Targeting the methyl erythritol phosphate (MEP) pathway for novel antimalarial, antibacterial and herbicidal drug discovery: Inhibition of 1-deoxy-d-xylulose-5-phosphate reductoisomerase (DXR) enzyme

Current Pharmaceutical Design

Volumn 13, Issue 11, 2007, Pages 1161-1177

  Singh, Nidhi ^a   Chevé, Gweneal ^a   Avery, Mitchell A ^a,b   McCurdy, Christopher R ^a,b  

^a UNIVERSITY OF MISSISSIPPI   (United States)

^b UNIVERSITY OF MISSISSIPPI   (United States)

Author keywords

DXP reductoisomerase; DXR; Fosmidomycin; FR900098; Isoprenoids; MEP pathway; Mevalonate

Indexed keywords

1 DEOXY DEXTRO XYLULOSE 5 PHOSPHATE REDUCTOISOMERASE; 2 METHYL DEXTRO ERYTHRITOL 4 PHOSPHATE; 3 (N ACETYL N HYDROXYAMINO)PROPYLPHOSPHONIC ACID; 4 (HYDROXYAMINO) 4 OXOBUTYLPHOSPHONIC ACID; ANTIINFECTIVE AGENT; ANTIMALARIAL AGENT; ANTISPOROZOAL AGENT; CLINDAMYCIN; DITERPENOID; DRUG ANALOG; ENZYME INHIBITOR; FOSMIDOMYCIN; HERBICIDE; ISOMERASE; ISOMERASE INHIBITOR; ISOPRENOID; KETOL ACID REDUCTOISOMERASE; LINCOMYCIN; LINCOSAMIDE; MEVALONIC ACID; NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; PHOSPHATE; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; AMINO TERMINAL SEQUENCE; ANTIBACTERIAL ACTIVITY; ANTIMALARIAL ACTIVITY; BIOSYNTHESIS; CARBOXY TERMINAL SEQUENCE; CATALYSIS; CHEMICAL REACTION; CLINICAL TRIAL; CRYSTAL STRUCTURE; DRUG BIOAVAILABILITY; DRUG HALF LIFE; DRUG SYNTHESIS; ENZYME ACTIVITY; ENZYME STRUCTURE; HERBICIDAL ACTIVITY; HUMAN; IC 50; MALARIA; MOLECULAR MODEL; MONOTHERAPY; NONHUMAN; PRIORITY JOURNAL; PROTEIN TARGETING; REACTION ANALYSIS; REVIEW; STEREOCHEMISTRY;

ALDOSE-KETOSE ISOMERASES; ANIMALS; ANTI-BACTERIAL AGENTS; ANTIMALARIALS; DRUG DELIVERY SYSTEMS; DRUG DESIGN; ENZYME INHIBITORS; ERYTHRITOL; HERBICIDES; HUMANS; MULTIENZYME COMPLEXES; OXIDOREDUCTASES; SUGAR PHOSPHATES;

EID: 34248596742     PISSN: 13816128     EISSN: None     Source Type: Journal    
DOI: 10.2174/138161207780618939     Document Type: Review

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