Aerosol Delivery and Modern Mechanical Ventilation: In Vitro/In Vivo Evaluation

American Journal of Respiratory and Critical Care Medicine

Volumn 168, Issue 10, 2003, Pages 1205-1209

  Miller, Dorisanne D ^b   Amin, Mohammad M ^b   Palmer, Lucy B ^b   Shah, Akbar R ^b   Smaldone, Gerald C ^a  

^a STONY BROOK UNIVERSITY   (United States)

^b NONE

Author keywords

Aerosolized antibiotics; Bronchodilators; Humidification; Nebulizers; Sputum

Indexed keywords

AMIKACIN; ANTIBIOTIC AGENT; GENTAMICIN; SALBUTAMOL; VANCOMYCIN;

AEROSOL; ARTICLE; ARTIFICIAL VENTILATION; CHRONIC OBSTRUCTIVE LUNG DISEASE; CLINICAL ARTICLE; CONTROLLED STUDY; CORRELATION ANALYSIS; DRUG DELIVERY SYSTEM; DRUG SPUTUM LEVEL; HUMAN; HUMIDITY; IN VITRO STUDY; IN VIVO STUDY; INHALATION; MEDICAL NEBULIZER; NEBULIZATION; PNEUMONIA; PRIORITY JOURNAL; QUALITY CONTROL; REPRODUCIBILITY; RESPIRATORY FAILURE; VALIDATION PROCESS; VENTILATOR;

ADMINISTRATION, INHALATION; AEROSOLS; ALBUTEROL; ANTI-BACTERIAL AGENTS; BRONCHODILATOR AGENTS; HUMANS; MODELS, BIOLOGICAL; PREDICTIVE VALUE OF TESTS; REPRODUCIBILITY OF RESULTS; RESPIRATION DISORDERS; RESPIRATION, ARTIFICIAL; SPUTUM;

EID: 0242468642     PISSN: 1073449X     EISSN: None     Source Type: Journal    
DOI: 10.1164/rccm.200210-1167OC     Document Type: Article

References (16)

1. Diot P, Morra L, Smaldone GC. Albuterol delivery in a model of mechanical ventilation: comparison of metered-dose inhaler and nebulizer efficiency. Am J Respir Crit Care Med 1995;152:1391-1394.
2. O'Riordan TG, Palmer LB, Smaldone GC. Aerosol deposition in mechanically ventilated patients: optimizing nebulizer delivery. Am J Respir Crit Care Med 1994;150:1474-1475.
3. O'Doherty MJ, Thomas SHL, Page CJ, Treacher DF, Nunan TO. Delivery of a nebulized aerosol to a lung model during mechanical ventilation: effect of ventilator settings and nebulizer type, position, and volume of fill. Am Rev Respir Dis 1992;146:383-388.
4. Dhand R, Tobin MJ. Inhaled bronchodilator therapy in mechanically ventilated patients. Am J Respir Crit Care Med 1997;156:3-10.
5. Palmer LB, Smaldone GC, Simon SR, O'Riordan TG, Cuccia A. Aerosolized antibiotics in mechanically ventilated patients: delivery and response. Crit Care Med 1998;26:31-39.
6. Thomas SH, O'Doherty MJ, Fidler HM, Page CJ, Treacher DF, Nunan TO. Pulmonary deposition of a nebulised aerosol during mechanical ventilation. Thorax 1993;48:154-159.
7. Fuller HD, Dolovich MB, Posmituck G, Wong Pack W, Newhouse MT. Pressurized aerosol verses jet aerosol delivery to mechanically ventilated patients. Am Rev Respir Dis 1990;141:440-444.
8. O'Riordan TG, Kleinman LI, Hughes K, Smaldone GC. Predicting aerosol deposition during neonatal ventilation: feasibility of bench testing. Respir Care 1994;39:1162-1168.
9. Smaldone GC. Enhanced in vitro delivery of budesonide via continuous and breath-actuated nebulization. Eur Respir J 2000;16:540s.
10. Miller D, Smith S, Hughes K, Smaldone GC. Drug delivery via nebulizer during mechanical ventilation: an update. Am J Respir Crit Care Med 2002;165:A377.
11. McPeck M, Tandon R, Hughes K, Smaldone GC. Aerosol delivery during continuous nebulization. Chest 1997;111:1200-1205.
12. O'Riordan T, Greco MJ, Perry RJ, Smaldone GC. Nebulizer function during mechanical ventilation. Am J Respir Crit Care Med 1992;145: 1117-1122.
13. Palmer LB, Smaldone GC, O'Riordan TG, Morra L. Tracheal aspirates in chronically mechanically ventilated patients: a human model of gram-negative infection and airway inflammation. Chest 1995;108: 1326-1332.
14. McPeck M, O'Riordan TG, Smaldone GC. Choice of mechanical ventilator: influence on nebulizer performance. Respir Care 1993;38:887-895.
15. Ilowite JS, Gorvoy JD, Smaldone GC. Quantitative deposition of aerosolized gentamicin in cystic fibrosis. Am Rev Respir Dis 1987;136:1445-1449.
16. Dhand R, Tobin MJ. Bronchodilator delivery with metered dose inhalers in mechanically ventilated patients. Eur Respir J 1996;9:585-595.