Potentially predictive and manipulable blood serum correlates of aging in the healthy human male: Progressive decreases in bioavailable testosterone, dehydroepiandrosterone sulfate, and the ratio of insulin-like growth factor 1 to growth hormone

Proceedings of the National Academy of Sciences of the United States of America

Volumn 94, Issue 14, 1997, Pages 7537-7542

  Morley, John E ^a,b   Kaiser, Fran ^a,b   Raum, William J ^c   Perry III, H Mitchell ^a,b   Flood, James F ^a,b   Jensen, Judy ^a,b   Silver, Andrew J ^a,b   Roberts, Eugene ^d  

^a VETERANS AFFAIRS MEDICAL CENTER   (United States)

^b SAINT LOUIS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c HARBOR UCLA MEDICAL CENTER   (United States)

^d CITY OF HOPE NATIONAL MEDICAL CENTER   (United States)

Author keywords

Learning; Memory; Pregnenolone sulfate; Vestibular function

Indexed keywords

GROWTH HORMONE; PRASTERONE SULFATE; PREGNENOLONE SULFATE; SOMATOMEDIN C; TESTOSTERONE;

ADULT; AGED; AGING; ARTICLE; COGNITION; GROWTH HORMONE BLOOD LEVEL; HUMAN; HUMAN EXPERIMENT; LEARNING; MALE; MEMORY; NEUROENDOCRINOLOGY; NORMAL HUMAN; PRIORITY JOURNAL; STEROID BLOOD LEVEL; STEROID METABOLISM; VESTIBULAR FUNCTION;

ADULT; AGED; AGED, 80 AND OVER; AGING; CROSS-SECTIONAL STUDIES; DEHYDROEPIANDROSTERONE SULFATE; HUMAN GROWTH HORMONE; HUMANS; INSULIN-LIKE GROWTH FACTOR I; MALE; MIDDLE AGED; PREDICTIVE VALUE OF TESTS; REGRESSION ANALYSIS; TESTOSTERONE;

EID: 0030744143     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.94.14.7537     Document Type: Article

References (51)

1. Roberts, E. (1991) Neurochem. Res. 16, 409-421.
2. Parker, L. N. (1989) Adrenal Androgens in Clinical Medicine (Academic, New York).
3. Roberts, E. (1990) Prog. Brain Res. 86, 339-355.
4. Kalimi, M. & Regelson, W., eds. (1990) The Biological Role of Dehydroepiandrosterone (DHEA) (de Gruyter, Berlin).
5. Bellino, F. L., Daynes, R. A., Hornsby, P. J., Lavrin, D. H. & Nestler, J. E., eds. (1995) Dehydroepiandrosterone (DHEA) and Aging (New York Academy of Sciences, New York).
6. Roberts, E. (1995) Biochem. Pharmacol. 49, 1-16.
7. Guth, L., Zhang, Z. & Roberts, E. (1994) Proc. Natl. Acad. Sci. USA 91, 12308-12312.
8. Baulieu, E.-E. (1996) J. Clin. Endocrinol. Metab. 81, 3147-3151.
9. Korenman, S. G., Morley, J. E., Mooradian, A. D., Davis, S. S., Kaiser, F. E., Silver, A. J., Viosca, S. P. & Garza, D. (1990) J. Clin. Endocrinol. Metab. 71, 963-969.
10. Mungas, D. (1983) J. Consult. Clin. Psychol. 51, 848-855.
11. Rev. A. ( 1964) L'Examen Clinique en Psychologie (Press Universitaire de France, Paris).
12. Ryan, J. J., Rosenberg, S. J. & Mittenberg, W. (1984) Int. J. Clin. Neuropsychol. 6, 239-241.
13. Goodglass, H. & Kaplan, E. (1983) The Assessment of Aphasia and Related Disorders (Lea & Febiger, Philadelphia), 2nd Ed.
14. Wilson, R. S., Kaszniak, A. W. & Fox, J. H. (1981) Cortex 17, 41-48.
15. Folstein, M. F., Folstein, S. E. & McHugh, P. R. (1975) J. Psychiatr. Res. 12, 189-198.
16. Miller, W. L. (1988) Endocr. Rev. 9, 295-318.
17. Bostrom, H., Bromster, D., Nordenstam, H. & Wengle, B. (1968) Scand. J. Gastroenterol. 3, 369-375.
18. Milewich, L. & Whisenant, M. G. (1982) J. Clin. Endocrinol. Metab. 54, 969-974.
19. Leszczynski, D. E. & Schafer, R. M. (1991) Biochim. Biophys. Acta 1083, 18-28.
20. Belanger, B., Roy, R. & Belanger, A. (1992) Steroids 57, 430-436.
21. Hobkirk, R. (1985) Can. J. Biochem. Cell Biol. 63, 1127-1144.
22. Munroe, D. G. & Chang, P. L. (1987) Am. J. Hum. Genet. 40, 102-114.
23. Van Eldere, J., Robben, J., DePauw, G., Merckx, R. & Eyssen, H. (1988) Appl. Environ. Microbiol. 54, 2112-2117.
24. Wang, D. Y., Bulbrook, R. D., Ellis, F. & Coombs, M. M. (1967) J. Endocrinol. 39, 395-403.
25. Nankin, H. R. & Calkins, J. H. (1986) J. Clin. Endocrinol. Metab. 63, 1418-1420.
26. Manni, A., Pardridge, W. M., Cefalu, W., Nisula, B. C, Bardin, C. W., Santner, S. J. & Santen, R. J. (1985) J. Clin. Endocrinol. Metab. 61, 705-710.
27. Vermeulen, A., Verdonck, L., Van der Straeten, M. & Orie, N. (1969) J. Clin. Endocrinol. 29, 1470-1480.
28. Miller, W. L., Auchus, R. J. & Geller, D.H. (1997) Steroids 62, 133-142.
29. Roberts, E. & Fitten, L. J. (1990) in The Biological Role of Dehydroepiandrosterone (DHEA), eds. Kalimi, M. & Regelson, W. (de Gruyter, Berlin), pp. 43-63.
30. Peters, T., Jr. (1996) All About Albumin (Academic, San Diego).
31. Wang, D. Y. & Bulbrook, R. D. (1967) J. Endocrinol. 39, 405-413.
32. Romeu, A. M., Martino, E. E. & Stoppani, A. O. M. (1975) Biochim. Biophys. Acta 409, 376-386.
33. Romeu, A. M., Martino, E. E. & Stoppani, A. O. M. (1976) Biochim. Biophys. Acta 439, 175-193.
34. Cekan, S. Z., Xing, S. & Ritzén, M. (1984) Experientia 40, 949-951.
35. Fischer, M. J. E., Bos, O. J. M., van der Linden, R. F., Wilting, J. & Janssen, L. H. M. (1993) Biochem. Pharmacol. 45, 2411-2416.
36. Morales, A. J., Nolan, J. J., Nelson, J. C. & Yen, S. S. C. (1994) J. Clin. Endocrinol Metab. 78, 1360-1367.
37. Cacicedo, L., de los Frailes, M. T., Lorenzo, M. J. & Franco, F. S. (1993) Ann. N.Y. Acad. Sci. 692, 287-290.
38. Gershengorn, M. C. (1986) Annu. Rev. Physiol. 48, 515-526.
39. Le Dafniet, M., Le Dafniet, M., Gamier, P., Bression, D., Brandi, A. M., Racadot, J. & Peillon, F. (1985) Horm. Metab. Res. 17, 476-479.
40. Wilson, V. J. & Jones, G. M. (1979) Mammalian Vestibular Physiology (Plenum, New York).
41. Nieto-Bona, M. P., Garcia-Segura, L. M. & Torres-Aleman, I. (1993) J. Neurosci. Res. 36, 520-527.
42. Torres-Aleman, I., Pons, S. & Garcia-Segura, L. M. (1991) Brain Res. 564, 348-351.
43. Castro-Alamancos, M. A. & Torres-Aleman, I. (1994) Proc. Natl. Acad. Sci. USA 91, 10203-10207.
44. Flood, J. F., Morley, J. E. & Roberts, E. (1995) Proc. Natl. Acad. Sci. USA 92, 10806-10810.
45. Lewis, G. F., Alessi, C. A., Imperial, J. G. & Refetoff, S. (1991) J. Clin. Endocrinol. Metab. 73, 843-849.
46. Nishikawa, M., Inada, M., Naito, K., Ishii, H., Tanaka, K., Mashio, Y. & Imura, H. (1981) J. Clin. Endocrinol. Metab. 52, 517-522.
47. Garnier, P. E., Roger, M., Chaussain, J. L., Canlorbe, P. & Job, J. C. (1983) Acta Endocrinol. 103, 433-440.
48. Teng, E. L., Wimer, C., Roberts, E., Damasio, A. R., Eslinger, P. J., Folstein, M. F., Tune, L. E., Whitehouse, P. J., Bardolph, E. L., Chui, H. C. & Henderson, V. W. (1989) J. Clin. Exp. Neuropsychol. 11, 899-912.
49. Parker, S. W. (1993) Clin. Electroenceph. 24, 151-159.
50. Morley, J. E., Perry, H. M., III. Kaiser, F. E., Kraenzle, D., Jensen, J., Houston, K., Mattammal, M. & Perry, H. M., Jr. (1993) J. Am. Geriatr. Soc. 41, 149-152.
51. Urban, R. J., Bodenburg, Y. H., Gilkison, C., Foxworth, J., Coggan, A. R., Wolfe, R. R. & Ferrando, A. (1995) Am. J. Physiol. 269, E820-E826.