Development of aerosol drug delivery with helium oxygen gas mixtures

Journal of Aerosol Medicine: Deposition, Clearance, and Effects in the Lung

Volumn 17, Issue 4, 2004, Pages 299-309

  Corcoran, Tim E ^a,c   Gamard, Stephan ^b  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^b PRAXAIR INC   (United States)

^c UNIVERSITY OF PITTSBURGH MEDICAL CENTER   (United States)

Author keywords

Aerosol drug; Aerosol therapy; Atomization gas; Heliox; Helium; Nebulizer

Indexed keywords

BRONCHODILATING AGENT; HELIOX; HELIUM; IPRATROPIUM BROMIDE; OXYGEN; SALBUTAMOL;

AEROSOL; ARTIFICIAL VENTILATION; CHRONIC OBSTRUCTIVE LUNG DISEASE; CLINICAL TRIAL; DRUG DELIVERY SYSTEM; FLOW RATE; FORCED EXPIRATORY VOLUME; HELIUM OXYGEN BREATHING; HUMAN; NEBULIZATION; NONHUMAN; PHYSICS; REVIEW; THEORY; TIDAL VOLUME;

ADMINISTRATION, INHALATION; AEROSOLS; CLINICAL TRIALS; HELIUM; HUMANS; LUNG; NEBULIZERS AND VAPORIZERS; OXYGEN; PARTICLE SIZE;

EID: 12244306501     PISSN: 08942684     EISSN: None     Source Type: Journal    
DOI: 10.1089/jam.2004.17.299     Document Type: Review

References (49)

1. Rodrigo, G.J., Rodrigo, C., Pollack, C.V., et al. 2003. Use of helium-oxygen mixtures in the treatment of acute asthma. Chest 123:891-896.
2. Ho, A.M.-H., Lee, A., Karmakar, M.K., et al. 2003. Heliox vs. air-oxygen mixtures for the treatment of patients with acute asthma. Chest 123:882-890.
3. Raznjevic, K. 1976. Handbook of Thermodynamic Tables and Charts. McGraw-Hill, New York.
4. Dekker, E. 1961. Transition between laminar and turbulent flow in the human trachea. J. Appl. Physiol. 166:1060-1064.
5. Papamoschou, D. 1995. Theoretical validation of the respiratory benefits of helium-oxygen mixtures. Respir. Physiol. 99:183-190.
6. th Ed., Williams and Wilkins, Baltimore.
7. Gluck, E.H., Onorato, D.J., and Castriotta, R. 1990. Helium-oxygen mixtures in intubated patients with status asthmaticus and respiratory acidosis. Chest 98:693-698.
8. Ho, A.M-H., Dio, P.W., Karmakar, M.K., et al. 2002. Use of heliox in critical airway obstruction. Physical and physiological considerations in choosing the optimum helium:oxygen mix. Resuscitation 52:297-300.
9. 2 mixtures on maximal oxygen consumption in normoxic and hypoxic men. J. Physiol. 503:215-221.
10. 2. J. Appl. Physiol. 94:685-693.
11. Pedersen, O.P., and Nielsen, T.M. 1976. The critical transmural pressure of the airway. Acta Physiol. Scand. 97:426-446.
12. Kudukis, T.M., Manthous, C.A., Schmidt, G.A., et al. 1997. Inhaled helium-oxygen revisited: effect of inhaling helium-oxygen during the treatment of status asthmaticus in children. Chest 1302:217-224.
13. Kass, J.E., and Terregino, C.A. 1999. The effect of heliox in acute severe asthma: a randomized controlled trial. Chest 116:296-300.
14. Kass, J.E., and Castriotta, R.J. 1995. Heliox therapy in acute severe asthma. Chest 107:757-760.
15. Schaeffer, E.M., Pohlman, A., Morgan, S., et al. 1999. Oxygenation in status asthmaticus improves during ventilation with helium-oxygen. Crit. Care Med. 27:2666-2670.
16. Manthous, C.A., Hall, J.B., Caputo, M.A., et al. 1995. Heliox improves pulsus paradoxus and peak expiratory flow in nonintubated patients with severe asthma. Am. J. Respir. Crit. Care Med. 151:310-314.
17. Verbeek, P.R., and Chopra, A. 1998. Heliox does not improve FEV1 in acute asthma patients. J. Emerg. Med. 16:545-548.
18. Carter, E.R., Webb, C.R., and Moffit, D.R. 1996. Evaluation of heliox in children hospitalized with acute severe asthma: a randomized crossover trial. Chest 109:1256-1261.
19. Shiue, S.T., and Gluck, E.H. 1989. The use of helium-oxygen mixtures in the support of patients with status asthmaticus and respiratory acidosis. J. Asthma 26:177-180.
20. Diehl, J.L., Mercat, A., Guérot, E., et al. 2002. Helium/oxygen mixture reduces the work of breathing at the end of the weaning process in patients with severe chronic obstructive pulmonary disease. Crit. Care Med. 31:1415-1420.
21. Jaber, S., Carlucci, A., Boussarsar, M., et al. 2001. Helium-oxygen in the postextubation period decreases inspiratory effort. Am. J. Respir. Crit. Care Med. 164:633-637.
22. Jaber, S., Fodil, R., Carlucci, A., et al. 2000. Noninvasive ventilation with helium-oxygen in acute exacerbations of chronic obstructive pulmonary disease. Am. J. Respir. Crit. Care Med. 161:1191-1200.
23. Jollier, P., Tassaux, D., Thouret, J.M., et al. 1999. Beneficial effects of helium-oxygen versus air:oxygen noninvasive pressure support ventilation in patients with decompensated chronic obstructive pulmonary disease. Crit. Care Med. 27:2422-2429.
24. Jolliet, P., Tassaux, D., Roeseler, J., et al., 2003. Helium-oxygen versus air-oxygen noninvasive pressure support in decompensated chronic obstructive disease: a prospective, multicenter study. Crit. Care Med. 31:878-884.
25. Gainier, M., Arnal, J.M., Gerbeaux, P., et al. 2003. Helium-oxygen reduces work of breathing in mechanically ventilated patients with chronic obstructive pulmonary disease. Intensive Care Med. 29:1666-1670.
26. Katz, A., Gentile, M.A., Craig, D.M., et al. 2001. Heliox improves gas exchange during high-frequency ventilation in a pediatric model of acute lung injury. Am. J. Respir. Crit. Care Med. 164:260-264.
27. Katz, A.L., Gentile, M.A., Craig, D.M., et al. 2003. Heliox does not affect gas exchange during high-frequency oscillatory ventilation if tidal volume is held constant. Crit. Care Med. 31:2006-2009.
28. 2 transport in a model of high-frequency oscillation comparing two oscillators. Crit. Care Med. 31:1759-1763.
29. Siddappa, R., Dowhy, M.S., Rotta, A.T., et al. 2003. Heliox enhances carbon dioxide clearance fron lungs of normal rabbits during low bias flow oscillation. Pediatr. Crit. Care 4:89-93.
30. Worth, H., Nüsse, W., and Piper, J., 1978. Determination of binary diffusion coefficients of various gas species used in respiratory physiology. Respir. Physiol. 32:15-26.
31. Nixon, W., and Pack, A. 1980 Effect of altered gas diffusivity on alveolar gas exchange-a theoretical study. J. Appl. Physiol. Respir. Environ. Exerc. Physiol. 48:147-153.
32. Lefebvre, A. 1989. Atomization and Sprays, Taylor and Francis, West Lafayette, IN.
33. Heyder, J., Gebhart, J., Rudolf, G., et al. 1986. Deposition of particles in the human respiratory tract in the size range of 0.005-15 μm. J. Aerosol Sci. 17:811-825.
34. Corcoran, T.E., Dauber, J.H., Chigier, N., et al. 2002. Improving drug delivery from medical nebulizers: the effects of increased nebulizer flow rates and reservoirs. J. Aerosol Med. 15:271-282.
35. Piva, J.P., Menna Barreto, S.S., Zelmanovitz, F., et al. 2002. Heliox versus oxygen for nebulized aerosol therapy in children with lower airway obstruction. Pediatr. Crit. Care Med. 3:6-10.
36. Hess, D.R., Acosta, F.L., Ritz, R.H., et al. 1999. The effect of heliox on nebulizer function using a β-agonist bronchodilator. Chest 115:184-189.
37. Comer, J.K., Kleinstreuer, C., and Kim, C.S. 2001. Flow structures and particle deposition patterns in double-bifurcation airway models. Part 2. Aerosol transport and deposition. J. Fluid Mech. 435:55-80.
38. Anderson, M., Svartengren, M., Bylin, G., et al. 1993. Deposition in asthmatics of particles inhaled in air or helium-oxygen. Am. Rev. Respir. Dis. 147:524-528.
39. Henderson, S.O., Pravin, A., Kilaghbian, T., et al. 1999. Use of heliox-driven nebulizer therapy in the treatment of acute asthma. Ann. Emerg. Med. 33:141-146.
40. de Boisblanc, B.P., DeBleiux, Resweber, S., et al. 2000. Randomized trial of the use of heliox as a driving gas for updraft nebulization of bronchodilators in the emergent treatment of acute exacerbations of chronic obstructive pulmonary disease. Crit. Care Med. 28:3177-3180.
41. Dorfman, T., Shipley, E.R., Burton, J.H., et al. 2000. Inhaled heliox does not benefit ED patients with moderate to severe asthma. Am. J. Emerg. Med. 18:495-497.
42. Rose, J.S., Panacek, E. A., and Miller, P. 2002. Prospective randomized trial of heliox-driven continuous nebulizers in the treatment of asthma in the emergency department. J. Emerg. Med. 22:133-137.
43. Kress, J.P., Noth, I., Gehlbach, B.K., et al. 2002. The utility of albuterol nebulized with heliox during acute asthma exacerbations. Am. J. Respir. Crit. Care Med. 165:1317-1321.
44. Bag, R., Bandi, V., Fromm, R.E., Jr., et al. 2002. The effect of heliox-driven bronchodilator aerosol therapy on pulmonary function tests in patients with asthma. J. Asthma 39:659-665.
45. Lanoix, R., Lanigan, M.D., Radeo, M.S., et al. 2003. A prospective, randomized trial to evaluate heliox as a delivery vehicle to nebulize albuterol in acute asthma exacerbations in the emergency department. Acad. Emerg. Med. 10:507.
46. Kim, I.K., Phrampus, E., Venkataraman, S., et al. 2003. Heliox-driven albuterol nebulization in the treatment of children with moderate to severe asthma, Presented at the Pediatric Academic Societies. Annual Meeting, Seattle.
47. Goode, M.L., Fink, J., Dhand, R., et al. 2001. Improvement in aerosol delivery with helium-oxygen mixtures during mechanical ventilation. Am. J. Respir. Crit. Care Med. 163:109-114.
48. Corcoran, I.E., Shortall, B.P., Kim, I.K., et al. 2003. Aerosol drug delivery using heliox and nebulizer reservoirs: results from an MRI-based pediatric model. J. Aerosol Med. 16:263-271.
49. Habib, D.M., Garner, S.S., and Brandeburg, S. 1999. Effect of helium-oxygen on delivery of albuterol in a pediatric, volume-cycled, ventilated lung model. Pharmacotherapy 19:143-149.