Design, synthesis, and X-ray crystallographic studies of α-aryl substituted fosmidomycin analogues as inhibitors of mycobacterium tuberculosis 1-deoxy-d-xylulose 5-phosphate reductoisomerase

Journal of Medicinal Chemistry

Volumn 54, Issue 14, 2011, Pages 4964-4976

  Andaloussi, Mounir ^a   Henriksson, Lena M ^a   Wiȩckowska, Anna ^a   Lindh, Martin ^a   Björkelid, Christofer ^a   Larsson, Anna M ^a   Suresh, Surisetti ^a   Iyer, Harini ^c   Srinivasa, Bachally R ^c   Bergfors, Terese ^a   Unge, Torsten ^a   Mowbray, Sherry L ^a,b   Larhed, Mats ^a   Jones, T Alwyn ^a   Karlén, Anders ^a  

^a UPPSALA UNIVERSITY   (Sweden)

^b SWEDISH UNIVERSITY OF AGRICULTURAL SCIENCES   (Sweden)

^c ASTRAZENECA   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

1 DEOXY D XYLULOSE 5 PHOSPHATE REDUCTOISOMERASE; 3 (N HYDROXYACETAMIDO) 1 (3,4 DICHLOROPHENYL)PROPYLPHOSPHONIC ACID; 3 (N HYDROXYFORMAMIDO) 1 (3,4 DICHLOROPHENYL)PROPYLPHOSPHONIC ACID; [3 (N HYDROXYACETAMIDO) 1 PHENYL]PROPYLPHOSPHONIC ACID; DIETHYL [1 (3,4 DICHLOROPHENYL) 3 (N HYDROXYACETAMIDO)PROPYL]PHOSPHONATE; DIETHYL [1 (3,4 DICHLOROPHENYL) 3 (N HYDROXYFORMAMIDO)PROPYL]PHOSPHONATE; FOSMIDOMYCIN; OXIDOREDUCTASE; UNCLASSIFIED DRUG;

ARTICLE; CRYSTAL STRUCTURE; DRUG DESIGN; DRUG SYNTHESIS; IC 50; MINIMUM INHIBITORY CONCENTRATION; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PATHOGENESIS; PHYSICAL CHEMISTRY; PLASMODIUM; X RAY CRYSTALLOGRAPHY;

ALDOSE-KETOSE ISOMERASES; ANTITUBERCULAR AGENTS; CATALYTIC DOMAIN; CRYSTALLOGRAPHY, X-RAY; DRUG DESIGN; FOSFOMYCIN; MODELS, MOLECULAR; MULTIENZYME COMPLEXES; MYCOBACTERIUM TUBERCULOSIS; OXIDOREDUCTASES; PROTEIN BINDING; PROTEIN CONFORMATION; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 79960652249     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm2000085     Document Type: Article

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