MGMT methylation is associated primarily with the germline CT SNP (rs16906252) in colorectal cancer and normal colonic mucosa

Modern Pathology

Volumn 22, Issue 12, 2009, Pages 1588-1599

  Hawkins, Nicholas J ^a   Lee, James H F ^b   Wong, Justin J L ^a   Kwok, Chau To ^a,b   Ward, Robyn L ^a,b   Hitchins, Megan P ^a,b  

^a UNIVERSITY OF NEW SOUTH WALES   (Australia)

^b UNIVERSITY OF NEW SOUTH WALES   (Australia)

Author keywords

Colorectal cancer; Methylation; MGMT; SNP

Indexed keywords

BISULFITE; METHYLATED DNA PROTEIN CYSTEINE METHYLTRANSFERASE;

ADULT; AGED; ALLELE; ARTICLE; CANCER GENETICS; CANCER INVASION; COLON MUCOSA; COLORECTAL CANCER; DNA METHYLATION; FEMALE; GENE MUTATION; GERM LINE GENE THERAPY; HUMAN; HUMAN TISSUE; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; SINGLE NUCLEOTIDE POLYMORPHISM;

ADULT; AGED; AGED, 80 AND OVER; AUSTRALIA; CARCINOMA; CHROMOSOMES, HUMAN, PAIR 10; COLORECTAL NEOPLASMS; CYCLIN-DEPENDENT KINASE INHIBITOR P16; DNA METHYLATION; DNA MODIFICATION METHYLASES; DNA REPAIR ENZYMES; EPIGENESIS, GENETIC; FEMALE; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GENE EXPRESSION REGULATION, NEOPLASTIC; GENE FREQUENCY; GENETIC PREDISPOSITION TO DISEASE; GERM-LINE MUTATION; HUMANS; IMMUNOHISTOCHEMISTRY; INTESTINAL MUCOSA; MALE; MIDDLE AGED; NEOPLASM INVASIVENESS; NEOPLASM STAGING; ODDS RATIO; PHENOTYPE; POLYMERASE CHAIN REACTION; POLYMORPHISM, SINGLE NUCLEOTIDE; PROSPECTIVE STUDIES; PROTO-ONCOGENE PROTEINS; RAS PROTEINS; TUMOR SUPPRESSOR PROTEINS;

EID: 71149121511     PISSN: 08933952     EISSN: 15300285     Source Type: Journal    
DOI: 10.1038/modpathol.2009.130     Document Type: Article

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