High folic acid consumption leads to pseudo-MTHFR deficiency, altered lipid metabolism, and liver injury in mice

American Journal of Clinical Nutrition

Volumn 101, Issue 3, 2015, Pages 646-658

  Christensen, Karen E ^a   Mikael, Leonie G ^a   Leung, Kit Yi ^b   Lévesque, Nancy ^a   Deng, Liyuan ^a   Wu, Qing ^a   Malysheva, Olga V ^c   Best, Ana ^d   Caudill, Marie A ^c   Greene, Nicholas D E ^b   Rozen, Rima ^a  

^a MONTREAL CHILDREN S HOSPITAL   (Canada)

^b UNIVERSITY COLLEGE LONDON   (United Kingdom)

^c Department of Obstetrics Gynecology   (United States)

^d MCGILL UNIVERSITY   (Canada)

Author keywords

Choline metabolism; Folic acid; Lipid metabolism; Liver; Methylenetetrahydrofolate reductase

Indexed keywords

CHOLESTEROL 7ALPHA MONOOXYGENASE; CHOLINE; FARNESOID X RECEPTOR; FOLIC ACID; MESSENGER RNA; PHOSPHATIDYLCHOLINE; S ADENOSYLHOMOCYSTEINE; S ADENOSYLMETHIONINE; STEROL REGULATORY ELEMENT BINDING PROTEIN 1; ENZYME INHIBITOR; METHYLENETETRAHYDROFOLATE REDUCTASE (NADPH2);

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CHOLESTEROL METABOLISM; CONTROLLED STUDY; DIET SUPPLEMENTATION; DNA POLYMORPHISM; ENZYME DEFICIENCY; ENZYME SYNTHESIS; FOLATE METABOLISM; FOLIC ACID BLOOD LEVEL; FOOD INTAKE; GENE EXPRESSION; GENETIC VARIABILITY; GENOTYPE; HOMOZYGOSITY; IN VITRO STUDY; INVESTIGATIVE PROCEDURES; LIPID METABOLISM; LIPOGENESIS; LIVER HISTOLOGY; LIVER INJURY; LIVER WEIGHT; MALE; METHYLENETETRAHYDROFOLATE REDUCTASE DEFICIENCY; MOUSE; NONALCOHOLIC FATTY LIVER; NONHUMAN; SPLEEN WEIGHT; ANIMAL; ANTAGONISTS AND INHIBITORS; BAGG ALBINO MOUSE; DEFICIENCY; GENE EXPRESSION REGULATION; GENETICS; GERMFREE ANIMAL; HETEROZYGOTE; HOMOCYSTINURIA; INTOXICATION; LIVER; METABOLISM; METHYLATION; MUSCLE SPASTICITY; MUTANT MOUSE STRAIN; MUTATION; NON-ALCOHOLIC FATTY LIVER DISEASE; ORGAN SIZE; PATHOLOGY; PATHOPHYSIOLOGY; PSYCHOTIC DISORDERS;

MUS;

ANIMALS; DIETARY SUPPLEMENTS; ENZYME INHIBITORS; FOLIC ACID; GENE EXPRESSION REGULATION; HETEROZYGOTE; HOMOCYSTINURIA; LIPID METABOLISM; LIPOGENESIS; LIVER; MALE; METHYLATION; METHYLENETETRAHYDROFOLATE REDUCTASE (NADPH2); MICE, INBRED BALB C; MICE, MUTANT STRAINS; MUSCLE SPASTICITY; MUTATION; NON-ALCOHOLIC FATTY LIVER DISEASE; ORGAN SIZE; PSYCHOTIC DISORDERS; SPECIFIC PATHOGEN-FREE ORGANISMS;

EID: 84928919955     PISSN: 00029165     EISSN: 19383207     Source Type: Journal    
DOI: 10.3945/ajcn.114.086603     Document Type: Article

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