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Volumn 93, Issue 2, 2011, Pages 348-355

MTHFR C677T genotype influences the isotopic enrichment of one-carbon metabolites in folate-compromised men consuming d9-choline

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOBUTYRIC ACID; 5,10 METHYLENETETRAHYDROFOLATE REDUCTASE (FADH2); BETAINE; CARBON; CHOLINE; CYSTATHIONINE; CYSTEINE; DEUTERIUM; FOLIC ACID; GLYCINE; HOMOCYSTEINE; METHIONINE; PHOSPHATIDYLCHOLINE; SARCOSINE; SERINE;

EID: 79251524576     PISSN: 00029165     EISSN: 19383207     Source Type: Journal    
DOI: 10.3945/ajcn.110.005975     Document Type: Article
Times cited : (68)

References (34)
  • 2
    • 0037203313 scopus 로고    scopus 로고
    • Phosphatidylcholine and cell death
    • Cui Z, Houweling M. Phosphatidylcholine and cell death. Biochim Biophys Acta 2002;1585:87-96.
    • (2002) Biochim Biophys Acta , vol.1585 , pp. 87-96
    • Cui, Z.1    Houweling, M.2
  • 3
    • 0037186623 scopus 로고    scopus 로고
    • Kinetic analyses of liver phosphatidylcholine and phosphatidylethanolamine biosynthesis using 13C NMR spectroscopy
    • Reo NV, Adinehzadeh M, Foy B. Kinetic analyses of liver phosphatidylcholine and phosphatidylethanolamine biosynthesis using 13C NMR spectroscopy. Biochim Biophys Acta 2002;1580:171-88.
    • (2002) Biochim Biophys Acta , vol.1580 , pp. 171-188
    • Reo, N.V.1    Adinehzadeh, M.2    Foy, B.3
  • 4
    • 0036327615 scopus 로고    scopus 로고
    • Diet, methyl donors and DNA methylation: Interactions between dietary folate, methionine and choline
    • Niculescu MD, Zeisel S. Diet, methyl donors and DNA methylation: interactions between dietary folate, methionine and choline. J Nutr 2002;132:2333S-5S.
    • (2002) J Nutr , vol.132
    • Niculescu, M.D.1    Zeisel, S.2
  • 5
    • 33747186460 scopus 로고    scopus 로고
    • S-Adenosyl-l-methionine: Beyond the universal methyl group donor
    • DOI 10.1016/j.phytochem.2006.04.019, PII S0031942206002251
    • Roje S. S-Adenosyl-L-methionine: beyond the universal methyl group donor. Phytochemistry 2006;67:1686-98. (Pubitemid 44233619)
    • (2006) Phytochemistry , vol.67 , Issue.15 , pp. 1686-1698
    • Roje, S.1
  • 6
    • 0023833533 scopus 로고
    • The active synthesis of phosphatidylcholine is required for very low density lipoprotein secretion from rat hepatocytes
    • Yao ZM, Vance DE. The active synthesis of phosphatidylcholine is required for very low density lipoprotein secretion from rat hepatocytes. J Biol Chem 1988;263:2998-3004.
    • (1988) J Biol Chem , vol.263 , pp. 2998-3004
    • Yao, Z.M.1    Vance, D.E.2
  • 7
    • 0034870968 scopus 로고    scopus 로고
    • Choline deficiency causes reversible hepatic abnormalities in patients receiving parenteral nutrition: Proof of a human choline requirement: A placebo-controlled trial
    • Buchman A, Ament M, Sohel M, et al. Choline deficiency causes reversible hepatic abnormalities in patients receiving parenteral nutrition: proof of a human choline requirement: a placebo-controlled trial. J Parenter Enteral Nutr 2001;25:260-8.
    • (2001) J Parenter Enteral Nutr , vol.25 , pp. 260-268
    • Buchman, A.1    Ament, M.2    Sohel, M.3
  • 8
    • 3042696730 scopus 로고    scopus 로고
    • Elevated serum creatine phosphokinase in choline-deficient humans: Mechanistic studies in C2C12 mouse myoblasts
    • da Costa K, Badea M, Fischer L, Zeisel S. Elevated serum creatine phosphokinase in choline-deficient humans: mechanistic studies in C2C12 mouse myoblasts. Am J Clin Nutr 2004;80:163-70.
    • (2004) Am J Clin Nutr , vol.80 , pp. 163-170
    • Da Costa, K.1    Badea, M.2    Fischer, L.3    Zeisel, S.4
  • 10
    • 34447278090 scopus 로고    scopus 로고
    • Lymphocyte gene expression in subjects fed a low-choline diet differs between those who develop organ dysfunction and those who do not
    • Niculescu MD, da Costa K, Fischer L, Zeisel S. Lymphocyte gene expression in subjects fed a low-choline diet differs between those who develop organ dysfunction and those who do not. Am J Clin Nutr 2007;86:230-9.
    • (2007) Am J Clin Nutr , vol.86 , pp. 230-239
    • Niculescu, M.D.1    Da Costa, K.2    Fischer, L.3    Zeisel, S.4
  • 11
    • 38949156619 scopus 로고    scopus 로고
    • Dietary choline and betaine intakes in relation to concentrations of inflammatory markers in healthy adults: The ATTICA study
    • Detopoulou P, Panagiotakos D, Antonopoulou S, Pitsavos C, Stefanadis C. Dietary choline and betaine intakes in relation to concentrations of inflammatory markers in healthy adults: the ATTICA study. Am J Clin Nutr 2008;87:424-30.
    • (2008) Am J Clin Nutr , vol.87 , pp. 424-430
    • Detopoulou, P.1    Panagiotakos, D.2    Antonopoulou, S.3    Pitsavos, C.4    Stefanadis, C.5
  • 12
    • 3242698799 scopus 로고    scopus 로고
    • Periconceptional dietary intake of choline and betaine and neural tube defects in offspring
    • Shaw GM, Carmichael S, Yang W, Selvin S, Schaffer D. Periconceptional dietary intake of choline and betaine and neural tube defects in offspring. Am J Epidemiol 2004;160:102-9.
    • (2004) Am J Epidemiol , vol.160 , pp. 102-109
    • Shaw, G.M.1    Carmichael, S.2    Yang, W.3    Selvin, S.4    Schaffer, D.5
  • 13
    • 44949151096 scopus 로고    scopus 로고
    • Choline metabolism and risk of breast cancer in a population-based study
    • Xu X, Gammon M, Zeisel S, et al. Choline metabolism and risk of breast cancer in a population-based study. FASEB J 2008;22:2045-52.
    • (2008) FASEB J , vol.22 , pp. 2045-2052
    • Xu, X.1    Gammon, M.2    Zeisel, S.3
  • 15
    • 85057908352 scopus 로고    scopus 로고
    • Genetic variation: Effect on folate metabolism and health
    • Bailey LB, ed. Boca Raton, FL: CRC Press
    • Christensen KE, Rozen R. Genetic variation: effect on folate metabolism and health. In: Bailey LB, ed. Folate in health and disease. Boca Raton, FL: CRC Press, 2009;75-110.
    • (2009) Folate in Health and Disease , pp. 75-110
    • Christensen, K.E.1    Rozen, R.2
  • 16
    • 38149118639 scopus 로고    scopus 로고
    • Folate intake at RDA levels is inadequate for Mexican American men with the methylenetetrahydrofolate reductase 677TT genotype
    • Solis C, Veenema K, Ivanov AA, et al. Folate intake at RDA levels is inadequate for Mexican American men with the methylenetetrahydrofolate reductase 677TT genotype. J Nutr 2008;138:67-72.
    • (2008) J Nutr , vol.138 , pp. 67-72
    • Solis, C.1    Veenema, K.2    Ivanov, A.A.3
  • 17
    • 51749099188 scopus 로고    scopus 로고
    • Adequate Intake levels of choline are sufficient for preventing elevations in serum markers of liver dysfunction in Mexican American men but are not optimal for minimizing plasma total homocysteine increases after a methionine load
    • Veenema K, Solis C, Li R, et al. Adequate Intake levels of choline are sufficient for preventing elevations in serum markers of liver dysfunction in Mexican American men but are not optimal for minimizing plasma total homocysteine increases after a methionine load. Am J Clin Nutr 2008;88:685-92.
    • (2008) Am J Clin Nutr , vol.88 , pp. 685-692
    • Veenema, K.1    Solis, C.2    Li, R.3
  • 18
    • 0038671834 scopus 로고    scopus 로고
    • Methylenetetrahydrofolate reductase 677C-. T variant modulates folate status response to controlled folate intakes in young women
    • Guinotte CL, Burns M, Axume J, et al. Methylenetetrahydrofolate reductase 677C-. T variant modulates folate status response to controlled folate intakes in young women. J Nutr 2003;133:1272-80.
    • (2003) J Nutr , vol.133 , pp. 1272-1280
    • Guinotte, C.L.1    Burns, M.2    Axume, J.3
  • 19
    • 0029049553 scopus 로고
    • A candidate genetic risk factor for vascular disease: A common mutation in methylenetetrahydrofolate reductase
    • Frosst P, Blom H, Milos R, et al. A candidate genetic risk factor for vascular disease: a common mutation in methylenetetrahydrofolate reductase. Nat Genet 1995;10:111-3.
    • (1995) Nat Genet , vol.10 , pp. 111-113
    • Frosst, P.1    Blom, H.2    Milos, R.3
  • 20
    • 0037307164 scopus 로고    scopus 로고
    • Determination of choline, betaine, and dimethylglycine in plasma by a high-throughput method based on normal-phase chromatography-tandem mass spectrometry
    • Holm PI, Ueland P, Kvalheim G, Lien E. Determination of choline, betaine, and dimethylglycine in plasma by a high-throughput method based on normal-phase chromatography-tandem mass spectrometry. Clin Chem 2003;49:286-94.
    • (2003) Clin Chem , vol.49 , pp. 286-294
    • Holm, P.I.1    Ueland, P.2    Kvalheim, G.3    Lien, E.4
  • 21
    • 0037106401 scopus 로고    scopus 로고
    • Quantitation of choline and its metabolites in tissues and foods by liquid chromatography/electrospray ionization-isotope dilution mass spectrometry
    • Koc H, Mar MH, Ranasinghe A, Swenberg JA, Zeisel SH. Quantitation of choline and its metabolites in tissues and foods by liquid chromatography/ electrospray ionization-isotope dilution mass spectrometry. Anal Chem 2002;74:4734-40.
    • (2002) Anal Chem , vol.74 , pp. 4734-4740
    • Koc, H.1    Mar, M.H.2    Ranasinghe, A.3    Swenberg, J.A.4    Zeisel, S.H.5
  • 22
    • 38749098623 scopus 로고    scopus 로고
    • Folate intake and the MTHFR C677T genotype influence choline status in young Mexican American women
    • Abratte CM, Wang W, Li R, Moriarty DJ, Caudill MA. Folate intake and the MTHFR C677T genotype influence choline status in young Mexican American women. J Nutr Biochem 2008;19:158-65.
    • (2008) J Nutr Biochem , vol.19 , pp. 158-165
    • Abratte, C.M.1    Wang, W.2    Li, R.3    Moriarty, D.J.4    Caudill, M.A.5
  • 23
    • 0025121012 scopus 로고
    • Comparison of deuterated leucine, valine and lysine in the measurement of human apolipoprotein A-I and B-100 kinetics
    • Lichtenstein AH, Cohn JS, Hachey DL, Millar JS, Ordovas JM, Schaefer EJ. Comparison of deuterated leucine, valine and lysine in the measurement of human apolipoprotein A-I and B-100 kinetics. J Lipid Res 1990;31:1693-701.
    • (1990) J Lipid Res , vol.31 , pp. 1693-1701
    • Lichtenstein, A.H.1    Cohn, J.S.2    Hachey, D.L.3    Millar, J.S.4    Ordovas, J.M.5    Schaefer, E.J.6
  • 24
    • 0942265677 scopus 로고    scopus 로고
    • Tracer-derived total and folate- dependent homocysteine remethylation and synthesis rates in humans indicate that serine is the main one-carbon donor
    • Published erratum appears in Am J Physiol Endocrinol Metab 2004;286:E674
    • Davis SR, Stacpoole PW, Williamson J, et al. Tracer-derived total and folate- dependent homocysteine remethylation and synthesis rates in humans indicate that serine is the main one-carbon donor. Am J Physiol Endocrinol Metab 2004;286:E272-9 (Published erratum appears in Am J Physiol Endocrinol Metab 2004;286:E674).
    • (2004) Am J Physiol Endocrinol Metab , vol.286
    • Davis, S.R.1    Stacpoole, P.W.2    Williamson, J.3
  • 25
    • 0027160548 scopus 로고
    • Elevation of serum cystathionine levels in patients with cobalamin and folate deficiency
    • Stabler SP, Lindenbaum J, Savage DG, Allen RH. Elevation of serum cystathionine in patients with cobalamin and folate deficiency. Blood 1993;81:3404-13. (Pubitemid 23172927)
    • (1993) Blood , vol.81 , Issue.12 , pp. 3404-3413
    • Stabler, S.P.1    Lindenbaum, J.2    Savage, D.G.3    Allen, R.H.4
  • 26
    • 0027515431 scopus 로고
    • Serum betaine, N,N-dimethylglycine and N-methylglycine levels in patients with cobalamin and folate deficiency and related inborn errors of metabolism
    • Allen RH, Stabler SP, Lindenbaum J. Serum betaine, N,N-dimethylglycine and N-methylglycine levels in patients with cobalamin and folate deficiency and related inborn errors of metabolism. Metabolism 1993;42:1448-60.
    • (1993) Metabolism , vol.42 , pp. 1448-1460
    • Allen, R.H.1    Stabler, S.P.2    Lindenbaum, J.3
  • 27
    • 0037053284 scopus 로고    scopus 로고
    • Disruption of choline methyl group donation for phosphatidylethanolamine methylation in hepatocarcinoma cells
    • DeLong CJ, Hicks AM, Cui Z. Disruption of choline methyl group donation for phosphatidylethanolamine methylation in hepatocarcinoma cells. J Biol Chem 2002;277:17217-25.
    • (2002) J Biol Chem , vol.277 , pp. 17217-17225
    • DeLong, C.J.1    Hicks, A.M.2    Cui, Z.3
  • 28
    • 0030044041 scopus 로고    scopus 로고
    • Expression of phosphatidylethanolamine N-methyltransferase-2 is markedly enhanced in long term choline-deficient rats
    • Cui Z, Vance DE. Expression of phosphatidylethanolamine N-methyltransferase-2 is markedly enhanced in long term choline-deficient rats. J Biol Chem 1996;271:2839-43.
    • (1996) J Biol Chem , vol.271 , pp. 2839-2843
    • Cui, Z.1    Vance, D.E.2
  • 29
    • 0033569752 scopus 로고    scopus 로고
    • Molecular distinction of phosphatidylcholine synthesis between the CDP-choline pathway and phosphatidylethanolamine methylation pathway
    • DeLong CJ, Shen Y-J, Thomas MJ, Cui Z. Molecular distinction of phosphatidylcholine synthesis between the CDP-choline pathway and phosphatidylethanolamine methylation pathway. J Biol Chem 1999;274:29683-8.
    • (1999) J Biol Chem , vol.274 , pp. 29683-29688
    • DeLong, C.J.1    Shen, Y.-J.2    Thomas, M.J.3    Cui, Z.4
  • 30
    • 0242577796 scopus 로고    scopus 로고
    • Phosphatidylethanolamine N-methyltransferase activity and dietary choline regulate liver-plasma lipid flux and essential fatty acid metabolism in mice
    • Watkins SM, Zhu X, Zeisel SH. Phosphatidylethanolamine N-methyltransferase activity and dietary choline regulate liver-plasma lipid flux and essential fatty acid metabolism in mice. J Nutr 2003;133:3386-91.
    • (2003) J Nutr , vol.133 , pp. 3386-3391
    • Watkins, S.M.1    Zhu, X.2    Zeisel, S.H.3
  • 31
    • 0037364454 scopus 로고    scopus 로고
    • Homocysteine-betaine interactions in a murine model of 5,10-methylenetetrahydrofolate reductase deficiency
    • Schwahn BC, Chen Z, Laryear MD, et al. Homocysteine-betaine interactions in a murine model of 5,10-methylenetetrahydrofolate reductase deficiency. FASEB J 2003;17:512-4.
    • (2003) FASEB J , vol.17 , pp. 512-514
    • Schwahn, B.C.1    Chen, Z.2    Laryear, M.D.3
  • 32
    • 0021867328 scopus 로고
    • Inhibition of glycine N-methyltransferase activity by folate derivatives: Implications for regulation of methyl group metabolism
    • DOI 10.1016/S0006-291X(85)80006-1
    • Wagner C, Briggs W, Cook R. Inhibition of glycine N-methyltransferase activity by folate derivatives: implications for regulation of methyl group metabolism. Biochem Biophys Res Commun 1985;127:746-52. (Pubitemid 15037591)
    • (1985) Biochemical and Biophysical Research Communications , vol.127 , Issue.3 , pp. 746-752
    • Wagner, C.1    Briggs, W.T.2    Cook, R.J.3
  • 33
    • 0343049169 scopus 로고    scopus 로고
    • Inhibition of glycine N-methyltransferase by 5-methyltetrahydrofolate pentaglutamate
    • Yeo EJ, Briggs WT, Wagner C. Inhibition of glycine N-methyltransferase by 5-methyltetrahydrofolate pentaglutamate. J Biol Chem 1999;274:37559-64.
    • (1999) J Biol Chem , vol.274 , pp. 37559-37564
    • Yeo, E.J.1    Briggs, W.T.2    Wagner, C.3
  • 34
    • 0033038503 scopus 로고    scopus 로고
    • Mass isotopomer distribution analysis at eight years: Theoretical, analytic and experimental considerations
    • Hellerstein MK, Neese RA. Mass isotopomer distribution analysis at eight years: theoretical, analytic and experimental considerations. Am J Physiol 1999;276:E1146-70.
    • (1999) Am J Physiol , vol.276
    • Hellerstein, M.K.1    Neese, R.A.2


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