Glucopsychosine increases cytosolic calcium to induce calpain-mediated apoptosis of acute myeloid leukemia cells

Cancer Letters

Volumn 348, Issue 1-2, 2014, Pages 29-37

  Angka, Leonard ^a   Lee, Eric A ^a   Rota, Sarah G ^a   Hanlon, Thomas ^a   Sukhai, Mahadeo ^b   Minden, Mark ^c   McMillan, Elliott M ^a   Quadrilatero, Joe ^a   Spagnuolo, Paul A ^a  

^a UNIVERSITY OF WATERLOO   (Canada)

^b UNIVERSITY HEALTH NETWORK   (Canada)

^c PRINCESS MARGARET HOSPITAL   (Canada)

Author keywords

Acute myeloid leukemia; Calcium; Calpain; Glucopsychosine; Nutraceuticals

Indexed keywords

CALCIUM; CALCIUM CHANNEL; CALPAIN; GLUCOPSYCHOSINE; PSYCHOSINE; UNCLASSIFIED DRUG;

ACUTE GRANULOCYTIC LEUKEMIA; APOPTOSIS; ARTICLE; CELL DEATH; CELL GROWTH; CELL VIABILITY; EXTRACELLULAR CALCIUM; HEMATOPOIETIC CELL; HUMAN; HUMAN CELL; PRIORITY JOURNAL; TUMOR GROWTH; TUMOR VOLUME; TUMOR XENOGRAFT;

ACUTE MYELOID LEUKEMIA; CALCIUM; CALPAIN; GLUCOPSYCHOSINE; NUTRACEUTICALS;

ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; CALCIUM; CALCIUM CHANNELS; CALPAIN; CELL LINE, TUMOR; CELL PROLIFERATION; CELL SURVIVAL; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; LEUKEMIA, MYELOID, ACUTE; MICE; MICE, INBRED NOD; MICE, SCID; PSYCHOSINE; SIGNAL TRANSDUCTION; TIME FACTORS; TUMOR BURDEN; TUMOR CELLS, CULTURED; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84900473493     PISSN: 03043835     EISSN: 18727980     Source Type: Journal    
DOI: 10.1016/j.canlet.2014.03.003     Document Type: Article

References (43)

1. Lowenberg B., Downing J.R., Burnett A. Acute myeloid leukemia. New Engl. J. Med. 1999, 341:1051-1062.
2. Burnett A., Wetzler M., Lowenberg B. Therapeutic advances in acute myeloid leukemia. J. Clin. Oncol.: Official J. Am. Soc. Clin. Oncol. 2011, 29:487-494.
3. Shipley J.L., Butera J.N. Acute myelogenous leukemia. Exp. Hematol. 2009, 37:649-658.
4. Khan I., Altman J.K., Licht J.D. New strategies in acute myeloid leukemia: redefining prognostic markers to guide therapy. Clin. Cancer Res.: Official J. Am. Assoc. Cancer Res. 2012, 18:5163-5171.
5. McDermott S.P., Eppert K., Notta F., Isaac M., Datti A., Al-Awar R., Wrana J., Minden M.D., Dick J.E. A small molecule screening strategy with validation on human leukemia stem cells uncovers the therapeutic efficacy of kinetin riboside. Blood 2012, 119:1200-1207.
6. Guzman M.L., Rossi R.M., Karnischky L., Li X., Peterson D.R., Howard D.S., Jordan C.T. The sesquiterpene lactone parthenolide induces apoptosis of human acute myelogenous leukemia stem and progenitor cells. Blood 2005, 105:4163-4169.
7. Spagnuolo P.A., Hu J., Hurren R., Wang X., Gronda M., Sukhai M.A., Di Meo A., Boss J., Ashali I., Beheshti Zavareh R., Fine N., Simpson C.D., Sharmeen S., Rottapel R., Schimmer A.D. The antihelmintic flubendazole inhibits microtubule function through a mechanism distinct from Vinca alkaloids and displays preclinical activity in leukemia and myeloma. Blood 2010, 115:4824-4833.
8. Spagnuolo P.A., Hurren R., Gronda M., Maclean N., Datti A., Basheer A., Lin F.H., Wang X., Wrana J., Schimmer A.D. Inhibition of intracellular dipeptidyl peptidases 8 and 9 enhances parthenolide's anti-leukemic activity. Leukemia: Official J. Leukemia Soc. Am., Leukemia Res. Fund, UK 2013.
9. Skrtic M., Sriskanthadevan S., Jhas B., Gebbia M., Wang X., Wang Z., Hurren R., Jitkova Y., Gronda M., Maclean N., Lai C.K., Eberhard Y., Bartoszko J., Spagnuolo P., Rutledge A.C., Datti A., Ketela T., Moffat J., Robinson B.H., Cameron J.H., Wrana J., Eaves C.J., Minden M.D., Wang J.C., Dick J.E., Humphries K., Nislow C., Giaever G., Schimmer A.D. Inhibition of mitochondrial translation as a therapeutic strategy for human acute myeloid leukemia. Cancer Cell 2011, 20:674-688.
10. Revankar C.M., Advani S.H., Naik N.R. Altered Ca2+ homeostasis in polymorphonuclear leukocytes from chronic myeloid leukaemia patients. Mol. Cancer 2006, 5:65.
11. Dam A.D., Mitchell A.S., Quadrilatero J. Induction of mitochondrial biogenesis protects against caspase-dependent and caspase-independent apoptosis in L6 myoblasts. Biochimica et Biophysica Acta 2013.
12. Payton J.E., Grieselhuber N.R., Chang L.W., Murakami M., Geiss G.K., Link D.C., Nagarajan R., Watson M.A., Ley T.J. High throughput digital quantification of mRNA abundance in primary human acute myeloid Leukemia samples. J. Clin. Invest. 2009, 119:1714-1726.
13. Chaitanya G.V., Steven A.J., Babu P.P. PARP-1 cleavage fragments: signatures of cell-death proteases in neurodegeneration. Cell Commun. Signaling: CCS 2010, 8:31.
14. Artus C., Maquarre E., Moubarak R.S., Delettre C., Jasmin C., Susin S.A., Robert-Lezenes J. CD44 ligation induces caspase-independent cell death via a novel calpain/AIF pathway in human erythroleukemia cells. Oncogene 2006, 25:5741-5751.
15. Hashiguchi K., Zhang-Akiyama Q.M. Establishment of human cell lines lacking mitochondrial DNA. Methods Mol. Biol. 2009, 554:383-391.
16. Gamen S., Anel A., Montoya J., Marzo I., Pineiro A., Naval J. MtDNA-depleted U937 cells are sensitive to TNF and Fas-mediated cytotoxicity. FEBS Lett. 1995, 376:15-18.
17. Ferraresi R., Troiano L., Pinti M., Roat E., Lugli E., Quaglino D., Taverna D., Bellizzi D., Passarino G., Cossarizza A. Resistance of mtDNA-depleted cells to apoptosis. Cytometry Part A: J. Int. Soc. Anal. Cytol. 2008, 73:528-537.
18. Lloyd-Evans E., Pelled D., Riebeling C., Bodennec J., de-Morgan A., Waller H., Schiffmann R., Futerman A.H. Glucosylceramide and glucosylsphingosine modulate calcium mobilization from brain microsomes via different mechanisms. J. Biol. Chem. 2003, 278:23594-23599.
19. Orrenius S., Zhivotovsky B., Nicotera P. Regulation of cell death: the calcium-apoptosis link. Nat. Rev. Mol. Cell Biol. 2003, 4:552-565.
20. Monteith G.R., McAndrew D., Faddy H.M., Roberts-Thomson S.J. Calcium and cancer: targeting Ca2+ transport. Nat. Rev. Cancer 2007, 7:519-530.
21. Garattini E., Parrella E., Diomede L., Gianni M., Kalac Y., Merlini L., Simoni D., Zanier R., Ferrara F.F., Chiarucci I., Carminati P., Terao M., Pisano C. ST1926, a novel and orally active retinoid-related molecule inducing apoptosis in myeloid leukemia cells: modulation of intracellular calcium homeostasis. Blood 2004, 103:194-207.
22. Siau C., Bennett G.J. Dysregulation of cellular calcium homeostasis in chemotherapy-evoked painful peripheral neuropathy. Anesth. Analg. 2006, 102:1485-1490.
23. Monette R., Potvin L., Baines D., Laprade R., Schwartz J.L. Interaction between calcium ions and bacillus thuringiensis toxin activity against Sf9 Cells (Spodoptera frugiperda, Lepidoptera). Appl. Environ. Microbiol. 1997, 63:440-447.
24. Sukhai M.A., Prabha S., Hurren R., Rutledge A.C., Lee A.Y., Sriskanthadevan S., Sun H., Wang X., Skrtic M., Seneviratne A., Cusimano M., Jhas B., Gronda M., Maclean N., Cho E.E., Spagnuolo P.A., Sharmeen S., Gebbia M., Urbanus M., Eppert K., Dissanayake D., Jonet A., Dassonville-Klimpt A., Li X., Datti A., Ohashi P.S., Wrana J., Rogers I., Sonnet P., Ellis W.Y., Corey S.J., Eaves C., Minden M.D., Wang J.C., Dick J.E., Nislow C., Giaever G., Schimmer A.D. Lysosomal disruption preferentially targets acute myeloid leukemia cells and progenitors. J. Clin. Invest. 2012.
25. Lai L.P., Su M.J., Lin J.L., Lin F.Y., Tsai C.H., Chen Y.S., Huang S.K., Tseng Y.Z., Lien W.P. Down-regulation of L-type calcium channel and sarcoplasmic reticular Ca(2+)-ATPase mRNA in human atrial fibrillation without significant change in the mRNA of ryanodine receptor, calsequestrin and phospholamban: an insight into the mechanism of atrial electrical remodeling. J. Am. Coll. Cardiol. 1999, 33:1231-1237.
26. Liu X., Rusch N.J., Striessnig J., Sarna S.K. Down-regulation of L-type calcium channels in inflamed circular smooth muscle cells of the canine colon. Gastroenterology 2001, 120:480-489.
27. Li X.M., Yang J.M., Hu D.H., Hou F.Q., Zhao M., Zhu X.H., Wang Y., Li J.G., Hu P., Chen L., Qin L.N., Gao T.M. Contribution of downregulation of L-type calcium currents to delayed neuronal death in rat hippocampus after global cerebral ischemia and reperfusion. J. Neurosci.: Official J. Soc. Neurosci. 2007, 27:5249-5259.
28. Soboloff J., Zhang Y., Minden M., Berger S.A. Sensitivity of myeloid leukemia cells to calcium influx blockade: application to bone marrow purging. Exp. Hematol. 2002, 30:1219-1226.
29. Niapour M., Farr C., Minden M., Berger S.A. Elevated calpain activity in acute myelogenous leukemia correlates with decreased calpastatin expression. Blood Cancer J. 2012, 2:e51.
30. Goll D.E., Thompson V.F., Li H., Wei W., Cong J. The calpain system. Physiol. Rev. 2003, 83:731-801.
31. O'Donovan N., Crown J., Stunell H., Hill A.D., McDermott E., O'Higgins N., Duffy M.J. Caspase 3 in breast cancer. Clin. Cancer Res.: Official J. Am. Assoc. Cancer Res. 2003, 9:738-742.
32. Hartmann A., Hunot S., Michel P.P., Muriel M.P., Vyas S., Faucheux B.A., Mouatt-Prigent A., Turmel H., Srinivasan A., Ruberg M., Evan G.I., Agid Y., Hirsch E.C. Caspase-3: a vulnerability factor and final effector in apoptotic death of dopaminergic neurons in Parkinson's disease. Proc. Nat. Acad. Sci. USA 2000, 97:2875-2880.
33. Shalimar D., Das P., Sreenivas V., Gupta S.D., Panda S.K., Makharia G.K. Mechanism of villous atrophy in celiac disease: role of apoptosis and epithelial regeneration. Arch. Pathol. Lab. Med. 2013, 137:1262-1269.
34. Jeong J.C., Shin W.Y., Kim T.H., Kwon C.H., Kim J.H., Kim Y.K., Kim K.H. Silibinin induces apoptosis via calpain-dependent AIF nuclear translocation in U87MG human glioma cell death. J. Exp. Clin. Cancer Res.: CR 2011, 30:44.
35. Yanamandra N., Buzzeo R.W., Gabriel M., Hazlehurst L.A., Mari Y., Beaupre D.M., Cuevas J. Tipifarnib-induced apoptosis in acute myeloid leukemia and multiple myeloma cells depends on Ca2+ influx through plasma membrane Ca2+ channels. J. Pharmacol. Exp. Ther. 2011, 337:636-643.
36. Jensen R.G. The composition of bovine milk lipids: January 1995 to December 2000. J. Dairy Sci. 2002, 85:295-350.
37. Milner J.A. Nutrition and cancer: essential elements for a roadmap. Cancer Lett. 2008, 269:189-198.
38. Igisu H., Hamasaki N., Ito A., Ou W. Inhibition of cytochrome c oxidase and hemolysis caused by lysosphingolipids. Lipids 1988, 23:345-348.
39. Jatana M., Giri S., Singh A.K. Apoptotic positive cells in Krabbe brain and induction of apoptosis in rat C6 glial cells by psychosine. Neurosci. Lett. 2002, 330:183-187.
40. Schueler U.H., Kolter T., Kaneski C.R., Blusztajn J.K., Herkenham M., Sandhoff K., Brady R.O. Toxicity of glucosylsphingosine (glucopsychosine) to cultured neuronal cells: a model system for assessing neuronal damage in Gaucher disease type 2 and 3. Neurobiol. Disease 2003, 14:595-601.
41. Dekker N., van Dussen L., Hollak C.E., Overkleeft H., Scheij S., Ghauharali K., van Breemen M.J., Ferraz M.J., Groener J.E., Maas M., Wijburg F.A., Speijer D., Tylki-Szymanska A., Mistry P.K., Boot R.G., Aerts J.M. Elevated plasma glucosylsphingosine in Gaucher disease: relation to phenotype, storage cell markers, and therapeutic response. Blood 2011, 118. e118-127.
42. Beutler E. Gaucher disease: new molecular approaches to diagnosis and treatment. Science 1992, 256:794-799.
43. Zimran A., Kay A., Gelbart T., Garver P., Thurston D., Saven A., Beutler E. Gaucher disease. Clinical, laboratory, radiologic, and genetic features of 53 patients. Medicine 1992, 71:337-353.