메뉴 건너뛰기




Volumn 12, Issue 6, 2015, Pages 889-900

Nebulizers for drug delivery to the lungs

Author keywords

Droplet formation; Droplet sizing; Inhalation drug delivery; Jet nebulizers; Nebulizers; Respiratory drug delivery; Vibrating membrane; Vibrating mesh

Indexed keywords

BRONCHODILATING AGENT; SALBUTAMOL SULFATE; AEROSOL;

EID: 84929742263     PISSN: 17425247     EISSN: 17447593     Source Type: Journal    
DOI: 10.1517/17425247.2015.995087     Document Type: Review
Times cited : (138)

References (104)
  • 2
    • 84861116554 scopus 로고    scopus 로고
    • Nebulized anticoagulants for acute lung injury -A systematic review of preclinical and clinical investigations
    • Tuinman PR, Dixon B, Levi M, et al. Nebulized anticoagulants for acute lung injury -A systematic review of preclinical and clinical investigations. Crit Care 2012;16:R70
    • (2012) Crit Care , vol.16 , pp. R70
    • Tuinman, P.R.1    Dixon, B.2    Levi, M.3
  • 3
    • 84870255889 scopus 로고    scopus 로고
    • Aerosolized antibiotics for ventilatorassociated pneumonia lessons from experimental studies
    • Rouby JJ, Bouhemad B, Monsel A, et al. Aerosolized antibiotics for ventilatorassociated pneumonia lessons from experimental studies. Anesthesiology 2012;117:1364-80
    • (2012) Anesthesiology , vol.117 , pp. 1364-1380
    • Rouby, J.J.1    Bouhemad, B.2    Monsel, A.3
  • 4
    • 84922529381 scopus 로고    scopus 로고
    • Nebulized medications for the treatment of dyspnea: A literature review
    • Boyden JY, Connor SR, Otolorin L, et al. Nebulized medications for the treatment of dyspnea: A literature review. J Aerosol Med Pulm Drug Deliv 2014. doi:10.1089/jamp.2014.1136
    • (2014) J Aerosol Med Pulm Drug Deliv
    • Boyden, J.Y.1    Connor, S.R.2    Otolorin, L.3
  • 5
    • 84888354291 scopus 로고    scopus 로고
    • Holding chambers spacers) versus nebulisers for beta-Agonist treatment of acute asthma
    • Cates CJ, Welsh EJ, Rowe BH. Holding chambers (spacers) versus nebulisers for beta-Agonist treatment of acute asthma. Cochrane Database Syst Rev 2013;9:CD000052
    • (2013) Cochrane Database Syst Rev , vol.9 , pp. CD000052
    • Cates, C.J.1    Welsh, E.J.2    Rowe, B.H.3
  • 6
    • 64549117379 scopus 로고    scopus 로고
    • Systemic treatment by inhalation of macromolecules -principles, problems, and examples
    • Siekmeier R, Scheuch G. Systemic treatment by inhalation of macromolecules -principles, problems, and examples. J Physiol Pharmacol 2008;59:53-79
    • (2008) J Physiol Pharmacol , vol.59 , pp. 53-79
    • Siekmeier, R.1    Scheuch, G.2
  • 7
    • 84888139291 scopus 로고    scopus 로고
    • Pharmaceutical aerosol sprays for drug delivery to the lungs
    • Ashgriz N editor Springer MA, USA
    • Finlay WH. Pharmaceutical aerosol sprays for drug delivery to the lungs. In: Ashgriz N, editor. Hanbook of atomization and sprays: theory and applications. Springer; MA, USA: 2011. p. 899-908
    • (2011) Hanbook of Atomization and Sprays: Theory and Applications , pp. 899-908
    • Finlay, W.H.1
  • 9
    • 21344459885 scopus 로고    scopus 로고
    • Effect of jet nebulization on DNA: Identifying the dominant degradation mechanism and mitigation methods
    • Lentz YK, Worden LR, Anchordoquy TJ, Lengsfeld CS. Effect of jet nebulization on DNA: identifying the dominant degradation mechanism and mitigation methods. J Aerosol Sci 2005;36:973-90
    • (2005) J Aerosol Sci , vol.36 , pp. 973-990
    • Lentz, Y.K.1    Worden, L.R.2    Anchordoquy, T.J.3    Lengsfeld, C.S.4
  • 10
    • 84944891495 scopus 로고    scopus 로고
    • Protein stability in pulmonary drug delivery via nebulization
    • Hertel SP, Winter G, Friess W. Protein stability in pulmonary drug delivery via nebulization. Adv Drug Deliv Rev 2014. doi:10.1016/j.addr.2014.10.003
    • (2014) Adv Drug Deliv Rev
    • Hertel, S.P.1    Winter, G.2    Friess, W.3
  • 11
    • 78349308280 scopus 로고    scopus 로고
    • Stabilizing protein formulations during air-jet nebulization
    • Albasarah YY, Somavarapu S, Taylor KM. Stabilizing protein formulations during air-jet nebulization. Int J Pharm 2010;402:140-5
    • (2010) Int J Pharm , vol.402 , pp. 140-145
    • Albasarah, Y.Y.1    Somavarapu, S.2    Taylor, K.M.3
  • 12
    • 84892934085 scopus 로고    scopus 로고
    • Comparison of numerical simulations to experiments for atomization in a jet nebulizer
    • Lelong N, Vecellio L, de Gelicourt YS, et al. Comparison of numerical simulations to experiments for atomization in a jet nebulizer. PLoS One 2013;8:e78659
    • (2013) PLoS One , vol.8 , pp. e78659
    • Lelong, N.1    Vecellio, L.2    De Gelicourt, Y.S.3
  • 13
    • 0031347332 scopus 로고    scopus 로고
    • American Society of Mechanical Engineers Fluids Engineering Division (Publication) FED. Seventh Intl Conference on Liquid Atomization (ICLASS -97), Seoul, Korea
    • Corcoran TE, Mansour A, Chigier N. Medical atomization design for inhalation therapy. American Society of Mechanical Engineers, Fluids Engineering Division (Publication) FED. Seventh Intl Conference on Liquid Atomization (ICLASS -97), Seoul, Korea 1997;244:255-63
    • (1997) Medical Atomization Design for Inhalation Therapy , vol.244 , pp. 255-263
    • Corcoran, T.E.1    Mansour, A.2    Chigier, N.3
  • 14
    • 84881539706 scopus 로고    scopus 로고
    • Liposomal formulations for inhalation
    • Cipolla D, Gonda I, Chan HK. Liposomal formulations for inhalation. Ther Deliv 2013;4:1047-72
    • (2013) Ther Deliv , vol.4 , pp. 1047-1072
    • Cipolla, D.1    Gonda, I.2    Chan, H.K.3
  • 16
    • 84891539394 scopus 로고    scopus 로고
    • The effects of suspension particle size on the performance of air-jet, ultrasonic and vibrating-mesh nebulisers
    • Najlah M, Parveen I, Alhnan MA, et al. The effects of suspension particle size on the performance of air-jet, ultrasonic and vibrating-mesh nebulisers. Int J Pharm 2014;461:234-41
    • (2014) Int J Pharm , vol.461 , pp. 234-241
    • Najlah, M.1    Parveen, I.2    Alhnan, M.A.3
  • 17
    • 0031389997 scopus 로고    scopus 로고
    • Predicting regional lung dosages of a nebulized suspension: Pulmicort budesonide)
    • Finlay WH, Stapleton KW, Zuberbuhler P. Predicting regional lung dosages of a nebulized suspension: pulmicort (budesonide). Particul Sci Technol 1997;15:243-51
    • (1997) Particul Sci Technol , vol.15 , pp. 243-251
    • Finlay, W.H.1    Stapleton, K.W.2    Zuberbuhler, P.3
  • 18
    • 77952688985 scopus 로고    scopus 로고
    • Ultrasonic nebulization platforms for pulmonary drug delivery
    • Yeo LY, Friend JR, McIntosh MP, et al. Ultrasonic nebulization platforms for pulmonary drug delivery. Expert Opin Drug Deliv 2010;7:663-79
    • (2010) Expert Opin Drug Deliv , vol.7 , pp. 663-679
    • Yeo, L.Y.1    Friend, J.R.2    McIntosh, M.P.3
  • 19
    • 0029586446 scopus 로고
    • Nebulization of fluids of different physicochemical properties with air-jet and ultrasonic nebulizers
    • Mccallion ON, Taylor KM, Thomas M, Taylor AJ. Nebulization of fluids of different physicochemical properties with air-jet and ultrasonic nebulizers. Pharm Res 1995;12:1682-8
    • (1995) Pharm Res , vol.12 , pp. 1682-1688
    • McCallion, O.N.1    Taylor, K.M.2    Thomas, M.3    Taylor, A.J.4
  • 20
    • 0025290635 scopus 로고
    • Droplets produced by medical nebulizers -some factors affecting their size and solute concentration
    • Phipps PR, Gonda I. Droplets produced by medical nebulizers -some factors affecting their size and solute concentration. Chest 1990;97:1327-32
    • (1990) Chest , vol.97 , pp. 1327-1332
    • Phipps, P.R.1    Gonda, I.2
  • 21
    • 0028118736 scopus 로고
    • Assessment of aerosol delivery systems for recombinant human deoxyribonuclease
    • Cipolla D, Clark AR, Chan HK, et al. Assessment of aerosol delivery systems for recombinant human deoxyribonuclease. STP Pharma Sci 1994;4:50-62
    • (1994) STP Pharma Sci , vol.4 , pp. 50-62
    • Cipolla, D.1    Clark, A.R.2    Chan, H.K.3
  • 22
    • 84901692006 scopus 로고    scopus 로고
    • Effective pulmonary delivery of an aerosolized plasmid DNA vaccine via surface acoustic wave nebulization
    • Rajapaksa AE, Ho JJ, Qi A, et al. Effective pulmonary delivery of an aerosolized plasmid DNA vaccine via surface acoustic wave nebulization. Respir Res 2014;15:60
    • (2014) Respir Res , vol.15 , pp. 60
    • Rajapaksa, A.E.1    Ho, J.J.2    Qi, A.3
  • 23
    • 69549124208 scopus 로고    scopus 로고
    • Miniature inhalation therapy platform using surface acoustic wave microfluidic atomization
    • Qi A, Friend JR, Yeo LY, et al. Miniature inhalation therapy platform using surface acoustic wave microfluidic atomization. Lab Chip 2009;9:2184-93
    • (2009) Lab Chip , vol.9 , pp. 2184-2193
    • Qi, A.1    Friend, J.R.2    Yeo, L.Y.3
  • 24
    • 23644458446 scopus 로고    scopus 로고
    • The customised electronic nebuliser: A new category of liquid aerosol drug delivery systems
    • Knoch M, Keller M. The customised electronic nebuliser: A new category of liquid aerosol drug delivery systems. Expert Opin Drug Deliv 2005;2:377-90
    • (2005) Expert Opin Drug Deliv , vol.2 , pp. 377-390
    • Knoch, M.1    Keller, M.2
  • 25
    • 34250874038 scopus 로고    scopus 로고
    • The omron microair vibrating mesh technology nebuliser, a 21st century approach to inhalation therapy
    • Newman S, Gee-Turner A. The omron microair vibrating mesh technology nebuliser, a 21st century approach to inhalation therapy. J Appl Ther Res 2005;5:29-33
    • (2005) J Appl Ther Res , vol.5 , pp. 29-33
    • Newman, S.1    Gee-Turner, A.2
  • 26
    • 0031426144 scopus 로고    scopus 로고
    • Morphine pharmacokinetics after pulmonary administration from a novel aerosol delivery system
    • Ward ME, Woodhouse A, Mather LE, et al. Morphine pharmacokinetics after pulmonary administration from a novel aerosol delivery system. Clin Pharmacol Ther 1997;62:596-609
    • (1997) Clin Pharmacol Ther , vol.62 , pp. 596-609
    • Ward, M.E.1    Woodhouse, A.2    Mather, L.E.3
  • 29
    • 0031646978 scopus 로고    scopus 로고
    • Estimating the type of hygroscopic behavior exhibited by aqueous droplets
    • Finlay WH. Estimating the type of hygroscopic behavior exhibited by aqueous droplets. J Aerosol Med 1998;11:221-9
    • (1998) J Aerosol Med , vol.11 , pp. 221-229
    • Finlay, W.H.1
  • 30
    • 33845586500 scopus 로고    scopus 로고
    • Hygroscopic growth and evaporation in an aerosol with boundary heat and mass transfer
    • Saleh R, Shihadeh A. Hygroscopic growth and evaporation in an aerosol with boundary heat and mass transfer. J Aerosol Sci 2007;38:1-16
    • (2007) J Aerosol Sci , vol.38 , pp. 1-16
    • Saleh, R.1    Shihadeh, A.2
  • 31
    • 0032890101 scopus 로고    scopus 로고
    • Undersizing of droplets from a vented nebulizer caused by aerosol heating during transit through an Anderson impactor
    • Finlay WH, Stapleton KW. Undersizing of droplets from a vented nebulizer caused by aerosol heating during transit through an Anderson impactor. J Aerosol Sci 1999;30:105-9
    • (1999) J Aerosol Sci , vol.30 , pp. 105-109
    • Finlay, W.H.1    Stapleton, K.W.2
  • 32
    • 45549084538 scopus 로고    scopus 로고
    • Cooling the NGI -An approach to size a nebulised aerosol more accurately
    • Dennis J, Berg E, Sandell D, et al. Cooling the NGI -An approach to size a nebulised aerosol more accurately. Pharmeur Sci Notes 2008;2008:27-30
    • (2008) Pharmeur Sci Notes , vol.2008 , pp. 27-30
    • Dennis, J.1    Berg, E.2    Sandell, D.3
  • 33
    • 0034492461 scopus 로고    scopus 로고
    • Comparison of nebulized particle size distribution with malvern laser diffraction analyzer versus andersen cascade impactor and low-flow marple personal cascade impactor
    • Kwong WT, Ho SL, Coates AL. Comparison of nebulized particle size distribution with malvern laser diffraction analyzer versus andersen cascade impactor and low-flow marple personal cascade impactor. J Aerosol Med 2000;13:303-14
    • (2000) J Aerosol Med , vol.13 , pp. 303-314
    • Kwong, W.T.1    Ho, S.L.2    Coates, A.L.3
  • 34
    • 1642555982 scopus 로고    scopus 로고
    • Effect of tubing deposition, breathing pattern, and temperature on aerosol mass distribution measured by cascade impactor
    • Gurses BK, Smaldone GC. Effect of tubing deposition, breathing pattern, and temperature on aerosol mass distribution measured by cascade impactor. J Aerosol Med 2003;16:387-94
    • (2003) J Aerosol Med , vol.16 , pp. 387-394
    • Gurses, B.K.1    Smaldone, G.C.2
  • 35
    • 0033990466 scopus 로고    scopus 로고
    • Optical measurement of nebulizer sprays: A quantitative comparison of diffraction, phase doppler interferometry, and time of flight techniques
    • Corcoran TE, Hitron R, Humphrey W, Chigier N. Optical measurement of nebulizer sprays: A quantitative comparison of diffraction, phase doppler interferometry, and time of flight techniques. J Aerosol Sci 2000;31:35-50
    • (2000) J Aerosol Sci , vol.31 , pp. 35-50
    • Corcoran, T.E.1    Hitron, R.2    Humphrey, W.3    Chigier, N.4
  • 36
    • 0028673374 scopus 로고
    • An in vitro method for measuring regional dosages delivered by jet nebulizers
    • Stapleton KW, Finlay WH, Zuberbuhler P. An in vitro method for measuring regional dosages delivered by jet nebulizers. J Aerosol Med 1994;7:325-44
    • (1994) J Aerosol Med , vol.7 , pp. 325-344
    • Stapleton, K.W.1    Finlay, W.H.2    Zuberbuhler, P.3
  • 37
    • 0028954464 scopus 로고
    • The use of laser diffraction for the evaluation of the aerosol clouds generated by medical nebulizers
    • Clark AR. The use of laser diffraction for the evaluation of the aerosol clouds generated by medical nebulizers. Int J Pharm 1995;115:69-78
    • (1995) Int J Pharm , vol.115 , pp. 69-78
    • Clark, A.R.1
  • 38
    • 84897086060 scopus 로고    scopus 로고
    • Comparison of laser diffraction measurements by mastersizer X and spraytec to characterize droplet size distribution of medical liquid aerosols
    • Lelong N, Junqua-Moullet A, Diot P, Vecellio L. Comparison of laser diffraction measurements by mastersizer X and spraytec to characterize droplet size distribution of medical liquid aerosols. J Aerosol Med 2014;27:94-102
    • (2014) J Aerosol Med , vol.27 , pp. 94-102
    • Lelong, N.1    Junqua-Moullet, A.2    Diot, P.3    Vecellio, L.4
  • 39
    • 84923173210 scopus 로고    scopus 로고
    • Nasal versus oral aerosol delivery to the "lungs" in infants and toddlers
    • Amirav I, Borojeni AA, Halamish A, et al. Nasal versus oral aerosol delivery to the "lungs" in infants and toddlers. Pediatr Pulmonol 2014. doi:10.1002/ppul.22999
    • (2014) Pediatr Pulmonol
    • Amirav, I.1    Borojeni, A.A.2    Halamish, A.3
  • 40
    • 0034938148 scopus 로고    scopus 로고
    • Effective once-daily administration of budesonide inhalation suspension by nebulizer with facemasks or mouthpieces for persistent asthma in infants and young children
    • Georgitis JW, McWilliams B, Cruz-Rivera M, et al. Effective once-daily administration of budesonide inhalation suspension by nebulizer with facemasks or mouthpieces for persistent asthma in infants and young children. Pediatr Asthma Allergy Immunol 2001;15:3-13
    • (2001) Pediatr Asthma Allergy Immunol , vol.15 , pp. 3-13
    • Georgitis, J.W.1    McWilliams, B.2    Cruz-Rivera, M.3
  • 41
    • 0036095368 scopus 로고    scopus 로고
    • Mouthpiece versus facemask for delivery of nebulized salbutamol in exacerbated childhood asthma
    • Kishida M, Suzuki I, Kabayama H, et al. Mouthpiece versus facemask for delivery of nebulized salbutamol in exacerbated childhood asthma. J Asthma 2002;39:337-9
    • (2002) J Asthma , vol.39 , pp. 337-339
    • Kishida, M.1    Suzuki, I.2    Kabayama, H.3
  • 42
    • 0033836983 scopus 로고    scopus 로고
    • Comparable efficacy of administration with face mask or mouthpiece of nebulized budesonide inhalation suspension for infants and young children with persistent asthma
    • Mellon M, Leflein J, Walton-Bowen K, et al. Comparable efficacy of administration with face mask or mouthpiece of nebulized budesonide inhalation suspension for infants and young children with persistent asthma. Am J Respir Crit Care Med 2000;162:593-8
    • (2000) Am J Respir Crit Care Med , vol.162 , pp. 593-598
    • Mellon, M.1    Leflein, J.2    Walton-Bowen, K.3
  • 43
    • 0034895786 scopus 로고    scopus 로고
    • European respiratory society guidelines on the use of nebulisers
    • Boe J, Dennis JH, ODriscoll BR. European respiratory society guidelines on the use of nebulisers. Eur Respir J 2001;18:228-42
    • (2001) Eur Respir J , vol.18 , pp. 228-242
    • Boe, J.1    Dennis, J.H.2    Odriscoll, B.R.3
  • 44
    • 39449093951 scopus 로고    scopus 로고
    • Facial and ocular deposition of nebulized budesonide -Effects of face mask design
    • Harris KW, Smaldone GC. Facial and ocular deposition of nebulized budesonide -Effects of face mask design. Chest 2008;133:482-8
    • (2008) Chest , vol.133 , pp. 482-488
    • Harris, K.W.1    Smaldone, G.C.2
  • 46
    • 0043033237 scopus 로고    scopus 로고
    • Nebuliser hood compared to mask in wheezy infants: Aerosol therapy without tears!
    • Amirav I, Balanov I, Gorenberg M, et al. Nebuliser hood compared to mask in wheezy infants: Aerosol therapy without tears!. Arch Dis Child 2003;88:719-23
    • (2003) Arch Dis Child , vol.88 , pp. 719-723
    • Amirav, I.1    Balanov, I.2    Gorenberg, M.3
  • 47
    • 27744605707 scopus 로고    scopus 로고
    • Aerosol delivery in respiratory syncytial virus bronchiolitis hood or face mask?
    • Amirav I, Oron A, Tal G, et al. Aerosol delivery in respiratory syncytial virus bronchiolitis: hood or face mask? J Pediatr 2005;147:627-31
    • (2005) J Pediatr , vol.147 , pp. 627-631
    • Amirav, I.1    Oron, A.2    Tal, G.3
  • 48
    • 84901710758 scopus 로고    scopus 로고
    • Hood nebulization: Effects of head direction and breathing mode on particle inhalability and deposition in a 7-month-old infant model
    • Kim J, Xi J, Si X, et al. Hood nebulization: effects of head direction and breathing mode on particle inhalability and deposition in a 7-month-old infant model. J Aerosol Med Pulm Drug Deliv 2014;27:209-18
    • (2014) J Aerosol Med Pulm Drug Deliv , vol.27 , pp. 209-218
    • Kim, J.1    Xi, J.2    Si, X.3
  • 49
    • 31344435101 scopus 로고    scopus 로고
    • Hood versus mask nebulization in infants with evolving bronchopulmonary dysplasia in the neonatal intensive care unit
    • Kugelman A, Amirav I, Mor F, et al. Hood versus mask nebulization in infants with evolving bronchopulmonary dysplasia in the neonatal intensive care unit. J Perinatol 2006;26:31-6
    • (2006) J Perinatol , vol.26 , pp. 31-36
    • Kugelman, A.1    Amirav, I.2    Mor, F.3
  • 50
    • 0031836818 scopus 로고    scopus 로고
    • Variations in predicted regional lung deposition of salbutamol sulphate between 19 nebulizer types
    • Finlay WH, Stapleton KW, Zuberbuhler P. Variations in predicted regional lung deposition of salbutamol sulphate between 19 nebulizer types. J Aerosol Med 1998;11:65-80
    • (1998) J Aerosol Med , vol.11 , pp. 65-80
    • Finlay, W.H.1    Stapleton, K.W.2    Zuberbuhler, P.3
  • 51
    • 84929804280 scopus 로고    scopus 로고
    • Part 1: nebulizing systems and their components 52. ISO. Anaesthetic and respiratory equipment -Nebulizing systems and components
    • CEN. Respiratory therapy equipment -Part 1: nebulizing systems and their components 52. ISO. Anaesthetic and respiratory equipment -Nebulizing systems and components
    • CEN. Respiratory Therapy Equipment
  • 53
    • 0027529296 scopus 로고
    • Deposition in asthmatics of particles inhaled in air or in helium-oxygen
    • Anderson M, Svartengren M, Bylin G, et al. Deposition in asthmatics of particles inhaled in air or in helium-oxygen. Am Rev Respir Dis 1993;147:524-8
    • (1993) Am Rev Respir Dis , vol.147 , pp. 524-528
    • Anderson, M.1    Svartengren, M.2    Bylin, G.3
  • 54
    • 0141763844 scopus 로고    scopus 로고
    • Aerosol drug delivery using heliox and nebulizer reservoirs: Results from an MRI-based pediatric model
    • Corcoran TE, Shortall BP, Kim IK, et al. Aerosol drug delivery using heliox and nebulizer reservoirs: results from an MRI-based pediatric model. J Aerosol Med 2003;16:263-71
    • (2003) J Aerosol Med , vol.16 , pp. 263-271
    • Corcoran, T.E.1    Shortall, B.P.2    Kim, I.K.3
  • 55
    • 4644256226 scopus 로고    scopus 로고
    • Aerosol deposition in the human respiratory tract breathing air and 80:20 heliox
    • Darquenne C, Prisk GK. Aerosol deposition in the human respiratory tract breathing air and 80:20 heliox. J Aerosol Med 2004;17:278-85
    • (2004) J Aerosol Med , vol.17 , pp. 278-285
    • Darquenne, C.1    Prisk, G.K.2
  • 56
    • 84897106168 scopus 로고    scopus 로고
    • Using helium-oxygen to improve regional deposition of inhaled particles: Mechanical principles
    • Katz I, Pichelin M, Montesantos S, et al. Using helium-oxygen to improve regional deposition of inhaled particles: mechanical principles. J Aerosol Med Pulm Drug Deliv 2014;27:71-80
    • (2014) J Aerosol Med Pulm Drug Deliv , vol.27 , pp. 71-80
    • Katz, I.1    Pichelin, M.2    Montesantos, S.3
  • 57
    • 33747203797 scopus 로고    scopus 로고
    • Heliox-driven albuterol nebulization for asthma exacerbations: An overview
    • Kim IK, Saville AL, Sikes KL, Corcoran TE. Heliox-driven albuterol nebulization for asthma exacerbations: An overview. Respir Care 2006;51:613-18
    • (2006) Respir Care , vol.51 , pp. 613-618
    • Kim, I.K.1    Saville, A.L.2    Sikes, K.L.3    Corcoran, T.E.4
  • 58
    • 12244306501 scopus 로고    scopus 로고
    • Development of aerosol drug delivery with helium oxygen gas mixtures
    • Corcoran TE, Gamard S. Development of aerosol drug delivery with helium oxygen gas mixtures. J Aerosol Med 2004;17:299-309
    • (2004) J Aerosol Med , vol.17 , pp. 299-309
    • Corcoran, T.E.1    Gamard, S.2
  • 59
    • 33747180167 scopus 로고    scopus 로고
    • Opportunities and risks of using heliox in your clinical practice
    • Fink JB. Opportunities and risks of using heliox in your clinical practice. Respir Care 2006;51:651-60
    • (2006) Respir Care , vol.51 , pp. 651-660
    • Fink, J.B.1
  • 60
    • 78649904289 scopus 로고    scopus 로고
    • Laser diffraction characterization of droplet size distributions produced by vibrating mesh nebulization in air and a helium-oxygen mixture
    • Martin AR, Gleske J, Katz IM, et al. Laser diffraction characterization of droplet size distributions produced by vibrating mesh nebulization in air and a helium-oxygen mixture. J Aerosol Sci 2010;41:1159-66
    • (2010) J Aerosol Sci , vol.41 , pp. 1159-1166
    • Martin, A.R.1    Gleske, J.2    Katz, I.M.3
  • 61
    • 37549061382 scopus 로고    scopus 로고
    • The effects of Heliox on the output and particle-size distribution of salbutamol using jet and vibrating mesh nebulizers
    • OCallaghan C, White J, Jackson J, et al. The effects of Heliox on the output and particle-size distribution of salbutamol using jet and vibrating mesh nebulizers. J Aerosol Med 2007;20:434-44
    • (2007) J Aerosol Med , vol.20 , pp. 434-444
    • Ocallaghan, C.1    White, J.2    Jackson, J.3
  • 62
    • 84891666522 scopus 로고    scopus 로고
    • Metered dose inhalers versus nebulizers for aerosol bronchodilator delivery for adult patients receiving mechanical ventilation in critical care units
    • Holland A, Smith F, Penny K, et al. Metered dose inhalers versus nebulizers for aerosol bronchodilator delivery for adult patients receiving mechanical ventilation in critical care units. Cochrane Database Syst Rev 2013;6:CD008863
    • (2013) Cochrane Database Syst Rev , vol.6 , pp. CD008863
    • Holland, A.1    Smith, F.2    Penny, K.3
  • 63
    • 84903151026 scopus 로고    scopus 로고
    • A randomized double-blind placebo-controlled dose-escalation phase 1 study of aerosolized amikacin and fosfomycin delivered via the pari investigational eflow inline nebulizer system in mechanically ventilated patients
    • Montgomery AB, Vallance S, Abuan T, et al. A randomized double-blind placebo-controlled dose-escalation phase 1 study of aerosolized amikacin and fosfomycin delivered via the pari investigational eflow inline nebulizer system in mechanically ventilated patients. J Aerosol Med Pulm Drug Deliv 2014;27(6):441-48
    • (2014) J Aerosol Med Pulm Drug Deliv , vol.27 , Issue.6 , pp. 441-448
    • Montgomery, A.B.1    Vallance, S.2    Abuan, T.3
  • 64
    • 84870241714 scopus 로고    scopus 로고
    • Efficacy of high-dose nebulized colistin in ventilatorassociated pneumonia caused by multidrug-resistant pseudomonas aeruginosa and acinetobacter baumannii
    • Lu Q, Luo R, Bodin L, et al. Efficacy of high-dose nebulized colistin in ventilatorassociated pneumonia caused by multidrug-resistant pseudomonas aeruginosa and acinetobacter baumannii. Anesthesiology 2012;117:1335-47
    • (2012) Anesthesiology , vol.117 , pp. 1335-1347
    • Lu, Q.1    Luo, R.2    Bodin, L.3
  • 65
    • 80155142495 scopus 로고    scopus 로고
    • Aerosolized antibiotics for treating hospital-Acquired and ventilatorassociated pneumonia
    • Wood G. Aerosolized antibiotics for treating hospital-Acquired and ventilatorassociated pneumonia. Expert Rev Anti Infect Ther 2011;9:993-1000
    • (2011) Expert Rev Anti Infect Ther , vol.9 , pp. 993-1000
    • Wood, G.1
  • 66
    • 82455199209 scopus 로고    scopus 로고
    • Inhaled antibiotic therapy for ventilator-Associated tracheobronchitis and ventilator-Associated pneumonia: An update
    • Abu-Salah T, Dhand R. Inhaled antibiotic therapy for ventilator-Associated tracheobronchitis and ventilator-Associated pneumonia: An update. Adv Ther 2011;28:728-47
    • (2011) Adv Ther , vol.28 , pp. 728-747
    • Abu-Salah, T.1    Dhand, R.2
  • 67
    • 80051573600 scopus 로고    scopus 로고
    • Nebulized ceftazidime and amikacin in ventilatorassociated pneumonia caused by pseudomonas aeruginosa
    • Lu Q, Yang J, Liu Z, et al. Nebulized ceftazidime and amikacin in ventilatorassociated pneumonia caused by pseudomonas aeruginosa. Am J Respir Crit Care Med 2011;184:106-15
    • (2011) Am J Respir Crit Care Med , vol.184 , pp. 106-115
    • Lu, Q.1    Yang, J.2    Liu, Z.3
  • 68
    • 0024352943 scopus 로고
    • Continuous in-line nebulizers complicate pressure support ventilation
    • Beaty CD, Ritz RH, Benson MS. Continuous in-line nebulizers complicate pressure support ventilation. Chest 1989;96:1360-3
    • (1989) Chest , vol.96 , pp. 1360-1363
    • Beaty, C.D.1    Ritz, R.H.2    Benson, M.S.3
  • 69
    • 0242468642 scopus 로고    scopus 로고
    • Aerosol delivery and modern mechanical ventilation -In vitro/in vivo evaluation
    • Miller DD, Amin MM, Palmer LB, et al. Aerosol delivery and modern mechanical ventilation -In vitro/in vivo evaluation. Am J Respir Crit Care Med 2003;168:1205-9
    • (2003) Am J Respir Crit Care Med , vol.168 , pp. 1205-1209
    • Miller, D.D.1    Amin, M.M.2    Palmer, L.B.3
  • 70
    • 84870437433 scopus 로고    scopus 로고
    • Inhalation therapy in patients receiving mechanical ventilation: An update
    • Ari A, Fink JB, Dhand R. Inhalation therapy in patients receiving mechanical ventilation: An update. J Aerosol Med Pulm Drug Deliv 2012;25:319-32
    • (2012) J Aerosol Med Pulm Drug Deliv , vol.25 , pp. 319-332
    • Ari, A.1    Fink, J.B.2    Dhand, R.3
  • 71
    • 0030927781 scopus 로고    scopus 로고
    • Nebuliser therapy in the intensive care unit
    • Odoherty MJ, Thomas SH. Nebuliser therapy in the intensive care unit. Thorax 1997;52:S56-9
    • (1997) Thorax , vol.52 , pp. S56-9
    • Odoherty, M.J.1    Thomas, S.H.2
  • 72
    • 0026728835 scopus 로고
    • Delivery of a nebulized aerosol to a lung model during mechanical ventilation -effect of ventilator settings and nebulizer type, position, and volume of fill
    • Odoherty MJ, Thomas SH, Page CJ, et al. Delivery of a nebulized aerosol to a lung model during mechanical ventilation -effect of ventilator settings and nebulizer type, position, and volume of fill. Am Rev Respir Dis 1992;146:383-8
    • (1992) Am Rev Respir Dis , vol.146 , pp. 383-388
    • Odoherty, M.J.1    Thomas, S.H.2    Page, C.J.3
  • 73
    • 0023473104 scopus 로고
    • Effects of nebulizer mode and position in mechanical ventilator circuit on dose efficiency
    • Hughes JM, Saez J. Effects of nebulizer mode and position in mechanical ventilator circuit on dose efficiency. Respir Care 1987;32:1131-5
    • (1987) Respir Care , vol.32 , pp. 1131-1135
    • Hughes, J.M.1    Saez, J.2
  • 74
    • 77955480004 scopus 로고    scopus 로고
    • Evaluation of aerosol generator devices at 3 locations in humidified and non-humidified circuits during adult mechanical ventilation
    • Ari A, Areabi H, Fink JB. Evaluation of aerosol generator devices at 3 locations in humidified and non-humidified circuits during adult mechanical ventilation. Respir Care 2010;55:837-44
    • (2010) Respir Care , vol.55 , pp. 837-844
    • Ari, A.1    Areabi, H.2    Fink, J.B.3
  • 75
    • 0028040181 scopus 로고
    • Aerosol deposition in mechanically ventilated patients -optimizing nebulizer delivery
    • Oriordan TG, Palmer LB, Smaldone GC. Aerosol deposition in mechanically ventilated patients -optimizing nebulizer delivery. Am J Respir Crit Care Med 1994;149:214-19
    • (1994) Am J Respir Crit Care Med , vol.149 , pp. 214-219
    • Oriordan, T.G.1    Palmer, L.B.2    Smaldone, G.C.3
  • 77
    • 0028873969 scopus 로고
    • Effect of a spacer on pulmonary aerosol deposition from a jet nebulizer during mechanical ventilation
    • Harvey CJ, Odoherty MJ, Page CJ, et al. Effect of a spacer on pulmonary aerosol deposition from a jet nebulizer during mechanical ventilation. Thorax 1995;50:50-3
    • (1995) Thorax , vol.50 , pp. 50-53
    • Harvey, C.J.1    Odoherty, M.J.2    Page, C.J.3
  • 78
    • 0027404436 scopus 로고
    • Pulmonary deposition of a nebulized aerosol during mechanical ventilation
    • Thomas SH, Odoherty MJ, Fidler HM, et al. Pulmonary deposition of a nebulized aerosol during mechanical ventilation. Thorax 1993;48:154-9
    • (1993) Thorax , vol.48 , pp. 154-159
    • Thomas, S.H.1    Odoherty, M.J.2    Fidler, H.M.3
  • 80
    • 80053502758 scopus 로고    scopus 로고
    • An in vitro assessment of aerosol delivery through patient breathing circuits used with medical air or a helium-oxygen mixture
    • Martin AR, Ang A, Katz IM, et al. An in vitro assessment of aerosol delivery through patient breathing circuits used with medical air or a helium-oxygen mixture. J Aerosol Med Pulm Drug Deliv 2011;24:225-34
    • (2011) J Aerosol Med Pulm Drug Deliv , vol.24 , pp. 225-234
    • Martin, A.R.1    Ang, A.2    Katz, I.M.3
  • 81
    • 77955507884 scopus 로고    scopus 로고
    • Influence of nebulizer type, position, and bias flow on aerosol drug delivery in simulated pediatric and adult lung models during mechanical ventilation
    • Ari A, Atalay OT, Harwood R, et al. Influence of nebulizer type, position, and bias flow on aerosol drug delivery in simulated pediatric and adult lung models during mechanical ventilation. Respir Care 2010;55:845-51
    • (2010) Respir Care , vol.55 , pp. 845-851
    • Ari, A.1    Atalay, O.T.2    Harwood, R.3
  • 82
    • 22044454812 scopus 로고    scopus 로고
    • Aerosol deposition in neonatal ventilation
    • Dubus JC, Vecellio L, De Monte M, et al. Aerosol deposition in neonatal ventilation. Pediatr Res 2005;58:10-14
    • (2005) Pediatr Res , vol.58 , pp. 10-14
    • Dubus, J.C.1    Vecellio, L.2    De Monte, M.3
  • 83
    • 84879386427 scopus 로고    scopus 로고
    • Albuterol delivery by 4 different nebulizers placed in different positions in a pediatric ventilator in vitro model
    • Berlinski A, Willis RJ. Albuterol delivery by 4 different nebulizers placed in different positions in a pediatric ventilator in vitro model. Respir Care 2013;58:1124-33
    • (2013) Respir Care , vol.58 , pp. 1124-1133
    • Berlinski, A.1    Willis, R.J.2
  • 84
    • 84859386983 scopus 로고    scopus 로고
    • Aerosol therapy in patients receiving noninvasive positive pressure ventilation
    • Dhand R. Aerosol therapy in patients receiving noninvasive positive pressure ventilation. J Aerosol Med Pulm Drug Deliv 2012;25:63-78
    • (2012) J Aerosol Med Pulm Drug Deliv , vol.25 , pp. 63-78
    • Dhand, R.1
  • 85
    • 84873625768 scopus 로고    scopus 로고
    • Noninvasive ventilation coupled with nebulization during asthma crises: A randomized controlled trial
    • Galindo-Filho VC, Brandao DC, Ferreira Rde C, et al. Noninvasive ventilation coupled with nebulization during asthma crises: A randomized controlled trial. Respir Care 2013;58:241-9
    • (2013) Respir Care , vol.58 , pp. 241-249
    • Galindo-Filho, V.C.1    Brandao, D.C.2    Ferreira Rde, C.3
  • 86
    • 84897084643 scopus 로고    scopus 로고
    • Influence of exhalation valve and nebulizer position on albuterol delivery during noninvasive positive pressure ventilation
    • Dai B, Kang J, Sun LF, et al. Influence of exhalation valve and nebulizer position on albuterol delivery during noninvasive positive pressure ventilation. J Aerosol Med Pulm Drug Deliv 2014;27:125-32
    • (2014) J Aerosol Med Pulm Drug Deliv , vol.27 , pp. 125-132
    • Dai, B.1    Kang, J.2    Sun, L.F.3
  • 87
    • 84881488335 scopus 로고    scopus 로고
    • Bronchodilator delivery during simulated pediatric noninvasive ventilation
    • White CC, Crotwell DN, Shen S, et al. Bronchodilator delivery during simulated pediatric noninvasive ventilation. Respir Care 2013;58:1459-66
    • (2013) Respir Care , vol.58 , pp. 1459-1466
    • White, C.C.1    Crotwell, D.N.2    Shen, S.3
  • 88
    • 80054714784 scopus 로고    scopus 로고
    • The relative lung and systemic bioavailability of terbutaline following nebulisation in non-invasively ventilated patients
    • Abdelrahim M, Plant P, Chrystyn H. The relative lung and systemic bioavailability of terbutaline following nebulisation in non-invasively ventilated patients. Int J Pharm 2011;420:313-18
    • (2011) Int J Pharm , vol.420 , pp. 313-318
    • Abdelrahim, M.1    Plant, P.2    Chrystyn, H.3
  • 89
    • 77954909965 scopus 로고    scopus 로고
    • In-vitro characterisation of the nebulised dose during non-invasive ventilation
    • Abdelrahim ME, Plant P, Chrystyn H. In-vitro characterisation of the nebulised dose during non-invasive ventilation. J Pharm Pharmacol 2010;62:966-72
    • (2010) J Pharm Pharmacol , vol.62 , pp. 966-972
    • Abdelrahim, M.E.1    Plant, P.2    Chrystyn, H.3
  • 90
    • 84859103635 scopus 로고    scopus 로고
    • Inhaler mishandling is very common in patients with chronic airflow obstruction and long-term home nebuliser use
    • Melani AS, Canessa P, Coloretti I, et al. Inhaler mishandling is very common in patients with chronic airflow obstruction and long-term home nebuliser use. Respir Med 2012;106:668-76
    • (2012) Respir Med , vol.106 , pp. 668-676
    • Melani, A.S.1    Canessa, P.2    Coloretti, I.3
  • 91
    • 0030000524 scopus 로고    scopus 로고
    • Guidelines for the use of nebulizers in the home and at domiciliary sites -Report of a consensus conference
    • ODonohue WJ, Baker JP, Dexter JR, et al. Guidelines for the use of nebulizers in the home and at domiciliary sites -Report of a consensus conference. Chest 1996;109:814-20
    • (1996) Chest , vol.109 , pp. 814-820
    • Odonohue, W.J.1    Baker, J.P.2    Dexter, J.R.3
  • 92
    • 84890469602 scopus 로고    scopus 로고
    • Inhaled antibiotics to treat lung infection
    • Cipolla D, Chan HK. Inhaled antibiotics to treat lung infection. Pharm Pat Anal 2013;2:647-63
    • (2013) Pharm Pat Anal , vol.2 , pp. 647-663
    • Cipolla, D.1    Chan, H.K.2
  • 93
    • 70349394321 scopus 로고    scopus 로고
    • Changes in performance of the pari eflow (R) rapid and pari LC plus (TM) during 6 months use by CF patients
    • Rottier BL, van Erp CJ, Sluyter TS, et al. Changes in performance of the pari eflow (R) rapid and pari LC plus (TM) during 6 months use by CF patients. J Aerosol Med Pulm Drug Deliv 2009;22:263-9
    • (2009) J Aerosol Med Pulm Drug Deliv , vol.22 , pp. 263-269
    • Rottier, B.L.1    Van Erp, C.J.2    Sluyter, T.S.3
  • 94
    • 77950615516 scopus 로고    scopus 로고
    • Domiciliary experience of the target inhalation mode (TIM) breathing maneuver in patients with cystic fibrosis
    • Denyer J, Black A, Nikander K, et al. Domiciliary experience of the target inhalation mode (TIM) breathing maneuver in patients with cystic fibrosis. J Aerosol Med Pulm Drug Deliv 2010;23:S45-54
    • (2010) J Aerosol Med Pulm Drug Deliv , vol.23 , pp. S45-54
    • Denyer, J.1    Black, A.2    Nikander, K.3
  • 95
    • 77950606953 scopus 로고    scopus 로고
    • The adaptive aerosol delivery (AAD) technology: Past, present, and future
    • Denyer J, Dyche T. The adaptive aerosol delivery (AAD) technology: past, present, and future. J Aerosol Med Pulm Drug Deliv 2010;23:S1-S10
    • (2010) J Aerosol Med Pulm Drug Deliv , vol.23 , pp. S1-S10
    • Denyer, J.1    Dyche, T.2
  • 96
    • 77955504099 scopus 로고    scopus 로고
    • Novel devices for individualized controlled inhalation can optimize aerosol therapy in efficacy, patient care and power of clinical trials
    • Fischer A, Stegemann J, Scheuch G, Siekmeier R. Novel devices for individualized controlled inhalation can optimize aerosol therapy in efficacy, patient care and power of clinical trials. Eur J Med Res 2009;14(Suppl 4):71-7
    • (2009) Eur J Med Res , vol.14 , pp. 71-77
    • Fischer, A.1    Stegemann, J.2    Scheuch, G.3    Siekmeier, R.4
  • 97
    • 40449091631 scopus 로고    scopus 로고
    • Novel approaches to enhance pulmonary delivery of proteins and peptides
    • Scheuch G, Siekmeier R. Novel approaches to enhance pulmonary delivery of proteins and peptides. J Physiol Pharmacol 2007;58:615-25
    • (2007) J Physiol Pharmacol , vol.58 , pp. 615-625
    • Scheuch, G.1    Siekmeier, R.2
  • 99
    • 4444364706 scopus 로고    scopus 로고
    • A review of the development of Respimat ((R)) Soft Mist (TM) Inhaler
    • Dalby R, Spallek M, Voshaar T. A review of the development of Respimat ((R)) Soft Mist (TM) Inhaler. Int J Pharm 2004;283:1-9
    • (2004) Int J Pharm , vol.283 , pp. 1-9
    • Dalby, R.1    Spallek, M.2    Voshaar, T.3
  • 100
    • 25844472597 scopus 로고    scopus 로고
    • Comparison of the aerosol velocity and spray duration of Respimat (R) Soft Mist (TM) Inhaler and pressurized metered dose inhalers
    • Hochrainer D, Holz H, Kreher C, et al. Comparison of the aerosol velocity and spray duration of Respimat (R) Soft Mist (TM) Inhaler and pressurized metered dose inhalers. J Aerosol Med 2005;18:273-82
    • (2005) J Aerosol Med , vol.18 , pp. 273-282
    • Hochrainer, D.1    Holz, H.2    Kreher, C.3
  • 101
    • 84885734407 scopus 로고    scopus 로고
    • Tiotropium respimat inhaler and the risk of death in COPD
    • Wise RA, Anzueto A, Cotton D, et al. Tiotropium respimat inhaler and the risk of death in COPD. N Engl J Med 2013;369:1491-501
    • (2013) N Engl J Med , vol.369 , pp. 1491-1501
    • Wise, R.A.1    Anzueto, A.2    Cotton, D.3
  • 102
    • 77449096192 scopus 로고    scopus 로고
    • Patient preferences for inhaler devices in chronic obstructive pulmonary disease: Experience with Respimat soft mist inhaler
    • Hodder R, Price D. Patient preferences for inhaler devices in chronic obstructive pulmonary disease: experience with Respimat soft mist inhaler. Int J Chron Obstruct Pulmon Dis 2009;4:381-90
    • (2009) Int J Chron Obstruct Pulmon Dis , vol.4 , pp. 381-390
    • Hodder, R.1    Price, D.2
  • 103
    • 50849121444 scopus 로고    scopus 로고
    • The science of aerosol delivery in cystic fibrosis
    • Geller DE. The science of aerosol delivery in cystic fibrosis. Pediatr Pulmonol 2008;43:S5-S17
    • (2008) Pediatr Pulmonol , vol.43 , pp. S5-S17
    • Geller, D.E.1
  • 104
    • 0030916624 scopus 로고    scopus 로고
    • The science of nebulised drug delivery
    • OCallaghan C, Barry PW. The science of nebulised drug delivery. Thorax 1997;52:S32-44
    • (1997) Thorax , vol.52 , pp. S32-44
    • Ocallaghan, C.1    Barry, P.W.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.