Proof-of-concept randomized controlled trial of pregnenolone in schizophrenia

Psychopharmacology

Volumn 231, Issue 17, 2014, Pages 3647-3662

  Marx, Christine E ^a,b   Lee, Jimmy ^c   Subramaniam, Mythily ^c   Rapisarda, Attilio ^c   Bautista, Dianne C T ^d,e   Chan, Edwin ^d,e   Kilts, Jason D ^a,b   Buchanan, Robert W ^f   Wai, Eu Pui ^c   Verma, Swapna ^c   Sim, Kang ^c   Hariram, Jayaraman ^c   Jacob, Rajesh ^c   Keefe, Richard S E ^a,d   Chong, Siow Ann ^c,d  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

^b DURHAM VA MEDICAL CENTER   (United States)

^c INSTITUTE OF MENTAL HEALTH   (Singapore)

^d DUKE NUS MEDICAL SCHOOL   (Singapore)

^e SINGAPORE CLINICAL RESEARCH INSTITUTE   (Singapore)

^f UNIVERSITY OF MARYLAND   (United States)

Author keywords

Allopregnanolone; Cognition; Function; MCCB; Neurosteroid; Pregnenolone; RCT; Schizophrenia; Therapeutic; Treatment; UPSA

Indexed keywords

NEUROSTEROID; PLACEBO; PREGNENOLONE; AGENTS INTERACTING WITH TRANSMITTER, HORMONE OR DRUG RECEPTORS; NEUROLEPTIC AGENT;

ADULT; ARTICLE; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG EFFICACY; DRUG SAFETY; DRUG TOLERABILITY; FEMALE; FUNCTIONAL STATUS; HUMAN; MAJOR CLINICAL STUDY; MALE; MATRICS CONSENSUS COGNITIVE BATTERY; MENTAL DISEASE ASSESSMENT; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SCALE FOR ASSESSMENT OF NEGATIVE SYMPTOMS; SCHIZOPHRENIA; SCORING SYSTEM; SINGAPORE; UCSD PERFORMANCE BASED SKILLS ASSESSMENT BRIEF; UNSPECIFIED SIDE EFFECT; BLOOD; CHEMISTRY; COGNITION; DIAGNOSTIC AND STATISTICAL MANUAL OF MENTAL DISORDERS; DOUBLE BLIND PROCEDURE; DRUG EFFECTS; PSYCHOLOGICAL RATING SCALE; PSYCHOLOGY; SEXUAL DEVELOPMENT; TREATMENT OUTCOME;

ADULT; ANTIPSYCHOTIC AGENTS; COGNITION; DIAGNOSTIC AND STATISTICAL MANUAL OF MENTAL DISORDERS; DOUBLE-BLIND METHOD; FEMALE; HUMANS; MALE; NEUROTRANSMITTER AGENTS; PREGNENOLONE; PSYCHIATRIC STATUS RATING SCALES; SCHIZOPHRENIA; SCHIZOPHRENIC PSYCHOLOGY; SEX CHARACTERISTICS; TREATMENT OUTCOME;

EID: 84930278788     PISSN: 00333158     EISSN: 14322072     Source Type: Journal    
DOI: 10.1007/s00213-014-3673-4     Document Type: Article

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