Isthmin targets cell-surface GRP78 and triggers apoptosis via induction of mitochondrial dysfunction

Cell Death and Differentiation

Volumn 21, Issue 5, 2014, Pages 797-810

  Chen, M ^a   Zhang, Y ^a   Yu, V C ^a   Chong, Y S ^b   Yoshioka, T ^c   Ge, R ^a  

^a NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^b NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^c AKITA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

angiogenesis; apoptosis; cancer; GRP78; Isthmin; mitochondrial dysfunction

Indexed keywords

ADENINE NUCLEOTIDE TRANSLOCASE; CHLORPROMAZINE; CLATHRIN; CLATHRIN HEAVY CHAIN; GLUCOSE REGULATED PROTEIN 78; ISTHMIN; NYSTATIN; PROTEIN; UNCLASSIFIED DRUG; ANGIOGENESIS INHIBITOR; HEAT SHOCK PROTEIN; ISTHMIN PROTEIN, MOUSE; MOLECULAR CHAPERONE GRP78;

ANGIOGENESIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIANGIOGENIC ACTIVITY; APOPTOSIS; APOPTOSIS ASSAY; ARTICLE; BREAST CARCINOMA; CANCER CELL; CELL ADHESION ASSAY; CELL FRACTIONATION; CELL PROLIFERATION; CONTROLLED STUDY; CYTOSOL; DISORDERS OF MITOCHONDRIAL FUNCTIONS; ENDOCYTOSIS; ENDOTHELIUM CELL; FEMALE; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; MASS SPECTROMETRY; MELANOMA B16; MITOCHONDRIAL MEMBRANE POTENTIAL; MOUSE; NICK END LABELING; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN TARGETING; WESTERN BLOTTING; 3T3 CELL LINE; ANIMAL; BAGG ALBINO MOUSE; CELL GROWTH; GENETIC TRANSFECTION; GENETICS; HEK293 CELL LINE; METABOLISM; MITOCHONDRION; NEOVASCULARIZATION (PATHOLOGY); PHYSIOLOGY; TUMOR CELL LINE; UMBILICAL VEIN ENDOTHELIAL CELL;

MUS;

ANGIOGENESIS INHIBITORS; ANIMALS; APOPTOSIS; CELL FRACTIONATION; CELL GROWTH PROCESSES; CELL LINE, TUMOR; FEMALE; HEAT-SHOCK PROTEINS; HEK293 CELLS; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; HUMANS; MICE; MICE, INBRED BALB C; MITOCHONDRIA; NEOVASCULARIZATION, PATHOLOGIC; NIH 3T3 CELLS; PROTEINS; SWISS 3T3 CELLS; TRANSFECTION;

EID: 84898045838     PISSN: 13509047     EISSN: 14765403     Source Type: Journal    
DOI: 10.1038/cdd.2014.3     Document Type: Article

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