Thioredoxin-interacting protein is required for endothelial NLRP3 inflammasome activation and cell death in a rat model of high-fat diet

Diabetologia

Volumn 57, Issue 2, 2014, Pages 413-423

  Mohamed, Islam N ^a,b,c   Hafez, Sherif S ^a,c   Fairaq, Arwa ^a,c   Ergul, Adviye ^a,b,c   Imig, John D ^d   El Remessy, Azza B ^a,b,c  

^a UNIVERSITY OF GEORGIA   (United States)

^b MEDICAL COLLEGE OF GEORGIA   (United States)

^c VETERANS AFFAIRS MEDICAL CENTER   (United States)

^d MEDICAL COLLEGE OF WISCONSIN   (United States)

Author keywords

Caspase 1; High fat diet; Hypertension; IL 1 ; Inflammasome; Inflammation; NLRP3; Obesity; Oxidative stress; Retinal acellular capillaries; TXNIP

Indexed keywords

3 NITROTYROSINE; CASPASE 3; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INFLAMMASOME; INTERLEUKIN 1BETA; INTERLEUKIN 1BETA CONVERTING ENZYME; NOD LIKE RECEPTOR PYRIN DOMAIN CONTAINING 3; PALMITIC ACID; THIOREDOXIN INTERACTING PROTEIN; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; ASTROCYTE; CELL DEATH; CONTROLLED STUDY; CYTOKINE RELEASE; ENDOTHELIUM CELL; ENZYME ACTIVATION; GLIA CELL; HUMAN; HUMAN CELL; IMMUNOLOCALIZATION; IN VITRO STUDY; IN VIVO STUDY; LIPID DIET; LIPID PEROXIDATION; MALE; METABOLIC SYNDROME X; MUELLER CELL; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN CLEAVAGE; PROTEIN EXPRESSION; RAT; RETINA CELL; SPONTANEOUSLY HYPERTENSIVE RAT; UPREGULATION;

ANIMALS; CARRIER PROTEINS; CASPASE INHIBITORS; CELL DEATH; DIET, HIGH-FAT; ENDOTHELIAL CELLS; EYE DISEASES; INFLAMMASOMES; INFLAMMATION; MALE; MICROCIRCULATION; NF-KAPPA B; OBESITY; OXIDATIVE STRESS; RATS; RATS, WISTAR; RECEPTORS, CYTOPLASMIC AND NUCLEAR; RETINA;

EID: 84893663061     PISSN: 0012186X     EISSN: 14320428     Source Type: Journal    
DOI: 10.1007/s00125-013-3101-z     Document Type: Article

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