메뉴 건너뛰기




Volumn 43, Issue 3, 2015, Pages 581-600

Cantharidin induces apoptosis through the calcium/PKC-regulated endoplasmic reticulum stress pathway in human bladder cancer cells

Author keywords

Bladder Cancer Cells; Calcium; Cantharidin; ER Stress; PKC

Indexed keywords

CALCIUM; CALPAIN; CANTHARIDIN; CASPASE; CASPASE 12; CASPASE 3; CASPASE 7; CASPASE 9; GLUCOSE REGULATED PROTEIN 78; INITIATION FACTOR 2ALPHA; PROCASPASE 12; PROTEIN KINASE C; UNCLASSIFIED DRUG; ANTINEOPLASTIC AGENT;

EID: 84929149437     PISSN: 0192415X     EISSN: 17936853     Source Type: Journal    
DOI: 10.1142/S0192415X15500366     Document Type: Article
Times cited : (36)

References (54)
  • 3
    • 84871132239 scopus 로고    scopus 로고
    • Chloroacetic acid induced neuronal cells death through oxidative stress-mediated p38-MAPK activation pathway regulated mitochondria-dependent apoptotic signals
    • Chen, C.H., S.J. Chen, C.C. Su, C.C. Yen, T.J. Tseng, T.R. Jinn, F.C. Tang, K.L. Chen, Y.C. Su, K.I. Lee, D.Z. Hung and C.F. Huang. Chloroacetic acid induced neuronal cells death through oxidative stress-mediated p38-MAPK activation pathway regulated mitochondria-dependent apoptotic signals. Toxicology 303: 72-82, 2013a.
    • (2013) Toxicology , vol.303 , pp. 72-82
    • Chen, C.H.1    Chen, S.J.2    Su, C.C.3    Yen, C.C.4    Tseng, T.J.5    Jinn, T.R.6    Tang, F.C.7    Chen, K.L.8    Su, Y.C.9    Lee, K.I.10    Hung, D.Z.11    Huang, C.F.12
  • 4
    • 84898045838 scopus 로고    scopus 로고
    • Isthmin targets cell-surface GRP78 and triggers apoptosis via induction of mitochondrial dysfunction
    • Chen, M., Y. Zhang, V.C. Yu, Y.S. Chong, T. Ge and R. Yoshioka. Isthmin targets cell-surface GRP78 and triggers apoptosis via induction of mitochondrial dysfunction. Cell Death Differ. 21: 797-810, 2014.
    • (2014) Cell Death Differ. , vol.21 , pp. 797-810
    • Chen, M.1    Zhang, Y.2    Yu, V.C.3    Chong, Y.S.4    Ge, T.5    Yoshioka, R.6
  • 5
    • 84876098016 scopus 로고    scopus 로고
    • Remodeling of calcium signaling in tumor progression
    • Chen, Y.F., Y.T. Chen, W.T. Chiu and M.R. Shen. Remodeling of calcium signaling in tumor progression. J. Biomed. Sci. 20: 23, 2013b.
    • (2013) J. Biomed. Sci. , vol.20 , pp. 23
    • Chen, Y.F.1    Chen, Y.T.2    Chiu, W.T.3    Shen, M.R.4
  • 6
    • 77949874077 scopus 로고    scopus 로고
    • Honokiol induces cell apoptosis in human chondrosarcoma cells through mitochondrial dysfunction and endoplasmic reticulum stress
    • Chen, Y.J., C.L. Wu, J.F. Liu, Y.C. Fong, S.F. Hsu, T.M. Li, Y.C. Su, S.H. Liu and C.H. Tang. Honokiol induces cell apoptosis in human chondrosarcoma cells through mitochondrial dysfunction and endoplasmic reticulum stress. Cancer Lett. 291: 20-30, 2010.
    • (2010) Cancer Lett. , vol.291 , pp. 20-30
    • Chen, Y.J.1    Wu, C.L.2    Liu, J.F.3    Fong, Y.C.4    Hsu, S.F.5    Li, T.M.6    Su, Y.C.7    Liu, S.H.8    Tang, C.H.9
  • 7
    • 84894432757 scopus 로고    scopus 로고
    • Glucose deprivation induces reticulum stress by the PERK pathway and caspase-7-and calpain-mediated caspase-12 activation
    • de la Cadena, S.G., K. Hernandez-Fonseca, I. Camacho-Arroyo and L. Massieu. Glucose deprivation induces reticulum stress by the PERK pathway and caspase-7-and calpain-mediated caspase-12 activation. Apoptosis 19: 414-427, 2014.
    • (2014) Apoptosis , vol.19 , pp. 414-427
    • De La Cadena, S.G.1    Hernandez-Fonseca, K.2    Camacho-Arroyo, I.3    Massieu, L.4
  • 8
    • 58349097747 scopus 로고    scopus 로고
    • Synergistic apoptosis induction in leukemic cells by the phosphatase inhibitor salubrinal and proteasome inhibitors
    • Drexler, H.C. Synergistic apoptosis induction in leukemic cells by the phosphatase inhibitor salubrinal and proteasome inhibitors. PLoS One 4: e4161, 2009.
    • (2009) PLoS One , vol.4 , pp. e4161
    • Drexler, H.C.1
  • 9
    • 79956342525 scopus 로고    scopus 로고
    • Crude extracts of Agaricus brasiliensis induce apoptosis in human oral cancer CAL 27 cells through a mitochondria-dependent pathway
    • Fan, M.J., Y.C. Lin, H.D. Shih, J.S. Yang, K.C. Liu, S.T. Yang, C.Y. Lin, R.S. Wu, C.S. Yu, Y.C. Ko and J.G. Chung. Crude extracts of Agaricus brasiliensis induce apoptosis in human oral cancer CAL 27 cells through a mitochondria-dependent pathway. In Vivo 25: 355-366, 2011.
    • (2011) Vivo , vol.25 , pp. 355-366
    • Fan, M.J.1    Lin, Y.C.2    Shih, H.D.3    Yang, J.S.4    Liu, K.C.5    Yang, S.T.6    Lin, C.Y.7    Wu, R.S.8    Yu, C.S.9    Ko, Y.C.10    Chung, J.G.11
  • 10
    • 70349777048 scopus 로고    scopus 로고
    • Regulation of apoptosis by the unfolded protein response
    • Fribley, A., K. Zhang and R.J. Kaufman. Regulation of apoptosis by the unfolded protein response. Methods Mol. Biol. 559: 191-204, 2009.
    • (2009) Methods Mol. Biol. , vol.559 , pp. 191-204
    • Fribley, A.1    Zhang, K.2    Kaufman, R.J.3
  • 11
    • 84873091064 scopus 로고    scopus 로고
    • Implication of eIF2alpha kinase GCN2 in induction of apoptosis and endoplasmic reticulum stress-responsive genes by sodium salicylate
    • Gentz, S.H., C.M. Bertollo, E.M. Souza-Fagundes and A.M. da Silva. Implication of eIF2alpha kinase GCN2 in induction of apoptosis and endoplasmic reticulum stress-responsive genes by sodium salicylate. J. Pharm. Pharmacol. 65: 430-440, 2012.
    • (2012) J. Pharm. Pharmacol. , vol.65 , pp. 430-440
    • Gentz, S.H.1    Bertollo, C.M.2    Souza-Fagundes, E.M.3    Da Silva, A.M.4
  • 14
    • 0027217027 scopus 로고
    • Cantharidin, another natural toxin that inhibits the activity of serine/threonine protein phosphatases types 1 and 2A
    • Honkanen, R.E. Cantharidin, another natural toxin that inhibits the activity of serine/threonine protein phosphatases types 1 and 2A. FEBS Lett. 330: 283-286, 1993.
    • (1993) FEBS Lett. , vol.330 , pp. 283-286
    • Honkanen, R.E.1
  • 15
    • 33646751454 scopus 로고    scopus 로고
    • Cantharidin-induced cytotoxicity and cyclooxygenase 2 expression in human bladder carcinoma cell line
    • Huan, S.K, H.H. Lee, D.Z. Liu, C.C. Wu and C.C. Wang. Cantharidin-induced cytotoxicity and cyclooxygenase 2 expression in human bladder carcinoma cell line. Toxicology 223: 136-143, 2006.
    • (2006) Toxicology , vol.223 , pp. 136-143
    • Huan, S.K.1    Lee, H.H.2    Liu, D.Z.3    Wu, C.C.4    Wang, C.C.5
  • 16
    • 79951734217 scopus 로고    scopus 로고
    • Extract of lotus leaf (Nelumbo nucifera) and its active constituent catechin with insulin secretagogue activity
    • Huang, C.F., Y.W. Chen, C.Y. Yang, H.Y. Lin, T.D. Way, W. Chiang and S.H. Liu. Extract of lotus leaf (Nelumbo nucifera) and its active constituent catechin with insulin secretagogue activity. J. Agric. Food Chem. 59: 1087-1094, 2011a.
    • (2011) J. Agric. Food Chem. , vol.59 , pp. 1087-1094
    • Huang, C.F.1    Chen, Y.W.2    Yang, C.Y.3    Lin, H.Y.4    Way, T.D.5    Chiang, W.6    Liu, S.H.7
  • 18
    • 79952327221 scopus 로고    scopus 로고
    • Cantharidin induces G2/M phase arrest and apoptosis in human colorectal cancer colo 205 cells through inhibition of CDK1 activity and caspase-dependent signaling pathways
    • Huang, W.W., S.W. Ko, H.Y. Tsai, J.G. Chung, J.H. Chiang, K.T. Chen, Y.C. Chen, H.Y. Chen, Y.F. Chen and J.S. Yang. Cantharidin induces G2/M phase arrest and apoptosis in human colorectal cancer colo 205 cells through inhibition of CDK1 activity and caspase-dependent signaling pathways. Int. J. Oncol. 38: 1067-1073, 2011c.
    • (2011) Int. J. Oncol. , vol.38 , pp. 1067-1073
    • Huang, W.W.1    Ko, S.W.2    Tsai, H.Y.3    Chung, J.G.4    Chiang, J.H.5    Chen, K.T.6    Chen, Y.C.7    Chen, H.Y.8    Chen, Y.F.9    Yang, J.S.10
  • 19
    • 84862797137 scopus 로고    scopus 로고
    • Bufalin induces G(0)/G(1) phase arrest through inhibiting the levels of cyclin D, cyclin E, CDK2 and CDK4, and triggers apoptosis via mitochondrial signaling pathway in T24 human bladder cancer cells
    • Huang, W.W., J.S. Yang, S.J. Pai, P.P. Wu, S.J. Chang, F.S. Chueh, M.J. Fan, S.M. Chiou, H.M. Kuo, C.C. Yeh, P.Y. Chen, M. Tsuzuki and J.G. Chung. Bufalin induces G(0)/G(1) phase arrest through inhibiting the levels of cyclin D, cyclin E, CDK2 and CDK4, and triggers apoptosis via mitochondrial signaling pathway in T24 human bladder cancer cells. Mutat. Res. 732: 26-33, 2012.
    • (2012) Mutat. Res. , vol.732 , pp. 26-33
    • Huang, W.W.1    Yang, J.S.2    Pai, S.J.3    Wu, P.P.4    Chang, S.J.5    Chueh, F.S.6    Fan, M.J.7    Chiou, S.M.8    Kuo, H.M.9    Yeh, C.C.10    Chen, P.Y.11    Tsuzuki, M.12    Chung, J.G.13
  • 20
    • 84885415875 scopus 로고    scopus 로고
    • The natural compound cantharidin induces cancer cell death through inhibition of heat shock protein 70 (HSP70) and Bcl-2-associated athanogene domain 3 (BAG3) expression by blocking heat shock factor 1 (HSF1) binding to promoters
    • Kim, J.A., Y. Kim, B.M. Kwon and D.C. Han. The natural compound cantharidin induces cancer cell death through inhibition of heat shock protein 70 (HSP70) and Bcl-2-associated athanogene domain 3 (BAG3) expression by blocking heat shock factor 1 (HSF1) binding to promoters. J. Biol. Chem. 288: 28713-28726, 2013.
    • (2013) J. Biol. Chem. , vol.288 , pp. 28713-28726
    • Kim, J.A.1    Kim, Y.2    Kwon, B.M.3    Han, D.C.4
  • 21
    • 77957873171 scopus 로고    scopus 로고
    • Cantharidin induces apoptosis in human bladder cancer TSGH 8301 cells through mitochondria-dependent signal pathways
    • Kuo, J.H., Y.L. Chu, J.S. Yang, J.P. Lin, K.C. Lai, H.M. Kuo, T.C. Hsia and J.G. Chung. Cantharidin induces apoptosis in human bladder cancer TSGH 8301 cells through mitochondria-dependent signal pathways. Int. J. Oncol. 37: 1243-1250, 2010.
    • (2010) Int. J. Oncol. , vol.37 , pp. 1243-1250
    • Kuo, J.H.1    Chu, Y.L.2    Yang, J.S.3    Lin, J.P.4    Lai, K.C.5    Kuo, H.M.6    Hsia, T.C.7    Chung, J.G.8
  • 23
    • 84897002606 scopus 로고    scopus 로고
    • ER stress-induced eIF2-alpha phosphorylation underlies sensitivity of striatal neurons to pathogenic huntingtin
    • Leitman, J., B. Barak, R. Benyair, M. Shenkman, U. Ashery, F.U. Hartl and G.Z. Lederkremer. ER stress-induced eIF2-alpha phosphorylation underlies sensitivity of striatal neurons to pathogenic huntingtin. PLoS One 9: e90803, 2014.
    • (2014) PLoS One , vol.9
    • Leitman, J.1    Barak, B.2    Benyair, R.3    Shenkman, M.4    Ashery, U.5    Hartl, F.U.6    Lederkremer, G.Z.7
  • 24
    • 33646373219 scopus 로고    scopus 로고
    • Endoplasmic reticulum stress-induced apoptosis: Multiple pathways and activation of p53-up-regulated modulator of apoptosis (PUMA) and NOXA by p53
    • Li, J., B. Lee and A.S. Lee. Endoplasmic reticulum stress-induced apoptosis: Multiple pathways and activation of p53-up-regulated modulator of apoptosis (PUMA) and NOXA by p53. J. Biol. Chem. 281: 7260-7270, 2006.
    • (2006) J. Biol. Chem. , vol.281 , pp. 7260-7270
    • Li, J.1    Lee, B.2    Lee, A.S.3
  • 25
    • 79952739700 scopus 로고    scopus 로고
    • PP2A inhibitors induce apoptosis in pancreatic cancer cell line PANC-1 through persistent phosphorylation of IKKalpha and sustained activation of the NF-kappaB pathway
    • Li, W., Z. Chen, Y. Zong, F. Gong, Y. Zhu, J. Lv, J. Zhang, L. Xie, Y. Sun, Y. Miao, M. Tao, X. Han and Z. Xu. PP2A inhibitors induce apoptosis in pancreatic cancer cell line PANC-1 through persistent phosphorylation of IKKalpha and sustained activation of the NF-kappaB pathway. Cancer Lett. 304: 117-127, 2011.
    • (2011) Cancer Lett. , vol.304 , pp. 117-127
    • Li, W.1    Chen, Z.2    Zong, Y.3    Gong, F.4    Zhu, Y.5    Lv, J.6    Zhang, J.7    Xie, L.8    Sun, Y.9    Miao, Y.10    Tao, M.11    Han, X.12    Xu, Z.13
  • 26
    • 84904330544 scopus 로고    scopus 로고
    • Lotus leaf (Nelumbo nucifera) and its active constituents prevent inflammatory responses in macrophages via a JNK/NF-κB signaling pathway
    • Liu S.H., T.H. Lu, C.C. Su, I.S. Lay, H.Y. Lin, K.M. Fang, T.J. Ho, K.L. Chen, Y.C. Su, W.C. Chiang and Y.W. Chen. Lotus leaf (Nelumbo nucifera) and its active constituents prevent inflammatory responses in macrophages via a JNK/NF-κB signaling pathway. Am. J. Chin. Med. 42: 869-889, 2014.
    • (2014) Am. J. Chin. Med. , vol.42 , pp. 869-889
    • Liu, S.H.1    Lu, T.H.2    Su, C.C.3    Lay, I.S.4    Lin, H.Y.5    Fang, K.M.6    Ho, T.J.7    Chen, K.L.8    Su, Y.C.9    Chiang, W.C.10    Chen, Y.W.11
  • 27
    • 84913530181 scopus 로고    scopus 로고
    • Chloroacetic acid triggers apoptosis in neuronal cells via the reactive oxygen species-induced endoplasmic reticulum stress signaling pathway
    • Lu, T.H., C.C. Su, F.C. Tang, C.H. Chen, C.C. Yen, K.M. Fang, K.I. Lee, D.Z. Hung and Y.W. Chen. Chloroacetic acid triggers apoptosis in neuronal cells via the reactive oxygen species-induced endoplasmic reticulum stress signaling pathway. Chem. Biol Interact. 225: 1-12, 2015.
    • (2015) Chem. Biol Interact. , vol.225 , pp. 1-12
    • Lu, T.H.1    Su, C.C.2    Tang, F.C.3    Chen, C.H.4    Yen, C.C.5    Fang, K.M.6    Lee, K.I.7    Hung, D.Z.8    Chen, Y.W.9
  • 28
    • 84887550914 scopus 로고    scopus 로고
    • Arsenic induces reactive oxygen species-caused neuronal cell apoptosis through JNK/ERK-mediated mitochondria-dependent and GRP 78/CHOP-regulated pathways
    • Lu, T.H., T.J. Tseng, C.C. Su, F.C. Tang, C.C. Yen, Y.Y. Liu, C.Y. Yang, C.C. Wu, K.L. Chen, D.Z. Hung and Y.W. Chen. Arsenic induces reactive oxygen species-caused neuronal cell apoptosis through JNK/ERK-mediated mitochondria-dependent and GRP 78/CHOP-regulated pathways. Toxicology Lett. 224: 130-140, 2014.
    • (2014) Toxicology Lett. , vol.224 , pp. 130-140
    • Lu, T.H.1    Tseng, T.J.2    Su, C.C.3    Tang, F.C.4    Yen, C.C.5    Liu, Y.Y.6    Yang, C.Y.7    Wu, C.C.8    Chen, K.L.9    Hung, D.Z.10    Chen, Y.W.11
  • 29
    • 84878389927 scopus 로고    scopus 로고
    • Zinc and copper levels in bladder cancer: A systematic review and metaanalysis
    • Mao, S. and S. Huang. Zinc and copper levels in bladder cancer: A systematic review and metaanalysis. Biol. Trace Elem. Res. 153: 5-10, 2013.
    • (2013) Biol. Trace Elem. Res. , vol.153 , pp. 5-10
    • Mao, S.1    Huang, S.2
  • 30
    • 35948958991 scopus 로고    scopus 로고
    • Regulation of docetaxel-induced apoptosis of human melanoma cells by different isoforms of protein kinase C
    • Mhaidat, N.M., R.F. Thorne, X.D. Zhang and P. Hersey. Regulation of docetaxel-induced apoptosis of human melanoma cells by different isoforms of protein kinase C. Mol. Cancer Res. 5: 1073-1081, 2007.
    • (2007) Mol. Cancer Res. , vol.5 , pp. 1073-1081
    • Mhaidat, N.M.1    Thorne, R.F.2    Zhang, X.D.3    Hersey, P.4
  • 31
    • 0034221202 scopus 로고    scopus 로고
    • The role of protein kinase C isoforms in cell proliferation and apoptosis
    • Musashi, M., S. Ota and N. Shiroshita. The role of protein kinase C isoforms in cell proliferation and apoptosis. Int. J. Hematol. 72: 12-19, 2000.
    • (2000) Int. J. Hematol. , vol.72 , pp. 12-19
    • Musashi, M.1    Ota, S.2    Shiroshita, N.3
  • 32
    • 0030892234 scopus 로고    scopus 로고
    • Apoptosis by death factor
    • Nagata, S. Apoptosis by death factor. Cell 88: 355-365, 1997.
    • (1997) Cell , vol.88 , pp. 355-365
    • Nagata, S.1
  • 33
    • 0034698878 scopus 로고    scopus 로고
    • Cross-talk between two cysteine protease families. Activation of caspase-12 by calpain in apoptosis
    • Nakagawa, T. and J. Yuan. Cross-talk between two cysteine protease families. Activation of caspase-12 by calpain in apoptosis. J. Cell. Biol. 150: 887-894, 2000.
    • (2000) J. Cell. Biol. , vol.150 , pp. 887-894
    • Nakagawa, T.1    Yuan, J.2
  • 34
    • 33646348963 scopus 로고    scopus 로고
    • Signal transduction mechanism involved in Clostridium perfringens alpha-toxin-induced superoxide anion generation in rabbit neutrophils
    • Oda, M., S. Ikari, T. Matsuno, Y. Morimune, M. Nagahama and J. Sakurai. Signal transduction mechanism involved in Clostridium perfringens alpha-toxin-induced superoxide anion generation in rabbit neutrophils. Infect. Immun. 74: 2876-2886, 2006.
    • (2006) Infect. Immun. , vol.74 , pp. 2876-2886
    • Oda, M.1    Ikari, S.2    Matsuno, T.3    Morimune, Y.4    Nagahama, M.5    Sakurai, J.6
  • 35
    • 84862900308 scopus 로고    scopus 로고
    • T-type voltage-activated calcium channel Cav3.1, but not Cav3.2, is involved in the inhibition of proliferation and apoptosis in MCF-7 human breast cancer cells
    • Ohkubo, T. and J. Yamazaki. T-type voltage-activated calcium channel Cav3.1, but not Cav3.2, is involved in the inhibition of proliferation and apoptosis in MCF-7 human breast cancer cells. Int. J. Oncol. 41: 267-275, 2012.
    • (2012) Int. J. Oncol. , vol.41 , pp. 267-275
    • Ohkubo, T.1    Yamazaki, J.2
  • 36
    • 42549153340 scopus 로고    scopus 로고
    • The PKCdelta-Abl complex communicates ER stress to the mitochondria - An essential step in subsequent apoptosis
    • Qi, X and D. Mochly-Rosen. The PKCdelta-Abl complex communicates ER stress to the mitochondria - an essential step in subsequent apoptosis. J. Cell. Sci. 121: 804-813, 2008.
    • (2008) J. Cell. Sci. , vol.121 , pp. 804-813
    • Qi, X.1    Mochly-Rosen, D.2
  • 37
    • 50049106530 scopus 로고    scopus 로고
    • Charting calcium-regulated apoptosis pathways using chemical biology: Role of calmodulin kinase II
    • Olofsson, M.H., A.M. Havelka, S. Brnjic, M.C. Shoshan and S. Linder. Charting calcium-regulated apoptosis pathways using chemical biology: Role of calmodulin kinase II. BMC Chem. Biol. 8: 2, 2008.
    • (2008) BMC Chem. Biol. , vol.8 , pp. 2
    • Olofsson, M.H.1    Havelka, A.M.2    Brnjic, S.3    Shoshan, M.C.4    Linder, S.5
  • 39
    • 54949110895 scopus 로고    scopus 로고
    • Calcium and apoptosis: ER-mitochondria Ca2+ transfer in the control of apoptosis
    • Pinton, P., C. Giorgi, R. Siviero, E. Zecchini and R. Rizzuto. Calcium and apoptosis: ER-mitochondria Ca2+ transfer in the control of apoptosis. Oncogene 27: 6407-6418, 2008.
    • (2008) Oncogene , vol.27 , pp. 6407-6418
    • Pinton, P.1    Giorgi, C.2    Siviero, R.3    Zecchini, E.4    Rizzuto, R.5
  • 41
    • 50149116996 scopus 로고    scopus 로고
    • Cantharidin induces apoptosis of human multiple myeloma cells via inhibition of the JAK/STAT pathway
    • Sagawa, M., T. Nakazato, H. Uchida, Y. Ikeda and M. Kizaki. Cantharidin induces apoptosis of human multiple myeloma cells via inhibition of the JAK/STAT pathway. Cancer Sci. 99, 1820-1826, 2008.
    • (2008) Cancer Sci. , vol.99 , pp. 1820-1826
    • Sagawa, M.1    Nakazato, T.2    Uchida, H.3    Ikeda, Y.4    Kizaki, M.5
  • 42
    • 17044414424 scopus 로고    scopus 로고
    • New insights into cyclins, CDKs, and cell cycle control
    • Sanchez, I. and B.D. Dynlacht. New insights into cyclins, CDKs, and cell cycle control. Semin. Cell Dev. Biol. 16: 311-321, 2005.
    • (2005) Semin. Cell Dev. Biol. , vol.16 , pp. 311-321
    • Sanchez, I.1    Dynlacht, B.D.2
  • 43
    • 60549106248 scopus 로고    scopus 로고
    • Inhibition of eIF2alpha dephosphorylation maximizes bortezomib efficiency and eliminates quiescent multiple myeloma cells surviving proteasome inhibitor therapy
    • Schewe, D.M. and J.A. Aguirre-Ghiso. Inhibition of eIF2alpha dephosphorylation maximizes bortezomib efficiency and eliminates quiescent multiple myeloma cells surviving proteasome inhibitor therapy. Cancer Res. 69: 1545-1552, 2009.
    • (2009) Cancer Res. , vol.69 , pp. 1545-1552
    • Schewe, D.M.1    Aguirre-Ghiso, J.A.2
  • 44
    • 84900295626 scopus 로고    scopus 로고
    • Endoplasmic reticulum stress: Its role in disease and novel prospects for therapy
    • Schonthal, A.H. Endoplasmic reticulum stress: Its role in disease and novel prospects for therapy. Scientifica (Cairo) 2012: 857516, 2012.
    • (2012) Scientifica (Cairo) , vol.2012 , pp. 857516
    • Schonthal, A.H.1
  • 45
    • 0017745032 scopus 로고
    • Studies on a cyclic nucleotide-independent protein kinase and its proenzyme in mammalian tissues. I. Purification and characterization of an active enzyme from bovine cerebellum
    • Takai, Y., A. Kishimoto, M. Inoue and Y. Nishizuka. Studies on a cyclic nucleotide-independent protein kinase and its proenzyme in mammalian tissues. I. Purification and characterization of an active enzyme from bovine cerebellum. J. Biol. Chem. 252: 7603-7609, 1977.
    • (1977) J. Biol. Chem. , vol.252 , pp. 7603-7609
    • Takai, Y.1    Kishimoto, A.2    Inoue, M.3    Nishizuka, Y.4
  • 47
    • 84896740664 scopus 로고    scopus 로고
    • Inhibition of eIF2alpha dephosphorylation enhances TRAIL-induced apoptosis in hepatoma cells
    • Teng, Y., M. Gao, J. Wang, Q. Kong, H. Hua, T. Luo and Y. Jiang. Inhibition of eIF2alpha dephosphorylation enhances TRAIL-induced apoptosis in hepatoma cells. Cell Death Dis. 5: e1060, 2014.
    • (2014) Cell Death Dis. , vol.5 , pp. e1060
    • Teng, Y.1    Gao, M.2    Wang, J.3    Kong, Q.4    Hua, H.5    Luo, T.6    Jiang, Y.7
  • 48
    • 0034622104 scopus 로고    scopus 로고
    • Cytotoxic effects of cantharidin on the growth of normal and carcinoma cells
    • Wang, C.C., C.H. Wu, K.J. Hsieh, K.Y. Yen and L.L. Yang. Cytotoxic effects of cantharidin on the growth of normal and carcinoma cells. Toxicology 147: 77-87, 2000.
    • (2000) Toxicology , vol.147 , pp. 77-87
    • Wang, C.C.1    Wu, C.H.2    Hsieh, K.J.3    Yen, K.Y.4    Yang, L.L.5
  • 49
    • 0024428817 scopus 로고
    • Medical uses of mylabris in ancient China and recent studies
    • Wang, G.S. Medical uses of mylabris in ancient China and recent studies. J. Ethnopharmacol. 26: 147-162, 1989.
    • (1989) J. Ethnopharmacol. , vol.26 , pp. 147-162
    • Wang, G.S.1
  • 50
    • 76749152448 scopus 로고    scopus 로고
    • SnapShot: The unfolded protein response
    • e2
    • Wiseman, R.L., C.M. Haynes and D. Ron. SnapShot: The unfolded protein response. Cell 140: 590-590.e2, 2010.
    • (2010) Cell , vol.140 , pp. 590-590
    • Wiseman, R.L.1    Haynes, C.M.2    Ron, D.3
  • 51
    • 84913611594 scopus 로고    scopus 로고
    • Sialic acid rescues repurified lipopolysaccharideinduced acute renal failure via inhibiting TLR4/PKC/gp91-mediated endoplasmic reticulum stress, apoptosis, autophagy, and pyroptosis signaling
    • Yang, C.C., C.A. Yao, J.C. Yang and C.T. Chien. Sialic acid rescues repurified lipopolysaccharideinduced acute renal failure via inhibiting TLR4/PKC/gp91-mediated endoplasmic reticulum stress, apoptosis, autophagy, and pyroptosis signaling. Toxicol. Sci. 141: 155-165, 2014.
    • (2014) Toxicol. Sci. , vol.141 , pp. 155-165
    • Yang, C.C.1    Yao, C.A.2    Yang, J.C.3    Chien, C.T.4
  • 53
    • 84867605425 scopus 로고    scopus 로고
    • Ursolic acid induces ER stress response to activate ASK1-JNK signaling and induce apoptosis in human bladder cancer T24 cells
    • Zheng, Q.Y., P.P. Li, F.S. Jin, C. Yao, G.H. Zhang, T. Zang and X. Ai. Ursolic acid induces ER stress response to activate ASK1-JNK signaling and induce apoptosis in human bladder cancer T24 cells. Cell. Signal. 25: 206-213, 2013.
    • (2013) Cell. Signal. , vol.25 , pp. 206-213
    • Zheng, Q.Y.1    Li, P.P.2    Jin, F.S.3    Yao, C.4    Zhang, G.H.5    Zang, T.6    Ai, X.7
  • 54
    • 0028824725 scopus 로고
    • Roles of calcium in the regulation of apoptosis in HL-60 promyelocytic leukemia cells
    • Zhu, W.H. and T.T. Loh. Roles of calcium in the regulation of apoptosis in HL-60 promyelocytic leukemia cells. Life Sci. 57: 2091-2099, 1995.
    • (1995) Life Sci. , vol.57 , pp. 2091-2099
    • Zhu, W.H.1    Loh, T.T.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.