The natural compound cantharidin induces cancer cell death through inhibition of heat shock protein 70 (HSP70) and Bcl-2-associated athanogene domain 3 (BAG3) expression by blocking heat shock factor 1 (HSF1) binding to promoters

Journal of Biological Chemistry

Volumn 288, Issue 40, 2013, Pages 28713-28726

  Kim, Joo Ae ^a,b   Kim, Youngmi ^a,b   Kwon, Byoung Mog ^a,b   Han, Dong Cho ^a,b  

^a Korea Research Institute of Bioscience and Biotechnology (KRIBB)   (South Korea)

^b University of Science and Technology (UST)   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIAPOPTOTIC; BCL-2 FAMILY PROTEINS; CANCER CELLS; DOWN-REGULATION; HEAT SHOCK PROTEIN 70; HEAT-SHOCK FACTOR 1; NATURAL COMPOUNDS; TARGET MOLECULE;

CELL DEATH;

PROTEINS;

CANTHARIDIN; HEAT SHOCK PROTEIN 70; HEAT SHOCK TRANSCRIPTION FACTOR 1; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MESSENGER RNA; PHOSPHOPROTEIN PHOSPHATASE 2A; POSITIVE TRANSCRIPTION ELONGATION FACTOR B; PROTEIN BCL XL; PROTEIN MCL 1; PUMA PROTEIN; RNA POLYMERASE II; SMALL INTERFERING RNA;

ANTINEOPLASTIC ACTIVITY; ARTICLE; BINDING AFFINITY; CANCER CELL CULTURE; CANCER CELL DESTRUCTION; CARBOXY TERMINAL SEQUENCE; CELL ASSAY; CELL STRAIN HCT116; CHROMATIN IMMUNOPRECIPITATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFICACY; DRUG MECHANISM; ENZYME INHIBITION; HUMAN; HUMAN CELL; IC 50; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; PROTEIN TARGETING;

APOPTOSIS; BCL-2 FAMILY PROTEINS; CANCER THERAPY; DRUG SCREENING; HEAT SHOCK PROTEIN; PP2A;

ACETYLATION; ADAPTOR PROTEINS, SIGNAL TRANSDUCING; BCL-X PROTEIN; CANTHARIDIN; CELL DEATH; CELL LINE, TUMOR; CELL NUCLEUS; CELL PROLIFERATION; DNA-BINDING PROTEINS; DRUG SCREENING ASSAYS, ANTITUMOR; G2 PHASE CELL CYCLE CHECKPOINTS; GENE EXPRESSION REGULATION, NEOPLASTIC; HEAT-SHOCK RESPONSE; HSP70 HEAT-SHOCK PROTEINS; HUMANS; MITOSIS; MODELS, BIOLOGICAL; MYELOID CELL LEUKEMIA SEQUENCE 1 PROTEIN; NEOPLASMS; POSITIVE TRANSCRIPTIONAL ELONGATION FACTOR B; PROMOTER REGIONS, GENETIC; PROTEASE INHIBITORS; PROTEIN BINDING; PROTEIN PHOSPHATASE 2; PROTEIN TRANSPORT; PROTO-ONCOGENE PROTEINS C-BCL-2; TRANSCRIPTION FACTORS;

EID: 84885415875     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M113.488346     Document Type: Article

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