The retrograde response and other pathways of interorganelle communication in yeast replicative aging

Sub-Cellular Biochemistry

Volumn 57, Issue , 2015, Pages 79-100

  Jazwinski, S Michal ^a  

^a TULANE UNIVERSITY HEALTH SCIENCES CENTER   (United States)

Author keywords

Aging; Longevity; Mitochondria; Retrograde response; Yeast

Indexed keywords

MAMMALIA;

AGING; CALORIC RESTRICTION; CELL DIVISION; CELL NUCLEUS; CHROMATIN ASSEMBLY AND DISASSEMBLY; ENERGY METABOLISM; GENE EXPRESSION REGULATION; GENETICS; GROWTH, DEVELOPMENT AND AGING; LONGEVITY; METABOLISM; MITOCHONDRION; SIGNAL TRANSDUCTION; TIME; YEAST;

AGING; CALORIC RESTRICTION; CELL DIVISION; CELL NUCLEUS; CHROMATIN ASSEMBLY AND DISASSEMBLY; ENERGY METABOLISM; GENE EXPRESSION REGULATION, FUNGAL; LONGEVITY; MITOCHONDRIA; SIGNAL TRANSDUCTION; TIME FACTORS; YEASTS;

EID: 84930201480     PISSN: 03060225     EISSN: None     Source Type: Journal    
DOI: 10.1007/978-94-007-2561-4_4     Document Type: Article

References (115)

1. Aronova S, Wedaman K et al (2008) Regulation of ceramide biosynthesis by TOR complex 2. Cell Metab 7(2):148–158
2. Barros MH, Bandy B et al (2004) Higher respiratory activity decreases mitochondrial reactive oxygen release and increases life span in Saccharomyces cerevisiae. J Biol Chem 279(48):49883–49888
3. Berger KH, Yaffe MP (1998) Prohibitin family members interact genetically with mitochondrial inheritance components in Saccharomyces cerevisiae. Mol Cell Biol 18(7):4043–4052
4. Bhatia-Kissova I, Camougrand N (2010) Mitophagy in yeast: actors and physiological roles. FEMS Yeast Res 10(8):1023–1034
5. Bhattacharyya S, Rolfsmeier ML et al (2002) Identification of RTG2 as a modifier gene for CTG*CAG repeat instability in Saccharomyces cerevisiae. Genetics 162(2):579–589
6. Borghouts C, Benguria A et al (2004) Rtg2 protein links metabolism and genome stability in yeast longevity. Genetics 166(2):765–777
7. Breitkreutz A, Choi H et al (2010) A global protein kinase and phosphatase interaction network in yeast. Science 328(5981):1043–1046
8. Broek D, Samiy N et al (1985) Differential activation of yeast adenylate cyclase by wild-type and mutant RAS proteins. Cell 41(3):763–769
9. Butow RA, Avadhani NG (2004) Mitochondrial signaling: the retrograde response. Mol Cell 14(1):1–15
10. Chen EJ, Kaiser CA (2002) Amino acids regulate the intracellular trafficking of the general amino acid permease of Saccharomycescerevisiae. Proc Natl Acad Sci USA 99(23):14837–1484
11. Chen EJ, Kaiser CA (2003) LST8 negatively regulates amino acid biosynthesis as a component of the TOR pathway. J Cell Biol 161(2):333–347
12. Chen JB, Sun J et al (1990) Prolongation of the yeast life span by the v-Ha-RAS oncogene. Mol Microbiol 4(12):2081–208
13. Chen S, Liu D et al (2010) Loss of mitochondrial DNA in the yeast cardiolipin synthase crd1 mutant leads to up-regulation of the protein kinase Swe1p that regulates the G2/M transition. J Biol Chem 285(14):10397–10407
14. Chen S, Tarsio M et al (2008) Cardiolipin mediates cross-talk between mitochondria and the vacuole. Mol Biol Cell 19(12):5047–5058
15. Chen XJ, Wang X et al (2005) Aconitase couples metabolic regulation to mitochondrial DNA maintenance. Science 307(5710):714–717
16. Collier JJ, Doan TT et al (2003) c-Myc is required for the glucose-mediated induction of metabolic enzyme genes. J Biol Chem 278(8):6588–6595
17. Cristina D, Cary M et al (2009) A regulated response to impaired respiration slows behavioral rates and increases lifespan in Caenorhabditis elegans. PLoS Genet 5(4):e1000450
18. D’Mello NP, Childress AM et al (1994) Cloning and characterization of LAG1, a longevity-assurance gene in yeast. J Biol Chem 269(22):15451–15459
19. Dejean L, Beauvoit B et al (2002) Activation of Ras cascade increases the mitochondrial enzyme content of respiratory competent yeast. Biochem Biophys Res Commun 293(5):1383–1388
20. Delsite RL, Rasmussen LJ et al (2003) Mitochondrial impairment is accompanied by impaired oxidative DNA repair in the nucleus. Mutagenesis 18(6):497–503
21. Dickson RC (2010) Roles for sphingolipids in Saccharomyces cerevisiae. Adv Exp Med Biol 688:217–231
22. Dillin A, Hsu AL et al (2002) Rates of behavior and aging specified by mitochondrial function during development. Science 298(5602):2398–2401
23. Dilova I, Aronova S et al (2004) Tor signaling and nutrient-based signals converge on Mks1p phosphorylation to regulate expression of Rtg1.Rtg3p-dependent target genes. J Biol Chem 279(45):46527–46535
24. Dilova I, Chen CY et al (2002) Mks1 in concert with TOR signaling negatively regulates RTG target gene expression in S. cerevisiae. Curr Biol 12(5):389–395
25. Egilmez NK, Jazwinski SM (1989) Evidence for the involvement of a cytoplasmic factor in the aging of the yeast Saccharomyces cerevisiae. J Bacteriol 171(1):37–42
26. Eisenberg T, Knauer H et al (2009) Induction of autophagy by spermidine promotes longevity. Nat Cell Biol 11(11):1305–1314
27. Eldakak A, Rancati G et al (2010) Asymmetrically inherited multidrug resistance transporters are recessive determinants in cellular replicative ageing. Nat Cell Biol 12(8):799–805
28. Epstein CB, Waddle JA et al (2001) Genome-wide responses to mitochondrial dysfunction. Mol Biol Cell 12(2):297–308
29. Forsberg H, Ljungdahl PO (2001) Sensors of extracellular nutrients in Saccharomyces cerevisiae. Curr Genet 40(2):91–109
30. Giannattasio S, Liu Z et al (2005) Retrograde response to mitochondrial dysfunction is separable from TOR1/2 regulation of retrograde gene expression. J Biol Chem 280(52):42528–42535
31. Guaragnella N, Butow RA (2003) ATO3 encoding a putative outward ammonium transporter is an RTG-independent retrograde responsive gene regulated by GCN4 and the Ssy1-Ptr3-Ssy5 amino acid sensor system. J Biol Chem 278(46):45882–45887
32. Guillas I, Kirchman PA et al (2001) C26-CoA-dependent ceramide synthesis of Saccharomyces cerevisiae is operated by Lag1p and Lac1p. EMBO J 20(11):2655–2665
33. Hallstrom TC, Moye-Rowley WS (2000) Multiple signals from dysfunctional mitochondria activate the pleiotropic drug resistance pathway in Saccharomyces cerevisiae. J Biol Chem 275(48):37347–37356
34. Heddi A, Lestienne P et al (1993) Mitochondrial DNA expression in mitochondrial myopathies and coordinated expression of nuclear genes involved in ATP production. J Biol Chem 268(16):12156–12163
35. Heeren G, Rinnerthaler M et al (2009) The mitochondrial ribosomal protein of the large subunit, Afo1p, determines cellular longevity through mitochondrial back-signaling via TOR1. Aging (Albany NY) 1(7):622–636
36. Hlavata L, Aguilaniu H et al (2003) The oncogenic RAS2(val19) mutation locks respiration, independently of PKA, in a mode prone to generate ROS. EMBO J 22(13):3337–3345
37. Huisinga KL, Pugh BF (2004) A genome-wide housekeeping role for TFIID and a highly regulated stress-related role for SAGA in Saccharomyces cerevisiae. Mol Cell 13(4):573–585
38. Jazwinski SM (1999) Molecular mechanisms of yeast longevity. Trends Microbiol 7(6):247–252
39. Jazwinski SM (2000) Metabolic control and gene dysregulation in yeast aging. Ann NY Acad Sci 908:21–30
40. Jazwinski SM (2003) Yeast longevity and aging. In: Osiewacz HD (ed) Aging of organisms. Kluwer, Dordrecht, pp 1–30
41. Jazwinski SM (2004) Yeast replicative life span – the mitochondrial connection. FEMS Yeast Res 5(2):119–125
42. Jazwinski SM (2005) The retrograde response links metabolism with stress responses, chromatin-dependent gene activation, and genome stability in yeast aging. Gene 354:22–27
43. Jia Y, Rothermel B et al (1997) A basic helix-loop-helix-leucine zipper transcription complex in yeast functions in a signaling pathway from mitochondria to the nucleus. Mol Cell Biol 17(3):1110–1117
44. Jiang JC, Jaruga E et al (2000) An intervention resembling caloric restriction prolongs life span and retards aging in yeast. FASEB J 14(14):2135–2137
45. Jiang JC, Kirchman PA et al (1998) Homologs of the yeast longevity gene LAG1 in Caenorhabditis elegans and human. Genome Res 8(12):1259–1272
46. Jiang JC, Kirchman PA et al (2004) Suppressor analysis points to the subtle role of the LAG1 ceramide synthase gene in determining yeast longevity. Exp Gerontol 39(7):999–1009
47. Journo D, Mor A et al (2009) Aup1-mediated regulation of Rtg3 during mitophagy. J Biol Chem 284(51):35885–35895
48. Kaeberlein M, Powers RW 3rd et al (2005) Regulation of yeast replicative life span by TOR and Sch9 in response to nutrients. Science 310(5751):1193–1196
49. Kamada Y, Fujioka Y et al (2005) Tor2 directly phosphorylates the AGC kinase Ypk2 to regulate actin polarization. Mol Cell Biol 25(16):7239–7248
50. Kamada Y, Yoshino K et al (2010) Tor directly controls the Atg1 kinase complex to regulate autophagy. Mol Cell Biol 30(4):1049–1058
51. Kanki T, Wang K et al (2009) A genomic screen for yeast mutants defective in selective mitochondria autophagy. Mol Biol Cell 20(22):4730–4738
52. Kennedy BK, Austriaco NR et al (1995) Mutation in the silencing gene SIR4 can delay aging in S. cerevisiae. Cell 80(3):485–496
53. Kim S, Benguria A et al (1999) Modulation of life-span by histone deacetylase genes in Saccharomyces cerevisiae. Mol Biol Cell 10(10):3125–3136
54. Kim S, Ohkuni K et al (2004) The histone acetyltransferase GCN5 modulates the retrograde response and genome stability determining yeast longevity. Biogerontology 5(5):305–316
55. Kirchman PA, Kim S et al (1999) Interorganelle signaling is a determinant of longevity in Saccharomyces cerevisiae. Genetics 152(1):179–190
56. Kirchman PA, Miceli MV et al (2003) Prohibitins and Ras2 protein cooperate in the maintenance of mitochondrial function during yeast aging. Acta Biochim Pol 50(4):1039–1056
57. Kissova I, Deffieu M et al (2004) Uth1p is involved in the autophagic degradation of mitochondria. J Biol Chem 279(37):39068–39074
58. Kissova I, Salin B et al (2007) Selective and non-selective autophagic degradation of mitochondria in yeast. Autophagy 3(4):329–336
59. Klinger H, Rinnerthaler M et al (2010) Quantitation of (a)symmetric inheritance of functional and of oxidatively damaged mitochondrial aconitase in the cell division of old yeast mother cells. Exp Gerontol 45(7–8):533–542
60. Kolaczkowski M, Kolaczkowska A et al (2004) Differential regulation of ceramide synthase components LAC1 and LAG1 in Saccharomyces cerevisiae. Eukaryot Cell 3(4):880–892
61. Komeili A, Wedaman KP et al (2000) Mechanism of metabolic control. Target of rapamycin signaling links nitrogen quality to the activity of the Rtg1 and Rtg3 transcription factors. J Cell Biol 151(4):863–878
62. Koonin EV (1994) Yeast protein controlling inter-organelle communication is related to bacterial phosphatases containing the Hsp 70-type ATP-binding domain. Trends Biochem Sci 19(4):156–157
63. Kornmann B, Walter P (2010) ERMES-mediated ER-mitochondria contacts: molecular hubs for the regulation of mitochondrial biology. J Cell Sci 123(Pt 9):1389–1393
64. Lai CY, Jaruga E et al (2002) A mutation in the ATP2 gene abrogates the age asymmetry between mother and daughter cells of the yeast Saccharomyces cerevisiae. Genetics 162(1):73–87
65. Laun P, Pichova A et al (2001) Aged mother cells of Saccharomyces cerevisiae show markers of oxidative stress and apoptosis. Mol Microbiol 39(5):1166–1173
66. Lee SS, Lee RY et al (2003) A systematic RNAi screen identifies a critical role for mitochondria in C. elegans longevity. Nat Genet 33(1):40–48
67. Liao X, Butow RA (1993) RTG1 and RTG2: two yeast genes required for a novel path of communication from mitochondria to the nucleus. Cell 72(1):61–71
68. Liao XS, Small WC et al (1991) Intramitochondrial functions regulate nonmitochondrial citrate synthase (CIT2) expression in Saccharomyces cerevisiae. Mol Cell Biol 11(1):38–46
69. Liu Z, Butow RA (1999) A transcriptional switch in the expression of yeast tricarboxylic acid cycle genes in response to a reduction or loss of respiratory function. Mol Cell Biol 19(10):6720–6728
70. Liu Z, Butow RA (2006) Mitochondrial retrograde signaling. Annu Rev Genet 40:159–185
71. Liu Z, Sekito T et al (2001) RTG-dependent mitochondria to nucleus signaling is negatively regulated by the seven WD-repeat protein Lst8p. EMBO J 20(24):7209–7219
72. Liu Z, Sekito T et al (2003) Retrograde signaling is regulated by the dynamic interaction between Rtg2p and Mks1p. Mol Cell 12(2):401–411
73. Liu Z, Spirek M et al (2005) A novel degron-mediated degradation of the RTG pathway regulator, Mks1p, by SCFGrr1. Mol Biol Cell 16(10):4893–4904
74. Loewith R, Jacinto E et al (2002) Two TOR complexes, only one of which is rapamycin sensitive, have distinct roles in cell growth control. Mol Cell 10(3):457–468
75. Massari ME, Grant PA et al (1999) A conserved motif present in a class of helix-loop-helix proteins activates transcription by direct recruitment of the SAGA complex. Mol Cell 4(1):63–73
76. Matsuura A, Anraku Y (1993) Characterization of the MKS1 gene, a new negative regulator of the Ras-cyclic AMP pathway in Saccharomyces cerevisiae. Mol Gen Genet 238(1–2):6–16
77. McMurray MA, Gottschling DE (2003) An age-induced switch to a hyper-recombinational state. Science 301(5641):1908–1911
78. Miceli MV, Jazwinski SM (2005) Common and cell type-specific responses of human cells to mitochondrial dysfunction. Exp Cell Res 302(2):270–280
79. Mortimer RK, Johnston JR (1959) Life span of individual yeast cells. Nature 183:1751–1752
80. Mosch HU, Roberts RL et al (1996) Ras2 signals via the Cdc42/Ste20/mitogen-activated protein kinase module to induce filamentous growth in Saccharomyces cerevisiae. Proc Natl Acad Sci USA 93(11):5352–5356
81. Moye-Rowley WS (2005) Retrograde regulation of multidrug resistance in Saccharomyces cerevisiae. Gene 354:15–21
82. Nijtmans LG, de Jong L et al (2000) Prohibitins act as a membrane-bound chaperone for the stabilization of mitochondrial proteins. EMBO J 19(11):2444–2451
83. Palkova Z, Devaux F et al (2002) Ammonia pulses and metabolic oscillations guide yeast colony development. Mol Biol Cell 13(11):3901–3914
84. Parikh VS, Morgan MM et al (1987) The mitochondrial genotype can influence nuclear gene expression in yeast. Science 235(4788):576–580
85. Passos JF, Saretzki G et al (2007) Mitochondrial dysfunction accounts for the stochastic heterogeneity in telomere-dependent senescence. PLoS Biol 5(5):e110
86. Pichova A, Vondrakova D et al (1997) Mutants in the Saccharomyces cerevisiae RAS2 gene influence life span, cytoskeleton, and regulation of mitosis. Can J Microbiol 43(8):774–781
87. Piper PW, Jones GW et al (2002) The shortened replicative life span of prohibitin mutants of yeast appears to be due to defective mitochondrial segregation in old mother cells. Aging Cell 1(2):149–157
88. Poyton RO, McEwen JE (1996) Crosstalk between nuclear and mitochondrial genomes. Annu Rev Biochem 65:563–607
89. Pray-Grant MG, Schieltz D et al (2002) The novel SLIK histone acetyltransferase complex functions in the yeast retrograde response pathway. Mol Cell Biol 22(24):8774–8786
90. Rasmussen AK, Chatterjee A et al (2003) Mitochondria-mediated nuclear mutator phenotype in Saccharomyces cerevisiae. Nucl Acid Res 31(14):3909–3917
91. Reinke A, Anderson S et al (2004) TOR complex 1 includes a novel component, Tco89p (YPL180w), and cooperates with Ssd1p to maintain cellular integrity in Saccharomyces cerevisiae. J Biol Chem 279(15):14752–14762
92. Roberg KJ, Bickel S et al (1997) Control of amino acid permease sorting in the late secretory pathway of Saccharomyces cerevisiae by SEC13, LST4, LST7 and LST8. Genetics 147(4):1569–1584
93. Rothermel BA, Shyjan AW et al (1995) Transactivation by Rtg1p, a basic helix-loop-helix protein that functions in communication between mitochondria and the nucleus in yeast. J Biol Chem 270(49):29476–29482
94. Rothermel BA, Thornton JL et al (1997) Rtg3p, a basic helix-loop-helix/leucine zipper protein that functions in mitochondrial-induced changes in gene expression, contains independent activation domains. J Biol Chem 272(32):19801–19807
95. Scheckhuber CQ, Erjavec N et al (2007) Reducing mitochondrial fission results in increased life span and fitness of two fungal ageing models. Nat Cell Biol 9(1):99–105
96. Schorling S, Vallee B et al (2001) Lag1p and Lac1p are essential for the Acyl-CoA-dependent ceramide synthase reaction in Saccharomyces cerevisae. Mol Biol Cell 12(11):3417–3427
97. Sekito T, Liu Z et al (2002) RTG-dependent mitochondria-to-nucleus signaling is regulated by MKS1 and is linked to formation of yeast prion [URE3]. Mol Biol Cell 13(3):795–804
98. Sekito T, J et al (2000) Mitochondria-to-nuclear signaling is regulated by the subcellular localization of the transcription factors Rtg1p and Rtg3p. Mol Biol Cell 11(6):2103–2115
99. Small WC, Brodeur RD et al (1995) Enzymatic and metabolic studies on retrograde regulation mutants of yeast. Biochemistry 34(16):5569–5576
100. Spedale G, Mischerikow N et al (2010) Identification of Pep4p as the protease responsible for formation of the SAGA-related SLIK protein complex. J Biol Chem 285(30):22793–22799
101. Srinivasan V, Kriete A et al (2010) Comparing the yeast retrograde response and NF-kappaB stress responses: implications for aging. Aging Cell 9(6):933–941
102. Steffen KK, MacKay VL et al (2008) Yeast life span extension by depletion of 60 s ribosomal subunits is mediated by Gcn4. Cell 133(2):292–302
103. Stockl P, Zankl C et al (2007) Partial uncoupling of oxidative phosphorylation induces premature senescence in human fibroblasts and yeast mother cells. Free Radic Biol Med 43(6):947–958
104. Sun J, Kale SP et al (1994) Divergent roles of RAS1 and RAS2 in yeast longevity. J Biol Chem 269(28):18638–18645
105. Tate JJ, Cox KH et al (2002) Mks1p is required for negative regulation of retrograde gene expression in Saccharomyces cerevisiae but does not affect nitrogen catabolite repression-sensitive gene expression. J Biol Chem 277(23):20477–20482
106. Thevissen K, Yen WL et al (2010) Skn1 and Ipt1 negatively regulate autophagy in Saccharomyces cerevisiae. FEMS Microbiol Lett 303(2):163–168
107. Traven A, Wong JM et al (2001) Interorganellar communication. Altered nuclear gene expression profiles in a yeast mitochondrial dna mutant. J Biol Chem 276(6):4020–4027
108. van Heusden GP, Steensma HY (2001) 14-3-3 Proteins are essential for regulation of RTG3-dependent transcription in Saccharomyces cerevisiae. Yeast 18(16):1479–1491
109. Vanfleteren JR, De Vreese A (1995) The gerontogenes age-1 and daf-2 determine metabolic rate potential in aging Caenorhabditis elegans. FASEB J 9(13):1355–1361
110. Veatch JR, McMurray MA et al (2009) Mitochondrial dysfunction leads to nuclear genome instability via an iron-sulfur cluster defect. Cell 137(7):1247–1258
111. Wang J, Jiang JC et al (2010) Gene regulatory changes in yeast during life extension by nutrient limitation. Exp Gerontol 45(7–8):621–631
112. Wang X, Zuo X et al (2008) Reduced cytosolic protein synthesis suppresses mitochondrial degeneration. Nat Cell Biol 10(9):1090–1097
113. Wedaman KP, Reinke A et al (2003) Tor kinases are in distinct membrane-associated protein complexes in Saccharomyces cerevisiae. Mol Biol Cell 14(3):1204–1220
114. Woo DK, Poyton RO (2009) The absence of a mitochondrial genome in rho0 yeast cells extends lifespan independently of retrograde regulation. Exp Gerontol 44(6–7):390–397
115. Wullschleger S, Loewith R et al (2006) TOR signaling in growth and metabolism. Cell 124(3):471–484