IspE inhibitors identified by a combination of in silico and in vitro high-throughput screening.

PloS one

Volumn 7, Issue 4, 2012, Pages

  Tidten Luksch, Naomi ^a   Grimaldi, Raffaella ^b   Torrie, Leah S ^b   Frearson, Julie A ^b   Hunter, William N ^b   Brenk, Ruth ^b  

^a UNIVERSITY OF DUNDEE   (United Kingdom)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIN DEPENDENT KINASE 2; ESCHERICHIA COLI PROTEIN; HEMITERPENE; ISOPENTENYL DIPHOSPHATE; ISPE PROTEIN, E COLI; LIGAND; ORGANOPHOSPHORUS COMPOUND; PHOSPHOTRANSFERASE;

ARTICLE; BINDING SITE; CHEMISTRY; COMPUTER SIMULATION; DRUG ANTAGONISM; ENZYME SPECIFICITY; ESCHERICHIA COLI; HIGH THROUGHPUT SCREENING; HUMAN; METABOLISM; PROTEIN TERTIARY STRUCTURE; STRUCTURE ACTIVITY RELATION; X RAY CRYSTALLOGRAPHY;

BINDING SITES; COMPUTER SIMULATION; CRYSTALLOGRAPHY, X-RAY; CYCLIN-DEPENDENT KINASE 2; ESCHERICHIA COLI; ESCHERICHIA COLI PROTEINS; HEMITERPENES; HIGH-THROUGHPUT SCREENING ASSAYS; HUMANS; LIGANDS; ORGANOPHOSPHORUS COMPOUNDS; PHOSPHOTRANSFERASES (ALCOHOL GROUP ACCEPTOR); PROTEIN STRUCTURE, TERTIARY; STRUCTURE-ACTIVITY RELATIONSHIP; SUBSTRATE SPECIFICITY;

EID: 84866244446     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0035792     Document Type: Article

References (0)