Astragaloside IV and cycloastragenol are equally effective in inhibition of endoplasmic reticulum stress-associated TXNIP/NLRP3 inflammasome activation in the endothelium

Journal of Ethnopharmacology

Volumn 169, Issue , 2015, Pages 210-218

  Zhao, Yan ^a   Li, Qiang ^b   Zhao, Wenjun ^a   Li, Jia ^c,d   Sun, Yan ^c,d   Liu, Kang ^c,d   Liu, Baolin ^c,d   Zhang, Ning ^a  

^a SHANGHAI UNIVERSITY OF TRADITIONAL CHINESE MEDICINE   (China)

^b LONGHUA HOSPITAL AFFILIATED TO SHANGHAI UNIVERSITY OF TRADITIONAL CHINESE MEDICINE   (China)

^c CHINA PHARMACEUTICAL UNIVERSITY   (China)

^d NANJING UNIVERSITY OF CHINESE MEDICINE   (China)

Author keywords

Astragaloside IV; Cycloastragenol; Endoplasmic reticulum stress; Endothelial dysfunction; Inflammasome

Indexed keywords

ASTRAGALOSIDE IV; CASPASE 3; CRYOPYRIN; CYCLOASTRAGENOL; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; INFLAMMASOME; INTERLEUKIN 1BETA; INTERLEUKIN 1BETA CONVERTING ENZYME; INTERLEUKIN 6; PALMITIC ACID; PROTEIN IRE1; PROTEIN IRE1ALPHA; REACTIVE OXYGEN METABOLITE; SAPONIN; THIOREDOXIN INTERACTING PROTEIN; UNCLASSIFIED DRUG; ASTRAGALOSIDE A; CARRIER PROTEIN; ERN1 PROTEIN, HUMAN; NLRP3 PROTEIN, HUMAN; PROTEIN SERINE THREONINE KINASE; RIBONUCLEASE; SAPOGENIN; TRITERPENE; TXNIP PROTEIN, HUMAN;

APOPTOSIS; ARTICLE; CELL DEATH; CELL PROTECTION; CLINICAL EFFECTIVENESS; DRUG EFFICACY; ENDOPLASMIC RETICULUM STRESS; ENDOTHELIAL DYSFUNCTION; ENDOTHELIUM; ENDOTHELIUM CELL; ENZYME ACTIVATION; ENZYME INHIBITION; HUMAN; HUMAN CELL; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRION; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; CELL CULTURE; DRUG EFFECTS; METABOLISM; PHOSPHORYLATION;

ASTRAGALUS MEMBRANACEUS; FABACEAE;

APOPTOSIS; CARRIER PROTEINS; CASPASE 3; CELLS, CULTURED; ENDOPLASMIC RETICULUM STRESS; ENDORIBONUCLEASES; ENDOTHELIAL CELLS; HUMANS; INFLAMMASOMES; MEMBRANE POTENTIAL, MITOCHONDRIAL; PHOSPHORYLATION; PROTEIN-SERINE-THREONINE KINASES; REACTIVE OXYGEN SPECIES; SAPOGENINS; SAPONINS; TRITERPENES;

EID: 84929165139     PISSN: 03788741     EISSN: 18727573     Source Type: Journal    
DOI: 10.1016/j.jep.2015.04.030     Document Type: Article

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