The stability of recombinant human growth hormone in poly(lactic-co-glycolic acid) (PLGA) microspheres

Pharmaceutical Research

Volumn 14, Issue 4, 1997, Pages 420-425

  Cleland, Jeffrey L ^a   Mac, Anne ^a,b   Boyd, Brooks ^a,c   Yang, Janet ^a   Duenas, Eileen T ^a   Yeung, Douglas ^a   Brooks, Dennis ^a   Hsu, Chung ^a   Chu, Herman ^a   Mukku, Venkat ^a   Jones, Andrew J S ^a  

^a GENENTECH INC   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c University of California   (United States)

Author keywords

Degradation; Growth hormone; Microencapsulation; Poly(lactic co glycolic acid); Stability; Sustained release

Indexed keywords

HUMAN GROWTH HORMONE; MICROSPHERE; POLYGLACTIN;

ARTICLE; DRUG DEGRADATION; DRUG RELEASE; DRUG STABILITY; MICROENCAPSULATION; PRIORITY JOURNAL; SUSTAINED RELEASE FORMULATION;

CHROMATOGRAPHY, GEL; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CHROMATOGRAPHY, ION EXCHANGE; DRUG STABILITY; HUMAN GROWTH HORMONE; HUMANS; LACTIC ACID; MICROSPHERES; POLYGLYCOLIC ACID; POLYMERS; RECOMBINANT PROTEINS;

EID: 8244250126     PISSN: 07248741     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1012031012367     Document Type: Article

References (15)

1. J. L. Cleland and A. J. S. Jones. Pharm. Res. 13:1462-1473 (1996).
2. O. L. Johnson, J. L. Cleland, H. J. Lee, M. Charnis, E. Duenas, W. Jaworowicz, D. Shepard, A. Shahzamani, A. J. S. Jones, and S. D. Putney. Nature Med. 2:795-799 (1996).
3. R. Pearlman and T. A. Bewley, In: Stability and Characterization of Protein and Peptide Drugs: Case Histories, J. Y. Wang and R. Pearlman, Eds., Plenum Press, New York, pp. 1-58 (1993).
4. P. A. Burke. Proceed. Intern. Symp. Control. Rel. Bioact. Mater. 23:133-134 (1996).
5. J. L. Cleland, A. Lim, L. Barrón, E. T. Duenas, and M. F. Powell. J. Controlled Rel. in press (1997).
6. J. Yang and J. L. Cleland. J. Pharm. Sci., in press (1997).
7. G. Teshima and E. Canova-Davis. J. Chromatog. 625:207-215 (1992).
8. J. E. Battersby, W. S. Hancock, E. Canova-Davis, J. Q. Oeswein, and B. O'Connor. Int. J. Peptide Protein Res 44:215-222 (1994).
9. G. Teshima, J. T. Stults, V. Ling, and E. Canova-Davis. J. Biol. Chem. 266:13544-13547 (1991).
10. E. C. Roswall, V. R. Mukku, A. B. Chen, E. H. Hoff, H. Chu, P. A. McKay, K. C. Olson, J. E. Battersby, R. L. Gehant, A. Meunier, and R. L. Garnick. Biologicals 24:25-39 (1996).
11. F. W. Okumu, J. L. Cleland, and R. T. Borchardt. J. Controlled Rel., in press (1997).
12. J. L. Cleland. In: Vaccine Design: The Subunit Approach, M. F. Powell and M. Newman, Eds., Plenum Publishing, New York, NY, pp. 439-472 (1995).
13. N. Fogh-Andersen, B. M. Altura, B. T. Altura, and O. Siggaard-Andersen. Clin Chem. 41:1522-1525 (1995).
14. J. L. Cleland, E. T. Duenas, A. Daugherty, M. Marian, J. Yang, M. Wilson, A. Shahzamani, H. Chu, V. Mukku, Y.-F. Maa, C. Hsu, and A. J. S. Jones. Proceed. Intern. Symp. Control. Rel. Bioact. Mater. 22:143-144 (1995).
15. J. L. Cleland, E. T. Duenas, A. Dougherty, M. Marian, J. Yang, M. Wilson, A. C. Celniker, A. Shahzamani, V. Quarmby, M. Chu, V. Mukku, A. Mac, M. Roussakis, N. Gillette, B. Boyd, D. Yeung, D. Brooks, Y.-F. Maa, C. Hsu, and A. J. S. Jones. J. Controlled Rel. in press (1997).