MGMT promoter methylation, loss of expression and prognosis in 855 colorectal cancers

Cancer Causes and Control

Volumn 22, Issue 2, 2011, Pages 301-309

  Shima, Kaori ^a   Morikawa, Teppei ^a   Baba, Yoshifumi ^a   Nosho, Katsuhiko ^a   Suzuki, Maiko ^a   Yamauchi, Mai ^a   Hayashi, Marika ^a   Giovannucci, Edward ^b,c   Fuchs, Charles S ^a,b   Ogino, Shuji ^a,b  

^a HARVARD MEDICAL SCHOOL   (United States)

^b BRIGHAM AND WOMEN S HOSPITAL   (United States)

^c HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

Author keywords

Clinical outcome; Colon cancer; Epigenetics; Hypermethylation; MGMT

Indexed keywords

B RAF KINASE; CELL PROTEIN; CYCLIN DEPENDENT KINASE INHIBITOR 2A; GENOMIC DNA; K RAS PROTEIN; METHYLATED DNA PROTEIN CYSTEINE METHYLTRANSFERASE; NEUROGENIN 1; PROTEIN CACNA1G; PROTEIN LINE 1; PROTEIN MLH1; PROTEIN P53; PROTEIN PIK3CA; SOMATOMEDIN B; SUPPRESSOR OF CYTOKINE SIGNALING 1; TRANSCRIPTION FACTOR RUNX3; UNCLASSIFIED DRUG;

AGED; AMINO ACID SUBSTITUTION; ARTICLE; CANCER MORTALITY; CANCER SURVIVAL; CARCINOGENESIS; CLINICAL FEATURE; COHORT ANALYSIS; COLORECTAL CANCER; CONTROLLED STUDY; CPG ISLAND; DISEASE ASSOCIATION; FEMALE; GENE MUTATION; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MAJOR CLINICAL STUDY; MALE; MICROSATELLITE INSTABILITY; MICROSATELLITE MARKER; PHENOTYPE; PRIORITY JOURNAL; PROGNOSIS; PROMOTER REGION; PROSPECTIVE STUDY; PROTEIN DEPLETION; PROTEIN EXPRESSION; PROTEIN METHYLATION;

AGED; CARCINOMA; COHORT STUDIES; COLORECTAL NEOPLASMS; DNA METHYLATION; DNA MODIFICATION METHYLASES; DNA REPAIR ENZYMES; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; GENE SILENCING; HUMANS; MALE; MIDDLE AGED; PHOSPHATIDYLINOSITOL 3-KINASES; PROGNOSIS; PROMOTER REGIONS, GENETIC; PROTO-ONCOGENE PROTEINS; RAS PROTEINS; TUMOR MARKERS, BIOLOGICAL; TUMOR SUPPRESSOR PROTEINS;

EID: 79951726143     PISSN: 09575243     EISSN: 15737225     Source Type: Journal    
DOI: 10.1007/s10552-010-9698-z     Document Type: Article

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