Astragaloside IV inhibits doxorubicin-induced cardiomyocyte apoptosis mediated by mitochondrial apoptotic pathway via activating the PI3K/Akt pathway

Chemical and Pharmaceutical Bulletin

Volumn 62, Issue 1, 2014, Pages 45-53

  Jia, Yuanyuan ^a   Zuo, Daiying ^a   Li, Zengqiang ^a   Liu, Hanmo ^a   Dai, Zhengning ^a   Cai, Jiayi ^a   Pang, Lili ^a   Wu, Yingliang ^a  

^a SHENYANG PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

Akt pathway; Apoptosis; Astragaloside IV; Doxorubicin; Mitochondrial apoptotic pathway; Phosphatidylinositol 3 kinase (PI3K)

Indexed keywords

ADENOSINE TRIPHOSPHATE; ASTRAGALOSIDE IV; CASPASE 3; CASPASE 9; CREATINE KINASE MB; CYTOCHROME C; DOXORUBICIN; LACTATE DEHYDROGENASE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN BAD; PROTEIN BAX; PROTEIN BCL 2; PROTEIN KINASE B; PROTON TRANSPORTING ADENOSINE TRIPHOSPHATE SYNTHASE; REACTIVE OXYGEN METABOLITE; SUCCINATE DEHYDROGENASE;

ANIMAL CELL; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; ASTRAGALUS MEMBRANACEUS; BREAST CANCER; CANCER CELL; CELL KILLING; CELL SURVIVAL; CELL VIABILITY; COMPARATIVE STUDY; CONTROLLED STUDY; CRYOPROTECTION; CYTOTOXICITY; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; ENZYME RELEASE; HEART MUSCLE CELL; HUMAN; HUMAN CELL; IMMUNOCYTOCHEMISTRY; MITOCHONDRION; MTT ASSAY; NEWBORN; NONHUMAN; PROTEIN DEGRADATION; PROTEIN EXPRESSION; RAT;

ADENOSINE TRIPHOSPHATE; ANIMALS; APOPTOSIS; BCL-ASSOCIATED DEATH PROTEIN; CELLS, CULTURED; CREATINE KINASE, MITOCHONDRIAL FORM; CYTOCHROMES C; DOXORUBICIN; L-LACTATE DEHYDROGENASE; MITOCHONDRIA; MITOCHONDRIAL PROTON-TRANSLOCATING ATPASES; MYOCYTES, CARDIAC; PHOSPHATIDYLINOSITOL 3-KINASE; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-AKT; RATS; REACTIVE OXYGEN SPECIES; SAPONINS; SUCCINATE DEHYDROGENASE; TRITERPENES;

EID: 84892152852     PISSN: 00092363     EISSN: 13475223     Source Type: Journal    
DOI: 10.1248/cpb.c13-00556     Document Type: Article

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