Metered dose inhalers versus nebulizers for aerosol bronchodilator delivery for adult patients receiving mechanical ventilation in critical care units

Cochrane Database of Systematic Reviews

Volumn 2013, Issue 6, 2013, Pages

  Holland, Agi ^a   Smith, Fiona ^a   Penny, Kay ^a   Mccrossan, Gill ^a   Veitch, Linda ^a   Nicholson, Caroline ^b  

^a EDINBURGH NAPIER UNIVERSITY   (United Kingdom)

^b WESTERN GENERAL HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BRONCHODILATING AGENT; AEROSOL;

ADULT; ADVERSE EVENT; AEROSOL; AIRWAY RESISTANCE; ARTIFICIAL VENTILATION; CLINICAL EFFECTIVENESS; CRITICALLY ILL PATIENT; EVIDENCE BASED MEDICINE; HEMODYNAMICS; HUMAN; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL (TOPIC); REVIEW; SAMPLE SIZE; SYSTEMATIC REVIEW; COMPARATIVE STUDY; CRITICAL ILLNESS; DRUG EFFECTS; HEART RATE; INTENSIVE CARE UNIT; METERED DOSE INHALER; NEBULIZER; PHYSIOLOGY;

ADULT; AEROSOLS; AIRWAY RESISTANCE; BRONCHODILATOR AGENTS; CRITICAL ILLNESS; HEART RATE; HUMANS; INTENSIVE CARE UNITS; METERED DOSE INHALERS; NEBULIZERS AND VAPORIZERS; RANDOMIZED CONTROLLED TRIALS AS TOPIC; RESPIRATION, ARTIFICIAL;

EID: 84891666522     PISSN: None     EISSN: 1469493X     Source Type: Journal    
DOI: 10.1002/14651858.CD008863.pub2     Document Type: Review

References (49)

1. Gay PC, Hemant GP, Nelson SB, Gilles B, Hubmyr RD. Metered dose inhalers for bronchodilator delivery in intubated, mechanically ventilated patients. Chest 1991;99(1):66-71. [PUBMED: 1984989]
2. Guerin C, Chevre A, Dessirier P, Poncet T, Becquemin M, Dequin P, et al.Inhaled fenoterol-ipratropium bromide in mechanically ventilated patients with chronic obstructive pulmonary disease. American Journal of Respiratory and Critical Care Medicine 1999;159(4):1036-42.
3. Manthous CA, Hall JB, Schmidt GA, Wood LDH. Metered-dose inhaler versus nebulized albuterol in mechanically ventilated patients. American Review of Respiratory Disease 1993;148(6P+1):1567-70.
4. Duarte AG, Momii K, Bidani A. Bronchodilator therapy with MDI and spacer vs. nebulizer in mechanically ventilated patients; comparison of magnitude and duration of response. Respiratory Care 2000;45(7):817-23.
5. Fernandez A, Lazaro A, Garcia A, Aragon C, Cerda E. Bronchodilators in patients with chronic obstructive pulmonary disease on mechanical ventilation. American Review of Respiratory Disease. 1990;141:164-8.
6. Fuller HD, Dolovitch MB, Postmituck G, Pack WW, Newhouse MT. Pressurized aerosol versus jet aerosol delivery to mechanically ventilated patients. Comparison of dose to the lungs. The American Review of Respiratory Disease 1990;141(2):440-4.
7. Fuller HD, Dolovich MB, Turpie FH, Newhouse MT. Efficiency of bronchodilator aerosol delivery to the lungs from the metered dose Inhaler in mechanically ventilated patients. Chest 1994;105(1):214-8.
8. Gervais A, Begin P. Bronchodilation with a metered-dose Inhaler plus an extension, using tidal breathing vs jet nebulization. Chest 1987;92(5):822-4.
9. Gutierrez C, Nelson R. Short-term bronchodilation in mechanically ventilated patients receiving metaproterenol via small volume nebulizer (SVN) or metered-dose inhaler (MDI). A pilot study. Respiratory Care 1988;33(10):910.
10. Marik P, Hogan J, Krikorian J. A comparison of bronchodilator therapy delivered by nebulization and metered-dose inhaler in mechanically ventilated patients. Chest 1999;115(6):1653-7.
11. Waugh JB, Jones DF, Aranson R, Honig EG. Bronchodilator response with use of OptiVent versus Aerosol Cloud Enhancer metered-dose inhaler spacers in patients receiving ventilator assistance. Heart and Lung 1998;27(6):418-23.
12. Alvine GF, Rodgers P, Fitzsimmons KM, Ahrens RC. Disposable jet nebulizers. How reliable are they?. Chest 1992;101(2):316-9. [PUBMED: 1735247]
13. Ballard J, Lugo R, Salyer JW. A survey of albuterol administration practices in intubated patients in the neonatal intensive care unit. Respiratory Care 2002;47(1):31-8. [PUBMED: 11749685]
14. Beaty CD, Ritz RH, Benson MS. Continuous in-line nebulizers complicate pressure support ventilation. Chest 1989;96(6):1360-3. [PUBMED: 2582845]
15. Joint Formulary Committee. British National Formulary. 58. London: BMJ Group / RPS Publishing, September 2009.
16. Boucher BA, Kuhl DA, Coffey BC, Fabian TC. Drug use in a trauma intensive-care unit. American Journal of Hospital Pharmacy 1990;47(4):805-10. [PUBMED: 2321658]
17. Bowton, DL, Goldsmith, WM, Haponik, EF. Substitution of metered dose inhalers for hand held nebulizers. Success and cost savings in a large, acute care hospital. Chest 1992;101(2):305-8. [PUBMED: 1346514]
18. Brochard L, Mancebo J, Wysocki M, Lofaso F, Conti G, Rauss A, et al.Noninvasive ventilation for acute exacerbations of chronic obstructive pulmonary disease. The New England Journal of Medicine 1995;333(13):817-22. [PUBMED: 7651472]
19. Coleman DM, Kelly HW, McWilliams BC. Therapeutic aerosol delivery during mechanical ventilation. Annals of Pharmacotherapy 1996;30(6):644-55. [PUBMED: 8792952]
20. Crogan SJ, Bishop MJ. Delivery efficiency of metered dose aerosols given via endotracheal tubes. Anesthesiology 1989;70(6):1008-10. [PUBMED: 2729618]
21. Dhand R, Tobin MJ. Bronchodilator delivery with metered-dose inhalers in mechanically ventilated patients. European Respiratory Journal 1996;9:585-95. [PUBMED: 8730023]
22. Dhand, R, Tobin, MJ. Inhaled bronchodilator therapy in mechanically ventilated patients. American Journal of Respiratory and Critical Care Medicine 1997;156:3-10. [PUBMED: 9230718]
23. Dhand R. Maximising aerosol delivery during mechanical ventilation: go with the flow and go slow. Intensive Care Medicine 2003;29:1041-2. [PUBMED: 12918517]
24. Dhand R. Basic techniques for aerosol delivery during mechanical ventilation. Respiratory Care 2004;49(6):611-22. [PUBMED: 15165296]
25. Dhand R. Inhalation therapy with metered dose inhalers and dry powder inhalers in mechanically ventilated patients. Respiratory Care 2005;50(10):1331-45. [PUBMED: 16185369]
26. Dhand R. Bronchodilator Therapy. In: Tobin MJ editor(s). Principles and Practice of Mechanical Ventilation. 2. McGraw-Hill, 2006:1277-310.
27. Dhand R, Mercier E. Effective inhaled drug delivery to mechanically ventilated patients. Expert Opinion in Drug Delivery 2007;4(1):47-61. [PUBMED: 17184162]
28. Dhand R. Inhalation therapy in invasive and non-invasive mechanical ventilation. Current Opinion in Critical Care 2007;13:27-38. [PUBMED: 17198046]
29. Dhand R, Guntur VP. How best to deliver aerosol medications to mechanically ventilated patients. Clinics in Chest Medicine 2008;29(2):277-96. [PUBMED: 18440437]
30. Dolovich MB, Ahrens RC, Hess DR, Anderson P, Dhand R, Rau JL, et al.Device selection and outcomes of aerosol therapy:evidence-based guidelines. Chest 2005;127(1):335-71. [PUBMED: 5654001]
31. Egger M, Davey Smith G, Schneider M, Minder C. Bias in meta-analysis detected by a simple, graphical test. BMJ 1997;315(7109):629-34. [PUBMED: 9310563]
32. Elbourne DR, Altman DG, Higgins JPT, Curtin F, Worthington HV, Vail A. Meta-analyses involving cross-over trials: methodological issues. International Journal of Epidemiology 2002;31:140-9. [PUBMED: 11914310]
33. Fink JB, Tobin MJ, Dhand R. Bronchodilator therapy in mechanically ventilated patients. Respiratory Care 1999;44(1):53-69.
34. Fink JB, Dhand R, Grychowski J, Fahey PJ, Tobin MJ. Reconciling in vitro and in vivo measurements of aerosol delivery from a metered-dose inhaler during mechanical ventilation and defining efficiency-enhancing factors. American Journal of Respiratory and Critical Care Medicine 1999;159:63-8. [PUBMED: 9872819]
35. Georgopoulos D, Mouloudi E, Kondili E, Klimathianaki M. Bronchodilator delivery with metered-dose inhaler during mechanical ventilation. Critical Care 2000;4(4):227-34. [PUBMED: 11094505]
36. Global Strategy for the Diagnosis, Management and Prevention of Chronic Obstructive Lung Disease. Global initiative for chronic obstructive lung disease (GOLD). http://www.goldcopd.org. 2011 (accessed 17.10.12).
37. Guerin C, Fassier T, Bayle F, Lemasson S, Richard JC. Inhaled bronchodilator administration during mechanical ventilation: how to optimise it, and for which clinical benefit?. Journal of Aerosol Medicine and Pulmonary Drug Delivery 2008;21(1):85-96. [PUBMED: 18518835]
38. Hess D. Aerosol bronchodilator delivery during mechanical ventilation. Nebulizer or inhaler?. Chest 1991;100(4):1103-4. [PUBMED: 1914566]
39. Hess D. Aerosol delivery during mechanical ventilation. Minerva Anestesiologica 2002;68:321-5. [PUBMED: 12029238]
40. Higgins JPT, Green S (editors). Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0 [updated March 2011]. Available from www.cochrane-handbook.org 2011.
41. Jantz MA, Collop NA. Bronchodilator aerosol delivery in mechanical ventilation. Journal of Intensive Care Medicine 1999;14(4):166-83. [DOI: 10.1177/088506669901400402]
42. Johnson KL, Kearney PA, Johnson SB, Niblett JB, MacMillan NL, McClain RE. Closed versus open endotracheal suctioning: costs and physiological consequences. Critical Care Medicine 1994;22(4):658-66.
43. Loffert DT, Ikle D, Nelson HS. A Comparison of Jet Nebulizers. Chest 1994;106(6):1788-92. [PUBMED: 7988201]
44. National Institute of Clinical Excellence. Chronic obstructive pulmonary disease. Management of chronic obstructive pulmonary disease in adults in primary and secondary care (partial update). http://www.nice.org.uk/nicemedia/live/13029/49397/49397.pdf [accessed 30.08.10].
45. O'Doherty MJ, Thomas SHL. Nebuliser therapy in the intensive care unit. Thorax 1997;52(S2):s56-9. [PUBMED: 9155853]
46. Plant PK, Owen JL, Elliot MW. Early use of non-invasive ventilation for acute exacerbations of chronic obstructive pulmonary disease on general respiratory wards: a multicentre randomised controlled trial. Lancet 2000;355(9219):1931-5. [PUBMED: 10859037]
47. The Nordic Cochrane Centre, The Cochrane Collaboration. Review Manager (RevMan) Version 5.1. Copenhagen: The Nordic Cochrane Centre, The Cochrane Collaboration, 2011.
48. Rodriguez-Roisin R. COPD exacerbations 5: Management. Thorax 2006;61:535-44. [PUBMED: 16738044]
49. Rücker G, Schwarzer G, Carpenter J. Arcsine test for publication bias in meta-analyses with binary outcomes. Statistics in Medicine 2008;27(5):746-63. [PUBMED: 17592831]