Using helium-oxygen to improve regional deposition of inhaled particles: Mechanical principles

Journal of Aerosol Medicine and Pulmonary Drug Delivery

Volumn 27, Issue 2, 2014, Pages 71-80

  Katz, I ^a,b   Pichelin, M ^a   Montesantos, S ^a   Majoral, C ^a   Martin, A ^c   Conway, J ^d,e   Fleming, J ^e   Venegas, J ^f   Greenblatt, E ^f   Caillibotte, G ^a  

^a AIR LIQUIDE   (France)

^b LAFAYETTE COLLEGE   (United States)

^c Medical Gases   (United States)

^d UNIVERSITY OF SOUTHAMPTON   (United Kingdom)

^e UNIVERSITY HOSPITAL SOUTHAMPTON NHS FOUNDATION TRUST   (United Kingdom)

^f MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

Aerosol; CFD; Heliox; Helium; Imaging; Particle deposition

Indexed keywords

HELIUM; OXYGEN; AEROSOL; GAS; RADIOPHARMACEUTICAL AGENT; SERUM ALBUMIN; TECHNETIUM COMPLEX; TECHNETIUM TC 99M SERUM ALBUMIN;

AIR; AIRBORNE PARTICLE; AIRWAY OBSTRUCTION; ARTICLE; ASTHMA; CLINICAL ARTICLE; COMPUTATIONAL FLUID DYNAMICS; CONTROLLED STUDY; DIFFUSION; FLOW RATE; HELIUM OXYGEN BREATHING; HUMAN; IN VITRO STUDY; IN VIVO STUDY; LUNG MODEL; LUNG VENTILATION DISTRIBUTION; MECHANICS; SEDIMENTATION; SINGLE PHOTON EMISSION COMPUTER TOMOGRAPHY; THREE DIMENSIONAL IMAGING; AEROSOL; BIOLOGICAL MODEL; CASE CONTROL STUDY; CROSSOVER PROCEDURE; GAS; INHALATION; INHALATIONAL DRUG ADMINISTRATION; LUNG; METABOLISM; OXYGEN THERAPY; PARTICLE SIZE; PATHOPHYSIOLOGY; SCINTISCANNING;

ADMINISTRATION, INHALATION; AEROSOLS; ASTHMA; CASE-CONTROL STUDIES; CROSS-OVER STUDIES; GASES; HELIUM; HUMANS; INHALATION; LUNG; MODELS, BIOLOGICAL; ORGANOTECHNETIUM COMPOUNDS; OXYGEN INHALATION THERAPY; PARTICLE SIZE; RADIOPHARMACEUTICALS; SERUM ALBUMIN; TOMOGRAPHY, EMISSION-COMPUTED, SINGLE-PHOTON;

EID: 84897106168     PISSN: 19412711     EISSN: 19412703     Source Type: Journal    
DOI: 10.1089/jamp.2013.1072     Document Type: Article

References (47)

1. Hess DR, Fink JB, Venkataraman T, Kim IK, Myers TR, and Tano D: The history and physics of heliox. Respir Care. 200651:608-612.
2. Anderson M, Svartengren M, Bylin G, Philipson K, and Camner P: Deposition in asthmatics of particles inhaled in air or helium-oxygen. Am Rev Respir Dis. 1993147:524-528.
3. Corcoran TE, and Gamard S: Development of aerosol drug delivery with helium oxygen gas mixtures. J Aerosol Med. 200417:299-309.
4. Kim IK, Saville AL, Sikes KL, and Corcoran TE: Helioxdriven albuterol nebulization for asthma exacerbations: an overview. Respir Care. 200651:613-618.
5. Kim IK, Phrampus E, Venkataraman ST, Pitetti R, Saville AL, Corcoran TE, Gracely E, Funt N, and Thompson A: Helium/oxygen-driven albuterol nebulization in the treatment of children with moderate to severe asthma exacerbations: a randomized, controlled trial. Pediatrics. 2005 116:1127-1133.
6. Kim IK, and Corcoran T: Recent developments in heliox therapy for asthma and bronchiolitis. Clin Pediatr Emerg Med. 200910:68-74.
7. Kim IK, Phrampus E, Sikes K, Pendleton J, Saville A, Cocoran T, Gracely E, and Venkataraman S: Helium-oxygen therapy for infants with bronchioloitis. Arch Pediatr Adolesc Med. 2011165:1115-1122.
8. Liet J-M: Heliox is of minimal benefit in bronchiolitis but is more costly. J Pediatr. 2012160:883-884.
9. Darquenne C, and Prisk GK: Aerosol deposition in the human respiratory tract breathing air and 80:20 heliox. J Aerosol Med. 200417:278-285.
10. Svartengren M, Skogward P, Nebrink O, and Dahlbäck M: Regional deposition of inhaled Evans blue dye in mechanically ventilated rabbits with air or helium oxygen mixture. Exp Lung Res. 199824:159-172.
11. Peterson JB, Prisk GK, and Darquenne C: Aerosol deposition in the human lung periphery is increased by reduced density gas breathing. J Aerosol Med Pulm Drug Deliv. 200821:159-168.
12. Alcoforado L, Brandäo S, Rattes C, Brandäo D, Lima V, Ferreira Lima G, Fink JB, and Dornelas de Andrade A: Evaluation of lung function and deposition of aerosolized bronchodilators carried by heliox associated with positive expiratory pressure in stable asthmatics: a randomized clinical trial. Respir Med. 2013107:1178-1185.
13. Darquenne C: Aerosol deposition in health and disease. J Aerosol Med Pulm Drug Deliv. 201225:140-147.
14. 2. Med Gas Res. 20111:28.
15. Martonen TB: Analytical model of hygroscopic particle behavior in human airways. Bull Math Biol. 198244: 425-442.
16. Isaacs KK, Rosati JA, and Martonen TB: Mechanisms of particle deposition. In: LS Ruzer, and NH Harley, (eds). Aerosols Handbook: Measurement, Dosimetry, and Health Effects. CRC Press, Boca Raton, FL pp. 75-99, 2005.
17. Martonen TB, Rosati JA, and Isaacs KK: Modeling deposition of inhaled particles. In: LS Ruzer, and NH Harley, (eds). Aerosols Handbook: Measurement, Dosimetry, and Health Effects. CRC Press, Boca Raton, FL: pp. 113-125, 2005.
18. Sandeau J, Katz I, Fodil R, Louis B, Apiou-Sbirlea G, Caillibotte G, and Isabey D: CFD simulation of particle deposition in a reconstructed human oral extrathoracic airway for air and helium-oxygen mixtures. J Aerosol Sci. 201041:281-294.
19. Grgic B, Finlay WH, Burnell PKP, and Heenan AF: In vitro intersubject and intrasubject deposition measurements in realistic mouth-throat geometries. J Aerosol Sci. 200435: 1025-1040.
20. Katz IM, Martin AR, Muller P-A, Terzibachi K, Feng C-H, Caillibotte G, Sandeau J, and Texereau J: The ventilation distribution of helium-oxygen mixtures and the role of inertial losses in the presence of heterogeneous airway obstructions. J Biomech. 201144:1137-1143.
21. Martin AR, Katz I, Terzibachi K, Gouinaud L, Caillibotte G, and Texereau J: Bench and mathematical modeling of the effects of breathing a helium/oxygen mixture on expiratory time constants in the presence of heterogeneous airway obstructions. Biomed Eng Online. 201211:27.
22. Martin AR, Katz IM, Jenöfi K, Caillibotte G, Brochard L, and Texereau J: Bench experiments comparing simulated inspiratory effort when breathing helium-oxygen mixtures to that during positive pressure support with air. BMC Pulm Med. 201212:62.
23. Conway JH, Fleming JS, Majoral C, Katz I, Perchet D, Peebles C, Tossici-Bolt L, Collier L, Caillibotte G, Pichelin M, Sauret-Jackson V, Martonen T, Apiou-Sbirlea G, Muellinger B, Kroneberg P, Gleske J, Scheuch G, Texereau J, Martin A, Montesantos S, and Bennett M: Controlled, parametric, individualized, 2-D and 3-D imaging measurements of aerosol deposition in the respiratory tract of healthy human subjects for model validation. J Aerosol Sci. 201252:1-17.
24. Majoral C, Katz I, Fleming JS, Conway JH, Collier L, Pichelin M, Tossici-Bolt L, and Caillibotte G: Comparison of aerosol deposition pattern in healthy vs. asthmatic subjects. Presented at the European Respiratory Society Congress, September 2012.
25. Martin AR, Gleske J, Katz IM, Hartmann M, Mullinger B, Haussermann S, Caillibotte G, and Scheuch G: Laser diffraction characterization of droplet size distributions produced by vibrating mesh nebulization in air and a helium- oxygen mixture. J Aerosol Sci. 201041:1159-1166.
26. Fleming J, Conway J, Majoral C, Tossici-Bolt L, Katz I, Caillibotte G, Perchet D, Pichelin M, Muellinger B, Martonen T, Kroneberg P, and Apiou-Sbirlea G: The use of combined single photon emission computed tomography and X-ray computed tomography to assess the fate of inhaled aerosol. J Aerosol Med Pulm Drug Deliv. 2011 24:49-60.
27. Fleming JS, Conway JH, Holgate ST, Bailey AG, and Martonen TB: Comparison of methods for deriving aerosol deposition by airway generation from three-dimensional radionuclide imaging. J Aerosol Sci. 200031:1251-1259.
28. Montesantos S, Katz I, Fleming JS, Majoral C, Pichelin M, Dubau C, Piednor B, Conway JH, Texereau J, and Caillibotte G: Airway morphology from HRCT in healthy subjects and patients with moderate asthma. Anat Rec. 2013 296:852-866.
29. Dekker E: Transition between laminar and turbulent flow in human trachea. J Appl Physiol. 196116:1060-1064.
30. Longest PW, Hindle M, Choudhuri SD, and Xi J: Comparison of ambient and spray aerosol deposition in a standard induction port and more realistic mouth-throat geometry. J Aerosol Sci. 200839:572-591.
31. Zhang Z, and Kleinstreuer C: Airflow structures and nanoparticle deposition in a human upper airway model. J Comp Physiol. 2004198:178-210.
32. Heyder J, Gebhart J, Rudolf G, Schiller CF, and Stahlhofen W: Deposition of particles in the human respiratory tract in the size range 0.005-15 lm. J Aerosol Sci. 198617:811-825.
33. Gemci T, Shortall B, Allen GM, Cocoran TE, and Chigier N: A CFD study of the throat during aerosol drug delivery using heliox and air. J Aerosol Sci. 200334:1175-1192.
34. Kirby M, Svenningsen S, Kanhere N, Owrangi A, Wheatley A, Coxson H, Santyr G, Paterson NAM, McCormack DG, and Parraga G: Pulmonary ventilation visualized using hyperpolarized helium-3 and xenon-129 magnetic resonance imaging: differences in COPD and relationship to emphysema. J Appl Physiol. 2013114:707-715.
35. Svenningsen S, Kirby M, Starr D, Leary D, Wheatley A, Maksym GN, McCormack DG, and Parraga G: Hyperpolarized 3He and 129Xe MRI: differences in asthma before bronchodilation. J Magn Reson Imaging. 2013. [Epub ahead of print]
36. Kirby M, Wheatley A, Farag A, Ouriadov A, Santyr GE, McCormack DG, and Parraga G: Hyperpolarized helium-3 and xenon-129 magnetic resonance functional imaging in healthy volunteers and subjects with chronic obstructive pulmonary disease. Am J Respir Care Crit Med. 2012185: A3681.
37. Conway J, Fleming J, Bennett M, and Havelock T: The coimaging of gamma camera measurements of aerosol deposition and respiratory anatomy. J Aerosol Med Pulm Drug Deliv. 201326:123-130.
38. Venegas J, Winkler T, and Harris RS: Lung physiology and aerosol deposition imaged with positron emission tomography. J Aerosol Med Pulm Drug Deliv. 201326:1-8.
39. Piva JP, Menna Barreto SS, Zelmanovitz F, Amantéa S, and Cox P: Heliox versus oxygen for nebulized aerosol therapy in children with lower airway obstruction. Pediatr Crit Care Med. 20023:6-10.
40. Diehl J-L, Peigne V, Guérot E, Faisy C, Lecourt L, and Mercat A: Helium in the adult critical care setting. Ann Intensive Care. 20111:1-24.
41. Frazier MD, and Cheifetz IM: The role of heliox in paediatric respiratory disease. Paediatr Respir Rev. 201011: 46-53.
42. Moga AM, de Marchie M, Saey D, and Spahija J: Mechanisms of non-pharmacologic adjunct therapies used during exercise in COPD. Respir Med. 2012106:614-626.
43. Javaheri E, Shemirani FM, Pichelin M, Katz IM, Caillibotte G, Vehring R, and Finlay WH: Deposition modeling of hygroscopic saline aerosols in the human respiratory tract: comparison between air and helium-oxygen as carrier gases. J Aerosol Sci. 201364:81-93.
44. Martin A, Ang A, Katz I, Haussermann S, Caillibotte G, and Texereau J: An in vitro assessment of aerosol delivery through patient breathing circuits used with medical air or helium-oxygen mixture. J Aerosol Med Pulm Drug Deliv. 201124:225-234.
45. O'Callaghan C, White J, Jackson J, Crosby D, Dougill B, and Bland H: The effects of Heliox on the output and particle-size distribution of salbutamol using jet and vibrating mesh nebulizers. J Aerosol Med. 200720:434-444.
46. Goode ML, Fink JB, Dhand R, and Tobin MJ: Improvement in aerosol delivery with helium-oxygen mixtures during mechanical ventilation. Am J Respir Care Crit Med. 2001163:109-114.
47. Ari A, Harwood R, Sheard M, Dailey P, and Fink JB: In vitro comparison of heliox and oxygen in aerosol delivery using pediatric high flow nasal cannula. Pediatr Pulmonol. 201146:795-801.