Mechanisms underlying vasorelaxant action of astragaloside IV in isolated rat aortic rings

Clinical and Experimental Pharmacology and Physiology

Volumn 34, Issue 5-6, 2007, Pages 387-392

  Zhang, Chuan ^a   Wang, Xu Hui ^b   Zhong, Mei Fang ^b   Liu, Run Hui ^a   Li, Hui Liang ^a   Zhang, Wei Dong ^a,c   Chen, Hong ^b  

^a SECOND MILITARY MEDICAL UNIVERSITY   (China)

^b SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

^c SHANGHAI JIAO TONG UNIVERSITY   (China)

Author keywords

Aortic rings; Astragaloside IV; Endothelium; Nitric oxide; Vessel contraction and relaxation

Indexed keywords

1H 1,2,4 OXADIAZOLO[4,3 A]QUINOXALIN 1 ONE; ASTRAGALOSIDE IV; ASTRAGALUS MEMBRANACEUS EXTRACT; CALCIUM; CYCLIC GMP; GUANYLATE CYCLASE INHIBITOR; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE SYNTHASE; PHENYLEPHRINE; POTASSIUM CHLORIDE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AORTA; ARTERY ENDOTHELIUM; ARTICLE; CALCIUM TRANSPORT; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; DRUG MECHANISM; IN VITRO STUDY; IN VIVO STUDY; ISOLATED ARTERY; MALE; NONHUMAN; RAT; VASCULAR RING; VASODILATATION;

ACETYLCHOLINE; ANIMALS; AORTA, THORACIC; CALCIUM; CALCIUM CHLORIDE; CYCLIC GMP; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOTHELIUM, VASCULAR; INDOMETHACIN; INTRACELLULAR FLUID; MALE; MOLECULAR STRUCTURE; MUSCLE, SMOOTH, VASCULAR; NG-NITROARGININE METHYL ESTER; NITRIC OXIDE SYNTHASE; NITROARGININE; OXADIAZOLES; PHENYLEPHRINE; POTASSIUM CHLORIDE; QUINOXALINES; RATS; RATS, SPRAGUE-DAWLEY; SAPONINS; TRITERPENES; VASOCONSTRICTOR AGENTS; VASODILATION; VASODILATOR AGENTS;

EID: 33947636195     PISSN: 03051870     EISSN: 14401681     Source Type: Journal    
DOI: 10.1111/j.1440-1681.2007.04564.x     Document Type: Article

References (13)

1. Zhang BQ, Hu SJ, Hu Qiu LH. Diphasic effects of Astragalus membranaceus Bunge (Leguminosae) on vascular tone in rat thoracic aorta. Biol. Pharm. Bull. 2005; 28: 1450-4.
2. Li M, Zhang YD, Chen X et al. The actions of astragaloside IV on isolated thoracic rabbit aorta and right guinea pig atrium. J. Guangdong Univ. Med. Sci. 1997; 13: 219-21.
3. Zhang WD, Chen H, Zhang C, Li HL, Liu RH, Chen HZ. Astragaloside IV from Astragalus membranaceus shows cardioprotection during myocardial ischemia in vivo and in vitro. Planta Med. 2006; 72: 4-8.
4. Miao CY, Villeneuve N, Brunel-Jacquemin C et al. Chronic mild hyperhomocysteinemia induces aortic endothelial dysfunction but does not elevate arterial pressure in rats. J. Vasc. Res. 2005; 42: 148-56.
5. 2+ removal upon vascular smooth muscle contraction induced by noripenephrine, histamine and potassium. J. Pharmcol. Exp. Ther. 1968; 159: 91-7.
6. 2+ channels in rat aortic smooth muscle. Br. J. Anaesth. 1998; 81: 578-83.
7. Eckert RE, Karsten AJ, Utz J, Ziegler M. Regulation of renal artery smooth muscle tone by alpha1-adrenoceptors: Role of voltage-gated calcium channels and intracellular calcium stores. Urol. Res. 2000; 28: 122-7.
8. i oscillations underlying tonic contraction in the rabbit inferior vena cava. J. Physiol. 2001; 534: 641-50.
9. Moncada S, Palmer RMJ, Higgs EA. Biosynthesis of nitric oxide from l-arginine: A pathway for the regulation of cell function and communication. Biochem. Pharmacol. 1989; 38: 1709-15.
10. Zhang WD, Zhang C, Wang XH et al. Astragaloside IV dilates aortic vessels from normal and spontaneously hypertensive rats through endothelium-dependent and endothelium-independent ways. Planta Med. 2006; 72: 621-6.
11. Robertson BE, Schubert R, Hescheler J, Nelson MT. cGMP-dependent protein kinase activates Ca2+-activated K+ channels in cerebral artery smooth muscle cells. Am. J. Physiol. 1993; 265: C299-303.
12. Schini VB, Vanhoutte PM. l-arginine evokes both endothelium-dependent and -independent relaxations in l-arginine-depleted aortas of the rat. Circ. Res. 1991; 68: 209-16.
13. Tirapelli CR, Ambrosio SR, da Costa FB, Coutinho ST, de Oliveira DCR, de Oliveira AM. Analysis of the mechanisms underlying the vasorelaxant action of kaurenoic acid in the isolated rat aorta. Eur. J. Pharmacol. 2004; 492: 233-41.