The effects of Heliox on the output and particle-size distribution of salbutamol using jet and vibrating mesh nebulizers

Journal of Aerosol Medicine: Deposition, Clearance, and Effects in the Lung

Volumn 20, Issue 4, 2007, Pages 434-444

  O'Callaghan, Christopher ^a   White, Judy ^a   Jackson, Judith ^a   Crosby, David ^b   Dougill, Beatriz ^b   Bland, Hubert ^b  

^a UNIVERSITY OF LEICESTER   (United Kingdom)

^b BOC Group Plc UK   (United Kingdom)

Author keywords

Aerosol delivery; Asthma; COPD; Heliox; Nebulizer

Indexed keywords

HELIOX; HELIOX 21; SALBUTAMOL; UNCLASSIFIED DRUG;

AIRFLOW; ARTICLE; ASTHMA; BREATHING PATTERN; CHRONIC OBSTRUCTIVE LUNG DISEASE; DRUG DISTRIBUTION; EVALUATION; INTERMETHOD COMPARISON; JET NEBULIZER; MEDICAL NEBULIZER; PARTICLE SIZE; TIME; VIBRATING MESH NEBULIZER;

ADMINISTRATION, INHALATION; ALBUTEROL; ASTHMA; BRONCHODILATOR AGENTS; DRUG CARRIERS; EQUIPMENT DESIGN; GASES; HELIUM; HUMANS; NEBULIZERS AND VAPORIZERS; OXYGEN; PARTICLE SIZE; PULMONARY DISEASE, CHRONIC OBSTRUCTIVE; VIBRATION;

EID: 37549061382     PISSN: 08942684     EISSN: None     Source Type: Journal    
DOI: 10.1089/jam.2007.0614     Document Type: Article

References (25)

1. Hess, D.R., F.L. Acosta, R.H. Ritz, R.M. Kacmarek, C.A. Camargo, Jr. 1999. The effect of Heliox on nebuliser function using a beta-agonist bronchodilator. Chest 115:184-189.
2. 2 mixtures on maximal oxygen consumption in normoxic and hypoxic men. J. Physiol. 503(Pt 1):215-222.
3. 2. J. Appl. Physiol. 94:685-693.
4. Kim, K., E. Phrampus, S. Venkataraman, R. Pitetti, A. Saville, T. Corcoran, E. Gracely, N. Funt, and A. Thompson. 2005. Helium/oxygen-driven albuterol nebulisation in the treatment of children with moderate to severe asthma exacerbations: a randomised, controlled trial. Paediatrics 116:1127-1133.
5. Ho, A., A. Lee, M. Karmakar, P. Dion, D. Chung, and L. Contardi. 2003. Heliox vs air-oxygen mixtures for the treatment of patients with acute asthma. Chest 123:882-890.
6. Corcoran, T.E., and S. Gamard. 2004. Development of aerosol drug delivery with helium-oxygen gas mixtures. J. Aerosol Med. 17:299-309.
7. Collis, G.G., C.H. Cole, and P.N. Le Souef. 1990. Dilution of nebulised aerosols by air entrainment in children. Lancet 336:341-343.
8. Kress, J.P., I. Noth, B.K. Gehlbach, N. Barman, A.S. Pohlman, A. Miller, S. Morgan, J.B. Hall. 2002. The utility of albuterol nebulized with heliox during acute asthma exacerbations. Am. J. Respir. Crit. Care Med. 165:1317-1321.
9. Bag, R., V. Bandi, R.E. Fromm, Jr., and K.K. Guntupalli. 2002. The effect of heliox-driven bronchodilator aerosol therapy on pulmonary function tests in patients with asthma. J. Asthma 39:659-665.
10. Kim, I., E. Phrampus, and S. Venkataraman. 2003. Heliox-driven albuterol nebulization in the treatment of children with moderate to severe asthma. Presented at the Paediatric Academic Societies Annual Meeting, Seattle.
11. deBoisblanc, B.P., P. DeBleiux, S. Resweber, E.E. Fusco, and W.R. Summer. 2000. Randomized trial of the use of heliox as a driving gas for updraft nebulization of bronchodilators in the emergent treatment of acute exacerbations of chronic obstructive pulmonary disease. Crit. Care Med. 28:3177-3180.
12. Dorfman, T.A., E.R. Shipley, J.H. Burton, P. Jones, and S.A. Mette. 2000. Inhaled heliox does not benefit ED patients with moderate to severe asthma. Am. J. Emerg. Med. 18:495-497.
13. Lanoix, R., M. Lanigan, and M. Radeo. 2003. A prospective, randomized trial to evaluate heliox as a delivery vehicle to nebulize albuterol in acute asthma exacerbations in the emergency department. Acad. Emerg. Med. 10:507.
14. O'Callaghan, C. 1990. Particle size of beclomethasone dipropionate produced by two nebulisers and two spacing devices. Thorax 45:109-111.
15. Barry, P.W., and C. O'Callaghan. 1998. The output of budesonide from nebulizers. J. Allergy Clin. Immunol. 102:321-322.
16. Barry, P.W., and C. O'Callaghan. 1999. An in vitro analysis of the output of salbutamol from different nebulizers. Eur. Resp. J. 13:1164-1169
17. O'Callaghan, C., and P.W. Barry. 1997. The science of nebulised drug delivery. Thorax 52(Suppl 2):S31-S44.
18. O'Callaghan, C., A. Clark, and A. Milner. 1989. Why nebulise for more than five minutes? Arch. Dis. Child 64:1270-1273.
19. BS EN 13544-1. 2001. British Standard - respiratory therapy equipment Part 1: nebulizing systems and their components.
20. Berg, E., and L. Asking. 2004. Nebulizer Droplet Size Distribution - Refrigerated NGI at 15 L/Min. DHI Publishing, Raleigh, NC, 315-317.
21. Marple, V., D. Roberts, and J. Mitchell. 2004. A Proposal for the Use of the Next Generation Pharmaceutical Impactor (NGI) at Flow Rates between 15 and 30 L/Min. DHI Publishing, Raleigh NC, 701-703.
22. Newton, G., R. Carpenter, Y. Cheng, E. Barr, and H. Yeh. 1982. High-temperature-high-pressure cascade impactor design, performance and data analysis methods. J. Colloid Interface Sci. 87:279-290.
23. Hess, D. 2000. Nebulizers: principles and performance. Respir. Care 45:609-622.
24. Corcoran, T.E., J.H. Dauber, N. Chigier, and A.T. Iacono. 2002. Improving drug delivery from medical nebulizers: the effects of increased nebulizer flow rates and reservoirs. J. Aerosol Med. 15:271-282.
25. Piva, J.P., and S.S. Menna Barreto, F. Zelmanovitz, S. Amantea, and P. Cox. 2002. Heliox versus oxygen for nebulized aerosol therapy in children with lower airway obstruction. Pediatr. Crit Care Med. 3:6-10.