Investigation of the mechanisms of progesterone protection following oxygen-glucose deprivation in organotypic hippocampal slice cultures

Neuroscience Letters

Volumn 506, Issue 1, 2012, Pages 131-135

  Radley, Elizabeth ^a   Akram, Asha ^a   Grubb, Blair D ^a   Gibson, Claire L ^a  

^a UNIVERSITY OF LEICESTER   (United Kingdom)

Author keywords

Allopregnanolone; Hippocampal cultures; Neuroprotection; Oxygen glucose deprivation; Progesterone

Indexed keywords

3ALPHA HYDROXY 5ALPHA PREGNAN 20 ONE; 4 AMINOBUTYRIC ACID A RECEPTOR; FINASTERIDE; GLUCOSE; OXYGEN; PICROTOXIN; PROGESTERONE; PROPIDIUM IODIDE;

ANIMAL CELL; ANIMAL CELL CULTURE; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN METABOLISM; BRAIN SLICE; CELL DEATH; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG MECHANISM; HIPPOCAMPUS; IMMUNOHISTOCHEMISTRY; MOUSE; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL;

5-ALPHA REDUCTASE INHIBITORS; ANALYSIS OF VARIANCE; ANIMALS; ANIMALS, NEWBORN; ANOXIA; CELL DEATH; DOSE-RESPONSE RELATIONSHIP, DRUG; FINASTERIDE; GABA ANTAGONISTS; GLUCOSE; HIPPOCAMPUS; MICE; MICE, INBRED C57BL; NEUROPROTECTIVE AGENTS; ORGAN CULTURE TECHNIQUES; PICROTOXIN; PREGNANOLONE; PROGESTERONE; PROPIDIUM;

EID: 84855201025     PISSN: 03043940     EISSN: 18727972     Source Type: Journal    
DOI: 10.1016/j.neulet.2011.10.065     Document Type: Article

References (31)

1. Ardeshiri A., Kelley M.H., Korner I.P., Hurn P.D., Herson P.S. Mechanism of progesterone neuroprotection of rat cerebellar Purkinje cells following oxygen-glucose deprivation. Eur. J. Neurosci. 2006, 24:2567-2574.
2. Chen J., Chopp M., Li Y. Neuroprotective effects of progesterone after transient middle cerebral artery occlusion in rat. J. Neurol. Sci. 1999, 171:24-30.
3. Ciriza I., Azcoitia I., Garcia-Segura L.M. Reduced progesterone metabolites protect rat hippocampal neurons from kainic acid excitotoxicity in vivo. J. Neuroendocrinol. 2004, 16:58-63.
4. Ciriza I., Carrero P., Frye C.A., Garcia-Segura L.M. Reduced metabolites mediates neuroprotective effects of progesterone in the adult rat hippocampus. The synthetic progestin medroxyprogesterone acetate (Provera) is not neuroprotective. J. Neurobiol. 2006, 66:916-928.
5. Gahwiler B.H., Capogna M., Debanne D., McKinney R.A., Thompson S.M. Organotypic slice cultures: a technique has come of age. Trends Neurosci. 1997, 20:471-477.
6. Gee K.W. Steroid modulation of the GABA/benzodiazepine receptor-linked chloride ionophore. Mol. Neurobiol. 1998, 2:291-317.
7. Gibson C.L., Murphy S.P. Progesterone enhances functional recovery following middle cerebral artery occlusion in male mice. J. Cereb. Blood Flow Metab. 2004, 24:805-813.
8. Gibson C.L., Constantin D., Prior M.J., Bath P.M., Murphy S.P. Progesterone suppresses the inflammatory response and nitric oxide synthase-2 expression following cerebral ischemia. Exp. Neurol. 2005, 193:522-530.
9. Gibson C.L., Coomber B., Murphy S.P. Progesterone is neuroprotective following cerebral ischemia in reproductively ageing female mice. Brain 2011, 134:2125-2133.
10. He J., Evans C.O., Hoffman S.W., Oyesiku N.M., Stein D.G. Progesterone and allopregnanolone reduce inflammatory cytokines after traumatic brain injury. Exp. Neurol. 2004, 189:404-412.
11. Izumi Y., Murayama K., Tokuda K., Krishnan K., Covey D.F., Zorumski C.F. GABAergic neurosteroids mediate the effects of ethanol on long-term potentiation in rat hippocampal slices. Eur. J. Neurosci. 2007, 26:1881-1888.
12. Jiang N., Chopp M., Stein D., Feit H. Progesterone is neuroprotective after transient middle cerebral artery occlusion in male rats. Brain Res. 1996, 735:101-107.
13. Kokate T.G., Svensson B.E., Rogawski M.A. Anticonvulsant activity of neurosteroid: correlation with gamma-aminobutyric acid-evoked chloride current potentiation. J. Pharmacol. Exp. Ther. 1994, 270:1223-1229.
14. Lipski J., Wan C.K., Wan J.Z., Bai J.Z., Pi R., Li D. Neuroprotective potential of cetriaxone in in vitro models of stroke. Neuroscience 2007, 146:617-629.
15. Liu M., Kelley M.H., Herson P.S., Hurn P.D. Neuroprotection of sex steroids. Miner. Endocrinol. 2010, 35:127-143.
16. Lockhart E.M., Warner D.S., Pearlstein R.D., Penning D.H., Mehrabani S., Boustany R.M. Allopregnanolone attenuates N-methyl-d-aspartate-induced excitotoxicity and apoptosis in the human NT2 cell line in culture. Neurosci. Lett. 2002, 328:33-36.
17. Lyden P.D. GABA and neuroprotection. Int. Rev. Neurobiol. 1997, 40:233-258.
18. Lyden P., Shuaib A., Ng K., Levin K., Atkinson R.P., Rajput A., Wechsler L., Ashwood T., Claesson L., Odergren T., Salazar-Grueso E. Clomethiazole acute stroke study in ischemic stroke (CLASS-I): final results. Stroke 2002, 33:122-128. CLASS-I/H/T Investigators.
19. A receptor: mechanism of action and physiological significance. Prog. Neurobiol. 1992, 38:379-395.
20. Paul S.M., Purdy R.H. Neuroactive steroids. FASEB J. 1992, 6:2311-2322.
21. Roof R.L., Duvdevani R.R., Stein D.G. Gender influences outcome of brain injury: progesterone plays a protective role. Brain Res. 1993, 607:333-336.
22. Roof R.L., Hoffman S.W., Stein D. Progesterone protects against lipid peroxidation following traumatic brain injury in rats. Mol. Chem. Neuropathol. 1997, 31:1-11.
23. Rupprecht R., Reul J.M., Trapp T., van Steensel B., Wetzel C., Damm K., Zieglgansberger W., Holsboer F. Progesterone receptor-mediated effects of neuroactive steroids. Neuron 1993, 11:523-530.
24. Sayeed I., Guo Q., Hoffman S.W., Stein D.G. Allopregnanolone, a progesterone metabolite, is more effective than progesterone in reducing cortical infarct volume after middle cerebral artery occlusion, Ann. Emerg. Med. 2006, 47:381-389.
25. Schmidt-Kasner R., Freund T.F. Selective vulnerability of the hippocampus in brain ischemia. Neuroscience 1991, 40:599-636.
26. Schumacher M., Guennoun R., Stein D.G., De Nicola A.F. Progesterone: therapeutic opportunities for neuroprotection and myelin repair. Pharmacol. Ther. 2007, 116:77-106.
27. Smith S.S. Female sex steroid hormones: from receptors to networks to performance-actions on the sensorimotor system. Prog. Neurobiol. 1994, 44:55-86.
28. Stoppini L., Buchs P.A., Muller D. A simple method for organotypic cultures of nervous tissue. J. Neurosci. Methods 1991, 37:173-182.
29. Su T., Paradiso B., Long Y.-S., Liao W.-P., Simonato M. Evaluation of cell damage in organotypic hippocampal slice culture from adult mouse: a potential model system to study neuroprotection. Brain Res. 2011, 1385:68-76.
30. Wang J., Jiang C., Liu C., Li X., Chen N., Hao Y. Neuroprotective effects of progesterone following stroke in aged rats. Behav. Brain Res. 2010, 209:119-122.
31. Wright D.W., Kellerman A.L., Hertzberg V.S., Clark P.L., Frankel M., Goldstein F.C., Salomone J.P., Dent L.L., Harris O.A., Ander D.S., Lowery D.W., Patel M.M., Denson D.D., Gordon A.B., Wald M.M., Gupta S., Hoffman S.W., Stein D.G. ProTECT: a randomized clinical trial of progesterone for acute traumatic brain injury. Ann. Emerg. Med. 2007, 49:391-402.