Kinetic characterization and allosteric inhibition of the Yersinia pestis 1-deoxy-D-xylulose 5-phosphate reductoisomerase (MEP synthase)

PLoS ONE

Volumn 9, Issue 8, 2014, Pages

  Haymond, Amanda ^a   Johny, Chinchu ^a   Dowdy, Tyrone ^a   Schweibenz, Brandon ^a   Villarroel, Karen ^a   Young, Richard ^a   Mantooth, Clark J ^a   Patel, Trishal ^a   Bases, Jessica ^a   San Jose, Geraldine ^b   Jackson, Emily R ^b   Dowd, Cynthia S ^b   Couch, Robin D ^a  

^a GEORGE MASON UNIVERSITY   (United States)

^b GEORGE WASHINGTON UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1 DEOXY DEXTRO XYLULOSE 5 PHOSPHATE REDUCTOISOMERASE; 3 (N ACETYL N HYDROXYAMINO)PROPYLPHOSPHONIC ACID; BACTERIAL ENZYME; ENZYME INHIBITOR; FOSMIDOMYCIN; UNCLASSIFIED DRUG; 1-DEOXY-D-XYLULOSE 5-PHOSPHATE REDUCTOISOMERASE; 3-(N-ACETYL-N-HYDROXY)AMINOPROPYLPHOSPHONIC ACID; BACTERIAL PROTEIN; ERYTHRITOL; FOSFOMYCIN; ISOMERASE;

ALLOSTERISM; ARTICLE; BACTERIAL GROWTH; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFECT; DRUG POTENCY; DRUG STRUCTURE; DRUG TARGETING; ENZYME ASSAY; ENZYME INHIBITION; ENZYME KINETICS; ENZYME MECHANISM; ENZYME PURIFICATION; ENZYME REGULATION; GROWTH INHIBITION; HIGH THROUGHPUT SCREENING; IC 50; ISOMERIZATION; MOLECULAR CLONING; MOLECULAR LIBRARY; NONHUMAN; NUCLEOTIDE SEQUENCE; PROTEIN EXPRESSION; YERSINIA PESTIS; ANALOGS AND DERIVATIVES; BIOSYNTHESIS; CATALYSIS; CHEMISTRY; ENZYMOLOGY; GENETICS; KINETICS;

ALDOSE-KETOSE ISOMERASES; ALLOSTERIC REGULATION; BACTERIAL PROTEINS; CATALYSIS; ERYTHRITOL; FOSFOMYCIN; KINETICS; YERSINIA PESTIS;

EID: 84929490763     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0106243     Document Type: Article

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