Epitope scanning indicates structural differences in brain-derived monomeric and aggregated mutant prion proteins related to genetic prion diseases

Biochemical Journal

Volumn 454, Issue 3, 2013, Pages 417-425

  Tapella, Laura ^a   Stravalaci, Matteo ^b   Bastone, Antonio ^b   Biasini, Emiliano ^a   Gobbi, Marco ^b   Chiesa, Roberto ^a  

^a MARIO NEGRI INSTITUTE FOR PHARMACOLOGICAL RESEARCH   (Italy)

^b Department of Biochemistry and Molecular Pharmacology ^*  (Italy)

Author keywords

Genetic prion disease; Prion protein (PrP); Protein aggregation; Protein misfolding

Indexed keywords

EPITOPE; MONOCLONAL ANTIBODY; MUTANT PROTEIN; PRION PROTEIN; RECOMBINANT PROTEIN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN; BRAIN DISEASE; CREUTZFELDT JAKOB DISEASE; FATAL FAMILIAL INSOMNIA; GEL PERMEATION CHROMATOGRAPHY; GENE SEQUENCE; GENETIC DISORDER; GENETIC PRION DISEASE; GERSTMANN STRAUSSLER SCHEINKER SYNDROME; MOUSE; NEUROTOXICITY; NONHUMAN; PRION DISEASE; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN FOLDING; SURFACE PLASMON RESONANCE; TRANSGENIC MOUSE; VASCULAR AMYLOIDOSIS; WESTERN BLOTTING;

ANIMALS; ANTIBODIES, MONOCLONAL; BRAIN; CREUTZFELDT-JAKOB SYNDROME; DETERGENTS; EPITOPE MAPPING; GERSTMANN-STRAUSSLER-SCHEINKER DISEASE; HUMANS; MICE; MICE, INBRED C57BL; MICE, INBRED CBA; MICE, TRANSGENIC; MUTATION, MISSENSE; POLYMORPHISM, GENETIC; PRIONS; PROTEIN BINDING; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; SODIUM DODECYL SULFATE; SURFACE PLASMON RESONANCE;

EID: 84883427878     PISSN: 02646021     EISSN: 14708728     Source Type: Journal    
DOI: 10.1042/BJ20130563     Document Type: Article

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