Development of a novel sustained release formulation of recombinant human growth hormone using sodium hyaluronate microparticles

Journal of Controlled Release

Volumn 104, Issue 2, 2005, Pages 323-335

  Sun, Jin Kim ^a   Sei, Kwang Hahn ^a,c   Myung, Jin Kim ^a   Duk, Hee Kim ^b   Young, Phil Lee ^a  

^a LG Chemical Ltd   (South Korea)

^b Yonsei University   (South Korea)

^c CHUGAI PHARMACEUTICAL CO LTD   (Japan)

Author keywords

Human growth hormone; Lecithin; Medium chain triglyceride; Sodium hyaluronate; Spray drying; Sustained release formulation

Indexed keywords

DRYING; GENETIC ENGINEERING; HORMONES; OPTIMIZATION; PHARMACOKINETICS; SODIUM COMPOUNDS; SPRAYING; TOXICITY;

CYNOMOLGUS MONKEYS; SERUM; SOLID MICROPARTICLES; SPRAY DRYING TECHNOLOGY;

CONTROLLED DRUG DELIVERY;

EUTROPIN; HUMAN GROWTH HORMONE; HYALURONIC ACID;

ANIMAL EXPERIMENT; ARTICLE; BIOAVAILABILITY; CONTROLLED STUDY; DOG; DRUG ACTIVITY; DRUG FORMULATION; MALE; MONKEY; NONHUMAN; PARTICLE SIZE; PRIORITY JOURNAL; SPRAY DRYING; SUSTAINED DRUG RELEASE;

ANIMALS; CHEMISTRY, PHARMACEUTICAL; DELAYED-ACTION PREPARATIONS; DOGS; HUMAN GROWTH HORMONE; HYALURONIC ACID; INSULIN-LIKE GROWTH FACTOR I; MACACA FASCICULARIS; MALE;

EID: 19444373936     PISSN: 01683659     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jconrel.2005.02.012     Document Type: Article

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