Uniform double-walled polymer microspheres of controllable shell thickness

Journal of Controlled Release

Volumn 96, Issue 1, 2004, Pages 101-111

  Berkland, Cory ^a   Pollauf, Emily ^a   Pack, Daniel W ^a   Kim, Kyekyoon ^b  

^a UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

^b University of Illinois at Urbana Champaign   (United States)

Author keywords

Drug delivery; Poly(lactide co glycolide); Polyanhydride; Uniform double walled microspheres

Indexed keywords

ENCAPSULATION; JETS; NOZZLES; SHELLS (STRUCTURES);

COAXIAL JETS; POLYMER MICROSPHERES;

ORGANIC POLYMERS;

HEXANE; MICROSPHERE; POLY[(1,6 DICARBOXYPHENOXY)HEXANE]; POLYGLACTIN; POLYMER; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED RELEASE FORMULATION; DRUG DELIVERY SYSTEM; DRUG FORMULATION; ENCAPSULATION; FLOW RATE; PRIORITY JOURNAL; SOLVENT EXTRACTION; THICKNESS;

MICROSPHERES; POLYMERS; TECHNOLOGY, PHARMACEUTICAL;

EID: 1842473842     PISSN: 01683659     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jconrel.2004.01.018     Document Type: Article

References (37)

1. Wise D.L., Trantolo D.J., Marino R.T., Kitchell J.P. Opportunities and challenges in the design of implantable biodegradable polymeric systems for the delivery of anti-microbial agents and vaccines. Adv. Drug Deliv. Rev. 1:1987;19-39.
2. Lemmer B. Gurny R., Junginger H., Peppas N. Why Are So Many Biological Systems Periodic? 1992;11-24 Wissenschaftliche Verlagsgesellschaft, Stuttgart.
3. Cleland J.L., Lim A., Barron L., Duenas E.T., Powell M.F. Development of a single-shot subunit vaccine for HIV-1: Part 4. Optimizing microencapsulation and pulsatile release of MN rgp120 from biodegradable microspheres. J. Control. Release. 47:1997;135-150.
4. Cleland J.L. Single-administration vaccines: controlled-release technology to mimic repeated immunizations. TIBtech. 17:1999;25-29.
5. LaVan D.A., Lynn D.M., Langer R. Moving smaller in drug discovery and delivery. Nat. Rev. Drug Discov. 1:2002;77-84.
6. Leelarasamee N., Howard S.A., Malanga C.J., Ma J.K.H. A method for the preparation of polylactic acid microcapsules of controlled particle size and drug loading. J. Microencapsul. 5:1988;147-157.
7. Shiga K., Muramatsu N., Kondo T. Preparation of poly(D,L-lactide) and copoly(lactide-glycolide) microspheres of uniform size. J. Pharm. Pharmacol. 48:1996;891-895.
8. Berkland C., Kim K., Pack D.W. Fabrication of PLG microspheres with precisely controlled and monodisperse size distributions. J. Control. Release. 73:2001;59-74.
9. Berkland C., Kim K., Pack D. Precision polymer microparticles for controlled-release drug delivery. ACS Symp. Ser. 2002.
10. Bezemer J.M., Radersma R., Grijpma D.W., Dijkstra P.J., van Blitterswijk C.A., Feijen J. Microspheres for protein delivery prepared from amphiphilic multiblock copolymers: 2. Modulation of release rate. J. Control. Release. 67:2000;249-260.
11. Tracy M., Ward K., Firouzabadian L., Wang Y., Dong N., Qian R., Zhang Y. Factors affecting the degradation rate of poly(lactide-co-glycolide) microspheres in vivo and in vitro. Biomaterials. 20:1999;1057-1062.
12. Akbuga J. Effect of microsphere size and formulation factors on drug release from controlled-release furosemide microspheres. Drug Dev. Ind. Pharm. 17:1991;593-607.
13. Sansdrap P., Moes A.J. In vitro evaluation of the hydrolytic degradation of dispersed and aggregated poly(DL-lactide-co-glycolide) microspheres. J. Control. Release. 43:1997;47-58.
14. Lee T.H., Wang J., Wang C. Double-walled microspheres for the sustained release of a highly water soluble drug: characterization and irradiation studies. J. Control. Release. 83:2002;437-452.
15. Tabata Y., Ikada Y. Phagocytosis of polymer microspheres by macrophages. Adv. Polym. Sci. 94:1990;107-141.
16. Barrow E., Winchester G., Staas J., Quenelle D., Barrow W. Use of microsphere technology for targeted delivery of rifampin to Mycobacterium tuberculosis-infected macrophages. Antimicrob. Agents Chemother. 42:1998;2682-2689.
17. Dass C.R., Burton M.A. Microsphere-mediated targeted gene therapy of solid tumors. Drug Deliv. 6:1999;243-252.
18. Fu J., Fiegel J., Krauland E., Hanes J. New polymeric carriers for controlled drug delivery following inhalation or injection. Biomaterials. 23:2002;4425-4433.
19. Philipson K., Falk R., Svartengren M., Jarvis N., Bailey M., Bergmann R., Hofmann W., Camner P. Does lung retention of inhaled particles depend on their geometric diameter? Exp. Lung Res. 26:2000;437-455.
20. Delgado A., Soriano I., Sanchez E., Oliva M., Evora C. Radiolabelled biodegradable microspheres for lung imaging. Eur. J. Pharm. Biopharm. 50:2000;227-236.
21. Berkland C., Kipper M., Kim K., Narasimhan B., Pack D. Microsphere size, precipitation kinetics, and drug distribution control drug release from biodegradable polyanhydride microspheres. J. Control. Release. 94:2003;129-141.
22. Berkland C., Kim K., Pack D. PLG microsphere size controls drug release rate through several competing factors. Pharm. Res. 20:2003;1055-1062.
23. Berkland C., King M., Cox A., Kim K., Pack D. Precise control of PLG microsphere size provides enhanced control of drug release rate. J. Control. Release. 82:2002;137-147.
24. Yang Y.-Y., Shi M., Goh S.-H., Moochhala S., Ng S., Heller J. POE/PLGA composite microspheres: formation and in vitro behavior of double walled microspheres. J. Control. Release. 88:2003;201-213.
25. Kim K., Jang K.Y., Upadhye R.S. Hollow silica spheres of controlled size and porosity by sol-gel processing. J. Am. Ceram. Soc. 74:1991;1987-1992.
26. Kim N.K., Kim K., Payne D.A., Upadhye R.S. Fabrication of hollow silica aerogel spheres by a droplet generation method and sol-gel processing. J. Vac. Sci. Technol., A. 7:1989;1181-1184.
27. Guttman J.L., Hendricks C.D., Kim K., Turnbull R.J. An investigation of the effects of system parameters on the production of hollow hydrogen droplets. J. Appl. Phys. 50:1979;4139-4142.
28. Leach K., Noh K., Mathiowitz E. Effect of manufacturing conditions on the formation of double-walled polymer microspheres. J. Microencapsul. 16:1999;153-167.
29. Torza S., Mason G. Three-phase interactions in shear and electrical fields. J. Colloid Int. Sci. 33:1970;67-83.
30. Harkin W.D. The Physical Chemistry of Surface Films. 1952;Reinhold, New York.
31. Pekarek K.J., Jacob J.S., Mathiowitz E. Double-walled polymer microspheres for controlled drug release. Nature. 367:1994;258-260.
32. Hobbs S., Dekkers M., Watkins V. Effect of interfacial forces on polymer blend morphologies. Polymer. 29:1988;1598-1602.
33. Leach K.J., Takahashi S., Mathiowitz E. Degradation of double-walled polymer microspheres of PLLA and P(CPP:SA)20:80: II. In vivo degradation. Biomaterials. 19:1998;1981-1988.
34. Leach K.J., Mathiowitz E. Degradation of double-walled polymer microspheres of PLLA and P(CPP:SA)20:80: I. In vitro degradation. Biomaterials. 19:1998;1973-1980.
35. E. Mathiowitz, R. Langer, Multiwall polymeric microspheres, US Patent 5,912,017, 1999.
36. Pekarek K.J., Jacob J.S., Mathiowitz E. Double-walled polymer microspheres for controlled drug release. Nature. 367:1994;258-260.
37. Pekarek K.J., Jacob J.S., Mathiowitz E. One-step preparation of double-walled microspheres. Adv. Mater. 6:1994;684-687.