Inhibition of IspH, a [4Fe-4S]2+ enzyme involved in the biosynthesis of isoprenoids via the methylerythritol phosphate pathway

Journal of the American Chemical Society

Volumn 135, Issue 5, 2013, Pages 1816-1822

  Janthawornpong, Karnjapan ^a   Krasutsky, Sergiy ^b,c   Chaignon, Philippe ^a   Rohmer, Michel ^a   Poulter, C Dale ^b   Seemann, Myriam ^a  

^a UNIVERSITÉ DE STRASBOURG   (France)

^b UNIVERSITY OF UTAH   (United States)

^c ALBANY MOLECULAR RESEARCH INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIMICROBIAL DRUG; BINDING BEHAVIORS; DETAILED KINETICS; DIPHOSPHATES; E. COLI; ISOPENTENYL DIPHOSPHATE; ISOPRENOIDS; KINETIC INVESTIGATIONS; METHYLERYTHRITOL PHOSPHATE PATHWAYS; OH GROUP; PARASITE; PATHOGENIC BACTERIUM; POTENT INHIBITOR; THIOL GROUPS; TIGHT BINDING;

BIOCHEMISTRY; ESCHERICHIA COLI; LIPIDS;

ENZYMES;

4 HYDROXY 3 METHYLBUT 2 EN 1 YL DIPHOSPHATE; 4 MERCAPTO 3 METHYLBUT 2 EN 1 YL DIPHOSPHATE; 5 DEAZAFLAVINE DERIVATIVE; DIMETHYLALLYL DIPHOSPHATE; DITHIONITE; ENZYME INHIBITOR; HYDROXYL GROUP; IRON SULFUR PROTEIN; ISOPENTENYL DIPHOSPHATE; ISOPRENOID; METHYLERYTHRITOL PHOSPHATE; PARAQUAT; PHOSPHATE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; THIOL GROUP; UNCLASSIFIED DRUG;

ARTICLE; CATALYSIS; CONTROLLED STUDY; ENZYME BINDING; ENZYME INHIBITION; ENZYME KINETICS; ENZYME METABOLISM; ENZYME STRUCTURE; ENZYME SYNTHESIS; ESCHERICHIA COLI; IC 50; IN VITRO STUDY; METHYLERYTHRITOL PHOSPHATE PATHWAY; OXIDATION; REDUCTION; SIGNAL TRANSDUCTION;

BIOCATALYSIS; BIOSYNTHETIC PATHWAYS; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; ERYTHRITOL; ESCHERICHIA COLI PROTEINS; KINETICS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; OXIDOREDUCTASES; STRUCTURE-ACTIVITY RELATIONSHIP; SUGAR PHOSPHATES; TERPENES;

EID: 84873382823     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/ja309557s     Document Type: Article

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