A high-throughput screening assay for simultaneous selection of inhibitors of mycobacterium tuberculosis 1-deoxy-D-xylulose-5-phosphate synthase (Dxs) or 1-deoxy-D-xylulose 5-phosphate reductoisomerase (Dxr)

Journal of Biomolecular Screening

Volumn 16, Issue 3, 2011, Pages 303-312

  Humnabadkar, Vaishali ^a   Jha, Ramesh K ^a,b   Ghatnekar, Nuzhat ^a   De Sousa, Sunita M ^a  

^a ASTRAZENECA   (United Kingdom)

^b LOS ALAMOS NATIONAL LABORATORY   (United States)

Author keywords

1 deoxy D xylulose 5 phosphate reductoisomerase; 1 deoxy D xylulose 5 phosphate synthase; coupled assay; fosmidomycin; HTS assay; methylerythritol phosphate

Indexed keywords

1 DEOXY DEXTRO XYLULOSE 5 PHOSPHATE REDUCTOISOMERASE; 1 DEOXY DEXTRO XYLULOSE 5 PHOSPHATE SYNTHASE; 1 DEOXY DEXTRO XYLULOSE 5 PHOSPHATE SYNTHASE INHIBITOR; BACTERIAL ENZYME; ENZYME INHIBITOR; FLUOROPYRUVATE; FOSMIDOMYCIN; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; UNCLASSIFIED DRUG; XYLULOSE REDUCTASE;

ARTICLE; BINDING ASSAY; COST EFFECTIVENESS ANALYSIS; DRUG BINDING; DRUG COST; DRUG DETERMINATION; ENTHALPY; ENZYME ASSAY; ENZYME BINDING; HIGH THROUGHPUT SCREENING; IC 50; ISOTHERMAL TITRATION CALORIMETRY; MYCOBACTERIUM TUBERCULOSIS; PRIORITY JOURNAL;

ALDOSE-KETOSE ISOMERASES; ANTI-BACTERIAL AGENTS; ENZYME ACTIVATION; ENZYME INHIBITORS; FOSFOMYCIN; HIGH-THROUGHPUT SCREENING ASSAYS; MULTIENZYME COMPLEXES; MYCOBACTERIUM TUBERCULOSIS; OXIDOREDUCTASES; PROTEIN BINDING; REPRODUCIBILITY OF RESULTS; TRANSFERASES;

MYCOBACTERIUM TUBERCULOSIS;

EID: 79954618325     PISSN: 10870571     EISSN: 1552454X     Source Type: Journal    
DOI: 10.1177/1087057110394845     Document Type: Article

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