Electrostatic charge characteristics of jet nebulized aerosols

Journal of Aerosol Medicine and Pulmonary Drug Delivery

Volumn 23, Issue 3, 2010, Pages 149-159

  Kwok, Philip Chi Lip ^a   Trietsch, Sebastiaan J ^b   Kumon, Michiko ^a   Chan, Hak Kim ^a  

^a UNIVERSITY OF SYDNEY   (Australia)

^b LEIDEN UNIVERSITY   (Netherlands)

Author keywords

Electrical low pressure impactor (ELPI); Electrostatic charge; Jet nebulizer; Liquid aerosol; Saline

Indexed keywords

IPRATROPIUM BROMIDE; SALBUTAMOL; SODIUM CHLORIDE; TERBUTALINE; AEROSOL; BRONCHODILATING AGENT;

AEROSOL; ARTICLE; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; ELECTRICITY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMIDITY; NEBULIZATION; NEBULIZER; PARTICLE SIZE; CHEMISTRY; STATIC ELECTRICITY;

AEROSOLS; ALBUTEROL; BRONCHODILATOR AGENTS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DRUG DELIVERY SYSTEMS; IPRATROPIUM; NEBULIZERS AND VAPORIZERS; STATIC ELECTRICITY; TERBUTALINE;

EID: 77953944347     PISSN: 19412711     EISSN: 19412703     Source Type: Journal    
DOI: 10.1089/jamp.2009.0795     Document Type: Article

References (40)

1. Bailey AG: Electrostatic Spraying of Liquids. Research Studies Press, Somerset, England; 1988.
2. Jonassen N: Electrostatics. Chapman & Hall, New York; 1998.
3. Iribarne JV, and Mason BJ: Electrification accompanying the burst of bubbles in water and dilute aqueous solution. Trans Faraday Soc. 1967;63:2234-2245.
4. Jonas PR, and Mason BJ: Systematic charging of water droplets produced by break-up of liquid jets and filaments. Trans Faraday Soc. 1968;64:1971-1982.
5. Matteson MJ: The separation of charge at the gas-liquid interface by dispersion of various electrolyte solutions. J Colloid Interface Sci. 1971;37:879-890.
6. Lopatenko SV, Kontush SM, Malyarova LV, and Kolpakov AV: Optimization of the process of the charging of a liquid during dispersion. Colloid J USSR. 1987;49:691-696.
7. Yatsuzuka K, Mizuno Y, and Asano K: Electrification phenomena of pure water droplets dripping and sliding on a polymer surface. J Electrostat. 1994;32:157-171.
8. Yatsuzuka K, Higashiyama Y, and Asano K: Electrification of polymer surface caused by sliding ultrapure water. IEEE Transa Indust Appl. 1996;32:825-831.
9. Iribarne JV, and Klemes M: Electrification associated with droplet production from liquid jets. J Chem Soc Faraday Trans 1: Phys Chem Condensed Phases. 1974;70:1219-1227.
10. Kwok PCL, and Chan H-K: Measurement of electrostatic charge of nebulised aqueous droplets with the electrical low pressure impactor. In RN Dalby, PR Byron, J Peart, JD Suman, and SJ Farr (eds). Respiratory Drug Delivery IX. Davis Healthcare International, River Grove, IL; pp. 833-836, 2004.
11. Hashish AH, and Bailey AG: Administration of drugs using nebulisers: effect of electrostatic charge on aerosols. Instit Phys Conf Series. 1987;85:81-86.
12. Chow HY, and Mercer TT: Charges on droplets produced by atomization of solutions. Am Indust Hygiene Assoc J 1971;32:247-255.
13. Glover W, and Chan H-K: Electrostatic charge characterization of pharmaceutical aerosols using electrical lowpressure impaction (ELPI). J Aerosol Sci. 2004;35:755-764. (Pubitemid 38668673)
14. Kwok PCL, and Chan H-K: Effect of relative humidity on the electrostatic charge properties of dry powder inhaler aerosols. Pharmaceut Res. 2008;25:277-288.
15. Kwok PCL, Collins R, and Chan H-K: Effect of spacers on the electrostatic charge properties of metered dose inhaler aerosols. J Aerosol Sci. 2006;37:1671-1682.
16. Orban JC, and Peart J: Simultaneous electrostatic charge characterization and particle size analysis of metered dose inhalers (pMDIs) using the electrical low pressure impactor. In RN Dalby, PR Byron, J Peart, JD Suman, and SJ Farr (eds). Respiratory Drug Delivery IX. Davis Healthcare International, River Grove, IL; pp. 877-880, 2004.
17. Kotian R, and Peart J: Influence of formulation components on inherent electrostatic properties of HFA propelled solution pMDIs. In RN Dalby, PR Byron, J Peart, JD Suman, and SJ Farr (eds). Respiratory Drug Delivery X. Davis Healthcare International, River Grove, IL; pp. 947-950, 2006.
18. Young PM, Sung A, Traini D, Kwok P, Chiou H, and Chan H-K: Influence of humidity on the electrostatic charge and aerosol performance of dry powder inhaler carrier based systems. Pharmaceut Res. 2007;24:963-970.
19. Kwok PC, and Chan H-K: Solid forms and electrostatic properties of salbutamol sulfate. In RN Dalby, PR Byron, J Peart, JD Suman, SJ Farr, and PM Young (eds). Respiratory Drug Delivery 2008. Davis Healthcare International, River Grove, IL; pp. 919-922, 2008.
20. Telko MJ, Kujanpää J, and Hickey AJ: Investigation of triboelectric charging in dry powder inhalers using electrical low pressure impactor (ELPITM). Int J Pharmaceut. 2007; 336:352-360.
21. Kwok PCL, Noakes T, and Chan H-K: Effect of moisture on the electrostatic charge properties of metered dose inhaler aerosols. J Aerosol Sci. 2008;39:211-226.
22. Finlay WH, and Stapleton KW: The effect on regional lung deposition of coupled heat and mass transfer between hygroscopic doplets and their surrounding phase. J Aerosol Sci. 1995;26:655-670.
23. Finlay WH: The Mechanics of Inhaled Pharmaceutical Aerosols. Academic Press, London: UK; 2001.
24. de Boer AH, Hagedoorn P, and Frijlink HW: The choice of a compressor for the aerosolisation of tobramycin (TOBI-) with the PARI LC PLUS- reusable nebuliser. Int J Pharmaceut. 2003;268:59-69.
25. Stapleton KW, and Finlay WH: Errors in characterising nebulized particle size distributions with cascade impactors. J Aerosol Med. 1998;11(Suppl 1):S80-S83.
26. Hinds WC: Aerosol Technology: Properties, Behavior, and Measurement of Airborne Particles. John Wiley & Sons, New York, NY; 1999.
27. Phipps PR, and Gonda I: Droplets produced by medical nebulizers: some factors affecting their size and solute concentration. Chest. 1990;97:1327-1332.
28. Zhou Y, Ahuja A, Irvin CM, Kracko D, McDonald JD, and Cheng YS: Evaluation of nebulizer performance under various humidity conditions. J Aerosol Med. 2005;18:283-293.
29. Zhou Y, Ahuja A, Irvin CM, Kracko DA, McDonald JD, and Cheng Y-S: Medical nebulizer performance: effects of cascade impactor temperature. Respir Care. 2005;50:1077-1082.
30. Berg E, Svensson JO, and Asking L: Determination of nebulizer droplet size distribution: a method based on impactor refrigeration. J Aerosol Med. 2007;20:97-104.
31. Solomita M, and Smaldone GC: Reconciliation of cascade impaction during wet nebulization. J Aerosol Med Pulmon Drug Deliv. 2009;22:11-18.
32. Nerbrink OL, Pagels J, Pieron CA, and Dennis JH: Effect of humidity on constant output and breath enhanced nebulizer designs when tested in the EN 13544-1 EC Standard. Aerosol Sci Technol. 2003;37:282-292.
33. PARI LC- Reusable Nebulizer Brochure: PARI Respiratory Equipment, Inc, Midlothian, VA; 2007.
34. Chapman S: Carrier mobility spectra of spray electrified liquids. Phys Rev. 1937;184-190.
35. Vaaraslahti K, Laitinen A, and Keskinen J: Spray charging of droplets in a wet scrubber. J Air Waste Manage Assoc. 2002;52:175-180.
36. Rosell J, Gonda I, Schuster J, and Liu K: Use of electrolytes (ions in solution) to suppress charging of inhalation aerosols. US Published Application 2002=0106331 A1; 2002.
37. Matsui M, Murasaki N, Fujibayashi K, Peng YB, and Kishimoto Y: Electrification of pure water flowing down a trough set up with a resin sheet. J Electrostat. 1993;31:1-10.
38. Taflin DC, Ward TL, and Davis EJ: Electrified droplet fission and the Rayleigh limit. Langmuir. 1989;5:376-384.
39. Balachandran W, Machowski W, Gaura E, and Hudson C: Control of drug aerosol in human airways using electrostatic forces. J Electrostat. 1997;40-41:579-584.
40. Bailey AG, Hashish AH, and Williams TJ: Drug delivery by inhalation of charged particles. J Electrostat. 1998;44:3-10.