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Volumn 20, Issue 4, 2015, Pages 385-393

PLGA micro and nanoparticles in delivery of peptides and proteins; Problems and approaches

Author keywords

Drug delivery; PLGA; Polyesters; Polymeric carrier

Indexed keywords

BETA1A INTERFERON; BOTULINUM TOXIN A; CLOSTRIDIOPEPTIDASE A; FILGRASTIM; GOSERELIN; HUMAN GROWTH HORMONE; HUMAN INSULIN; LEUPRORELIN; MICROSPHERE; NANOPARTICLE; OCTREOTIDE; ORGANIC SOLVENT; PEPTIDES AND PROTEINS; POLOXAMER; POLYGLACTIN; POLYVINYL ALCOHOL; RECOMBINANT ALPHA2A INTERFERON; RECOMBINANT ALPHA2B INTERFERON; RECOMBINANT BLOOD CLOTTING FACTOR 8; RECOMBINANT BLOOD CLOTTING FACTOR 9; RECOMBINANT ERYTHROPOIETIN; WATER OIL CREAM; ZINC ACETATE; DRUG CARRIER; LACTIC ACID; PEPTIDE; POLYGLYCOLIC ACID; POLYLACTIC ACID-POLYGLYCOLIC ACID COPOLYMER; PROTEIN;

EID: 84929411952     PISSN: 10837450     EISSN: 10979867     Source Type: Journal    
DOI: 10.3109/10837450.2014.882940     Document Type: Article
Times cited : (112)

References (85)
  • 1
    • 0141567459 scopus 로고    scopus 로고
    • Physical stability of proteins in aqueous solution: Mechanism and driving forces in nonnative protein aggregation
    • Chi EY, Krishnan S, Randolph TW, Carpenter JF. Physical stability of proteins in aqueous solution: mechanism and driving forces in nonnative protein aggregation. Pharm Res 2003;20:1325-1336.
    • (2003) Pharm Res , vol.20 , pp. 1325-1336
    • Chi, E.Y.1    Krishnan, S.2    Randolph, T.W.3    Carpenter, J.F.4
  • 2
    • 50849139867 scopus 로고    scopus 로고
    • Enzyme stability and stabilization-aqueous and non-aqueous environment
    • Iyer PV, Ananthanarayan L. Enzyme stability and stabilization-aqueous and non-aqueous environment. Process Biochem 2008;43: 1019-1032.
    • (2008) Process Biochem , vol.43 , pp. 1019-1032
    • Iyer, P.V.1    Ananthanarayan, L.2
  • 3
    • 0035965502 scopus 로고    scopus 로고
    • Microencapsulation of dissociable human growth hormone aggregates within poly(D,L-lactic-co-glycolic acid) microparticles for sustained release
    • Kim HK, Park TG. Microencapsulation of dissociable human growth hormone aggregates within poly(D,L-lactic-co-glycolic acid) microparticles for sustained release. Int J Pharm 2001;229: 107-116.
    • (2001) Int J Pharm , vol.229 , pp. 107-116
    • Kim, H.K.1    Park, T.G.2
  • 4
    • 19444373936 scopus 로고    scopus 로고
    • Development of a novel sustained release formulation of recombinant human growth hormone using sodium hyaluronate microparticles
    • Kim SJ, Hahn SK, Kim MJ, et al. Development of a novel sustained release formulation of recombinant human growth hormone using sodium hyaluronate microparticles. J Control Release 2005;104: 323-335.
    • (2005) J Control Release , vol.104 , pp. 323-335
    • Kim, S.J.1    Hahn, S.K.2    Kim, M.J.3
  • 5
    • 84884512609 scopus 로고    scopus 로고
    • The protective effect of albumin on bevacizumab activity and stability in PLGA nanoparticles intended for retinal and choroidal neovascularization treatments
    • Varshochian R, Jeddi-Tehrani M, Mahmoudi AR, et al. The protective effect of albumin on bevacizumab activity and stability in PLGA nanoparticles intended for retinal and choroidal neovascularization treatments. Eur J Pharm Sci 2013;50:341-352.
    • (2013) Eur J Pharm Sci , vol.50 , pp. 341-352
    • Varshochian, R.1    Jeddi-Tehrani, M.2    Mahmoudi, A.R.3
  • 7
    • 84881660948 scopus 로고    scopus 로고
    • Nanoparticle-mediated delivery of TGF-beta1 miRNA plasmid for preventing flexor tendon adhesion formation
    • Zhou Y, Zhang L, Zhao W, et al. Nanoparticle-mediated delivery of TGF-beta1 miRNA plasmid for preventing flexor tendon adhesion formation. Biomaterials 2013;34:8269-8278.
    • (2013) Biomaterials , vol.34 , pp. 8269-8278
    • Zhou, Y.1    Zhang, L.2    Zhao, W.3
  • 8
    • 77953468519 scopus 로고    scopus 로고
    • Nanoparticles based on PLGA and its copolymer: An overview
    • Muthu MS. Nanoparticles based on PLGA and its copolymer: an overview. Asian J Pharm 2009;3:266-273.
    • (2009) Asian J Pharm , vol.3 , pp. 266-273
    • Muthu, M.S.1
  • 9
    • 34547766051 scopus 로고    scopus 로고
    • PLA nano-and microparticles for drug delivery: An overview of the methods of preparation
    • Lassalle Vn, Ferreira MaLn. PLA nano-and microparticles for drug delivery: an overview of the methods of preparation. Macromol Biosci 2007;7:767-783.
    • (2007) Macromol Biosci , vol.7 , pp. 767-783
    • Vn, L.1    Ferreira, M.L.2
  • 10
    • 34248658536 scopus 로고    scopus 로고
    • Stabilization of recombinant human growth hormone against emulsification-induced aggregation by Pluronic surfactants during microencapsulation
    • Wei G, Lu LF, Lu WY. Stabilization of recombinant human growth hormone against emulsification-induced aggregation by Pluronic surfactants during microencapsulation. Int J Pharm 2007;338: 125-132.
    • (2007) Int J Pharm , vol.338 , pp. 125-132
    • Wei, G.1    Lu, L.F.2    Lu, W.Y.3
  • 11
    • 65949099508 scopus 로고    scopus 로고
    • Poly(lactide-co-glycolide)-based micro and nanoparticles for the controlled drug delivery of vitamins
    • Stevanović M, Uskoković D. Poly(lactide-co-glycolide)-based micro and nanoparticles for the controlled drug delivery of vitamins. Curr Nanosci 2009;5:1-15.
    • (2009) Curr Nanosci , vol.5 , pp. 1-15
    • Stevanović, M.1    Uskoković, D.2
  • 12
    • 0034601882 scopus 로고    scopus 로고
    • Effect of preparation temperature on the characteristics and release profiles of PLGA microspheres containing protein fabricated by double-emulsion solvent extraction/evaporation method
    • Yanga Y-Y, Chiab H-H, Chung T-S. Effect of preparation temperature on the characteristics and release profiles of PLGA microspheres containing protein fabricated by double-emulsion solvent extraction/evaporation method. J Control Release 2000;69:81-96.
    • (2000) J Control Release , vol.69 , pp. 81-96
    • Yanga, Y.-Y.1    Chiab, H.-H.2    Chung, T.-S.3
  • 14
    • 43649108406 scopus 로고    scopus 로고
    • Microspheres as delivery systems for the controlled release of peptides and proteins
    • Saez V, Herna'ndez JR, Peniche C. Microspheres as delivery systems for the controlled release of peptides and proteins. Biotecnologia Aplicada 2007;24:108-116.
    • (2007) Biotecnologia Aplicada , vol.24 , pp. 108-116
    • Saez, V.1    Herna'ndez, J.R.2    Peniche, C.3
  • 15
    • 34848910216 scopus 로고    scopus 로고
    • Smart polymer based delivery systems for peptides and proteins
    • Al-Tahami K, Singh J. Smart polymer based delivery systems for peptides and proteins. Recent Pat Drug Deliv Formul 2007;1:65-71.
    • (2007) Recent Pat Drug Deliv Formul , vol.1 , pp. 65-71
    • Al-Tahami, K.1    Singh, J.2
  • 16
    • 44049090553 scopus 로고    scopus 로고
    • Polymeric delivery systems in biotechnology: A mini review
    • Narayani R. Polymeric delivery systems in biotechnology: A mini review. Trends Biomater Artif Organs. 2007;21:14-19.
    • (2007) Trends Biomater Artif Organs. , vol.21 , pp. 14-19
    • Narayani, R.1
  • 17
    • 65549096370 scopus 로고    scopus 로고
    • Poly(ethylene glycol)-modified proteins: Implications for poly(lactide-co-glycolide)-based microsphere delivery
    • Pai SS, Tilton RD, Przybycien TM. Poly(ethylene glycol)-modified proteins: implications for poly(lactide-co-glycolide)-based microsphere delivery. Am Assoc Pharm Sci 2009;11:88-98.
    • (2009) Am Assoc Pharm Sci , vol.11 , pp. 88-98
    • Pai, S.S.1    Tilton, R.D.2    Przybycien, T.M.3
  • 18
    • 63649138813 scopus 로고    scopus 로고
    • Polymer-based sustained-release dosage forms for protein drugs, challenges, and recent advances
    • Wu F, Jin T. Polymer-based sustained-release dosage forms for protein drugs, challenges, and recent advances. AAPS PharmSciTech 2008;9:1218-1229.
    • (2008) AAPS PharmSciTech , vol.9 , pp. 1218-1229
    • Wu, F.1    Jin, T.2
  • 19
    • 0031917242 scopus 로고    scopus 로고
    • A large-scale process to produce microencapsulation proteins
    • Herbert P, Murphy K, Johnson O, et al. A large-scale process to produce microencapsulation proteins. Pharm Res 1998;15:357-361.
    • (1998) Pharm Res , vol.15 , pp. 357-361
    • Herbert, P.1    Murphy, K.2    Johnson, O.3
  • 20
    • 52149099922 scopus 로고    scopus 로고
    • Development and characterization of polymeric microspheres for controlled release protein loaded drug delivery system
    • Ravi S, Peh KK, Darwis Y, et al. Development and characterization of polymeric microspheres for controlled release protein loaded drug delivery system. Indian J Pharm Sci 2008;70:303-309.
    • (2008) Indian J Pharm Sci , vol.70 , pp. 303-309
    • Ravi, S.1    Peh, K.K.2    Darwis, Y.3
  • 21
    • 23144467114 scopus 로고    scopus 로고
    • Effect of additives on the release of a model protein from PLGA microspheres
    • Kang F, Singh J. Effect of additives on the release of a model protein from PLGA microspheres. AAPS PharmSciTech 2001;2:1-7.
    • (2001) AAPS PharmSciTech , vol.2 , pp. 1-7
    • Kang, F.1    Singh, J.2
  • 22
    • 84908648161 scopus 로고    scopus 로고
    • Improved safety with intravenous insulin therapy for critically ill patients with renal failure
    • in press
    • Dickerson RN, Allison ML, Maish GO, 3rd, et al. Improved safety with intravenous insulin therapy for critically ill patients with renal failure. Nutrition 2013 (in press).
    • (2013) Nutrition
    • Dickerson, R.N.1    Allison, M.L.2    Maish, G.O.3
  • 23
    • 84929421978 scopus 로고    scopus 로고
    • Effect of recombinant human growth hormone on changes in height, bone mineral density, and body composition over 1-2 years in children with Hurler or Hunter syndrome
    • in press
    • Polgreen LE, Thomas W, Orchard PJ, et al. Effect of recombinant human growth hormone on changes in height, bone mineral density, and body composition over 1-2 years in children with Hurler or Hunter syndrome. Mol Genet Metab 2013 (in press).
    • (2013) Mol Genet Metab
    • Polgreen, L.E.1    Thomas, W.2    Orchard, P.J.3
  • 24
    • 84885423738 scopus 로고    scopus 로고
    • Long-term anti-FVIII antibody response in Bethesda-negative haemophilia A patients receiving continuous replacement therapy
    • Klintman J, Hillarp A, Berntorp E, Astermark J. Long-term anti-FVIII antibody response in Bethesda-negative haemophilia A patients receiving continuous replacement therapy. Br J Haematol 2013;163:385-392.
    • (2013) Br J Haematol , vol.163 , pp. 385-392
    • Klintman, J.1    Hillarp, A.2    Berntorp, E.3    Astermark, J.4
  • 25
    • 84355163092 scopus 로고    scopus 로고
    • Factor IX replacement to cover total knee replacement surgery in haemophilia B: A singlecentre experience, 2000-2010
    • Uprichard J, Adamidou D, Goddard NJ, et al. Factor IX replacement to cover total knee replacement surgery in haemophilia B: A singlecentre experience, 2000-2010. Haemophilia 2012;18:46-49.
    • (2012) Haemophilia , vol.18 , pp. 46-49
    • Uprichard, J.1    Adamidou, D.2    Goddard, N.J.3
  • 26
    • 84889680401 scopus 로고    scopus 로고
    • Efficacy and safety of once-monthly continuous erythropoietin receptor activator in patients with chronic renal anemia
    • Locatelli F, Mandolfo S, Menegato Adorati M, et al. Efficacy and safety of once-monthly continuous erythropoietin receptor activator in patients with chronic renal anemia. J Nephrol 2013;26: 1114-1121.
    • (2013) J Nephrol , vol.26 , pp. 1114-1121
    • Locatelli, F.1    Mandolfo, S.2    Menegato Adorati, M.3
  • 27
    • 84929421979 scopus 로고    scopus 로고
    • Subcutaneous vs. Intravenous GCSF for the treatment of neutropenia in hospitalized hematooncological patients: Randomized controlled trial
    • in press
    • Paul M, Ram R, Kugler E, et al. Subcutaneous vs. intravenous GCSF for the treatment of neutropenia in hospitalized hematooncological patients: randomized controlled trial. Am J Hematol 2013 (in press).
    • (2013) Am J Hematol
    • Paul, M.1    Ram, R.2    Kugler, E.3
  • 28
    • 84864266943 scopus 로고    scopus 로고
    • Evaluation of the role of rhIL-11 on hematological recovery in lymphoma patients after autologous hematopoietic stem cell transplantation
    • Yang JL, Shi YK, He XH, et al. Evaluation of the role of rhIL-11 on hematological recovery in lymphoma patients after autologous hematopoietic stem cell transplantation. Zhonghua Zhong Liu Za Zhi 2012;34:469-472.
    • (2012) Zhonghua Zhong Liu Za Zhi , vol.34 , pp. 469-472
    • Yang, J.L.1    Shi, Y.K.2    He, X.H.3
  • 29
    • 85056056429 scopus 로고    scopus 로고
    • Comparison of antiviral activity of recombinant and natural interferons against crimeancongo hemorrhagic Fever virus
    • Karlberg H, Lindegren G, Mirazimi A. Comparison of antiviral activity of recombinant and natural interferons against crimeancongo hemorrhagic Fever virus. Open Virol J 2010;4:38-41.
    • (2010) Open Virol J , vol.4 , pp. 38-41
    • Karlberg, H.1    Lindegren, G.2    Mirazimi, A.3
  • 30
    • 84894284109 scopus 로고    scopus 로고
    • Persistence of hepatitis C virus during and after otherwise clinically successful treatment of chronic hepatitis C with standard pegylated interferon alpha-2b and ribavirin therapy
    • Chen AY, Zeremski M, Chauhan R, et al. Persistence of hepatitis C virus during and after otherwise clinically successful treatment of chronic hepatitis C with standard pegylated interferon alpha-2b and ribavirin therapy. PLoS One 2013;8:e80078.
    • (2013) PLoS One , vol.8 , pp. e80078
    • Chen, A.Y.1    Zeremski, M.2    Chauhan, R.3
  • 31
    • 84883416256 scopus 로고    scopus 로고
    • Subcutaneous interferon beta-1a may protect against cognitive impairment in patients with relapsing-remitting multiple sclerosis: 5-year follow-up of the COGIMUS study
    • Patti F, Morra VB, Amato MP, et al. Subcutaneous interferon beta-1a may protect against cognitive impairment in patients with relapsing-remitting multiple sclerosis: 5-year follow-up of the COGIMUS study. PLoS One 2013;8:e74111.
    • (2013) PLoS One , vol.8 , pp. e74111
    • Patti, F.1    Morra, V.B.2    Amato, M.P.3
  • 32
    • 84877687939 scopus 로고    scopus 로고
    • Evidence-based review and assessment of botulinum neurotoxin for the treatment of movement disorders
    • Hallett M, Albanese A, Dressler D, et al. Evidence-based review and assessment of botulinum neurotoxin for the treatment of movement disorders. Toxicon 2013;67:94-114.
    • (2013) Toxicon , vol.67 , pp. 94-114
    • Hallett, M.1    Albanese, A.2    Dressler, D.3
  • 33
    • 80053115560 scopus 로고    scopus 로고
    • Treatment of Dupuytren's contracture by means of injectable collagenase: First clinical experiences
    • Spanholtz TA, Holzbach T, Wallmichrath J, et al. Treatment of Dupuytren's contracture by means of injectable collagenase: first clinical experiences. Handchir Mikrochir Plast Chir 2011;43: 275-280.
    • (2011) Handchir Mikrochir Plast Chir , vol.43 , pp. 275-280
    • Spanholtz, T.A.1    Holzbach, T.2    Wallmichrath, J.3
  • 34
    • 70449628953 scopus 로고    scopus 로고
    • Preparation and characterization of a polymeric (PLGA) nanoparticulate drug delivery system with simultaneous incorporation of chemotherapeutic and thermo-optical agents
    • Manchanda R, Fernandez-Fernandez A, Nagesetti A, McGoron AJ. Preparation and characterization of a polymeric (PLGA) nanoparticulate drug delivery system with simultaneous incorporation of chemotherapeutic and thermo-optical agents. Colloids Surf B: Biointerfaces 2010;75:260-267.
    • (2010) Colloids Surf B: Biointerfaces , vol.75 , pp. 260-267
    • Manchanda, R.1    Fernandez-Fernandez, A.2    Nagesetti, A.3    McGoron, A.J.4
  • 35
    • 0037093720 scopus 로고    scopus 로고
    • Biocompatible stabilizers in the preparation of PLGA nanoparticles: A factorial design study
    • Vandervoort J, Ludwig A. Biocompatible stabilizers in the preparation of PLGA nanoparticles: A factorial design study. Int J Pharm 2002;238:77-92.
    • (2002) Int J Pharm , vol.238 , pp. 77-92
    • Vandervoort, J.1    Ludwig, A.2
  • 36
    • 0002511336 scopus 로고    scopus 로고
    • Polyglycolide and polylactide
    • Domb AJ, Kost J, Wiseman DM, eds. Amsterdam: CRC Press
    • Perrin DE, English JP. Polyglycolide and polylactide. In: Domb AJ, Kost J, Wiseman DM, eds. Handbook of biodegradable polymers. Amsterdam: CRC Press; 1997:3-28.
    • (1997) Handbook of Biodegradable Polymers , pp. 3-28
    • Perrin, D.E.1    English, J.P.2
  • 37
    • 80052970386 scopus 로고    scopus 로고
    • Strategies for the nanoencapsulation of hydrophilic molecules in polymer-based nanoparticles
    • Vrignaud S, Benoit J-P, Saulnier P. Strategies for the nanoencapsulation of hydrophilic molecules in polymer-based nanoparticles. Biomaterials 2011;32:8593-8604.
    • (2011) Biomaterials , vol.32 , pp. 8593-8604
    • Vrignaud, S.1    Benoit, J.-P.2    Saulnier, P.3
  • 38
    • 0034580371 scopus 로고    scopus 로고
    • The manufacturing techniques of various drug loaded biodegradable poly (lactide-co-glycolide) (PLGA) devices
    • Jain RA. The manufacturing techniques of various drug loaded biodegradable poly (lactide-co-glycolide) (PLGA) devices. Biomaterials 2000;21:2475-2490.
    • (2000) Biomaterials , vol.21 , pp. 2475-2490
    • Jain, R.A.1
  • 39
    • 4844221183 scopus 로고    scopus 로고
    • Relationship between encapsulated drug particle size and initial release of recombinant human growth hormone from biodegradable microspheres
    • Costantino HR, Johnson OL, Zale SE. Relationship between encapsulated drug particle size and initial release of recombinant human growth hormone from biodegradable microspheres. J Pharm Sci 2004;93:2624-2634.
    • (2004) J Pharm Sci , vol.93 , pp. 2624-2634
    • Costantino, H.R.1    Johnson, O.L.2    Zale, S.E.3
  • 40
    • 8544246437 scopus 로고    scopus 로고
    • The stabilization and encapsulation of human growth hormone into biodegradable microspheres
    • Johnson OL, Jaworowicz W, Cleland JL, et al. The stabilization and encapsulation of human growth hormone into biodegradable microspheres. Pharm Res 1997;14:730-735.
    • (1997) Pharm Res , vol.14 , pp. 730-735
    • Johnson, O.L.1    Jaworowicz, W.2    Cleland, J.L.3
  • 42
    • 0141853257 scopus 로고    scopus 로고
    • Polymer degradation and in vitro release of a model protein from poly (D,Llactide-co-glycolide) nano-and microparticles
    • Panyam J, Dali MM, Sahoo SK, et al. Polymer degradation and in vitro release of a model protein from poly (D,Llactide-co-glycolide) nano-and microparticles. J Control Release 2003;92:173-187.
    • (2003) J Control Release , vol.92 , pp. 173-187
    • Panyam, J.1    Dali, M.M.2    Sahoo, S.K.3
  • 43
    • 0002914655 scopus 로고    scopus 로고
    • Polylactic and polyglycolic acids as drug delivery carriers
    • Wise DL, ed. New York: Marcel Dekker, Inc
    • Brannon-Peppas L, Vert M. Polylactic and polyglycolic acids as drug delivery carriers. In: Wise DL, ed. Handbook of pharmaceutical controlled release technology. New York: Marcel Dekker, Inc.; 2000:99-130.
    • (2000) Handbook of Pharmaceutical Controlled Release Technology , pp. 99-130
    • Brannon-Peppas, L.1    Vert, M.2
  • 44
    • 0033635054 scopus 로고    scopus 로고
    • Protein instability in poly (lactic-co-glycolic acid) microparticles
    • van de Weert M, Hennink WE, Jiskoot W. Protein instability in poly (lactic-co-glycolic acid) microparticles. Pharm Res 2000;17: 1159-1167.
    • (2000) Pharm Res , vol.17 , pp. 1159-1167
    • Van De Weert, M.1    Hennink, W.E.2    Jiskoot, W.3
  • 45
    • 23944526887 scopus 로고    scopus 로고
    • In vitro degradation of polyanhydride/polyester core-shell double-wall microspheres
    • Pollauf EJ, Berkland C, Kim KK, Pack DW. In vitro degradation of polyanhydride/polyester core-shell double-wall microspheres. Int J Pharm 2005;301:294-303.
    • (2005) Int J Pharm , vol.301 , pp. 294-303
    • Pollauf, E.J.1    Berkland, C.2    Kim, K.K.3    Pack, D.W.4
  • 46
    • 79955463389 scopus 로고    scopus 로고
    • Polymer nanoparticles: Preparation techniques and size-control parameters
    • Rao JP, Geckeler KE. Polymer nanoparticles: preparation techniques and size-control parameters. Progress Polym Sci 2011;36:887-913.
    • (2011) Progress Polym Sci , vol.36 , pp. 887-913
    • Rao, J.P.1    Geckeler, K.E.2
  • 47
    • 77954604842 scopus 로고    scopus 로고
    • Nanoparticle formulation for hydrophilic & hydrophobic drugs
    • Gupta VK, Karar P, Ramesh S, et al. Nanoparticle formulation for hydrophilic & hydrophobic drugs. Int J Res Pharm Sci 2010;1: 163-169.
    • (2010) Int J Res Pharm Sci , vol.1 , pp. 163-169
    • Gupta, V.K.1    Karar, P.2    Ramesh, S.3
  • 48
    • 74649085991 scopus 로고    scopus 로고
    • Method to enhance the encapsulation of biologically active molecules in PLGA nanoparticles
    • Sourabhan S, Kaladhar K, Sharma CP. Method to enhance the encapsulation of biologically active molecules in PLGA nanoparticles. Trends Biomater Artif Organs 2009;22:211-215.
    • (2009) Trends Biomater Artif Organs , vol.22 , pp. 211-215
    • Sourabhan, S.1    Kaladhar, K.2    Sharma, C.P.3
  • 49
    • 10744231648 scopus 로고    scopus 로고
    • A potential approach for decreasing the burst effect of protein from PLGA microspheres
    • Fu K, Harrell R, Zinski K, et al. A potential approach for decreasing the burst effect of protein from PLGA microspheres. J Pharm Sci 2003;92:1582-1591.
    • (2003) J Pharm Sci , vol.92 , pp. 1582-1591
    • Fu, K.1    Harrell, R.2    Zinski, K.3
  • 50
    • 4644340922 scopus 로고    scopus 로고
    • Control of encapsulation efficiency and initial burst in polymeric microparticle systems
    • Yeo Y, Park K. Control of encapsulation efficiency and initial burst in polymeric microparticle systems. Arch Pharm Res 2004;27:1-12.
    • (2004) Arch Pharm Res , vol.27 , pp. 1-12
    • Yeo, Y.1    Park, K.2
  • 51
    • 78449268414 scopus 로고    scopus 로고
    • Polymeric nanoparticles with biomedical applications
    • Cismaru L, Popa M. Polymeric nanoparticles with biomedical applications. Revue Roumaine de Chimie 2010;55:433-442.
    • (2010) Revue Roumaine de Chimie , vol.55 , pp. 433-442
    • Cismaru, L.1    Popa, M.2
  • 53
    • 0031398790 scopus 로고    scopus 로고
    • Microencapsulation of rh-erythropoietin, using biodegradable poly (D,L-lactideco-glycolide): Protein stability and the effects of stabilizing excipients
    • Morlock M, Koll H, Winter G, Kissel T. Microencapsulation of rh-erythropoietin, using biodegradable poly (D,L-lactideco-glycolide): protein stability and the effects of stabilizing excipients. Eur J Pharm Biopharm 1997;43:29-36.
    • (1997) Eur J Pharm Biopharm , vol.43 , pp. 29-36
    • Morlock, M.1    Koll, H.2    Winter, G.3    Kissel, T.4
  • 54
    • 0035255916 scopus 로고    scopus 로고
    • Morphology, drug distribution, and in vitro release prfiles of biodegradable polymeric microspheres containing protein fabricated by double-emulsion solvent extraction/ evaporation method
    • Yang Y-Y, Chung T-S, Ng NP. Morphology, drug distribution, and in vitro release prfiles of biodegradable polymeric microspheres containing protein fabricated by double-emulsion solvent extraction/ evaporation method. Biomaterials 2001;22:231-241.
    • (2001) Biomaterials , vol.22 , pp. 231-241
    • Yang, Y.-Y.1    Chung, T.-S.2    Ng, N.P.3
  • 55
    • 80051470316 scopus 로고    scopus 로고
    • Influence of process conditions on the mean size of PLGA nanoparticles
    • Feczkó T, Tóth J, Dósa G, Gyenis J. Influence of process conditions on the mean size of PLGA nanoparticles. Chem Eng Process 2011; 50:846-853.
    • (2011) Chem Eng Process , vol.50 , pp. 846-853
    • Feczkó, T.1    Tóth, J.2    Dósa, G.3    Gyenis, J.4
  • 56
    • 80051471387 scopus 로고    scopus 로고
    • Optimization of protein encapsulation in PLGA nanoparticles
    • Feczkó T, Tóth J, Dósa G, Gyenis J. Optimization of protein encapsulation in PLGA nanoparticles. Chem Eng Process 2011;50: 757-765.
    • (2011) Chem Eng Process , vol.50 , pp. 757-765
    • Feczkó, T.1    Tóth, J.2    Dósa, G.3    Gyenis, J.4
  • 57
    • 0001719160 scopus 로고    scopus 로고
    • Microencapsulation of human growth hormone within biodegradable polyester microspheres: Protein aggregation stability and incomplete release mechanism
    • Kim HK, Park TG. Microencapsulation of human growth hormone within biodegradable polyester microspheres: protein aggregation stability and incomplete release mechanism. Biotechnol Bioeng 1999;65:659-667.
    • (1999) Biotechnol Bioeng , vol.65 , pp. 659-667
    • Kim, H.K.1    Park, T.G.2
  • 58
    • 0034601266 scopus 로고    scopus 로고
    • Incorporation of protein in PLG-microspheres with retention of bioactivity
    • Sturesson C, Carlfors J. Incorporation of protein in PLG-microspheres with retention of bioactivity. J Control Release 2000;67: 171-178.
    • (2000) J Control Release , vol.67 , pp. 171-178
    • Sturesson, C.1    Carlfors, J.2
  • 59
    • 0034601882 scopus 로고    scopus 로고
    • Effect of preparation temperature on the characteristics and release profiles of PLGA microspheres containing protein fabricated by double-emulsion solvent extraction/ evaporation method
    • Yang Y-Y, Chia H-H, Chung T-S. Effect of preparation temperature on the characteristics and release profiles of PLGA microspheres containing protein fabricated by double-emulsion solvent extraction/ evaporation method. J Control Release 2000;69:81-96.
    • (2000) J Control Release , vol.69 , pp. 81-96
    • Yang, Y.-Y.1    Chia, H.-H.2    Chung, T.-S.3
  • 60
    • 3042856516 scopus 로고    scopus 로고
    • Comparative study on sustained release of human growth hormone from semi-crystalline poly(L-lactic acid) and amorphous poly(D,L-lactic-co-glycolic acid) microspheres: Morphological effect on protein release
    • Kim HK, Park TG. Comparative study on sustained release of human growth hormone from semi-crystalline poly(L-lactic acid) and amorphous poly(D,L-lactic-co-glycolic acid) microspheres: morphological effect on protein release. J Control Release 2004; 98:115-125.
    • (2004) J Control Release , vol.98 , pp. 115-125
    • Kim, H.K.1    Park, T.G.2
  • 61
    • 0037423787 scopus 로고    scopus 로고
    • Sustained release of human growth hormone from microcapsules prepared by a solvent evaporation technique
    • Takada S, Yamagata Y, Misaki M, et al. Sustained release of human growth hormone from microcapsules prepared by a solvent evaporation technique. J Control Release 2003;88:229-242.
    • (2003) J Control Release , vol.88 , pp. 229-242
    • Takada, S.1    Yamagata, Y.2    Misaki, M.3
  • 62
    • 34648843305 scopus 로고    scopus 로고
    • Effect of the microencapsulation of nanoparticles on the reduction of burst release
    • Hasan AS, Socha M, Lamprecht A, et al. Effect of the microencapsulation of nanoparticles on the reduction of burst release. Int J Pharm 2007;344:53-61.
    • (2007) Int J Pharm , vol.344 , pp. 53-61
    • Hasan, A.S.1    Socha, M.2    Lamprecht, A.3
  • 63
    • 0028965620 scopus 로고
    • Quality improvement of spray-dried, protein-loaded D, L-PLA microspheres by appropriate polymer solvent selection
    • Gander B, Wehrli E, Alder R, Merkle H. Quality improvement of spray-dried, protein-loaded D, L-PLA microspheres by appropriate polymer solvent selection. J Microencapsul 1995;12:83-97.
    • (1995) J Microencapsul , vol.12 , pp. 83-97
    • Gander, B.1    Wehrli, E.2    Alder, R.3    Merkle, H.4
  • 64
    • 33646164433 scopus 로고    scopus 로고
    • Biodegradable polymeric microspheres with "open/closed" pores for sustained release of human growth hormone
    • Kim HK, Chung HJ, Park TG. Biodegradable polymeric microspheres with "open/closed" pores for sustained release of human growth hormone. J Control Release 2006;112:167-174.
    • (2006) J Control Release , vol.112 , pp. 167-174
    • Kim, H.K.1    Chung, H.J.2    Park, T.G.3
  • 65
    • 58149152977 scopus 로고    scopus 로고
    • Development of protein delivery microsphere system by a novel S/O/O/W multi-emulsion
    • Yuan W, Wu F, Guo M, Jin T. Development of protein delivery microsphere system by a novel S/O/O/W multi-emulsion. Eur J Pharm Sci 2009;36:212-218.
    • (2009) Eur J Pharm Sci , vol.36 , pp. 212-218
    • Yuan, W.1    Wu, F.2    Guo, M.3    Jin, T.4
  • 66
    • 0029859532 scopus 로고    scopus 로고
    • Stable formulations of recombinant human growth hormone and interfron gama for microencapsulation in biodegradable microspheres
    • Cleland JL, Jones AJS. Stable formulations of recombinant human growth hormone and interfron gama for microencapsulation in biodegradable microspheres. Pharm Res 1996;13:1464-1475.
    • (1996) Pharm Res , vol.13 , pp. 1464-1475
    • Cleland, J.L.1    Jones, A.J.S.2
  • 67
    • 67349171877 scopus 로고    scopus 로고
    • Development of a sustainedrelease recombinant human growth hormone formulation
    • Kwak HH, Shim WS, Choi MK, et al. Development of a sustainedrelease recombinant human growth hormone formulation. J Control Release 2009;137:160-165.
    • (2009) J Control Release , vol.137 , pp. 160-165
    • Kwak, H.H.1    Shim, W.S.2    Choi, M.K.3
  • 68
    • 0033039914 scopus 로고    scopus 로고
    • Stabilization of proteins against methylene chloride/water interfaceinduced denaturation and aggregation
    • Sah H. Stabilization of proteins against methylene chloride/water interfaceinduced denaturation and aggregation. J Control Release 1999;58:143-151.
    • (1999) J Control Release , vol.58 , pp. 143-151
    • Sah, H.1
  • 69
    • 33645512835 scopus 로고    scopus 로고
    • Nanoprecipitation versus emulsion-based techniques for the encapsulation of proteins into biodegradable nanoparticles and process-related stability issues
    • Bilati U, Allémann E, Doelker E. Nanoprecipitation versus emulsion-based techniques for the encapsulation of proteins into biodegradable nanoparticles and process-related stability issues. AAPS PharmSciTech 2005;6:594-604.
    • (2005) AAPS PharmSciTech , vol.6 , pp. 594-604
    • Bilati, U.1    Allémann, E.2    Doelker, E.3
  • 70
    • 42749093836 scopus 로고    scopus 로고
    • Preparing polymer-based sustained-release systems without exposing proteins to water-oil or water-air interfaces and cross-linking reagents
    • Jin T, Zhu J, Wu F, et al. Preparing polymer-based sustained-release systems without exposing proteins to water-oil or water-air interfaces and cross-linking reagents. J Control Release 2008;128: 50-59.
    • (2008) J Control Release , vol.128 , pp. 50-59
    • Jin, T.1    Zhu, J.2    Wu, F.3
  • 71
    • 50149117923 scopus 로고    scopus 로고
    • Water-free microencapsulation of proteins within PLGA microparticles by spray drying using PEG-assisted protein solubilization technique in organic solvent
    • Mok H, Park TG. Water-free microencapsulation of proteins within PLGA microparticles by spray drying using PEG-assisted protein solubilization technique in organic solvent. Eur J Pharm Biopharm 2008;70:137-144.
    • (2008) Eur J Pharm Biopharm , vol.70 , pp. 137-144
    • Mok, H.1    Park, T.G.2
  • 72
    • 0033403807 scopus 로고    scopus 로고
    • Sustained release of human growth hormone from PLGA solution depot
    • Brodbeck KJ, Pushpala S, McHugh AJ. Sustained release of human growth hormone from PLGA solution depot. Pharm Res 1999;16: 1825-1829.
    • (1999) Pharm Res , vol.16 , pp. 1825-1829
    • Brodbeck, K.J.1    Pushpala, S.2    McHugh, A.J.3
  • 73
    • 28244495496 scopus 로고    scopus 로고
    • The influence of protein solubilisation, conformation and size on the burst release from poly (lactide-co-glycolide) microspheres
    • Duncan G, Jess TJ, Mohamed F, et al. The influence of protein solubilisation, conformation and size on the burst release from poly (lactide-co-glycolide) microspheres. J Control Release 2005;110: 34-48.
    • (2005) J Control Release , vol.110 , pp. 34-48
    • Duncan, G.1    Jess, T.J.2    Mohamed, F.3
  • 74
    • 24044485078 scopus 로고    scopus 로고
    • Novel long-acting crystal formulation of human growth hormone
    • Govardhan C, Khalaf N, Jung CW, et al. Novel long-acting crystal formulation of human growth hormone. Pharm Res 2005;22: 1461-1470.
    • (2005) Pharm Res , vol.22 , pp. 1461-1470
    • Govardhan, C.1    Khalaf, N.2    Jung, C.W.3
  • 75
    • 1542714402 scopus 로고    scopus 로고
    • Preparation of PLA and PLGA nanoparticles by binary organic solvent diffusion method
    • Xin-yu J, Chun-shan Z, Ke-wen T. Preparation of PLA and PLGA nanoparticles by binary organic solvent diffusion method. J Cent South Univ Technol 2003;10:202-206.
    • (2003) J Cent South Univ Technol , vol.10 , pp. 202-206
    • Xin-Yu, J.1    Chun-Shan, Z.2    Ke-Wen, T.3
  • 76
    • 0033981881 scopus 로고    scopus 로고
    • Influences of process parameters on nanoparticle preparation performed by a double emulsion pressure homogenization technique
    • Lamprecht A, Ubrich N, Pérez MH, et al. Influences of process parameters on nanoparticle preparation performed by a double emulsion pressure homogenization technique. Int J Pharm 2000;196: 177-182.
    • (2000) Int J Pharm , vol.196 , pp. 177-182
    • Lamprecht, A.1    Ubrich, N.2    Pérez, M.H.3
  • 77
    • 77954184214 scopus 로고    scopus 로고
    • Formation and degradation of biodegradable triple-layered microparticles
    • Lee WL, Hong M, Widjaja E, Loo SCJ. Formation and degradation of biodegradable triple-layered microparticles. Macromol Rapid Commun 2010;31:1193-1200.
    • (2010) Macromol Rapid Commun , vol.31 , pp. 1193-1200
    • Lee, W.L.1    Hong, M.2    Widjaja, E.3    Loo, S.C.J.4
  • 78
    • 84891923721 scopus 로고    scopus 로고
    • Albumin-based nanocomposite spheres for advanced drug delivery systems
    • Misak HE, Asmatulu R, Gopu JS, et al. Albumin-based nanocomposite spheres for advanced drug delivery systems. Biotechnol J 2014;9:163-170.
    • (2014) Biotechnol J , vol.9 , pp. 163-170
    • Misak, H.E.1    Asmatulu, R.2    Gopu, J.S.3
  • 79
    • 1842473842 scopus 로고    scopus 로고
    • Uniform double-walled polymer microspheres of controllable shell thickness
    • Berkland C, Pollauf E, Pack DW, Kim KK. Uniform double-walled polymer microspheres of controllable shell thickness. J Control Release 2004;96:101-111.
    • (2004) J Control Release , vol.96 , pp. 101-111
    • Berkland, C.1    Pollauf, E.2    Pack, D.W.3    Kim, K.K.4
  • 80
    • 84881503529 scopus 로고    scopus 로고
    • Long-acting inhalable chitosan-coated poly(lactic-co-glycolic acid) nanoparticles containing hydrophobically modified exendin-4 for treating type 2 diabetes
    • Lee C, Choi JS, Kim I, et al. Long-acting inhalable chitosan-coated poly(lactic-co-glycolic acid) nanoparticles containing hydrophobically modified exendin-4 for treating type 2 diabetes. Int J Nanomed 2013;8:2975-2983.
    • (2013) Int J Nanomed , vol.8 , pp. 2975-2983
    • Lee, C.1    Choi, J.S.2    Kim, I.3
  • 81
    • 11844260006 scopus 로고    scopus 로고
    • How cyclodextrin incorporation affects the properties of protein-loaded PLGA-based microspheres: The case of insulin/hydroxypropyl-beta cyclodextrin system
    • Rosa GD, Larobina D, Rotonda MIL, et al. How cyclodextrin incorporation affects the properties of protein-loaded PLGA-based microspheres: The case of insulin/hydroxypropyl-beta cyclodextrin system. J Control Release 2005;102:71-83.
    • (2005) J Control Release , vol.102 , pp. 71-83
    • Rosa, G.D.1    Larobina, D.2    Rotonda, M.I.L.3
  • 82
    • 0029069951 scopus 로고
    • Pefloxacine mesilate-and ofloxacin-loaded polyethylcyanoacrylate nanoparticles: Characterization of the colloidal drug carrier formulation
    • Fresta M, Puglisi G, Giammona G, et al. Pefloxacine mesilate-and ofloxacin-loaded polyethylcyanoacrylate nanoparticles: characterization of the colloidal drug carrier formulation. J Pharm Sci 1995; 84:895-902.
    • (1995) J Pharm Sci , vol.84 , pp. 895-902
    • Fresta, M.1    Puglisi, G.2    Giammona, G.3
  • 83
    • 8244250126 scopus 로고    scopus 로고
    • The stability of recombinant human growth hormone in poly(lactic-co-glycolic acid) (PLGA) microspheres
    • Cleland JL, Mac A, Boyd B, et al. The stability of recombinant human growth hormone in poly(lactic-co-glycolic acid) (PLGA) microspheres. Pharm Res 1997;14:420-425.
    • (1997) Pharm Res , vol.14 , pp. 420-425
    • Cleland, J.L.1    Mac, A.2    Boyd, B.3
  • 84
    • 58149166741 scopus 로고    scopus 로고
    • Novel composite microparticles for protein stabilization and delivery
    • Schoubben A, Blasi P, Giovagnoli S, et al. Novel composite microparticles for protein stabilization and delivery. Eur J Pharm Sci 2009;36:226-234.
    • (2009) Eur J Pharm Sci , vol.36 , pp. 226-234
    • Schoubben, A.1    Blasi, P.2    Giovagnoli, S.3
  • 85
    • 84892478123 scopus 로고    scopus 로고
    • Encapsulation of protein-polysaccharide HIP complex in polymeric nanoparticles
    • Gaudana R, Khurana V, Parenky A, Mitra AK. Encapsulation of protein-polysaccharide HIP complex in polymeric nanoparticles. J Drug Deliv 2011;2011:1-7.
    • (2011) J Drug Deliv , vol.2011 , pp. 1-7
    • Gaudana, R.1    Khurana, V.2    Parenky, A.3    Mitra, A.K.4


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