Mutant PrP Suppresses Glutamatergic Neurotransmission in Cerebellar Granule Neurons by Impairing Membrane Delivery of VGCC α 2δ-1 Subunit

Neuron

Volumn 74, Issue 2, 2012, Pages 300-313

  Senatore, Assunta ^a   Colleoni, Simona ^a   Verderio, Claudia ^b   Restelli, Elena ^a   Morini, Raffaella ^b   Condliffe, Steven B ^b,e   Bertani, Ilaria ^a   Mantovani, Susanna ^a   Canovi, Mara ^a   Micotti, Edoardo ^a   Forloni, Gianluigi ^a   Dolphin, Annette C ^c   Matteoli, Michela ^b,d   Gobbi, Marco ^a   Chiesa, Roberto ^a  

^a MARIO NEGRI INSTITUTE FOR PHARMACOLOGICAL RESEARCH   (Italy)

^b UNIVERSITY OF MILAN   (Italy)

^c UNIVERSITY COLLEGE LONDON   (United Kingdom)

^d HUMANITAS CLINICAL AND RESEARCH CENTER   (Italy)

^e UNIVERSITY OF OTAGO   (New Zealand)

Author keywords

[No Author keywords available]

Indexed keywords

GLUTAMIC ACID; PRION PROTEIN; UNCLASSIFIED DRUG; VOLTAGE GATED CALCIUM CHANNEL; VOLTAGE GATED CALCIUM CHANNEL ALPHA2 DELTA 1;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL SURFACE; CONTROLLED STUDY; DISEASE ASSOCIATION; ENDOPLASMIC RETICULUM; ENZYME REPRESSION; EXOCYTOSIS; GLUTAMATERGIC NEUROTRANSMISSION; GRANULE CELL; HUMAN; HUMAN CELL; INTRACELLULAR SIGNALING; LOCOMOTION; MEMBRANE TRANSPORT; MOLECULAR DYNAMICS; MOTOR DYSFUNCTION; MOUSE; MUTANT; NERVE DEGENERATION; NEUROTRANSMISSION; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN INTERACTION; PROTEIN METABOLISM; PROTEIN TRANSPORT;

AGE FACTORS; ANIMALS; ANIMALS, NEWBORN; BIOPHYSICS; CALCIUM; CALCIUM CHANNELS; CELLS, CULTURED; CEREBELLUM; DISEASE MODELS, ANIMAL; ELECTRIC STIMULATION; ENDOPLASMIC RETICULUM; GLUTAMIC ACID; GREEN FLUORESCENT PROTEINS; MAGNETIC RESONANCE IMAGING; MEMBRANE POTENTIALS; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; MOTOR ACTIVITY; MUTATION; NEURONS; PATCH-CLAMP TECHNIQUES; PRION DISEASES; PRIONS; PROTEIN TRANSPORT; REACTION TIME; ROTAROD PERFORMANCE TEST; SYNAPTIC TRANSMISSION; SYNAPTOSOMES;

EID: 84860288578     PISSN: 08966273     EISSN: 10974199     Source Type: Journal    
DOI: 10.1016/j.neuron.2012.02.027     Document Type: Article

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