A High Degree of LINE-1 Hypomethylation Is a Unique Feature of Early-Onset Colorectal Cancer

PLoS ONE

Volumn 7, Issue 9, 2012, Pages

  Antelo, Marina ^a   Balaguer, Francesc ^b,c   Shia, Jinru ^d   Shen, Yan ^b   Hur, Keun ^b   Moreira, Leticia ^c   Cuatrecasas, Miriam ^c   Bujanda, Luis ^e   Giraldez, Maria Dolores ^c   Takahashi, Masanobu ^b   Cabanne, Ana ^a   Barugel, Mario Edmundo ^a   Arnold, Mildred ^b   Roca, Enrique Luis ^a   Andreu, Montserrat ^f   Castellvi Bel, Sergi ^c   Llor, Xavier ^g   Jover, Rodrigo ^h   Castells, Antoni ^c   Boland, C Richard ^b   Goel, Ajay ^b   more..

^a Oncology and Pathology Sections   (Argentina)

^b BAYLOR UNIVERSITY MEDICAL CENTER   (United States)

^c UNIVERSITY OF BARCELONA   (Spain)

^d MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^e UNIVERSITY OF THE BASQUE COUNTRY UPV EHU   (Spain)

^f HOSPITAL DEL MAR   (Spain)

^g UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

^h HOSPITAL GENERAL UNIVERSITARIO DE ALICANTE   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

B RAF KINASE; DNA GLYCOSYLASE MUTY; LONG INTERSPERSED NUCLEOTIDE ELEMENT 1; MISMATCH REPAIR PROTEIN; PROTEIN MLH1; TUMOR MARKER; UNCLASSIFIED DRUG;

ADOLESCENT; ADULT; ARTICLE; CANCER LOCALIZATION; CANCER PROGNOSIS; CANCER STAGING; CANCER SURVIVAL; CHILD; COLORECTAL CANCER; CONTROLLED STUDY; EARLY CANCER; FEMALE; GENE MUTATION; GERM LINE; HEREDITARY NONPOLYPOSIS COLORECTAL CANCER; HUMAN; HUMAN TISSUE; MAJOR CLINICAL STUDY; MALE; MICROSATELLITE INSTABILITY; MUTATIONAL ANALYSIS; OVERALL SURVIVAL; PROTEIN EXPRESSION; PROTEIN METHYLATION; RECURRENT CANCER; SCHOOL CHILD; SOMATIC MUTATION; SURVIVAL TIME; TUMOR DIFFERENTIATION;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ADENOMA; ADULT; AGE OF ONSET; ARGENTINA; CASE-CONTROL STUDIES; COLORECTAL NEOPLASMS; COLORECTAL NEOPLASMS, HEREDITARY NONPOLYPOSIS; DNA GLYCOSYLASES; DNA METHYLATION; DNA-BINDING PROTEINS; FEMALE; GENE EXPRESSION; GERM-LINE MUTATION; HUMANS; LONG INTERSPERSED NUCLEOTIDE ELEMENTS; MALE; MICROSATELLITE INSTABILITY; MIDDLE AGED; NUCLEAR PROTEINS; PROTO-ONCOGENE PROTEINS B-RAF; SPAIN; SURVIVAL ANALYSIS; UNITED STATES;

EID: 84866707635     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0045357     Document Type: Article

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