doi. org/10.1155/2014/260348.
    • (2014) ScientificWorldJournal , vol.2014
    • Hudler, P.1    Kocevar, N.2    Komel, R.3
  • 87
    • 78349271955 scopus 로고    scopus 로고
    • The overmethylated genes in Helicobacter pylori-infected gastric mucosa are demethylated in gastric cancers
    • Hong SJ, Oh JH, Jeon EJ, Min KO, Kang MI, Choi SW, et al. The overmethylated genes in Helicobacter pylori-infected gastric mucosa are demethylated in gastric cancers. BMC Gastroenterol 2010;10:137. http://dx.doi.org/10.1186/1471- 230X-10-137.
    • (2010) BMC Gastroenterol , vol.10 , pp. 137
    • Hong, S.J.1    Oh, J.H.2    Jeon, E.J.3    Min, K.O.4    Kang, M.I.5    Choi, S.W.6
  • 88
    • 84907393776 scopus 로고    scopus 로고
    • E-cadherin and gastric cancer: Cause, consequence, and applications
    • Liu X, Chu KM. E-cadherin and gastric cancer: cause, consequence, and applications. Biomed Res Int 2014;2014:637308. http://dx.doi.org/10.1155/2014/637308.
    • (2014) Biomed Res Int , vol.2014
    • Liu, X.1    Chu, K.M.2
  • 89
    • 84879131073 scopus 로고    scopus 로고
    • Gene methylation in gastric cancer
    • Qu Y, Dang S, Hou P. Gene methylation in gastric cancer. Clin Chim Acta 2013;424:53-65. http://dx.doi.org/10.1016/j. cca.2013.05.002.
    • (2013) Clin Chim Acta , vol.424 , pp. 53-65
    • Qu, Y.1    Dang, S.2    Hou, P.3
  • 90
    • 84888203978 scopus 로고    scopus 로고
    • Molecular diagnostics in esophageal and gastric neoplasms
    • Zulfiqar M, Bhalla A, Weindel M, Shidham VB. Molecular diagnostics in esophageal and gastric neoplasms. Clin Lab Med 2013;33:867-73. http://dx.doi.org/10.1016/j. cll.2013.08.006.
    • (2013) Clin Lab Med , vol.33 , pp. 867-873
    • Zulfiqar, M.1    Bhalla, A.2    Weindel, M.3    Shidham, V.B.4
  • 91
    • 64249158774 scopus 로고    scopus 로고
    • DNA methylation status is inversely correlated with green tea intake and physical activity in gastric cancer patients
    • Yuasa Y, Nagasaki H, Akiyama Y, Hashimoto Y, Takizawa T, Kojima K, et al. DNA methylation status is inversely correlated with green tea intake and physical activity in gastric cancer patients. Int J Cancer 2009;124:2677-82. http:// dx.doi.org/10.1002/ijc.24231.
    • (2009) Int J Cancer , vol.124 , pp. 2677-2682
    • Yuasa, Y.1    Nagasaki, H.2    Akiyama, Y.3    Hashimoto, Y.4    Takizawa, T.5    Kojima, K.6
  • 92
    • 80052157951 scopus 로고    scopus 로고
    • Aberrant DNA methylation of cancer-associated genes in gastric cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC-EURGAST)
    • Balassiano K, Lima S, Jenab M, Overvad K, Tjonneland A, Boutron-Ruault MC, et al. Aberrant DNA methylation of cancer-associated genes in gastric cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC-EURGAST). Cancer Lett 2011;311:85-95. http://dx.doi. org/10.1016/j.canlet.2011.06.038.
    • (2011) Cancer Lett , vol.311 , pp. 85-95
    • Balassiano, K.1    Lima, S.2    Jenab, M.3    Overvad, K.4    Tjonneland, A.5    Boutron-Ruault, M.C.6
  • 93
    • 84896700012 scopus 로고    scopus 로고
    • Analysis of DNA methylation patterns associated with the gastric cancer genome
    • Cheng Y, Yan Z, Liu Y, Liang C, Xia H, Feng J et al. Analysis of DNA methylation patterns associated with the gastric cancer genome. Oncol Lett 2014;7:1021-26.
    • (2014) Oncol Lett , vol.7 , pp. 1021-1026
    • Cheng, Y.1    Yan, Z.2    Liu, Y.3    Liang, C.4    Xia, H.5    Feng, J.6
  • 94
    • 57149111920 scopus 로고    scopus 로고
    • Global hypomethylation of genomic DNA in cancerassociated myofibroblasts
    • Jiang L, Gonda TA, Gamble MV, Salas M, Seshan V, Tu S, et al. Global hypomethylation of genomic DNA in cancerassociated myofibroblasts. Cancer Res 2008;68:9900-8. http://dx.doi.org/10.1158/0008-5472.CAN-08-1319.
    • (2008) Cancer Res , vol.68 , pp. 9900-9908
    • Jiang, L.1    Gonda, T.A.2    Gamble, M.V.3    Salas, M.4    Seshan, V.5    Tu, S.6
  • 95
    • 84897930065 scopus 로고    scopus 로고
    • DNA methylation subgroups and the CpG island methylator phenotype in gastric cancer: A comprehensive profiling approach
    • Loh M, Liem N, Vaithilingam A, Lim PL, Sapari NS, Elahi E, et al. DNA methylation subgroups and the CpG island methylator phenotype in gastric cancer: a comprehensive profiling approach. BMC Gastroenterol 2014;14:55. http:// dx.doi.org/10.1186/1471-230X-14-55.
    • (2014) BMC Gastroenterol , vol.14 , pp. 55
    • Loh, M.1    Liem, N.2    Vaithilingam, A.3    Lim, P.L.4    Sapari, N.S.5    Elahi, E.6
  • 96
    • 84860462123 scopus 로고    scopus 로고
    • Clinical potential of DNA methylation in gastric cancer: A meta-analysis
    • Sapari NS, Loh M, Vaithilingam A, Soong R. Clinical potential of DNA methylation in gastric cancer: a meta-analysis. PLoS ONE 2012;7:e36275. http://dx.doi.org/10.1371/journal. pone.0036275.
    • (2012) PLoS ONE , vol.7
    • Sapari, N.S.1    Loh, M.2    Vaithilingam, A.3    Soong, R.4
  • 97
    • 84909580782 scopus 로고    scopus 로고
    • Methylation-mediated gene silencing as biomarkers of gastric cancer: A review
    • Nakamura J, Tanaka T, Kitajima Y, Noshiro H, Miyazaki K. Methylation-mediated gene silencing as biomarkers of gastric cancer: a review. World J Gastroenterol 2014;20:11991-2006. http://dx.doi.org/10.3748/wjg.v20.i34.11991.
    • (2014) World J Gastroenterol , vol.20 , pp. 11991-12006
    • Nakamura, J.1    Tanaka, T.2    Kitajima, Y.3    Noshiro, H.4    Miyazaki, K.5
  • 98
    • 84899912811 scopus 로고    scopus 로고
    • CpG island methylator phenotype, Helicobacter pylori, Epstein-Barr virus, and microsatellite instability and prognosis in gastric cancer: A systematic review and meta-analysis
    • Zong L, Seto Y. CpG island methylator phenotype, Helicobacter pylori, Epstein-Barr virus, and microsatellite instability and prognosis in gastric cancer: a systematic review and meta-analysis. PLoS ONE 2014;9:e86097. http://dx.doi. org/10.1371/journal.pone.0086097.
    • (2014) PLoS ONE , vol.9
    • Zong, L.1    Seto, Y.2
  • 99
    • 84862777258 scopus 로고    scopus 로고
    • Prediction of the risk for gastric cancer using candidate methylation markers in the non-neoplastic gastric mucosae
    • Shin CM, Kim N, Park JH, Kang GH, Kim JS, Jung HC, et al. Prediction of the risk for gastric cancer using candidate methylation markers in the non-neoplastic gastric mucosae. J Pathol 2012;226:654-65. http://dx.doi. org/10.1002/path.2990.
    • (2012) J Pathol , vol.226 , pp. 654-665
    • Shin, C.M.1    Kim, N.2    Park, J.H.3    Kang, G.H.4    Kim, J.S.5    Jung, H.C.6
  • 100
    • 84882629312 scopus 로고    scopus 로고
    • Serum Protein and Genetic Tumor Markers of Gastric Carcinoma
    • He CZ, Zhang KH.Serum Protein and Genetic Tumor Markers of Gastric Carcinoma. Asian Pacific J Cancer Prev 2013;14:3437-42. http://dx.doi.org/10.7314/APJCP.2013. 14.6.3437.
    • (2013) Asian Pacific J Cancer Prev , vol.14 , pp. 3437-3442
    • He, C.Z.1    Zhang, K.H.2
  • 101
    • 84861752999 scopus 로고    scopus 로고
    • Differential variability improves the identification of cancer risk markers in DNA methylation studies profiling precursor cancer lesions
    • Teschendorff AE, Widschwendter M. Differential variability improves the identification of cancer risk markers in DNA methylation studies profiling precursor cancer lesions. Bioinformatics 2012;28:1487-94. http://dx.doi.org/10.1093/bioinformatics/ bts170.
    • (2012) Bioinformatics , vol.28 , pp. 1487-1494
    • Teschendorff, A.E.1    Widschwendter, M.2


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