Mutant PrP is delayed in its exit from the endoplasmic reticulum, but neither wild-type nor mutant PrP undergoes retrotranslocation prior to proteasomal degradation

Journal of Biological Chemistry

Volumn 278, Issue 24, 2003, Pages 21732-21743

  Drisaldi, Bettina ^a,c   Stewart, Richard S ^a   Adles, Cheryl ^a   Stewart, Leanne R ^a   Quaglio, Elena ^a,b,d   Biasini, Emiliano ^b   Fioriti, Luana ^b   Chiesa, Roberto ^b   Harris, David A ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b DULBECCO TELETHON INSTITUTE   (Italy)

^c UNIVERSITY OF TORONTO   (Canada)

^d MARIO NEGRI INSTITUTE FOR PHARMACOLOGICAL RESEARCH   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MEMBRANES; BIOSYNTHESIS; CELL CULTURE; METABOLISM; MOLECULES; NITROGEN COMPOUNDS; PATHOLOGY; SYNTHESIS (CHEMICAL);

ENDOPLASMIC RETICULUM (ER);

NEUROLOGY;

ENDOGLYCOSIDASE H; GLYCOSIDASE; PRION PROTEIN; PROTEASOME; PROTEASOME INHIBITOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL CULTURE; CONTROLLED STUDY; CYTOPLASM; ENDOPLASMIC RETICULUM; GENETIC TRANSFECTION; MOLECULAR BIOLOGY; NERVE CELL CULTURE; NEUROLOGIC DISEASE; NONHUMAN; PRION; PRION DISEASE; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN METABOLISM; PROTEIN SYNTHESIS; PROTEIN TRANSPORT; RAT;

ANIMALS; BLOTTING, NORTHERN; BLOTTING, WESTERN; CEREBELLUM; CHO CELLS; CRICETINAE; CYSTEINE ENDOPEPTIDASES; CYTOPLASM; DETERGENTS; ENDOPLASMIC RETICULUM; GLYCOSYLATION; MICE; MICROSCOPY, FLUORESCENCE; MULTIENZYME COMPLEXES; MUTATION; PC12 CELLS; PRECIPITIN TESTS; PRIONS; PROTEASOME ENDOPEPTIDASE COMPLEX; RATS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; TIME FACTORS; TRANSFECTION;

ANIMALIA;

EID: 0038159514     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M213247200     Document Type: Article

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